CN109745359A - Be conducive to keep blood glucose balance and prevent diabetes and its composition of complication and preparation method thereof - Google Patents

Be conducive to keep blood glucose balance and prevent diabetes and its composition of complication and preparation method thereof Download PDF

Info

Publication number
CN109745359A
CN109745359A CN201910175836.8A CN201910175836A CN109745359A CN 109745359 A CN109745359 A CN 109745359A CN 201910175836 A CN201910175836 A CN 201910175836A CN 109745359 A CN109745359 A CN 109745359A
Authority
CN
China
Prior art keywords
parts
blood glucose
conducive
extract
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910175836.8A
Other languages
Chinese (zh)
Inventor
殷书梅
林新艳
储殷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201910175836.8A priority Critical patent/CN109745359A/en
Publication of CN109745359A publication Critical patent/CN109745359A/en
Pending legal-status Critical Current

Links

Abstract

Be conducive to keep blood glucose balance and prevent diabetes and its composition of complication and preparation method thereof, including following parts by weight of component: 20-400 parts of Gymnema sylvestre extract, be conducive to blood glucose balance plant or 20-400 parts of animal extracts, 20-400 parts of antioxidant, 0.1-20 parts of biotin.The extract for being conducive to blood glucose balance is selected from: one or more of the plant extracts such as cortex cinnamomi, faenum graecum, balsam pear, mulberry leaf, pueraria lobata or chitosan oligosaccharide, chitosan.Antioxidant is one or more of alpha-lipoic acid, vitamin C and/or vitamin E.Each ingredient is mutually cooperateed with by multifactor hypoglycemic mechanism, reaches regulating and controlling blood sugar jointly, reduces fat accumulation, prevents diabete peripheral herve pathology and other complication and other effects.The present composition can be used for any oral preparation, have the crowd of metabolic system obstacle to take suitable for prediabetes and diabetic population, obesity and people with hyperlipidemia etc..

Description

Be conducive to keep blood glucose balance and prevent diabetes and its complication composition and its Preparation method
Technical field
Be conducive to keep blood glucose balance and prevent diabetes and its concurrent the present invention relates to a kind of composition, especially one kind The composition of disease.The invention further relates to the preparation methods of this composition.
Background technique
The common chronic endocrine metabolism disease of diabetes spp, it is closely bound up with living habit.With modern all living creatures The flat raising of running water and the change of eating habit, at present diabetes prevalence sustainable growth.It is shown, is cut according to IDF latest data Only to 2015, in global range, just there is 1 people with diabetes in every 11 adults;There are 3.18 hundred million pre-diabetics, Diabetes prevalence is up to 8.8%, prediabetes illness rate 6.7%;If intervention is not added, to the year two thousand forty, every 10 adults In just there is 1 people to suffer from diabetes, prediabetes crowd is up to 4.81 hundred million;In addition, having nearly one in 4.15 hundred million diabetics Half (46.5%) crowd is not diagnosed.Hundred million dollars of the 12%(6730 of diabetes consumption global medical expense), to the year two thousand forty, diabetes Related medical expense will break through 802,000,000,000 dollars.2017, in Chinese 1.144 hundred million diabetics (20-79 years old), there is 34,100,000 Patient age was more than 65 years old;Diabetes prevalence is 10.9%, and age-standardized illness rate is 9.7%;There are about 84993 patients to die of Diabetes, wherein 33.8% age was less than 60 years old.The most front three country of 20-79 years old 2017 diabetic's quantity point Not Wei China, India and the U.S., diabetic (20-79 years old) quantity is respectively 1.144 hundred million, 72,900,000 and 30,200,000.And Global Children and teenager type 1 diabetes patient populations are about 1,100,000 within 2017, wherein the U.S., India and Brazilian patient populations First three is occupied, China comes the 4th.International Diabetes Federation discloses the 8th edition global diabetes map, the results show that Global diabetes adult patient (20-79 years old) had reached 4.25 hundred million by 2017 from 1.51 hundred million in 2000, increased nearly 2 times.In advance It counts by 2045, diabetic is likely to be breached 6.29 hundred million.
It is the main purpose for the treatment of diabetes that control blood glucose, which avoids complication, long in the treatment of diabetes It is neat using Diabetes Mellitus Knowledge education, dietary therapy, exercise therapy, drug therapy and blood sugar monitoring " five drive carriage " always since phase Also there is the mode using operative treatment obesity II patients with type Ⅰ DM in recent years in the comprehensive treatment that head is gone forward side by side.Wherein diet Control, movement and blood sugar monitoring need to be through entire treatments always, if simple lifestyle modification can not make glycemic control up to standard Further drug therapy should then be started.Therefore drug therapy becomes the most important means for the treatment of diabetes, divides Western medicine, biology Medicine, Chinese patent drug, treatment is based on Western medicine at present.It is oral according to selections such as the blood glucose level of patient, islet function and disease stages Antidiabetic drug and (or) insulin therapy, antidiabetic drug is broadly divided into biguanides according to mechanism of action difference, alpha-glucosidase inhibits Agent (acarbose, voglibose), Insulin secretagogues (sulfonylureas, meglitinide), insulin sensitizer (thiazolidinedione Class), GLP-1 receptor stimulating agent, DPP-IV inhibitor, SGLT2 inhibitor and trypsin class medicine.Although Western medicine hypoglycemic Clear mechanism, significant effect can effectively control blood sugar in diabetic patients index, but there are the drawbacks of be take for a long time can pair Human organ causes irreversible injury, and most of patients there is drug resistance tendency after cause not stop to replace drug, to body and mind and Economy causes centainly to bear.
In the case where taking antihypelipidemic product, taking some health care products together can also for prediabetes crowd or diabetic population Play the effect of control blood glucose.The health care product of country's listing is in the majority based on pueraria lobata, balsam pear, mulberry-leaf extract, external product In then based on balsam pear, green tea, faenum graecum, cortex cinnamomi, Gymnema sylvestre extract, price is relatively domestic universal higher.Prescription of the present invention Using the combination of Chinese and western medical science and nutrition, select Gymnema sylvestre extract and cinnamomum cassia extract, be aided with antioxidant, vitamin and The nutrients such as microelement play respective mechanism of action jointly, play in terms of being shown in control blood glucose through human feeding trial Good effect.
In State Intellectual property right patent database, in number of patent application CN00108854, CN99103588 two pieces patent of invention The treatment that Gymnema sylvestre extract is applied to diabetes is proposed respectively, but prescription is the application of single extract.
Summary of the invention
It is an object of the invention to provide one kind to help to maintain blood glucose balance, prevents the combination of diabetes and its complication Object, while a kind of preparation method of the drug being also disclosed.
In order to achieve the goal above, the present invention is the following technical schemes are provided: one kind helps to maintain blood glucose balance composition Component including following parts by weight: 20-400 parts of Gymnema sylvestre extract, be conducive to plant or the animal extracts 20- of blood glucose balance 400 parts, 20-400 parts of antioxidant, 0.1-20 parts of biotin.
The antioxidant can be the those skilled in the art such as alpha-lipoic acid, vitamin C, vitamin E expect obtain One or more kinds of antioxidants.
The plant or animal extracts for being conducive to blood glucose balance can use: cinnamomum cassia extract, chitosan oligosaccharide, chitosan, calabash The conceivable one kind of the those skilled in the art such as reed bar extract, Bitter Melon P.E, mulberry-leaf extract or kudzu root extract meaning Or the two or more substances conducive to blood glucose balance.
The parts by weight of further preferred component are as follows: 30-300 parts of Gymnema sylvestre extract, 30-300 parts of cinnamomum cassia extract, antioxygen 30-300 parts of agent, 0.1-10 parts of biotin.
The still further preferably parts by weight of component are as follows: 40-200 parts of Gymnema sylvestre extract, 40-200 parts of cinnamomum cassia extract, resist 40-200 parts of oxidant, 0.1-5 parts of biotin.
It preferably, also include the minor metallic element chromium of compound form.Chromium is 0.001-0.100.
Preferably, the trace element chromium in the chromium compound may be from Organic Chromium, Cr-enriched yeast, chromium gluconate, cigarette A combination of one or more in the raw material of other compound forms such as sour chromium, chromium methionine.
It preferably, also include the minor metallic element zinc of compound form.Zn-ef ficiency is 1-10.
Preferably, trace element zinc may be from zinc sulfate, zinc glutamate, zinc acetate, zinc lactate, Portugal in the zinc compound A combination of one or more in other compound form raw materials such as grape saccharic acid zinc, glycine zine, Zinc-rich saccharomyces cerevisiae.
Preferably, the composition also includes Vitamin D3.Vitamin D3 is 0.001-0.015.
Preferably, gymnemic acid content is 5-50% in the Gymnema sylvestre extract.
Preferably, cortex cinnamomi flavones content is 2-20% in the cinnamomum cassia extract.
Preferably, the cinnamomum cassia extract could alternatively be chitosan oligosaccharide, chitosan or faenum graecum, balsam pear, mulberry leaf, pueraria lobata Equal those skilled in the art anticipate conceivable one or more conducive to the substance of blood glucose balance.
Preferably, various dosage forms can be made in the composition, and preparation dosage form needs to increase auxiliary material.
Preferably, the auxiliary material can be expected for those skilled in the art such as superfine silica gel powder, talcum powder, magnesium stearates and obtain One or more, preferred magnesium stearate.
The technical solution for completing second invention task of the application is the above-mentioned system for helping to maintain blood glucose balance composition Preparation Method, which is characterized in that comprise the steps of:
S1, the Gymnema sylvestre extract in a kind of weight proportion for the composition for helping to maintain blood glucose balance, cortex cinnamomi are mentioned Object, alpha-lipoic acid, biotin, chromium compound, zinc compound, Vitamin D3, auxiliary material is taken to carry out sieving processing (50-150 respectively Mesh)
Chromium compound, biotin, the Vitamin D3 that S2, sieving of learning from else's experience are handled are sufficiently mixed uniformly;Then and in weight proportion The mixing of 1/4 to 3/4 Gymnema sylvestre extract, obtains composition (1)
S3,3/4 to 1/4 Gymnema sylvestre extract by composition described above (1), zinc compound, remaining weight proportion, cortex cinnamomi Extract, alpha-lipoic acid, auxiliary material are uniformly mixed to be conducive to keep the composition of blood glucose balance to this.
The beneficial effect of the present invention compared with the existing technology is:
The present composition selects the nutrients such as Chinese medical extract combination antioxidant, vitamin, minor metallic element, is sending out The sensibility for waving on respective mechanism of action mutually collaboration enhancing pancreas islet, promotes insulin secretion, reduces pancreas islet and resists, delay sugar and The blood glucose balance for maintaining human normal is assisted in absorption of the lipid in enteron aisle.Highest attention with Modern human populations to health, west The hepatic and renal function damage that medicine generates in body is increasingly taken seriously.Diabetes or potential crowd, obesity and people with hyperlipidemia Also being more prone to select some specific aims stronger the health food with auxiliary hyperglycemic improves own blood glucose and health indicator, subtracts The taking dose of Shaoxi medicine.The specific effective effect of the present invention compared with the prior art is as follows:
1, using Chinese and western medical science combination nutritional knowledge * to prescription scientific compatibility, multiple target effect realizes a variety of function such as hypoglycemic Effect.
The present composition selects natural plant essence, plays hypoglycemic jointly in conjunction with vitamin, microelement and alpha lipoic acid Mechanism.
Gymnema sylvestre extract has hypoglycemic, anti-caries tooth and inhibits sweet taste using gymnemic acid ingredient as main active The effects of reaction, inhibits absorption of the body to sugar, reduces blood glucose, and help repairs pancreas damaged cell, improves the secretion of insulin Amount.
Cortex cinnamomi is containing many kinds of substance such as volatile oil, terpene, polysaccharide, flavonoids, phenols and saponin(es.Country's health-care series produce at present The cinnamomum cassia extract Testing index chosen in product is based on cinnaldehydrum, polysaccharide, and wherein cinnamic acid ingredient has anti-inflammatory, antipyretic town Bitterly, the bioactivity such as antitumor, hypoglycemic, anti-obesity, resisting oxidation free radical activity.There is enhancing to be immunized, drop blood for polysaccharide component Sugar and other effects.This composition selects flavone component as efficiency index ingredient, passes through chalcones material incentive insulin receptor Autophosphorylation, promote glucose absorption and Glycogen synthesis, inhibit fatty steroids.Although in cytositimulation glucose It is direct that absorption aspects act on no medical insulin, but because Chinese medical extract has multiple target effect in vivo, is especially promoting Glycogen closes and has similar insulin action in terms of Glycogen synthase activity, identical as insulin signaling, stimulates insulin receptor.Meat Osmanthus flavones ingredient and insulin combination can be such that Glycogen synthesis increases after.
Alpha lipoic acid original is ratified by CFDA for treating Diabetic peripheral polyneuropathy.It is selected in the present composition Diabetic can not only be prevented by anti-oxidation function with alpha lipoic acid, neuropathy occurs, insulin can also be promoted extensive Multiple response, stimulation glucose synthesize hepatic glycogen, adjust function carbohydrate metabolism, are combined blood sugar decreasing effect with cortex cinnamomi flavones and gymnemic acid It becomes apparent, has obvious synergistic function.
Biotin is also known as biotin, biotin, is water soluble vitamin, also belongs to vitamin B complex, B7.It is synthesis dimension The necessary material of raw element C is fat and the indispensable substance of protein eubolism, can maintain human body natural's growth, development With normal human's functional health, be conducive to the health and regeneration of cell.Diabetic's blood biotin concentration is low compared with normal person, leads to Supplement biotin is crossed, facilitation is played to the adjusting of blood glucose.It is taken together when supplementing biotin combination minor metallic element chromium, It can obviously reduce the blood glucose level of patients with NIDDM.
Chromium is the important composition ingredient of glucose tolerance factor, increases the activity of insulin, participate in protein synthesis and The metabolism of nucleic acid, fat reduces body fat content.Chromium is closely related with glycometabolism, is that insulin performance blood sugar reducing function is required Element, Cr3+ by formed in conjunction with niacin GT or with amino acid formed other organo-chromium compounds cooperate with insulin play Its physiological function, mechanism of action are mainly that the insulin receptor adjusted on insulin and cell membrane by GTF forms disulfide bond, Insulin is promoted to play maximal biological effect.Chromium may also act to transphosphorylase and succinic acid dehydrogenation in glucose metabolism Enzyme increases the utilization of sugar;Promote the expression of glucose transporter (GLUT) -4mRNA, increases glucose transport.
Zn-ef ficiency: the generation of insulin needs zinc enzyme, and pancreas islet is usually present in pancreas in the form of insulin zinc, is taken the photograph The effect of insulin for reducing blood sugar can be delayed and extend by entering Zn-ef ficiency.
Vitamin D3: generation and insulin sensitivity, Intra-islet Apoptosis and immunoprotection with diabetes etc. are equal Relevant, internal deficiency can be such that the onset risk of 1 type and diabetes B improves.
Diabetes or patient's early period generally entail other diseases, such as hyperlipidemia, hypertension, metabolic disorder, pass through the above original Expect it is reasonably combined, while playing hypoglycemic mechanism, can also reducing blood lipid, it is anti-oxidant, prevent neuropathy, promote body recovery just Normal metabolic function.The present invention has further demonstrated its good result in terms of controlling blood glucose through human feeding trial.
2, insulin injection amount is reduced, mitigate patient suffering: cortex cinnamomi flavonoid active ingredient plays para-insulin sample in vivo Mechanism of action can be reduced in right amount with periodic detection fasting blood-glucose index by doctor's advice after the diabetic of insulin injection is oral Insulin injection amount.For patients, pain is both alleviated, financial burden is also reduced.
3, stablize diabetic's mood, be conducive to disease treatment and stabilization: because blood glucose is excessively high or unstable or complication etc. is more Factor influences, and often mood swing is larger by diabetic, leads to poor blood glucose control.Modern medicine discovery, people are depressed When, brain can stimulate body largely to secrete the hormone of some antagonism insulin secretions, lead to blood glucose rise.When situation is serious, even The decomposition that can accelerate fat, increases fatty acid in blood largely, leads to ketoacidosis.The preferred stearic acid of the present composition Magnesium is as auxiliary material, and not only because its property is stablized, while magnesium ion is to participate in a variety of physiological activities of human body and for necessary to human body Cation has the effect of setting the mind at rest well, adjusting immunity of organism, direct inhibitory activity substance release sensitizer, in advance Preventing bone rarefaction has with protective effect nervous system and cardiovascular and cerebrovascular, prevents migraine and hypoimmunity.In prescription On, Vitamin D3 is used in combination, internal serotonin, dopamine and noradrenaline levels can be improved, promotes patient's feelings Thread develops toward positive aspects, and caused depression in the case of prevention or alleviation long-term administration is more conducive to control blood glucose balance.
4, dose: it is raw material, dose that domestic hypoglycemic health-care product, which mostly uses balsam pear, pueraria lobata, mulberry leaf, American ginseng extract, It is larger, generally 4-6 or piece.The present composition selects optional No. 0 capsule shells filling, 3 times a day, 1 tablet each time, Opposite commercial product dose is small, easy to carry and use, and patient's degree of recognition is high, and compliance is more preferable.
The present invention is directed to onset diabetes mechanism, selects suitable active constituent and auxiliary material to carry out reasonably combined, arrives jointly Up to Conservative restoration, stimulation beta Cell of islet, increases insulin sensitivity, improve insulin resistance, adjust the function with stabilizing blood sugar Effect.The addition of other antioxidants can effectively remove free radical, protect peripheral nerve tissue, prevent diabete peripheral herve The generation of lesion and complication.
1. Gymnema sylvestre extract gymnema sylvestre mainly contains the ingredients such as saponins, terpene, flavones, polypeptide and sterol substance, Wherein oside compound is its main active.Gymnema sylvestre has 20 multinomial patents in Japan, the U.S., European application.It is printing Popular Utilization is spent for a long time, for antitumor, solution malaria, hypoglycemic and diuresis etc..In recent years, domestic and foreign scholars study discovery gymnema sylvestre Have the effects that hypoglycemic, anti-caries tooth and inhibits sweet taste reaction.Gymnema sylvestre can inhibit to eat the desire of sweet food, inhibit body to sugar Absorption, reduce blood glucose, help repair pancreas damaged cell, improve the secretory volume of insulin.
(1) hypoglycemic effect: Gymnema sylvestre extract and glucose or sucrose can obviously inhibit the liter of blood glucose level when sharing Height, and significantly reduce the secretion (tool dual regulation) of plasma insulin.In half in vitro test, gymnemic acid dose dependent Rat small intestine sugar transport transmembrane potential difference is reduced, Na+ dependence sugar transport carrier is inhibited, reduces active of the intestinal wall to glucose Transhipment.In the diabetes rat model caused by streptozotocin, Gymnema latifolium Wall. ex Wight extract can make the raised blood glucose value of rat and low Serum insulin level restore to normal, and rat insulin and β cell number are multiplied, and gymnema sylvestre is prompted to pass through reparation Or regenerating pancreas endocrine and increase insulin level, reach hypoglycemic effect and glycaemic homeostasis.Oral Gymnema latifolium Wall. ex Wight extracts It can make the reduction of moderate alloxan diabetes rats blood glucose level after object, and this is retained potency for after drug withdrawal 2 months or more, Serious and poisoning group does not cause blood glucose in diabetic rats to reduce, but can extend the time-to-live of rat.Gymnema latifolium Wall. ex Wight extract Giving Type I diabetes people (insulin-dependent) can make patient decline the demand of insulin, this effect may be with regeneration Or remaining β cell is repaired, so that it is related to enhance endogenous insulin secretion.Give 22 (non-insulins of type II diabetes people Dependent form) after conventional hypoglycemic survival dose can be made to reduce, 5 patients can interrupt conventional antidiabetic drug, receive Gymnema latifolium Wall. ex Wight extract benefit It fills treatment patients serum's insulin level to increase, Gymnema latifolium Wall. ex Wight extract is added in prompt can make type II diabetes people's β cytothesis Or it repairs.Gymnema latifolium Wall. ex Wight extract has no effect on normal rat liver glycogen content, but can obviously be dropped to raising with the rat of glucose Its low liver glycogen content, and this reduction effect of while sharing with exogenous insulin becomes apparent from.Gymnema latifolium Wall. ex Wight extract can press down The gastrin inhibitory polypeptide of glucokinase activator processed is secreted.Gymnemic acid II, III, IV, V and of gymnemasaponin Gymnemoside- f has inhibiting effect to rat small intestine segment glucose uptake.Separately studies have reported that Gymnema latifolium Wall. ex Wight extract Not by stimulation exocytosis but increase membrane permeability to stimulate the release of insulin.In addition, ox more dish in gymnema sylvestre Alcohol A 0.2mg/ml can completely inhibit absorption of the rat small intestine to glucose, show in addition to gymnemic acid, gymnema sylvestre it is hypoglycemic Effective component further includes Conduritol A.
(2) lipid-loweringing and study of anti-atherogenic effect: Gymnema latifolium Wall. ex Wight extract reduces streptozotocin diabetes rat and increases Serum cholesterol level, 25~100mg/kg continuous oral 2 weeks, dose dependent reduce high lipid food caused by hyperlipidemia it is big Mouse serum triglyceride, total cholesterol, very low density lipoprotein-cholesterol and low density lipoprotein-cholesterol are horizontal, and go up The low highdensity lipoprotein-cholesterol of hyperlipidemia rats and antiatherosclerosis index.Gymnema latifolium Wall. ex Wight extract The drop total cholesterol of 100mg/kg, the ability of triglycerides and antiatherosclerosis and isodose lipid-loweringing comparison medicine clofibrate It is close.Absorption of the gymnemic acid energy strong inhibition rat small intestine to oleic acid, and the effect has dose dependent and invertibity.Mouthful Taking gymnemic acid can cause steroid excretion in rat excrement to increase.Spontaneous hypertensive rat feeds blood after gymnema sylvestre Cholesterol concentration declines in liquid.
(3) inhibit sweet taste reaction: gymnema sylvestre may be by blocking gustatory surface sweet feel receiver to inhibit sweet taste anti- It answers, gymnemic acid can inhibit the sweet taste of rat to feel.Chewing Gymnema latifolium Wall. ex Wight can cause hypogeusia.Gymnemic acid is that sweet taste inhibits The main component of effect.
(4) anti-caries tooth acts on: caries preventive agent is made in Gymnema latifolium Wall. ex Wight by Japan in the form of tea, or anticarious tooth paste is made.
2. cinnamomum cassia extract is modern research shows that mainly contain volatile oil, diterpene and glucosides, flavonoids, polyphenol in cortex cinnamomi The compounds such as class.Flavone compound has treatment cardiovascular and cerebrovascular disease, antibacterial anti-inflammatory, analgesia, antiviral and antitumor, reduction The bioactivity such as blood glucose, reducing blood lipid and blood pressure, resisting oxidation free radical activity.Cinnamic acid is present in cortex cinnamomi in the form of transconfiguration In volatile oil, have treatment cardiovascular and cerebrovascular disease, antibacterial, anti-inflammatory, analgesia, antiviral and antitumor, reduce blood glucose, reducing blood lipid and The bioactivity such as blood pressure, resisting oxidation free radical activity.
(1) antidiabetic effect: the most significant feature of type 2 diabetic patient is insulin resistance, and glucose storage is caused to stay In blood, body is made to be in hyperglycemia state.Foreign study thinks that the main mechanism of cortex cinnamomi blood sugar reducing function is 1. to reactivate Fat cell enhances peripheral tissues and liver to the sensibility of insulin, makes peripheral tissues to Portugal to the respond of insulin The intake of grape sugar increases;2. enhancing skeletal muscle insulin transduction signal approach, so as to improve insulin resistance;3. adjusting pancreas The synthesis of island element signal and glycogen adjusts the boundary of hepatic glycogen;4. improve IR2 β, the tyrosine phosphorylation level of IRS2 from And improves the adjusting of internal insulin and improve utilization of the body to glucose.It is significant that domestic related experiment thinks that cortex cinnamomi has Hypoglycemic effect mainly plays blood sugar reducing function by the following aspects: 1. by protection, stimulation beta Cell of islet to increase blood The content of clear insulin;2. increasing the sensibility of insulin;3. improving insulin resistance;4. removing free radical, anti-grease matter Peroxidating;5. insulin analog effect.
Cinnamomum cassia extract can make sugar tolerance keep sensibility that is normal and enhancing body to insulin, and the phenols in CE is oligomeric Object, which has, mitigates diabetes effect, and the CE 14d for giving various dose can be substantially reduced animal pattern blood glucose level, improves periphery Insulin level, having reduces postprandial hyperglycemia effect.The more ketone of cinnamomum cassia extract methyl charles are to be by a kind of relative molecular mass 288 monomer, what the tetramer that the tripolymer and a kind of relative molecular mass that 2 kinds of relative molecular masses are 864 are 1152 formed Polymer is the oligomer of A type catechin, epicatechin and procyanidine, can increase insulin-dependent in test in vitro 20 times of glycometabolism, mechanism and its can with activating glycogen synzyme and inhibition glycogen synthetase -3- kinases activity, make to expose In the Phosphorylation of insulin receptor of the more ketone of methyl charles, excite the cascade reaction of insulin related.
IR level, enhancing in 3T3-L1 fat cell can be improved in more ketone of anthocyanidin A type polymer in cinnamomum cassia extract Tristetraprolin (TTP) and glucose transporter (GLUT) 4 are expressed, and TTPm RNA is improved, and reduce IRm RNA, simultaneously also Have the function of to anti-inflammatory cytokines and antiangiotensin.SUBASHBADU etc. has found that the cinnamic acid of various concentration can be with Dose-dependent form reduces blood glucose in diabetic rats, glycosylated hemoglobin (HbAlC), total plasma cholesterol (total Cholesterol, TC), triacylglycerol (triglycerides, TG) it is horizontal, this effect can partially restore lactic acid with it Dehydrogenase, acid p'tase, the activity of alkaline phosphatase (ester) enzyme are related.
Polyphenol compound in cinnamon water extract can enhance the bioactivity of insulin in vitro and in vivo, and The cortex cinnamomi polyphenol A type polymer isolated and purified is also used as the metabolism that insulin-like molecules improve internal glucose.Kim SH Deng to cortex cinnamomi polyphenol A type polymer carry out structure of modification, obtain a kind of novel hydroxyl cinnamic acid derivative menaphthyl ester, it is right After C57BL/Ksdb/db patients with type Ⅰ DM mouse is administered 12 weeks, the blood glucose level and peroxidatic reaction of lipid of mouse can obviously drop It is low.Zheng H etc. has extracted a series of Cortex Cinnamomi volatile oil ingredient, the constituents energy targeted activation nuclear factor E2 correlation factor 2(Nrf2), improve metabolic disorder caused by diabetic nephropathy, protect renal function.Separately there is studies have shown that cinnamomum cassia extract that can compete Property inhibit the activity of mammal alpha-glucosidase, reduce postprandial hyperglycemia, so that whole blood glucose tends to be steady, this and card wave The blood sugar reducing function of sugar is similar.Ziegenfuss etc. treats 22 prediabetes and metabolic syndrome patient with cinnamomum cassia extract, Two groups are randomly divided into, one group is given cinnamomum cassia extract, and another set gives placebo.As a result: cortex cinnamomi group fasting blood-glucose from (116.3 ± 12.8) mg/dL drops to (106.5 ± 20.1) mg/dL, and decline 8.4%, decline is obvious, meanwhile, shrink drops 3.8%, body mass index decline 0.7%.Research prompt, cortex cinnamomi can reduce prediabetes and metabolic syndrome patient suffers from diabetes And the risk of cardiovascular disease.Khan etc. uses placebo, gives cortex cinnamomi respectively to type 2 diabetic patient with 1,3 and 6g/d Crude drug is oral, and after the continuous 40d that takes medicine, detection finds that each cortex cinnamomi group can be such that fasting blood glucose level is decreased obviously, and averagely reduces by 18% ~29%.It is discontinued after 20 d, repetition measurement fasting blood sugar, cortex cinnamomi 6g group fasting blood sugar before being administered still than reducing.Prompt is small dose daily Amount (1~6g) intake cortex cinnamomi is conducive to treat and prevent diabetes B.In May, 2006 number publish " European clinical research it is miscellaneous Will " then report, 79 take orally the cortex cinnamomi water for being equivalent to 3g crude drug in diabetes B people (men and women is fifty-fifty) continuous 4 months for each person every day Extract, although the Hb A1C of these patients and blood lipid have no improvement, fasting blood-glucose averagely has dropped 10.3%, it can be seen that, Chinese cassia tree water extract has some improvement to diabetes B.Crawford uses randomized controlled trial, clinical from 3 bases Test center recruits 109 type 2 diabetic patients (HbA1c > 7.0%), is randomly divided into two groups, one group in original drug everyone The oral cortex cinnamomi for being equivalent to 1g daily, another group is placebo, maintains 90d.The results show that cortex cinnamomi group Hb A1c has dropped 0.83% (95% CI, 0.46~1.20), placebo Hb A1c have dropped 0.37% (95% CI, 0.15~0.59), prompt Cortex cinnamomi has therapeutic effect to diabetes B.58 type 2 diabetic patients are randomly divided into two groups by Akilen etc., and one group everyone is every Its oral cortex cinnamomi 2g, another group uses placebo, maintains 12 weeks.The results show that cortex cinnamomi group HbA1c is down to 7.86% by 8.22%, Systolic pressure is down to 129.2mmHg from 132.6mmHg, and diastolic pressure is down to 80.2mmHg by 85.2mmHg, and blood lipid is without substantially changeing;Peace Console agent group experiment front and back Hb A1c, systolic pressure, diastolic pressure, blood lipid level no significant difference.As a result prompt cortex cinnamomi helps In the HbA1c and blood pressure that reduce type 2 diabetic patient.
(2) anti-oxidant: cinnamomum cassia extract has good antioxidation, and essential oil is anti-oxidant and removing free radical activity takes Certainly in overall oxidation resistance, remove superoxide anion (CEO), removing hydroxyl radical free radical ability, anti-linoleic acid lipid peroxidation Ability, the ability for removing 1,1- diphenyl -2- trinitrophenyl-hydrazine (DPPH) free radical, the ethanol extract (EECC) of cortex cinnamomi are right The inhibiting effect of lipid peroxidation is better than vitamin E in FeCl2- vitamin C rat hepatocytes homogenate, and dosage is in 0.05- When 1.00mg/m L, the activity for removing super oxide anion and superoxides generation is most strong.
(3) anti-cardiovascular disease: modern pharmacology research shows that cortex cinnamomi can increase coronary blood flow, improves coronary artery and follows Ring and myocardial nutrition situation, therefore it is usually used in the prevention and treatment of the cardiovascular diseases such as coronary heart disease, arrhythmia cordis, rheumatic heart disease.According to report Road, main component cinnamic acid, cinnamic acid in Cortex Cinnamomi volatile oil etc. can protect rat model to occur together ischemia myocardial damage, this With the two reduce it is nitric oxide production production, anti-inflammatory, oxidation resistant activity is related.Hwa JS etc. separates and extracts chemical combination from cortex cinnamomi Object 2- methyl cinnamic aldehyde, and confirm that the compound can be reduced the endothelium of TNF-α activation using adult rat ischemia-reperfusion injury model Cell medium vessels cell adhesion molecule 1(VCAM-1) express and induce heme oxygenase 1(HO-1) generate to improve part Ischemia/reperfusion (I/R) damage.XueYL etc. is studies have shown that cinnamic acid can expand endothelium dependent/non-dependent rat smooth muscle Diastole, it is related that this with it can block the channel Ca+.It is a kind of that cinnamomum cassia extract, which studies more cardiovascular protective effect, Lignanoids compounds.The compound is a kind of novel thromboxane A2 receptor antagonist (TXA2) and the synthesis of potential thromboxane Enzyme inhibitor is able to suppress the proliferation of the vascular smooth muscle cells of thromboxane receptor mediation, dynamic to prevention vascular diseases and treatment Pulse atherosclerosis has latent effect.
(4) reducing blood lipid: diabetes are a kind of common endocrine metabolism diseases, are often accompanied by disorders of lipid metabolism and hyperlipemia Disease.Long term hyperglycemia, hyperlipidemia easily induced Diabetic cardio cerebrovascular affection.In the treatment of diabetes, reducing blood lipid is almost With it is hypoglycemic of equal importance.It is multinomial the experimental results showed that, Chinese traditional medicine cinnamon can also reduce blood lipid while hypoglycemic, prompt cortex cinnamomi It has certain effect to the prevention and treatment tool of diabetes and its complication.The researchs such as SungHeeKim find that cinnamomum cassia extract is administered 2 weeks Afterwards, significantly reduce db/db type mouse blood glucose level simultaneously, triacylglycerol, total cholesterol, enteral alpha-glucosidase activity are also bright It is aobvious to reduce.Serum insulin, high-density lipoprotein (HDL) level are increased significantly (P < 0.01) compared with control group.Alam Khan etc. 60 diabetes B patients clinical medications are studied, show that cortex cinnamomi can make triacylglycerol, low-density lipoprotein (LDL), total Cholesterol levels are decreased obviously (P < 0.05), have no significant effect to high density lipoprotein level.UbashBabuP etc. studies cinnamic acid-A tool Play the role of reducing blood glucose, promote serum lipids reduction.Experiment is research pair with the male diabetes Wistar rat that STZ induces As after 45d is administered in cinnamic acid, cortex cinnamomi treatment group diabetic mice blood glucose level, glycosylated hemoglobin, total cholesterol, trigalloyl are sweet Oil level significantly reduces (P < 0.05).Plasma insulin, hepatic glycogen, HDL are horizontal significantly raised, can restore aspartate transaminase (aspartateaminotransferase), alanine aminotransferase (alanineaminotransferase), lactic dehydrogenase (lactatedehydrogenase), alkaline phosphatase (alkalinephosphatase) and acid p'tase (acidphosphatase) is to normal level.
3. the utilization rate close relation of insulin in chromium, with human body, therefore it is referred to as glucose tolerance factor (letter Claim GTF), cell can be improved to insulin sensitivity, participate in the synthesis of protein and the metabolism of nucleic acid, fat, reduce internal Fat content.Chromium can also be such that immune system reinforces, improve body to undesirable condition with stress situation resistance.It is united according to research Meter discovery, chromium concn in diabetic's average blood, lower than normal person 40%.Current research discovery, chromium picolinate can mention A kind of quantity of activity AMP protein kinase (AMPK) relevant to metabolic pathway in high Skeletal Muscle Cell, to improve energy Amount balance and insulin function.Active AMP protein kinase (AMPK) is that control includes many metabolism ways such as blood glucose Sugar intake One important enzyme of diameter, and it is related with anti-insulin and type II diabetes.
Mending chromium, (including type 1 diabetes, diabetes B, gestational diabetes mellitus and class are solid to different types of diabetes are treated Diabetes caused by alcohol etc.) effectively.It is better than inorganic chromium using the effect of Organic Chromium, the machine chromium of common are have chromium picolinate, Nicotinate chromium, Cr-enriched yeast etc..The discovery chromium such as Vladeva can alleviate the insulin resistance of type 2 diabetic patient;Jovanovic Equal propositions supplement chromium picolinate can be used as the adjuvant treatment of gestational diabetes mellitus women;The discovery chromium such as Ravina not only can treat Type 1 diabetes, and it is also effective to diabetes caused by steroids.Chromium is played as the active constituent collaboration insulin of GTF to be made With, to sugar, fat, protein and nucleic acid metabolism play an important role, supplement chromium have become the battalion for being suitable for diabetic Support intervening measure.In addition, chromium helps to improve psychogenic baulimia and the caused sweet food intake of melancholy tendency is excessive.
Chromium is closely related with glycometabolism, can improve the metabolic efficiency of carbohydrate, reduces the accumulation of fat.It is solid that chromium can reduce total gallbladder Alcohol, the concentration for improving high-density lipoprotein (HDL).The daily 200 microgram chromium of clinical studies show can reduce blood total cholesterol Concentration.The chromium of daily 200-400 microgram facilitates body weight control, reduces ratio of the fat relative to lean tissue.Chromium is pancreas islet Element plays element necessary to blood sugar reducing function, and Cr3+ in conjunction with niacin by forming GT or forming other organic chromaking with amino acid It closes object collaboration insulin and plays its physiological function, mechanism of action is mainly the pancreas adjusted on insulin and cell membrane by GTF Island element receptor forms disulfide bond, and insulin is promoted to play maximal biological effect.Chromium may also act to the phosphorus in glucose metabolism Sour mutase and succinate dehydrogenase increase the utilization of sugar;Promote the expression of glucose transporter (GLUT) -4 mRNA, increases Glucose transport.
4. alpha-lipoic acid (Alpha Lipoic Acid) is a kind of similar vitaminic substance, is referred to as " super antioxygen Agent " is a kind of antioxidant of " function is at most and activity is most strong " in all antioxidants.
(1) patient is helped to reduce the dependence to insulin and hypoglycemic medicine.Alpha-lipoic acid is uniquely to have both fat-soluble and water The omnipotent ozone agent of dissolubility can be absorbed by each tissue internal organs, and active force is also more lasting than other antioxidants.Alpha-lipoic acid energy Enhance the absorption of diabetes B animals skeletal muscle and red blood cell to glucose, patient blood glucose can be reduced, improve cell to pancreas islet The sensitivity of element improves the glycemic control of diabetic by balance blood sugar, and patient is made to reduce hypoglycemic medicine or delay to inject pancreas The time of island element.
(2) diabetic's nerve fiber is protected, Peripheral neuropathy is treated in help.Foreign study proves that alpha lipoic acid can Clinical symptoms caused by diabete peripheral herve pathology are obviously improved, are recommended for adjuvant treatment Diabetic Peripheral in Germany Neuropathy is more than 30 years.Alpha lipoic acid can protect the nerve fiber of diabetic, reduce the incidence of neuropathy, Inflammation caused by nerve cell is treated due to proteins deposited in help.
(3) alpha-lipoic acid is a kind of superpower antioxidant, and oxidation resistance is 5-10 times of grape pip, and grape pip Oxidation resistance be ascorbic 20 times, 60 times of vitamin E again.The oxidative stress due to caused by hyperglycemia, free radical damage Wound, injury of blood vessel etc. will lead to nerve cell death, cause diabetic neuropathy, and the sense such as limbs pain, numbness occurs in patient Feel the lesions such as neuropathy and cranial nerve, autonomic nerve.And alpha-lipoic acid can regenerate antioxidant, remove free radical, weaken Oxidative stress is gradually recovered the substances such as nerve growth factor normally, and can stimulate nerve fiber regeneration.It is reported that daily mouth Alpha-lipoic acid is taken, less than 3 weeks, the limbs pain and pain and numbness of diabetic neuropathy patient improved, hence it is evident that discovery is through the person of controlling Its advanced glycation end products (AGE) lowers.Experiment in vitro shows that alpha-lipoic acid has lens opacities caused by glucose Single-minded protectiveness significantly improves crystalline intracorporal interior raw antioxidant gluthathione content, protects crystalline lens, can prevent diabetes Cataractogenesis.In addition, alpha-lipoic acid is formed due to reducing AGE, certain effect is also functioned to diabetic angiopathy is mitigated.
Alpha-lipoic acid is each diabetes or the necessary nutriment of patient for mild hyperglycemia occurred.Middle age After 45 years old, if there is the people of familial glycosuria disease genetic risk, even if not yet there are the clinical symptoms of diabetes, it can also drink It food, movement, body weight control and supplements the alpha-lipoic acid of low dosage and prevents and delay the generation of diabetes.It is having occurred and that in sugar The end of patient is urinated slightly or in the improvement of polyneuropathy, and daily taking dose is 500-600 milligrams, can divide 2-3 clothes With being taken altogether with food as far as possible to avoid gastrointestinal discomfort phenomenon, alpha-lipoic acid needs are taken could start to play effect at least three weeks Fruit only need to take 200-300 milligrams of alpha-lipoic acids daily for the patient of diabetes of light~moderate, general to maintain or in other The dosage that antioxidant content merges is general only to need 20-50 milligrams or so daily.Alpha-lipoic acid is for its other than diabetes His a variety of chronic diseases, such as the change of cardiovascular disease, liver-kidney diseases are also benefited with front.Alcohol or chemotoxic substances are made At neuropathy there is therapeutic effect, while also contributing to the reparation of the stimulated liver cell of long-term transition.In addition, in skin Nursing aspect lipoic acid has apparent anti-wrinkle effect, has a significant effect for prevention skin aging.
In short, alpha-lipoic acid can improve islet function and glucose metabolism, reduces AGE and form and weaken oxidative stress, have Help the generation for preventing heart disease and cerebral apoplexy.Since supply alpha-lipoic acid can enhance insulin effect, therefore it still can be reduced patient's pancreas The dosage of island element or antidiabetic drug.
5. biotin, i.e. biotin are conducive to the health and regeneration of cell.Diabetic can by supplement biotin To improve the adjusting of insulin and blood glucose.Diabetes are since (long-term direct stimulation, long-term crapulence are sudden and violent for h and E factor Food, long-term shortage movement) interaction, cause insulin absolute or hyposecretion and target tissue cell relatively is to insulin Sensibility reduces, and causes a series of metabolic disorder syndromes such as protein, fat, water and electrolyte, is a kind of metabolic disease. Biotin is indispensable in body generation energy process, may participate in some carbohydrate, fat and protein metabolism The normal work of enzyme plays a significant role in the metabolic activities such as gluconeogenesis, fatty acid synthesis, the decomposition of amino acid.Supplement life Object element can promote the decomposition of fat and carbohydrate, energy needed for making its quickening be converted to physical activity.Such as vivo biodistribution Plain lazy weight, fat will be accumulated in vivo and cause obesity.As drug, it can be used for treating artery sclerosis, apoplexy, rouge Class is metabolized the disease of not normal, hypertension, coronary heart disease and blood circulation disorder.
Have that researches show that diabetic's blood biotin concentration is low compared with normal person.Biotin replenishers combination minerals chromium It takes, the blood glucose level of type 2 diabetic patient can be reduced, may be promoted by the activity of influence glycometabolism key enzyme GCK and PCK1 Sugar entering glycolysis and Glycogen synthesis and inhibit gluconeogenesis, to influence postprandial blood sugar responsion.
6. the generation of zinc compound insulin needs zinc enzyme (protaminase), and pancreas islet is usually in the form of insulin zinc It is present in pancreas, can delays and extend the effect of insulin for reducing blood sugar.Blood sugar reducing function mechanism has: protection islet beta cell function, Promote insulin secretion;Increase insulin sensitivity, improves insulin resistance;Inhibit alpha-glucosidase activity, delays grape Sugar absorbs;Inhibit gluconeogenesis, promotes Glycogen synthesis;Promote utilization of the peripheral tissues to glucose;Strengthen immunity remains immune System integrity, directly participation cellular immunity and humoral immunity overall process;Improve diabetic retina's macular degeneration etc..
7, Vitamin D3: a kind of highest active form of biological metabolism rate, the 7- generated after cholesterol dehydrogenation in vitamin D Dehydrocholesterol can form Vitamin D3 through ultraviolet light irradiation, and generation and insulin sensitivity with diabetes, pancreas islet are thin Born of the same parents' apoptosis and immunoprotection etc. are relevant, play important function in the occurrence and development of diabetes B, in human body Deficiency will have the onset risk for increasing by 1 type and diabetes B.
Compared with prior art, control sugar of the invention, hypoglycemic effect are obvious, fasting blood-glucose can before taking 15.9 ± 2.06 (mmol/L) are reduced to 7.86 ± 1.06 (mmol/L);Serum cholesterol can before taking 4.70 ± 0.30 (mmol/L) 4.22 ± 0.19 (mmol/L) are reduced to.The present invention utilizes following two physiological mechanism control sugar, hypoglycemic for the first time: 1, By prevention or the depressive emotion of reduction of patient, the balance of blood glucose is controlled.2, it is originally used for the multiple surrounding mind for the treatment of diabetes Alpha lipoic acid through lesion can not only prevent diabetic by anti-oxidation function in the present invention and neuropathy occurs, also Insulin can be promoted to restore response, stimulation glucose synthesizes hepatic glycogen, function carbohydrate metabolism adjusted, with cortex cinnamomi flavones and gymnema sylvestre Acid combination blood sugar decreasing effect becomes apparent, and has obvious synergistic function.
Specific embodiment
The present invention is described in further details below by embodiment, these embodiments are only used to illustrate the present invention, and It does not limit the scope of the invention.
Embodiment 1: be conducive to keep blood glucose balance and prevent diabetes and its composition of complication and preparation method thereof.
Taking parts by weight is Gymnema sylvestre extract 150, cinnamomum cassia extract 80, zinc citrate 15, magnesium stearate 4.
(1) it will organize above and carry out 80 mesh sievings processing respectively.
(2) learn from else's experience sieving processing formula ratio Gymnema sylvestre extract, cinnamomum cassia extract, zinc citrate, magnesium stearate mixing Uniformly.
Obtain the composition for being conducive to keep blood glucose balance.
Embodiment 2
Taking parts by weight is Gymnema sylvestre extract 150, cinnamomum cassia extract 80, alpha lipoic acid 90, zinc citrate 15, magnesium stearate 4.
(1) it will organize above and carry out 80 mesh sievings processing respectively.
(2) it learns from else's experience and is sieved the formula ratio Gymnema sylvestre extract handled, cinnamomum cassia extract, alpha lipoic acid, magnesium stearate mixing It is even.
Obtain the composition for being conducive to keep blood glucose balance.
Embodiment 3
Taking parts by weight is Gymnema sylvestre extract 150, cinnamomum cassia extract 80, alpha lipoic acid 90, zinc citrate 15, chromium picolinate 0.13, biotin 0.2, Vitamin D3 0.005, magnesium stearate 4.
(1) it will organize above and carry out 80 mesh sievings processing respectively.
(2) formula ratio chromium picolinate, the biotin that sieving of learning from else's experience is handled are sufficiently mixed uniformly;Then in recipe quantity 2/ The mixing of 3 Gymnema sylvestre extracts, obtains mixture (1).
It (3) will above (1), zinc citrate, remaining formula ratio Gymnema sylvestre extract, cinnamomum cassia extract, alpha lipoic acid, auxiliary material It is uniformly mixed.
Obtain the composition for being conducive to keep blood glucose balance.
Embodiment 4:
Taking parts by weight is Gymnema sylvestre extract 80, chitosan 200, chromium picolinate 0.05, alpha lipoic acid 150, biotin 0.05, zinc citrate 22, superfine silica gel powder 1.
(1)-(3) operating procedure is the same as embodiment 3.
Embodiment 5
Taking parts by weight is Gymnema sylvestre extract 220, faenum graecum 30, chromium picolinate 0.2, alpha lipoic acid 50, biotin 0.3, Chinese holly Rafter acid zinc 10, magnesium stearate 6.
(1)-(3) operating procedure is the same as embodiment 3.
Embodiment 6
Taking parts by weight is Gymnema sylvestre extract 400, cinnamomum cassia extract 400, chromium picolinate 0.2, alpha lipoic acid 50, biotin 0.3, zinc citrate 10, talcum powder 6.
(1)-(3) operating procedure is the same as embodiment 3.
Embodiment 7
Take parts by weight be Gymnema sylvestre extract 400, cinnamomum cassia extract 400, alpha-lipoic acid 400, biotin 20, nicotinate chromium 0.1, Zinc gluconate 0.2, magnesium stearate 2.
(1)-(3) operating procedure is the same as embodiment 3.
Embodiment 8
Taking parts by weight is Gymnema sylvestre extract 300, cinnamomum cassia extract 30, alpha-lipoic acid 300, biotin 10, arsenic pyridine chromic formate 0.02, zinc citrate 0.5, magnesium stearate 3.
(1)-(3) operating procedure is the same as embodiment 3.
Embodiment 9
Taking parts by weight is Gymnema sylvestre extract 200, cinnamomum cassia extract 40, alpha-lipoic acid 200, biotin 5, arsenic pyridine chromic formate 0.02, zinc citrate 0.5, auxiliary material 3.
(1)-(3) operating procedure is the same as embodiment 3.
Embodiment 10
Taking parts by weight is Gymnema sylvestre extract 40, cinnamomum cassia extract 200, alpha-lipoic acid 40, biotin 0.1, arsenic pyridine chromic formate 0.02, zinc citrate 0.5, talcum powder 3.
(1)-(3) operating procedure is the same as embodiment 3.
Obtain the composition for being conducive to keep blood glucose balance.
Embodiment 11
Taking parts by weight is Gymnema sylvestre extract 200, cinnamomum cassia extract 200, alpha-lipoic acid 200, biotin 5, arsenic pyridine chromic formate 0.02, zinc citrate 0.5, magnesium stearate 2.
(1)-(3) operating procedure is the same as embodiment 3.
Obtain the composition for being conducive to keep blood glucose balance.
Embodiment 12
Taking parts by weight is Gymnema sylvestre extract 180, cinnamomum cassia extract 40, alpha-lipoic acid 40, biotin 4, arsenic pyridine chromic formate 0.5, zinc citrate 0.5, magnesium stearate 5.
(1)-(3) operating procedure is the same as embodiment 3.
Obtain the composition for being conducive to keep blood glucose balance.
Embodiment 13
Taking parts by weight is Gymnema sylvestre extract 300, mulberry-leaf extract 200, alpha-lipoic acid 200, biotin 2, arsenic pyridine chromic formate 0.3, zinc citrate 10, magnesium stearate 5.
(1)-(3) operating procedure is the same as embodiment 3.
Obtain the composition for being conducive to keep blood glucose balance.
Embodiment 14
Taking parts by weight is Gymnema sylvestre extract 250, kudzu root extract 200, alpha-lipoic acid 150, biotin 1.5, arsenic pyridine formic acid Chromium 0.1, zinc citrate 18, magnesium stearate 6.
(1)-(3) operating procedure is the same as embodiment 3.
Obtain the composition for being conducive to keep blood glucose balance.
5 composition of above embodiments 1- embodiment is filling with No. 0 capsule, selects 50 diabetics to carry out test-meal and grinds Study carefully, 3 times a day, one every time, continuously takes 2 months.As a result it see the table below.
Fasting blood-glucose, serum cholesterol variation before and after the human experiment of 5 sample of table embodiment 1- embodiment
Note: * with take it is preceding compared with, p < 0.01;# with take it is preceding compared with, p < 0.05.
P value, that is, probability reflects a possibility that a certain event occurs size.Statistics is according to obtained by significance test method P value, be generally to have a statistical difference with P < 0.05, P < 0.01 is to have significant statistical difference, P < 0.001 be have it is extremely significant Statistical difference.
Each 10 diabetics of above embodiments 1- embodiment 5 detect fasting blood-glucose and blood after test-meal 2 months respectively Clear cholesterol index, five groups of patient's fasting blood-glucose indexs of discovery make moderate progress before relatively taking orally, and data have conspicuousness more afterwards Statistical significance (P < 0.01).3 hypoglycemic effect of embodiment is substantially better than embodiment 1-2, embodiment 3-4, further demonstrates α sulphur Octanoic acid, the importance of chromium and biotin in Regulation of blood glucose;In terms of reducing serum cholesterol, five groups of serum gallbladders are solid after taking Alcohol index makes moderate progress before relatively taking orally, and wherein the oral front and back data of embodiment 2-5 are compared with conspicuousness statistical significance (P < 0.01), 4 effect of embodiment are best, it was confirmed that the effect of chitosan oligosaccharide is in terms of liposuction, lipid-loweringing.
Excellent treatment effect of the composition provided by the present invention for type II diabetes.It is wherein described in embodiment 3 to control The composition effect for treating type II diabetes and its complication is optimal, treatment type II diabetes as described in example 2 and its complication Composition take second place;Cinnamomum cassia extract is substituted for chitosan oligosaccharide or chitosan, faenum graecum, compatibility other compositions are also specific good Hypoglycemic effect, cortex cinnamomi effect are best.In addition, composition of the present invention also have to the complication of type II diabetes it is very good Therapeutic effect, mitigate patient suffering, do not occur adverse reaction relevant to composition after test-meal patient is oral.
Embodiment 15, it is essentially identical with the pharmacological action of embodiment 1-14, but the composition of composition is: Gymnema sylvestre extract 20 parts, 20 parts of cinnamomum cassia extract, 20 parts of alpha-lipoic acid, 0.1 part of biotin.
Embodiment 16, it is essentially identical with the pharmacological action of embodiment 1-14, but the composition of composition is: Gymnema sylvestre extract 400 parts, 400 parts of cinnamomum cassia extract, 400 parts of alpha-lipoic acid, 20 parts of biotin.
Embodiment 17, it is essentially identical with the pharmacological action of embodiment 1-14, but the composition of composition is: Gymnema sylvestre extract 20 parts, 400 parts of cinnamomum cassia extract, 20 parts of alpha-lipoic acid, 20 parts of biotin.
Embodiment 18, it is essentially identical with the pharmacological action of embodiment 1-14, but the composition of composition is: Gymnema sylvestre extract 400 parts, 20 parts of cinnamomum cassia extract, 400 parts of alpha-lipoic acid, 0.1 part of biotin.
Embodiment 19- embodiment 22, it is essentially identical with the pharmacological action of embodiment 15-18, but the wherein described cortex cinnamomi mentions Object is taken to be changed to chitosan oligosaccharide.Alpha-lipoic acid is changed to vitamin C.
Embodiment 23- embodiment 26, it is essentially identical with the pharmacological action of embodiment 15-18, but the wherein described cortex cinnamomi mentions Object is taken to be changed to chitosan respectively.Alpha-lipoic acid is changed to vitamin E.
Embodiment 27- embodiment 30, it is essentially identical with the pharmacological action of embodiment 15-18, but the wherein described cortex cinnamomi mentions Object is taken to be changed to fenugreek extract respectively.Alpha-lipoic acid is changed to the vitamin C and vitamin E of equal proportion.
Embodiment 31- embodiment 34, it is essentially identical with the pharmacological action of embodiment 15-18, but the wherein described cortex cinnamomi mentions Object is taken to be changed to Bitter Melon P.E.
Embodiment 35- embodiment 38, it is essentially identical with the pharmacological action of embodiment 15-18, but the wherein described cortex cinnamomi mentions Object is taken to be changed to mulberry-leaf extract.
Embodiment 39- embodiment 42, it is essentially identical with the pharmacological action of embodiment 15-18, but the wherein described cortex cinnamomi mentions Object is taken to be changed to kudzu root extract.
Embodiment 43, it is essentially identical with the pharmacological action of embodiment 1, but the parts by weight of the composition component are as follows: gymnema sylvestre 30 parts of extract, be conducive to blood glucose balance plant or 30 parts of animal extracts, 30 parts of antioxidant, 0.1 part of biotin.
Embodiment 44, it is essentially identical with the pharmacological action of embodiment 1, but the parts by weight of the composition component are as follows: gymnema sylvestre 300 parts of extract, be conducive to blood glucose balance plant or 300 parts of animal extracts, 300 parts of antioxidant, 10 parts of biotin.
Embodiment 45, it is essentially identical with the pharmacological action of embodiment 1, but the parts by weight of the composition component are as follows: gymnema sylvestre 30 parts of extract, be conducive to blood glucose balance plant or 300 parts of animal extracts, 30 parts of antioxidant, 10 parts of biotin.
Embodiment 46, it is essentially identical with the pharmacological action of embodiment 1, but the parts by weight of the composition component are as follows: gymnema sylvestre 300 parts of extract, be conducive to blood glucose balance plant or 30 parts of animal extracts, 300 parts of antioxidant, 0.1 part of biotin.
Embodiment 47, it is essentially identical with the pharmacological action of embodiment 1, but the parts by weight of the composition component are as follows: gymnema sylvestre 40 parts of extract, be conducive to blood glucose balance plant or 40 parts of animal extracts, 40 parts of antioxidant, 0.1 part of biotin.
Embodiment 48, it is essentially identical with the pharmacological action of embodiment 1, but the parts by weight of the composition component are as follows: gymnema sylvestre 200 parts of extract, be conducive to blood glucose balance plant or 200 parts of animal extracts, 200 parts of antioxidant, 5 parts of biotin.
Embodiment 49, it is essentially identical with the pharmacological action of embodiment 1, but the parts by weight of the composition component are as follows: gymnema sylvestre 40 parts of extract, be conducive to blood glucose balance plant or 200 parts of animal extracts, 40 parts of antioxidant, 5 parts of biotin.
Embodiment 50, it is essentially identical with the pharmacological action of embodiment 1, but the parts by weight of the composition component are as follows: gymnema sylvestre 200 parts of extract, be conducive to blood glucose balance plant or 40 parts of animal extracts, 200 parts of antioxidant, 0.1 part of biotin.
Embodiment 51, it is essentially identical with the pharmacological action of embodiment 1, but the composition also includes the micro- of compound form Metallic element chromium is measured, the parts by weight of chromium are 0.001.
Embodiment 52, it is essentially identical with the pharmacological action of embodiment 1, but the composition also includes the micro- of compound form Metallic element chromium is measured, the parts by weight of chromium are 0.05.
Embodiment 53, it is essentially identical with the pharmacological action of embodiment 1, but the composition also includes the micro- of compound form Metallic element zinc is measured, the parts by weight of Zn-ef ficiency are 1;The trace element zinc of the compound form is selected from: zinc sulfate, glutamic acid Zinc, zinc acetate, zinc lactate, zinc gluconate, glycine zine, a combination of one or more in Zinc-rich saccharomyces cerevisiae.
Embodiment 53, it is essentially identical with the pharmacological action of embodiment 1, but the composition also includes the micro- of compound form Metallic element zinc is measured, the parts by weight of Zn-ef ficiency are 10.
Embodiment 53, it is essentially identical with the pharmacological action of embodiment 1, but the composition also includes the micro gold of compound form Belong to element zinc, the parts by weight of Zn-ef ficiency are 5.
Embodiment 54, it is essentially identical with the pharmacological action of embodiment 1, but the composition also includes Vitamin D3, gallbladder calcium The parts by weight for changing alcohol are 0.001.
Embodiment 55, it is essentially identical with the pharmacological action of embodiment 1, but the composition also includes Vitamin D3, gallbladder calcium The parts by weight for changing alcohol are 0.015.
Embodiment 56, it is essentially identical with the pharmacological action of embodiment 1, but the composition also includes Vitamin D3, gallbladder calcium The parts by weight for changing alcohol are 0.008.
Compositions as described above formula and preparation are only exemplary embodiments of the invention, are not to the present invention Make the limitation of other forms, any person skilled in the art changed possibly also with technology contents shown in above-mentioned or It is modified as equivalent variations of equivalent embodiments.But without departing from the technical solutions of the present invention, technology according to the present invention Essence any simple modification, equivalent variations and remodeling to the above embodiments, still fall within the protection of technical solution of the present invention Range.

Claims (10)

1. a kind of composition for being conducive to keep blood glucose balance and prevent diabetes and its complication, which is characterized in that the combination Object includes following parts by weight of component: 20-400 parts of Gymnema sylvestre extract, being conducive to plant or the animal extracts 20- of blood glucose balance 400 parts, 20-400 parts of antioxidant, 0.1-20 parts of biotin.
2. the composition according to claim 1 for being conducive to keep blood glucose balance and prevent diabetes and its complication, Be characterized in that, the plant for being conducive to blood glucose balance or animal extracts are selected from: cinnamomum cassia extract, chitosan oligosaccharide, chitosan, One or more of fenugreek extract, Bitter Melon P.E, mulberry-leaf extract or kudzu root extract are flat conducive to blood glucose The substance of weighing apparatus.
3. the composition according to claim 1 for being conducive to keep blood glucose balance and prevent diabetes and its complication, It is characterized in that, the antioxidant is that one or more of alpha-lipoic acid, vitamin C and/or vitamin E are anti-oxidant Agent.
4. the composition according to claim 1 for being conducive to keep blood glucose balance and prevent diabetes and its complication, It is characterized in that, the parts by weight of the composition component are as follows: 30-300 parts of Gymnema sylvestre extract, be conducive to the plant or dynamic of blood glucose balance 30-300 parts of object extract, 30-300 parts of antioxidant, 0.1-10 parts of biotin.
5. the composition according to claim 4 for being conducive to keep blood glucose balance and prevent diabetes and its complication, It is characterized in that, the parts by weight of the composition component are as follows: 40-200 parts of Gymnema sylvestre extract, be conducive to the plant or dynamic of blood glucose balance 40-200 parts of object extract, 40-200 parts of antioxidant, 0.1-5 parts of biotin.
6. the composition according to claim 2 for being conducive to keep blood glucose balance and prevent diabetes and its complication, It is characterized in that, gymnemic acid content is 5-50% in the Gymnema sylvestre extract;Cortex cinnamomi flavones content is in the cinnamomum cassia extract 2-20%。
7. special according to the composition described in claim 1 for being conducive to keep blood glucose balance and prevent diabetes and its complication Sign is that the composition also includes the minor metallic element chromium of compound form, and the parts by weight of chromium are 0.001- 0.100;The minor metallic element chromium of the compound form is selected from: Organic Chromium, Cr-enriched yeast, chromium gluconate, nicotinate chromium, egg The combination of one or more of propylhomoserin chromium.
8. the composition according to claim 1 for being conducive to keep blood glucose balance and prevent diabetes and its complication, It is characterized in that, the composition also includes the minor metallic element zinc of compound form, and the parts by weight of Zn-ef ficiency are 1-10;It is described The trace element zinc of compound form is selected from: zinc sulfate, zinc glutamate, zinc acetate, zinc lactate, zinc gluconate, glycine zine, A combination of one or more in Zinc-rich saccharomyces cerevisiae.
9. the composition according to claim 1 for being conducive to keep blood glucose balance and prevent diabetes and its complication, It is characterized in that, the composition also includes Vitamin D3, and the parts by weight of Vitamin D3 are 0.001-0.015.
10. the preparation of the composition as claimed in claim 9 for being conducive to keep blood glucose balance and prevention diabetes and its complication Method, which is characterized in that the preparation method the following steps are included:
S1, the Gymnema sylvestre extract in a kind of weight proportion for the composition for helping to maintain blood glucose balance, cortex cinnamomi are mentioned Object, alpha-lipoic acid, biotin, chromium compound, zinc compound, Vitamin D3, auxiliary material is taken to carry out 50-150 mesh sieving processing respectively;
Chromium compound, biotin, the Vitamin D3 that S2, sieving of learning from else's experience are handled are sufficiently mixed uniformly;Then and in weight proportion The mixing of 1/4 to 3/4 Gymnema sylvestre extract, obtains composition (1);
S3,3/4 to 1/4 Gymnema sylvestre extract by composition described above (1), zinc compound, remaining weight proportion, cortex cinnamomi Extract, alpha-lipoic acid, auxiliary material are uniformly mixed;Obtain the composition for being conducive to keep blood glucose balance.
CN201910175836.8A 2019-03-08 2019-03-08 Be conducive to keep blood glucose balance and prevent diabetes and its composition of complication and preparation method thereof Pending CN109745359A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910175836.8A CN109745359A (en) 2019-03-08 2019-03-08 Be conducive to keep blood glucose balance and prevent diabetes and its composition of complication and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910175836.8A CN109745359A (en) 2019-03-08 2019-03-08 Be conducive to keep blood glucose balance and prevent diabetes and its composition of complication and preparation method thereof

Publications (1)

Publication Number Publication Date
CN109745359A true CN109745359A (en) 2019-05-14

Family

ID=66406915

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910175836.8A Pending CN109745359A (en) 2019-03-08 2019-03-08 Be conducive to keep blood glucose balance and prevent diabetes and its composition of complication and preparation method thereof

Country Status (1)

Country Link
CN (1) CN109745359A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110464757A (en) * 2019-08-16 2019-11-19 云南绿华食品有限公司 A kind of composition and preparation method thereof reducing blood glucose using Guava Leaf
CN110638996A (en) * 2019-11-01 2020-01-03 博生众康(厦门)医药生物技术股份有限公司 Blood glucose reducing compound for promoting islet regeneration and preparation method and application thereof
CN110960620A (en) * 2019-12-26 2020-04-07 郭晓 Pure natural traditional Chinese medicine prescription for preventing and treating diabetes
CN112042652A (en) * 2020-09-08 2020-12-08 黑龙江五谷庄园生态农业科技有限公司 Preparation of amino oligosaccharide chromium and application of amino oligosaccharide chromium to hawthorn
CN112057581A (en) * 2020-09-01 2020-12-11 李琳 Medicinal and edible dual-purpose composition for rapidly reducing blood fat and blood sugar and preparation method and application thereof
CN114190459A (en) * 2021-12-21 2022-03-18 昆明理工大学 Auxiliary blood sugar-reducing tea bag and preparation method thereof
CN115554388A (en) * 2022-11-03 2023-01-03 广州四季泰来生物技术有限公司 Nutrition balance formula for improving female polycystic ovarian hormone level and production process

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101138577A (en) * 2006-09-04 2008-03-12 江苏同禾药业有限公司 Lipoic acid health food and uses thereof
CN101437503A (en) * 2006-02-21 2009-05-20 阿斯特鲁姆医疗有限公司 Compositions to reduce blood glucose levels and treat diabetes
CN101982115A (en) * 2010-10-14 2011-03-02 张丽娜 Composite for preventing and curing diabetes chronic sugar poisoning
CN103463198A (en) * 2012-06-08 2013-12-25 苏州法莫生物技术有限公司 Traditional Chinese medicine composition for treating diabetes
CN106474190A (en) * 2015-10-16 2017-03-08 赫博美国际有限公司 A kind of medicine for treating type Ⅱdiabetes mellitus and complication and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101437503A (en) * 2006-02-21 2009-05-20 阿斯特鲁姆医疗有限公司 Compositions to reduce blood glucose levels and treat diabetes
CN101138577A (en) * 2006-09-04 2008-03-12 江苏同禾药业有限公司 Lipoic acid health food and uses thereof
CN101982115A (en) * 2010-10-14 2011-03-02 张丽娜 Composite for preventing and curing diabetes chronic sugar poisoning
CN103463198A (en) * 2012-06-08 2013-12-25 苏州法莫生物技术有限公司 Traditional Chinese medicine composition for treating diabetes
CN106474190A (en) * 2015-10-16 2017-03-08 赫博美国际有限公司 A kind of medicine for treating type Ⅱdiabetes mellitus and complication and preparation method thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
余元勋等主编: "《中国分子糖尿病学》", 30 April 2016, 安徽科学技术出版社 *
冯延民主编: "《壳寡糖与人类健康》", 31 March 2008, 吉林大学出版社 *
张彩山编著: "《糖尿病治疗与保养 自我调养有方法 血糖从此不再高》", 30 June 2018, 天津科学技术出版社 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110464757A (en) * 2019-08-16 2019-11-19 云南绿华食品有限公司 A kind of composition and preparation method thereof reducing blood glucose using Guava Leaf
CN110638996A (en) * 2019-11-01 2020-01-03 博生众康(厦门)医药生物技术股份有限公司 Blood glucose reducing compound for promoting islet regeneration and preparation method and application thereof
CN110638996B (en) * 2019-11-01 2022-07-15 博生众康(厦门)医药生物技术股份有限公司 Blood glucose reducing compound for promoting islet regeneration and preparation method and application thereof
CN110960620A (en) * 2019-12-26 2020-04-07 郭晓 Pure natural traditional Chinese medicine prescription for preventing and treating diabetes
CN112057581A (en) * 2020-09-01 2020-12-11 李琳 Medicinal and edible dual-purpose composition for rapidly reducing blood fat and blood sugar and preparation method and application thereof
CN112042652A (en) * 2020-09-08 2020-12-08 黑龙江五谷庄园生态农业科技有限公司 Preparation of amino oligosaccharide chromium and application of amino oligosaccharide chromium to hawthorn
CN114190459A (en) * 2021-12-21 2022-03-18 昆明理工大学 Auxiliary blood sugar-reducing tea bag and preparation method thereof
CN115554388A (en) * 2022-11-03 2023-01-03 广州四季泰来生物技术有限公司 Nutrition balance formula for improving female polycystic ovarian hormone level and production process

Similar Documents

Publication Publication Date Title
CN109745359A (en) Be conducive to keep blood glucose balance and prevent diabetes and its composition of complication and preparation method thereof
US7335651B2 (en) Compositions incorporating(-)-hydroxycitric acid and related methods for promoting fat oxidation
US20060269617A1 (en) Supplement compositions and method of use for enhancement of insulin sensitivity
CN101175416A (en) A method and composition for nutritionally improving glucose control and insulin action
CN112739222A (en) Anti-aging agent and anti-aging method
CN100998650A (en) Use of cinnamonum cassia for treating diabetes, its products and preparing method
CN107455625A (en) A kind of nutrient for plants beverage and its preparation technology with antifatigue weight losing function
CN110367422A (en) A kind of rhizoma polygonati mulberry leaf compound solid beverage and preparation method thereof
US20200197429A1 (en) Dietary supplement for glycemia control and diabetes prevention
CN107223981B (en) Composition containing soybean polypeptide argatroxin and preparation method thereof
KR20160141027A (en) Phamaceutical composition or healthy food comprising water extracts from Pleurotus eryngii var. ferulea (Pf.). for treating or preventing metabolic disorder
US7416750B1 (en) Composition to provide maintenance and nutritional support in glycemic control deficits
KR20150107938A (en) Composition for Improving Memory and Cognitive Function Comprising Psyllium husk
US20220062312A1 (en) Oral composition comprising b-escin and the use thereof
CA3022247C (en) Composition for treating diabetic disease
CN105106310A (en) Health product for auxiliary reduction of blood sugar
CN105533596A (en) Propolis, radix salviae miltiorrhizae and ginkgo leaf capsules and preparation method thereof
KR101147913B1 (en) Composition for controlling blood glucose level
KR20140147482A (en) Composition for preventing or treating prediabetes or diabetes comrising fractionation of Gentiana scabra extracts
US20230210802A1 (en) Composition for relieving hangover and improving liver function
Assemie The value of nutraceuticals in the management of metabolic syndrome
KR101692546B1 (en) A Multivitamin Composition for Alleviating Thyroid Disorders
KR20200056365A (en) Composition for preventing or treating prediabetes or diabetes comrising fractionation of Gentiana scabra extracts
Amagase A combination of various functional food ingredients as a weight management program: randomized, placebo-controlled, and double-blind human clinical studies
CN109567203A (en) A kind of auxiliary hyperglycemic, compound E Seye functional food of reducing blood lipid and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination