CN1524582A - Special auxiliary materials for floating slow-release tablet and preparation method thereof - Google Patents
Special auxiliary materials for floating slow-release tablet and preparation method thereof Download PDFInfo
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- CN1524582A CN1524582A CNA031047475A CN03104747A CN1524582A CN 1524582 A CN1524582 A CN 1524582A CN A031047475 A CNA031047475 A CN A031047475A CN 03104747 A CN03104747 A CN 03104747A CN 1524582 A CN1524582 A CN 1524582A
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- release tablet
- preparation
- slow release
- auxiliary materials
- special auxiliary
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Abstract
A special-purpose findings for floating slow release tablet medicine and method for preparation, characterized by that, it comprises Behenic acid glyceride 20-40%, hydroxypropylcellulose 15-35%, CMC 5-20%, starch gum 20-40%.
Description
Technical field
The invention belongs to the pharmaceutical production technical field, particularly float slow release tablet medicine auxiliary material and manufacture method.
Background technology
The drug variety of slow releasing tablet is a lot, and the preparation technology of these medicines is comparatively complicated, and general manufacturing enterprise is difficult to be grasped.And reappear poor performance with the slow releasing tablet of existing explained hereafter.Especially make the cimetidine slow releasing tablet, also requirement can be floating more than 4 hours in gastric juice both to have required to have slow releasing function, also do not make the kind of float slow release agent by retrieval up to now, can not satisfy the needs of pharmaceutical production.
Summary of the invention
Purpose one of the present invention provides a kind of can swimming in the gastric juice, had good sustained release effect, the simple float slow release tablet of manufacture method medicine auxiliary material and manufacture method.
The object of the present invention is achieved like this: it is to be combined by the following weight proportion raw material, and mountain Yu acid glyceride 20-40%, hypromellose 15-35%, carboxymethylstarch receive 5-20%, dextrin 20-40%.Its manufacture method is, with mountain Yu acid glyceride, hypromellose, carboxymethylstarch receive, dextrin crosses the 80-100 mesh sieve respectively, the mixing of weighing in proportion then, mixed fine powder is an ingredient powder.
The present invention has filled up the blank of float slow release tablet medicine adjuvant, and the adjuvant of making of above-mentioned raw materials is equipped with the medicine that other drug makes and can swims in the gastric juice, has the good slow release effect, and then improves drug effect.Manufacture method of the present invention is simple, processing ease.
The specific embodiment
Below in conjunction with embodiment in detail the present invention is described in detail.
Raw material weight proportioning embodiment of the present invention represents with following table:
| Material name | Weight percent content (%) | |||||
| Mountain Yu acid glyceride | 20 | ?30 | ?35 | ?40 | ?30 | ?25 |
| Hypromellose | 35 | ?15 | ?20 | ?25 | ?30 | ?32 |
| Carboxymethylstarch is received | 20 | ?15 | ?5 | ?15 | ?10 | ?8 |
| Dextrin | 15 | ?40 | ?40 | ?20 | ?30 | ?35 |
| Add up to | 100 | ?100 | ?100 | ?100 | ?100 | ?100 |
Manufacture method embodiment of the present invention
At first raw material is crossed the 80-100 mesh sieve respectively, the raw material after will sieving is then weighed in proportion and is mixed, and mixed fine powder is an adjuvant.Requirement according to made medicine adds an amount of binding agent in ingredient powder, mix homogeneously adds proper amount of lubricating agent and its compacting is in blocks after conventional operations such as granulation, drying, granulate.
Make embodiment: make the cimetidine slow releasing tablet, by making requirement, the PVP with 1% does binding agent, every adds ingredient powder 0.08g, the magnesium stearate of cimetidine medicine 0.15g and 0.02g (lubricant) is mixed compacting in flakes with it, the every heavy 0.232g of cimetidine slow releasing tablet.
The use amount of binding agent adds in right amount by the requirement of medicine.
Check every index all up to specification through the Hebei Province Institute for Drug Control with three batches of cimetidine slow releasing tablet that the present invention makes.(three pages of attached Hebei Province Institute for Drug Control survey reports).
Claims (2)
1, a kind of float slow release tablet medicine auxiliary material is characterized in that it is to be combined by the following weight proportion raw material, and mountain Yu acid glyceride 20-40%, hypromellose 15-35%, carboxymethylstarch receive 5-20%, dextrin 20-40%.
2, a kind of manufacture method of making float slow release tablet medicine auxiliary material, it is characterized in that, at first mountain Yu acid glyceride, hypromellose, carboxymethylstarch are received, dextrin crosses the 80-100 mesh sieve respectively, the mixing of weighing in proportion then, mixed fine powder is an ingredient powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031047475A CN1524582A (en) | 2003-02-28 | 2003-02-28 | Special auxiliary materials for floating slow-release tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031047475A CN1524582A (en) | 2003-02-28 | 2003-02-28 | Special auxiliary materials for floating slow-release tablet and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1524582A true CN1524582A (en) | 2004-09-01 |
Family
ID=34239168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031047475A Pending CN1524582A (en) | 2003-02-28 | 2003-02-28 | Special auxiliary materials for floating slow-release tablet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1524582A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013163738A1 (en) * | 2012-04-30 | 2013-11-07 | Mircea-Alexandru Mateescu | Complex containing carboxyl substituted starch and lipid for delayed delivery of active ingredients |
-
2003
- 2003-02-28 CN CNA031047475A patent/CN1524582A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013163738A1 (en) * | 2012-04-30 | 2013-11-07 | Mircea-Alexandru Mateescu | Complex containing carboxyl substituted starch and lipid for delayed delivery of active ingredients |
| US20150110883A1 (en) * | 2012-04-30 | 2015-04-23 | Mircea-Alexandru Mateescu | Complex containing carboxyl substituted starch and lipid for delayed delivery of active ingredients |
| US9220699B2 (en) | 2012-04-30 | 2015-12-29 | Karici Diagnostics Inc. | Complex containing carboxyl substituted starch and lipid for delayed delivery of active ingredients |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |