CN1526409B - Medicated food for preventing and treating several kinds of diseases such as: alcoholism, fatty liver, diabetes and its making process - Google Patents

Abstract

The present invention is medicine and food product for preventing and treating several kinds of diseases and its making process. The medicine and food product is one composition of essential fatty acid, composite vitamins, carnitine and nucleic acid; and is used as the material for producing food products, especially slimming food, as well as beverage, seasoning, health article, cosmetics, medicine, etc. The present invention can eliminate alcohol harm fast and radically, reduce cholesterol, saturated fatty acid and fat stored in body, reduce weight without rebound, and prevent and treat fattyliver, diabetes, cardiac and cerebral vascular diseases, etc.

Description

Do not have bounce-back control ethanol and poison fat fat glycogen urine cardiovascular and cerebrovascular disease dietotherapeutic nutriment and manufacture method

Background technology:

Beverage is consumer groups and the great consumer goods of consumption figure in people's daily life, its kind and classification numerous and complicated, but whether contain ethanol by it and can be divided into non-alcoholic drink and pick-me-up two big classes, therefore we can say everybody, all be its consumer everyday, because beverage comprises that all kinds of drinking waters itself that meet national drinking water standard all are good beverages as boiled water, pure water, mineral water etc., and not only be meant to have solute or solute also need reach certain density beverage, and generally speaking, common people can drink water every day; On the other hand, along with constantly improving of people's economy, the consuming capacity, people drink more and more and contain solute beverage especially alcoholic beverage such as medicated beer, fruit wine, Chinese liquor and amount is also increasing, history of drinking history is also more and more longer, suffer from numerous disease unconsciously, fall many old complaints such as various acute and chronic alcoholism, fatty liver etc., especially acute alcoholism, rescue that untimely meeting is rapidly dead, What is more and then have little time maybe can't rescue at all and dead immediately, this paints an alarming picture of the situation just to scare the audience absolutely not, because such incident and relevant reporting for work not are rare; The continuing to drink of existing these diseases then increased the weight of the state of an illness and most prognosis is bad, mortality rate is high as the alcoholic fatty liver prognosis is good mostly but as develop into alcoholic hepatitis then prognosis be just poor far beyond fatty liver: about 50% case fatality rate that can develop into liver cirrhosis and critically ill patient in 10-13 is above 40%, and merging hepatitis person prognosis is the poorest.

Except that alcoholic beverage and harm thereof, also have various diseases that serious equally day by day long-term diet energy surplus causes such as obesity, fatty liver, diabetes, cardiovascular and cerebrovascular disease etc., these diseases that even more serious is are interrelated, exist each other and develop deterioration basic.This is because liver organ is a big chemical plant, participates in the synthetic and metabolism of diversified chemical substance in the body, and lipid also is one of them; Overheap in liver forms fatty liver if energy surplus will make fat, serious in addition reach the liver weight in wet base more than 50%, the serious various normal functions of liver that reduce, further add various pathological changes conversely again and deepen the various state of an illness obesity, cardiovascular and cerebrovascular disease such as hyperlipemia, arteriosclerosis and diabetes etc. as the aforementioned, thereby form vicious cycle.

This shows, ethanol and diet energy surplus all are to cause fatty liver and arch-criminal fat as " beer belly " and a large amount of relevant diseases thereof, the two conversion in the metabolic similar process of liver self-energy, excess energy is that fat is also identical with the product of storage, promptly has the common general character, but ethanol causes protein denaturation and anesthetic action, its degraded intermediate product acetaldehyde etc. to also have strong toxicity in addition immediately, so the hazardness of the ethanol energy surplus more simple than meals is bigger also faster, prognosis is also poorer, so more answer guard key.

Obviously, remove immediately or alleviate significantly that ethanol is poisoned and the control fatty liver is that control comprises fatty liver this key and point of penetration promptly so-called " to catch brigands, first catch their king " in interior serial relevant disease.Though existing many medicines can be prevented and treated fatty liver, fact proved it nearly all is " curing the symptoms, not the disease ", and comprise that Chinese medicine all has serial toxic and side effects conscientiously to be propagated and to take precautions against.To this, my clearly proposition in the mandate patent of invention of ZL95113090.0 " control is drunk and the nutrient and the manufacture method of treatment of fatty liver caused and fat-reducing " " the highly seasoned serious side effect such as wind syndrome due to invasion of wind when drinking lattice that changed of Chinese medicine color depth " and " Chinese medicine be difficult to inherent shortcoming such as qualitative and quantitative analysis, the more difficult noxious substance of illustrating between each composition and may comprise the mechanism of action of human body etc. and toxicological effect thereof and be difficult to " in the popularization and application of many countries and regions; I still clearly point out emphatically in the mandate patent of invention of ZL98112238.8 " preventing and treating the medicine food cosmetic dual-purpose nutrient and the manufacture method of irritated mottle senility and obesity " " in the plant extraction liquid between some compositions and the heterogeneity and not clear, a lot of natural components itself that interact be exactly anaphylactogen, particularly natural component may contain equally noxious substance, therefore should correct have only natural component just can guarantee pure safe, all good etc. fact proved it is wrong viewpoint with natural ".These academic viewpoints that I have just proposed have many years ago obtained academia now and press extensively admits, report Chinese medicine and antibiotic as Xinhua News Agency Beijing JIUYUE in 2003 (reporter Duan Shiwen) on the 21st, the famous Chinese medicine PAIDU YANGYAN JIAONANG that antipyretic analgesic has become adverse drug reaction " three big chief culprits " and for example billions of yuans of the whole nation year production and marketing causes constipation and medicine (primary raw material Radix Et Rhizoma Rhei and Natrii Sulfas) dependency to illustrate that many expert calls " must change the outdated ideas of Chinese medicine safe without toxic side effect " and State Food and Drug Administration (FDA) issues in " package insert and tag control are stipulated " exposure draft and requires the Chinese medicine description should list untoward reaction in detail, the order of severity, important the arranging property of occurrence frequency or symptom system and necessity promptly from now on the Chinese medicine description also must to write " untoward reaction " exactly be toxic and side effects, so preventing and treating these diseases at present mainly must go on a diet and alleviating alcohol addiction by active, this just was difficult to allow most of people accept originally, more be difficult to " persevering ", because the fact proves patience and the willpower that majority are for want of enough repeatedly, quick-actingly take the fast method that intereferes seriously with health and product and be difficult to adhere to for a long time abandoning midway for pursuing, cause losing weight and alleviating alcohol addiction is made great efforts dies young or multiple fat, drink again and rebound; A few peoples " are possessed by the Devil " again, excessively make healthy irreversible lesion even death or alleviating alcohol addiction excessively sweep happy interest and the increase worried pressure such as remove difficulties and alleviate sufferings of celebrating joyously of a large amount of happinesses such as kith and kin's party because of going on a diet.Except that medicine, the operation as the cut-out the intestines and stomach with the minimizing energy matter the ability of digesting and assimilating to reduce fatty reserves, liposuctions etc. also can be removed superabundant fats, but these are cured the symptoms, not the disease especially and are the methods of seriously putting the cart before the horse, because these just typical " trimming the feet to fit the shoes ", a bit fail to stop, destroy any key and the key of lipogenesis, its side effect, sequela and consequence thereof are also very serious and be difficult to reverse part excision as the intestines and stomach, liposuction is unbalanced cause uneven, subcutaneous and the critical life of internal organs congestion severe patient, the operation receiveing person also has to bear the unavoidable huge misery brought because of operation and fear etc. to lose more than gain.

To sum up state, we think that these facts, reason and evidence suffice to show that human prior art do not have the specially good effect of effecting a permanent cure control medicine to serial diseases such as fatty livers, more do not have the well accepted dietotherapeutic product of people; Not only be difficult to lastingly, also be difficult to realize by people's active, also against consumers will and interests and objectively limited the development of consumption market and the enforcement of serial great state basic policies such as agricultural restructuring such as unfavorable national production and marketing profits tax, the industry of developing animal husbandry and suckle and increasing peasant income.

Goal of the invention and main theory and the innovation that intergrates with practice are the advantage brief introduction:

Purpose of the present invention is exactly to research and develop a kind of nothing bounce-back control ethanol and poison fat fat glycogen urine cardiovascular and cerebrovascular disease dietotherapeutic nutriment and manufacture method at the deficiency of human prior art, design also adopts the common segment glycerol of removing fat effectively to prevent the fat-reducing bounce-back and reach the purpose of effecting a permanent cure with blocking-up fatty acid synthctic fat again, and the micromolecule fatty acid that makes macromolecular triglyceride become single molecule after being removed because of glycerol is more conducive to infiltrate through skin or digests and assimilates into blood and makes corresponding pharmaceutical effectiveness better, rapider, also safer, because micromolecular antigenicity is little far beyond macromole, and its delivery, it is also more flexible to turn round, convenient, easily; Burden and harm to liver also significantly reduce, because the processing of triglyceride in liver be take off in branch three step fatty acid chain be per step reaction can only take off a fatty acid chain, so need just can finish the work for three times, liver is handled the burden of fat fatty acid is big three times than handling in other words, this is conspicuous; In addition, and since aforesaid because of having removed glycerol in advance, fundamentally taken precautions against the synthetic and accumulation of fat in liver, thus fundamentally taken precautions against fatty liver.Have again, though sugar and protein metabolism also can produce and provide the glycerol of synthctic fat, but fact proved that it is not the main source of the required glycerol of synthctic fat after all, because these metabolism and product thereof are mainly used in and preferentially satisfy the needs of energy metabolism and synthetic human body structural material, so only need the intake of suitable these foods of control just to be easy to control the synthetic quantity of glycerol, and this intake of controlling fat is come much easier, because the heat energy of fat (9000 kilocalories/gram) is sugar, more than one times of property food of starch and protein (4000 kilocalories/gram), and because of fat is not moisture is pure energy matter, so its effective volume also only has only the 1/4-8 (staple food such as daily meal on average is about 1/4-6, and liquid milk and non-alcoholic energy drink etc. is about 1/8-100) of sugar and starch food.In addition, the present invention is also comprehensive from many aspects to be replenished or strengthens inside and outside favorable factor to strengthen and the innovation effect, sees for details following.

The main scientific and technological principle of foundation of the present invention and other major advantage of the present invention briefly introduce as follows:

1, the place of human consumption fat is that the enzyme of small intestinal, digestion fat is a pancreatic lipase.Because of enzyme has strict Substratspezifitaet, pancreatic lipase is no exception, be can only hydrolyzed fat be 1 ester bond of triglyceride once as previously mentioned, must not die to be regardless of and triglyceride thoroughly could be degraded into three molecules of fatty acids and a part glycerol three times and be absorbed and go into liver and transform or utilize, through transforming or waiting the synthetic fat of other materials to be transported to that fatty tissue is stored or transport directly to fatty tissue without liver stores by sugar through the hepatic portal arteries and veins.But this suitable short chain (C8 is following) fatty acid, the then difficult thoroughly hydrolysis of the triglyceride of moderate-length (C8-C12) and above chain fatty acid, and the glycerol that long-chain fatty acid goes out with hydrolysis with long-chain fatty acid at intestinal wall in the part again synthetic glycerine three esters enter the digestion program once more and make digestive system produce the duplication of labour and tasteless increase digestive system burden; After long-chain fatty acid and glyceride thereof absorb, major part synthetic glycerine three esters and repeat the digestion again work of above-mentioned medium-chain fatty acid again on the endoplasmic reticulum of intestinal mucosa cells, finally go into blood plasma with triglyceride and a small amount of diglyceride and monoglyceride form, also through liver or directly transport the fatty tissue storage to, the fraction fatty acid then in order to esterified cholesterol form the cholesteryl ester be difficult to absorb (must be hydrolyzed into cholesterol and just can be absorbed, this mechanism help reducing excessive cholesterol enters human body and to the harm of human body).

On the other hand, when human body lacked the energy, the fat in the fatty tissue was become free fatty acid and glycerol by lipase hydrolysis, is transported to liver or the oxidized utilization of its hetero-organization through blood, and this a whole set of program is called fat and mobilizes.Fatty acid be easy to number of ways such as β-, ω-, α-, the generation of propanoic acid, ketoboidies and oxidised form and oxidized energy supply thoroughly is consumed after using, but glycerol then must form alpha-phosphate glycerol earlier in intracellular utilization again, this needs the activation process of glycerophosphokinase catalyzing glycerol, but this kinase whose activity is very low in muscle and the adipose cell, so it utilizes the ability of glycerol very weak again; In addition, the glycerol that produces during lipid mobilization in the fatty tissue is also main if it were not for being used for the resynthesis triglyceride, is transported into liver and carries out metabolism but follow blood flow.

According to above-mentioned situation, as seen fat-reducing back fatty tissue is bad but be unlikely to be used for again by fatty tissue once again synthctic fat rebounds to the glycerol metabolism that produces because of fat-reducing, is not in fatty tissue that to the metabolism of glycerol and treatment situation how liver so take precautions against key fat and that fat-reducing rebounds.Liver obviously has two kinds to select and the result to this, a kind of is as mentioned above glycerol to be activated to alpha-phosphate glycerol changes into and participates in carbohydrate metabolism from glycometabolic intermediate product dihydroxyacetone phosphate thoroughly to be consumed, so just blocked and continued the essential glycerol of essential condition-synthctic fat fat or bounce-back, thereby fundamentally prevent and treat obesity and just become a reality, because of activation glycerol needs ATP for activation energy, the precursor of ATP is that AMP is purine class nucleotide-adenylic acid, and purine class nucleotide is the IMP-inosinic acid, the AMP-adenylic acid, in human body, can look actual needs and direction in this between the GMP-guanyl automatically and change, because of human body often lacks nucleic acid and nucleotide, so compensation or additional nucleic acid and nucleotide are beneficial to the catabolism of glycerol and are beneficial to fat-reducing; Another kind is exactly that liver and normal function thereof are badly damaged, be exactly that liver function is low in fatty liver in brief, hepatitis, isochronous low liver function level of liver cirrhosis and disposal ability, the liver of this moment not only handle fat and the ability of glycerol not all right, and almost handle all serious influenced and serious decline of all substances metabolism and synthetic ability, again because fat, be addicted to drink and diabetics suffers from the different fatty liver of light and heavy degree more than 50% and its degree becomes positive correlation with the state of an illness, fatty liver often occurs in hepatitis again, before the liver cirrhosis and hepatitis, no matter the liver cirrhosis majority is also followed concurrent fatty liver and individual girth of a garment situation, so it is evident that, prevent and treat obesity or other diseases no matter be, all at first to prevent curing fatty liver, be only the correct road that effects a permanent cure and correct the selection, otherwise glycerol will be in liver again synthctic fat pile up and weight fat hepatopathy feelings and be transported to fatty tissue and further cause and increase the weight of obesity and other diseases.

Therefore; the heavy more liver function of the state of an illness is just poor more; can wilfully be again " misforttunes never come singly "; its fatty liver is also heavy more; cause liver function poorer; thereby formation vicious cycle; but fat must be taken in or do not handled to these people's liver again;, the subcutaneous and internal organs of human body keep the heat pad of body temperature and buffer mechanism bump because can having the preventing excessively heat radiation of fat and neonychium effect that protection internal organs and muscle are avoided damaging; child-bearing period women fat can't be too low, must reach that body weight 20-25% is above could the safety fertility, even otherwise be difficult to also easily miscarriage of pregnancy pregnancy.

For solving these conflicting difficult problems, these crowds of fatty acid supplying that glycerol is removed in the present invention's design replace fat to use, these difficult problems have just been solved well, all sidedly, because human body is requisite is fatty acid but not glycerol, do not have unnecessary glycerol also just unnecessary fat can not be arranged, so the problem of fatty liver and obesity just is readily solved and the method for effecting a permanent cure; In addition, the fatty required glycerol of the energy reserve of above-mentioned needed by human, can change into alpha-phosphate glycerol by aforesaid carbohydrate metabolism intermediate product dihydroxyacetone phosphate produces, and these reactions be reversible can automatic view volume in actual demand amount and direction regulate the conversion direction automatically, therefore, as previously mentioned, the absorption quality and quantity that we can be full diet by suitable control sugar and starch is relatively easily effectively regulated and control, even if function is normal and the also normal liver of work load, for avoiding increasing pathogenesis of fatty liver rate, so work is also necessary, because anti-overweighting controlled, prevent trouble before it happens.So these measures are one of important component parts of the great innovation advantage of the present invention series, and be applicable to that any crowd all gains everything and lose nothing.

2, since body fat except that only accounting for a fraction of glycerol of fat molecule, so its main amount partial fatty acid is transformed into the difficult transformation of acetone acid saccharogenesis because of its main metabolites S-acetyl-coenzyme-A can not drive in the wrong direction; Though and sugar can change fat into, but at first must be used to satisfy energy i (in vivo) metabolism and consumption, so as long as the i.e. excessive food consumption not of normal diet, do not have unnecessary sugar generally speaking, also just can not produce superabundant fats; And non-as previously mentioned fat food also is lower than fat and dies that this accomplishes than being easier to more 1 times because of containing big, the sugared energy of large quantity of moisture volume.Therefore the present invention has not only ensured the supply of the normal desired fats of human body, generation and the development that the while has been avoided serial diseases such as fatty liver and obesity again by the fatty acid form.

3, preceding liver and the fatty tissue addressed is that triglyceride is the most active position of lipogenesis, mucous membrane of small intestine also a large amount of again synthctic fats after lipid absorbs, but before add bright fatty tissue and be difficult to utilize again pure glycerin synthctic fat again, so liver and small intestinal have just become to utilize the main place of glycerol synthctic fat, but small intestinal just to food fat recombinate that is all, be ectogenic and the present invention just can effectively be stoped, itself do not breed create fatty; Liver is then different, it can be by being that start anew synthetic fatty acid and glycerol of raw material creates increment fat with sugar, so the obesity of control and relevant disease at first will be controlled the excessive absorption of sugar, but food is limit in inconvenience by force again as previously mentioned, therefore replace the fatty body that not only not only can ensure to the normal need of fat but also can prevent adipose hyperplasia with the fatty acid of no glycerol, also carry out oxidative metabolism and supply with need of body portion of energy and lower requirement and the intake of body, thereby effectively prevented and treated relevant diseases such as obesity and fatty liver sugar because of the superabundant fats acid that comprises generation such as fat-reducing.So this also is of the present invention one contribution greatly.

4, mobilize extremely strongly again under the situation of lasting and liver function decline, high fat diet, diabetes, pregnancy, vegetarian diets etc. such as other situation such as fatty liver at long-term hungry fat, significant quantities of fat, fatty acid and glycerol transport into liver, surpass transhipment and the disposal ability of liver and accumulate and synthetic again also accumulate in liver, cause fatty liver, be fatty liver then increase the weight of its state of an illness.The present invention removes the glycerol in the food, the generation of the dystrophic fatty liver that had both ensured the supply of normal fat of human body (glycerol can from carbohydrate metabolism) and fatty acid and avoided causing, blocked increment and synthesize the approach of new fats and be beneficial to remain valid and consume in the liver apace and accumulative superabundant fats the be highly advantageous to prevention and the treatment of relevant disease in the body because of hungry, vegetarian diet and these diseases, thereby obesity, fatty liver and harm thereof have effectively been taken precautions against, because precedingly said the simple fatty liver prognosis bona, there is not serious sequela.So this is again that the more and more higher sickness rate of of the present invention one big advantage, particularly dystrophic fat liver has been general and serious problem.

5; because ethanol and lipid metabolism need some special vitamin; one carbon-based group is a methyl; carnitine participates in; especially the interior content of triglyceride of back liver of drinking can improve 3-14 doubly; the significant quantities of fat of taking food again simultaneously of drinking will be more serious; eat i.e. " jorum wine; joint " the exactly often mutual again companion of being of meat and drink; encourage PD more and cause many new diseases; so more need these materials to prevent fatty degeneration of liver such as vitamin B2; prevent hepatic fibrosis such as vitamin A; class is square-bottomed bamboo basket Bu Su recklessly; help transports superabundant fats such as methyl from the liver transfer; increase liver detoxification ability such as vitamin C; protection hepatocyte such as vitamin E; strengthen fatty acid and transport into mitochondrion oxidative metabolism such as carnitine, the present invention has given comprehensive arrangement and has solved.The product raw material is greatly simplified among more aforesaid ZL95113090.0 of the present invention and the ZL98112238.8, this has important in theory and practical application meaning more, because complicated more its production technology of prescription is also complicated more, the production cycle is also long more, the equipment input is also big more, production and management cost will heighten; In addition; quality inspection project and internal control index are also very complicated; shelf life of products and shelf life are therefore short all the better; because of keeping forging ahead and more effective protection consumer's interests in the also very unfavorable market of increasing of above-mentioned multinomial integrated cost; it is just little to consumer and distributor's profit margin to make concessions as cost up, all unfavorable to production and marketing merchant and consumer.

6, because satisfied fatty acid is to cause fatty liver, angiosclerotic one of the main reasons, what promptly lack in the human body is unsaturated fatty acid; Again because the interior monounsaturated fatty acid of body is that oleic acid is up to more than 70% of human body storage fat, so shortage is polyunsaturated fatty acid; Because except that essential fatty acid is linoleic acid plus linolenic acid, can synthesize voluntarily in the remaining body in the polyunsaturated fatty acid, so the real shortage of human body is that essential fatty acid is a linoleic acid plus linolenic acid.But this two big class fat all contains glycerol, can breed the generation new fats equally in many occasions, so it is apparent, the product that the more aforesaid ZL98112238.8 of the present invention adopts the various fat of removing glycerol to make has to solve and stops fatty resynthesis, increases that carnitine forces fat oxidation and thoroughly consume, increase the main advantages that methyl significantly improves the more urgent major issues such as ability of serial relevant diseases such as control fatty liver, hyperlipidemia, hypercholesterolemia, and the range of choice of expensive nucleic acid is wideer is beneficial to the rare nucleic acid rational distribution of resources and cost descends; The more aforesaid ZL95113090.0 of the present invention has compensated essential fatty acid, nucleic acid, carnitine, thereby increased the function that serial corresponding great practical application is badly in need of, and more succinct, the emphasis effect of filling a prescription is given prominence to, is beneficial to heavy industrialization and transforms and implement, and the vitality that these are invented just institute promotes scientific and technological industry progress and development to be applied as purpose shortly, benefits consumer and serve as country's creation economic and social benefit.

7, human body not only needs fat (variable lipid) energy storage, also needs lipoid (elemental lipid) more important as organization part and very stable event as phospholipid, cholesterol etc., as limit food fat then also to limit and eaten lipoid, because they are present in the one in the ordinary course of things.The present invention does not have glycerine fatty acid and has not only remedied these defectives but also lose weight and can effectively prevent to lose weight and rebound, and achieves many things at one stroke.

8, because the height specificity of enzyme, be strict by three fatty acids order substeps on it, once fatty acid chain of a hydrolysis is a diglyceride when its hydrolyzing triglyceride, monoglyceride again, last complete hydrolysis becomes glycerol and fatty acid, and always elder generation is 1,3, back 2 (transferring to 1,3) order is hydrolyzed, so be easy to obtain pure fatty acid and glycerol, also is easy to obtain arbitrary net product in three aliphatic chains.This just for some overall nutritive values not high but wherein certain bar fatty acid chain again the utilization of valuable especially lipid reasonable resources created implementation condition and cost also low, because other compositions can be made the purposes of other non-edible purposes, during as industrial use etc., on the contrary can do when edible to be shortcoming become industrial use the time advantage, as being vegetable oil equally, high erucic acid to edible bad but high more good more when industrial, vice versa; And for three chains lipid of very nutritious value all, finish hydrolysis with then can selecting not have the single-minded optionally enzymic disposable in position, to simplify technology as saving substep and extract and favourable reduction raw materials consumption and cost such as separating.

Implement the concrete scheme of the present invention:

The present invention does not have bounce-back control ethanol and poisons fat fat glycogen urine cardiovascular and cerebrovascular disease dietotherapeutic nutriment by compound complete essential fatty acid, compound vitamin, and compound methyl, carnitine, nucleic acid is formed.

The raw material that nothing bounce-back control ethanol is poisoned fat fat glycogen urine cardiovascular and cerebrovascular disease dietotherapeutic nutriment is by weight:

Compound complete essential fatty acid 10-30 part

Compound vitamin 0-5 part

Compound methyl 0-5 part

Carnitine 0-1 part

Nucleic acid 0-5 part

Wherein, compound complete essential fatty acid is made up of linoleic acid, linolenic acid; Compound vitamin is by vitamin A, B ₂, C, E form; Compound methyl is made up of choline, methionine; Nucleic acid molecule DNA, RNA single with or shared, the micromolecule nucleotide list with or shared but must contain at least a in purine class nucleotide AMP, IMP, GMP, the inosine; Or the derivant of using the identical physiological function of tool of GB2760 and GB14880 approval substitutes said vitamin, methyl, nucleic acid or share, and consumption is by the conversion of tiring of active substance and physiology.

The manufacture method that nothing bounce-back control ethanol is poisoned fat fat glycogen urine cardiovascular and cerebrovascular disease dietotherapeutic nutriment is as follows:

1) preparation of compound complete essential fatty acid: get the linoleic fatty acids 8-25 part more than the food stage, the linolenic acid fatty acid 2-5 part more than the food stage respectively in sterilizing room, join in the rustless steel container of belt stirrer, 20-60 rev/min was stirred 3-5 minute, it is fully dissolved each other evenly, and airtight preservation is standby;

2) preparation of compound vitamin: take by weighing by VA0.001-0.01 part, VB2 0.1-0.3 part, VC1-2 part, VEI-2 part in sterilizing room, in the rustless steel mortar porphyrize 2-4 minute, fully grind well and be paste, airtight preservation is standby;

3) preparation of compound methyl: take by weighing by choline 1-2.5 part, methionine 1-2.5 part in sterilizing room, in the rustless steel mortar porphyrize 2-4 minute, it was standby fully to grind well airtight preservation;

4) there is not the preparation that bounce-back control ethanol is poisoned fat fat glycogen urine cardiovascular and cerebrovascular disease dietotherapeutic nutriment: in sterilizing room, with compound complete essential fatty acid, compound vitamin, compound methyl, carnitine, nucleic acid are pressed the formula proportion weighing, in having the stainless steel equipment of agitator, stirred 5-10 minute with 20-40 rev/min rotating speed, fully mixing product.

Do not have bounce-back control ethanol and poison the purposes of fat fat glycogen urine cardiovascular and cerebrovascular disease dietotherapeutic nutriment: as producing the particularly host of weight-reducing product, beverage, flavoring agent, health product, cosmetics, medicine and these products of food, consumption needs to use by the GMP-ordinary production.

Embodiment:

1, in sterilizing room, get compound complete essential fatty acid 10-30 part respectively, compound vitamin 1-5 part, compound methyl 1-5 part, carnitine 0.1-1 part, nucleic acid 1-5 part in having the stainless steel equipment of agitator, was stirred 5-10 minute with 20-40 rev/min rotating speed, fully mixing product, the reuse capsule is sealed to the oily ball of different size, weight and outward appearance, or is distributed into the flexible package punch of different size, weight and outward appearance, gets commodity diet food and medicine or host.Consumption is by normal need, and no dosage and crowd's restriction, but consider from economy and effect advise that 10-30 restrains for each person every day, and very few poor effect, excessive fat-reducing are too fast, all are unfavorable for health.Should advocate the relevant disease of science health slimming and control series,, also should not act with undue haste because obesity is " Rome is not build in one day ".

2, in sterilizing room, get compound complete essential fatty acid 1-3 part respectively, compound vitamin 0.1-0.5 part, compound methyl 0.1-0.5 part, carnitine 0.01-0.1 part in having the stainless steel equipment of agitator, was stirred 5-10 minute with 20-40 rev/min rotating speed, fully mixing beverage host, be used for beverage and particularly contain alcoholic beverage to remove ethanol and poison and to improve quality and taste flavor.Consumption is the ordinary production needs by GMP.

3, in the sterilizing room, get compound complete essential fatty acid 3-10 part respectively, compound vitamin 1-3 part, compound methyl 1-2 part, carnitine 0.1-1 part, flavour nucleotide such as purine class inosinic acid and miazines uridylic acid 1-5 part, in having the stainless steel equipment of agitator, stirred 5-10 minute with 20-40 rev/min rotating speed, fully mixing product, be used for flavoring agent and host, consumption needs by ordinary production.Nucleic acid in this example mainly be increase bright thus require soluble in water, so needn't be with other expensive nucleotide, because similar nucleotide is interconvertible in vivo with flavour nucleotide.

4, in sterilizing room, get compound complete essential fatty acid 10-20 part respectively, compound vitamin 1-2 part, compound methyl 1-2 part, carnitine 0.1-1 part, the micromolecule nucleoside is inosine 1-2 part, in having the stainless steel equipment of agitator, stirred 5-10 minute with 20-40 rev/min rotating speed, fully mixing product, be used for health product and cosmetics and host, consumption needs by ordinary production.Nucleic acid in this example mainly is subcutaneous and the heart, brain and internal blood vessel treatment, event requires soluble in water and strong penetration capacity is arranged, so with the micromolecule inosine and needn't be with other expensive nucleotide because the penetration capacity of inosine surpasses the inaccessiable nowhere general energy matter ATP-adenosine triphosphate of body, be unique nucleic acid material that can penetrate skin replacement ATP activating cell and remove cell fatigue.

The present invention's science and technology principle and advantage are replenished as follows:

1, rapidly thoroughly relieving alcohol harm of the present invention. Because essential fatty acid, vitamin and methyl can both linksystem for alcohol and various mesostate thereof make corresponding fast reaction such as anti-oxidant, stop and be converted into fat and be stored in the liver, make it towards energy supply and the conversion of composite structure material direction etc.

2, the present invention can effectively reduce cholesterol fast. Because cholesterol metabolic and transport out blood vessel and liver and need a large amount of essential fatty acids, vitamin and methyl activation in order to change and drainage, otherwise cholesterol will increase, cause fatty liver (3/4 cholesterol is synthetic by liver, food only account for 1/4), atherosclerotic, severe diabetes mellitus, kidney and syndrome etc., so the present invention is beneficial to these diseases of control.

3, the present invention can effectively reduce saturated fatty acid fast. Because the metabolism of saturated fatty acid needs the participation of a large amount of essential fatty acids, methyl and carnitine. Enter the function that mitochondria could oxidation such as the transhipment LCFA of carnitine, otherwise oxidation will be blocked, LCFA will be used to again synthctic fat; The metabolism of cholesterol and transhipment and saturated fatty acid contention essential fatty acid and methyl such as undersupply, will have a strong impact on simultaneously both eubolisms and cause above-mentioned various identical with similar serial disease.

So 4, the present invention can effectively reduce human body depot fat fat-reducing rapidly fast. Because oleic acid accounts for more than 70% of human body depot fat as previously mentioned, so fat main cause is that oleic acid is too many, the difficulty of losing weight with glycerine again synthctic fat easily again and rebounding easily, the aliphatic acid that adds no glycerine can force oleic acid be difficult to restore the effect that reaches outstanding fat-reducing and control Series correlation disease for fat, and need not to consider the whereabouts of essential fatty acid and the problem such as no side effect is arranged, because human body has lacked essential fatty acid very much, safeguard the skin with huge surface area such as human body only, mucous membrane, cell membrane and nerve center tissue just need a large amount of essential fatty acids, seriously supply falls short of demand often, unable to make ends meet, cause numerous disease such as dermatitis, neuritis etc. and be difficult to cure, because lacked the disease that causes by essential fatty acid, also can only could be treated and cure by essential fatty acid, and human body can not synthesize essential fatty acid, content also seldom in the food, comprise that various edible oils commonly used all are difficult to accomplish complete essential fatty acid and guarantee enough content, so the present invention is also very outstanding and important with respect to the advantage of existing edible oil, as can be used for improving its quality, strengthen its health care and effect.

5, all the components of the present invention all is that the state approval medicine-food two-purpose does not have again having no side effect of medicine, and safe and reliable cost saving effect is grand, and various component and effect is clear and definite again complementary, the comprehensive whole structure of having strengthened. The speed that participates in relieving alcohol harm such as vitamin and alcohol synchronously, carnitine participate in aliphatic acid that running comprises that alcohol metabolism produces also and rapidly, nucleic acid goes back repair cell damaged dna raising cell viability except fat-reducing is and helps rehabilitation, methyl and essential fatty acid balance cholesterol and the fatty eubolism of numerous disease and be the important source material of lipoid and hormone such as prostaglandin.

Claims (3)

1. do not have bounce-back control ethanol and poison fatty liver disease diabetes cardiovascular and cerebrovascular disease dietotherapeutic nutriment, it is characterized in that raw material is by weight:

Compound complete essential fatty acid 10-30 part

Compound vitamin 0-5 part

Compound methyl 0-5 part

Carnitine 0-1 part

Nucleic acid 0-5 part

Wherein, compound complete essential fatty acid is made up of linoleic acid, linolenic acid; Compound vitamin is by vitamin A, B ₂, C, E form; Compound methyl is made up of choline, methionine; Nucleic acid molecule DNA, RNA single with or shared, the micromolecule nucleotide list with or shared but must contain at least a in purine class nucleotide AMP, IMP, GMP, the inosine; Or the derivant of using the identical physiological function of tool of GB2760 and GB14880 approval substitutes said vitamin, methyl, nucleic acid or share, and consumption is by the conversion of tiring of active substance and physiology.

2. claim 1 does not have the manufacture method that bounce-back control ethanol is poisoned fatty liver disease diabetes cardiovascular and cerebrovascular disease dietotherapeutic nutriment, and is as follows:

1) preparation of compound complete essential fatty acid: get the linoleic fatty acids 8-25 part more than the food stage, the linolenic acid fatty acid 2-5 part more than the food stage respectively in sterilizing room, join in the rustless steel container of belt stirrer, 20-60 rev/min was stirred 3-5 minute, it is fully dissolved each other evenly, and airtight preservation is standby;

2) preparation of compound vitamin; Take by weighing by VA0.001-0.01 part, VB20.1-0.3 part, VC1-2 part, VE1-2 part in sterilizing room, in the rustless steel mortar porphyrize 2-4 minute, fully grind well and be paste, airtight preservation is standby;

3) preparation of compound methyl: take by weighing by choline 1-2.5 part, methionine 1-2.5 part in sterilizing room, in the rustless steel mortar porphyrize 2-4 minute, it was standby fully to grind well airtight preservation;

4) there is not the preparation that bounce-back control ethanol is poisoned fatty liver disease diabetes cardiovascular and cerebrovascular disease dietotherapeutic product: in sterilizing room, with compound complete essential fatty acid, compound vitamin, compound methyl, carnitine, nucleic acid are pressed the formula proportion weighing, in having the stainless steel equipment of agitator, stirred 5-10 minute with 20-40 rev/min rotating speed, fully mixing product.

3. claim 1 does not have the purposes that bounce-back control ethanol is poisoned fatty liver disease diabetes cardiovascular and cerebrovascular disease dietotherapeutic nutriment: as the host of producing weight-reducing product, beverage, flavoring agent, health product, cosmetics, medicine and these products, consumption needs to use by ordinary production.