CN1515293A - Natural medicine for reducing blood fat and its production method - Google Patents
Natural medicine for reducing blood fat and its production method Download PDFInfo
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- CN1515293A CN1515293A CNA031144187A CN03114418A CN1515293A CN 1515293 A CN1515293 A CN 1515293A CN A031144187 A CNA031144187 A CN A031144187A CN 03114418 A CN03114418 A CN 03114418A CN 1515293 A CN1515293 A CN 1515293A
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- blood fat
- fat reducing
- natural drug
- fruit
- extraction
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to a natural medicine for reducing blood lipid and its preparation method. It includes the fat extracted from fruit of ribes janczewskii, said fat contains unsaturated fatty acid including linolic acid, alpha-linolenic acid and gamma-linolenic acid. Its preparation method includes the following steps: fine selecting fruit, softening, pulverizing and extracting, its extracting method adopts supercritical CO2 extraction.
Description
One, technical field:
The present invention relates to a kind of natural drug, especially relate to a kind of natural drug and manufacture method thereof that is used for blood fat reducing.
Two, background technology:
At present, the hyperlipidemia sickness rate is in rising trend, has a strong impact on the healthy of people.The existing medicine that is used for blood fat reducing mostly is chemical synthetic drug greatly, and lipid-lowering effect is not obvious, and takes meeting generation toxic and side effects for a long time.Qinghai-Tibet Platean tea Fischer platymiscium fruit is rich in unsaturated fatty acid, and tentatively definite through pharmacology, this oils and fats can significantly reduce the content of cholesterol in serum, and rising serum high-density LP cholesterol level obviously reduces the blood viscosity in the whole blood.
Three, summary of the invention:
The present invention provides a kind of natural drug and manufacture method thereof that is used for blood fat reducing in order to solve the weak point in the above-mentioned background technology, and its lipid-lowering effect is obvious, technology advanced person, and product is pollution-free, and toxic and side effects is little.
For achieving the above object, the technical solution used in the present invention is:
A kind of natural drug that is used for blood fat reducing, its special character is: the fruit extract that comprises Qinghai-Tibet tea Fischer.
The oils and fats that comprises the Qinghai-Tibet tea Fischer fruit that extracts with extracting process.
The oils and fats of above-mentioned Qinghai-Tibet tea Fischer fruit includes unsaturated fatty acid.
Above-mentioned unsaturated fatty acid comprises linoleic acid, a-linolenic acid and gamma-Linolenic acid.
A kind of manufacture method that is used for the natural drug of blood fat reducing, its special character is: may further comprise the steps: fruit is selected → softening → pulverizing → extraction.
Above-mentioned extracting process can be CO
2Supercritical extraction.
Pressure can be 20～22MPa when extracting, and extraction temperature can be 30～50 ℃.
Flash trapping stage pressure can be 10～11MPa when extracting, and temperature can be 50～70 ℃; The secondary separating pressure can be 6～7MPa, and temperature can be 80～90 ℃.
Compared with prior art, the advantage and the effect that have of the present invention is as follows:
1, the present invention can significantly reduce the content of cholesterol in serum, and rising serum high-density LP cholesterol level obviously reduces the blood viscosity in the whole blood, and administration time is the obviously effect of triglyceride reducing and very low density lipoprotein (VLDL) in one month;
2, the present invention adopts supercritical CO
2Abstraction technique, high in technological content, product quality is excellent;
3, material collection of the present invention is in the pure land of Qinghai-Tibet Platean, and product does not have any pollution.
Four, the specific embodiment:
Adopt the fruit of Qinghai-Tibet resourceful tea Fischer platymiscium, select optimal acquisition season,, utilize present state-of-the-art supercritical CO through cleaning, peeling, rationally softening
2Abstraction technique extracts oils and fats and to obtain limpid green brown grease.Adopt high-resolution capillary gas chromatography, determine step by step that with standard sample include unsaturated fatty acid more than 90%, wherein linoleic acid is more than 40%, the a-linolenic acid is 5%, and gamma-Linolenic acid is more than 26%.
Embodiment:
Get the fruit 12kg of tea Fischer platymiscium, the fruit peeling is obtained sarcocarp, the selected back of sarcocarp was with 8%～9% water softening 2～4 hours, and softening temperature is 85 ℃.After softening sarcocarp is ground into the particle of 1.5mm～2.0mm, carries out supercritical CO then
2Extraction.CO
2Gas flow is 60kg, CO
2Flow is 45L/h, and extraction temperature is 40 ℃, and pressure is 22MPa, and the time is 7 hours.The flash trapping stage temperature is 60 ℃ during extraction, and pressure is 10MPa; The secondary separation temperature is 85 ℃, and pressure is 6MPa.
The present invention is through acute toxicity test, and the result shows: can not detect LD50 among the present invention, its maximum dosage-feeding is 120ml/kg.Carried out the trimestral long term toxicity test of rat oral gavage administration, the result: when rat 0.3ml/kg, 0.9ml/kg, 2.7ml/kg (being equivalent to 10,30, the 90 times amounts of Coming-of-Age Day with dosage respectively) gastric infusion, the present invention does not influence rat diet drinking-water, free activity and body weight gain.To 15 biochemical indicators of hematology (T-CHOL (CHO), triglyceride (TG), HDL-C (HDL), low-density lipoprotein cholesterol (LDL), C-VLDL VLDL), aspartic acid aminotransferase (AST), ALT (ALT), alkali phosphatase (ALP), blood urea nitrogen (BUN), total protein (TP), albumin (ALB), globulin (GLB), blood glucose (GLU), total bilirubin (T-BIL), creatinine (Cr)), 8 indexs of hematology (numeration of leukocyte (RBC), leukocyte differential count (SCR, MCR, LCR), red blood cell count(RBC) (RBC), hemoglobin (HB), platelet (PLC) and clotting time), the organ index of each important organ and important organ pathologic finding, remove 2.7ml/kg and obviously reduced serum triglycerides in three months in administration, outside the C-VLDL, do not see that other indexs have significant change.
Claims (8)
1, a kind of natural drug that is used for blood fat reducing is characterized in that: the fruit extract that comprises Qinghai-Tibet tea Fischer.
2, a kind of natural drug that is used for blood fat reducing according to claim 1 is characterized in that: the oils and fats that comprises the Qinghai-Tibet tea Fischer fruit that extracts with extracting process.
3, a kind of natural drug that is used for blood fat reducing according to claim 2 is characterized in that: the oils and fats of described Qinghai-Tibet tea Fischer fruit includes unsaturated fatty acid.
4, a kind of natural drug that is used for blood fat reducing according to claim 3, it is characterized in that: described unsaturated fatty acid comprises linoleic acid, a-linolenic acid and gamma-Linolenic acid.
5, a kind of manufacture method that is used for the natural drug of blood fat reducing is characterized in that: may further comprise the steps: fruit is selected → and softening → pulverizing → extraction.
6, a kind of manufacture method that is used for the natural drug of blood fat reducing according to claim 5, it is characterized in that: described extracting process is CO
2Supercritical extraction.
7, a kind of manufacture method that is used for the natural drug of blood fat reducing according to claim 6, it is characterized in that: pressure is 20～22MPa during extraction, extraction temperature is 30～50 ℃.
8, a kind of manufacture method that is used for the natural drug of blood fat reducing according to claim 7, it is characterized in that: flash trapping stage pressure is 10～11MPa during extraction, temperature is 50～70 ℃; The secondary separating pressure is 6～7MPa, and temperature is 80～90 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031144187A CN100386101C (en) | 2003-01-09 | 2003-01-09 | Natural medicine for reducing blood fat and its production method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031144187A CN100386101C (en) | 2003-01-09 | 2003-01-09 | Natural medicine for reducing blood fat and its production method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1515293A true CN1515293A (en) | 2004-07-28 |
| CN100386101C CN100386101C (en) | 2008-05-07 |
Family
ID=34239349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031144187A Expired - Fee Related CN100386101C (en) | 2003-01-09 | 2003-01-09 | Natural medicine for reducing blood fat and its production method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100386101C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1332010C (en) * | 2004-09-07 | 2007-08-15 | 中国科学院武汉植物园 | Preparation and purification method for plant linoleic acid |
| CN114432364A (en) * | 2022-03-07 | 2022-05-06 | 中国科学院西北高原生物研究所 | Anti-inflammatory and blood fat-reducing composition, product, preparation method and application thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1128808C (en) * | 1999-09-20 | 2003-11-26 | 西安交通大学 | Cassia protein extracting process |
-
2003
- 2003-01-09 CN CNB031144187A patent/CN100386101C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1332010C (en) * | 2004-09-07 | 2007-08-15 | 中国科学院武汉植物园 | Preparation and purification method for plant linoleic acid |
| CN114432364A (en) * | 2022-03-07 | 2022-05-06 | 中国科学院西北高原生物研究所 | Anti-inflammatory and blood fat-reducing composition, product, preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100386101C (en) | 2008-05-07 |
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Granted publication date: 20080507 Termination date: 20100209 |