CN1514726B - 新型药物组合物 - Google Patents

新型药物组合物 Download PDF

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Publication number
CN1514726B
CN1514726B CN028114981A CN02811498A CN1514726B CN 1514726 B CN1514726 B CN 1514726B CN 028114981 A CN028114981 A CN 028114981A CN 02811498 A CN02811498 A CN 02811498A CN 1514726 B CN1514726 B CN 1514726B
Authority
CN
China
Prior art keywords
fatty acid
soap
acid
orlistat
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN028114981A
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English (en)
Chinese (zh)
Other versions
CN1514726A (zh
Inventor
K·梅德
L·C·沙伊布勒
H·斯特芬
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koplar Pharmaceutical Pharmaceutical Co Ltd
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN1514726A publication Critical patent/CN1514726A/zh
Application granted granted Critical
Publication of CN1514726B publication Critical patent/CN1514726B/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Position Fixing By Use Of Radio Waves (AREA)
CN028114981A 2001-06-06 2002-05-31 新型药物组合物 Expired - Lifetime CN1514726B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01113792.4 2001-06-06
EP01113792 2001-06-06
PCT/EP2002/005958 WO2002098413A2 (en) 2001-06-06 2002-05-31 Pharmaceutical compositions comprising orlistat and fatty acids and/or salts thereof

Publications (2)

Publication Number Publication Date
CN1514726A CN1514726A (zh) 2004-07-21
CN1514726B true CN1514726B (zh) 2010-10-06

Family

ID=8177653

Family Applications (1)

Application Number Title Priority Date Filing Date
CN028114981A Expired - Lifetime CN1514726B (zh) 2001-06-06 2002-05-31 新型药物组合物

Country Status (21)

Country Link
US (1) US6730319B2 (https=)
EP (1) EP1399153B1 (https=)
JP (1) JP4558313B2 (https=)
KR (1) KR100613946B1 (https=)
CN (1) CN1514726B (https=)
AR (1) AR037490A1 (https=)
AT (1) ATE375155T1 (https=)
AU (1) AU2002319189B2 (https=)
BR (1) BR0210267A (https=)
CA (1) CA2448035C (https=)
DE (1) DE60222898T2 (https=)
DK (1) DK1399153T3 (https=)
ES (1) ES2292782T3 (https=)
GT (1) GT200200105A (https=)
MX (1) MXPA03011041A (https=)
PA (1) PA8546501A1 (https=)
PE (1) PE20030262A1 (https=)
PT (1) PT1399153E (https=)
UY (2) UY3901U (https=)
WO (1) WO2002098413A2 (https=)
ZA (1) ZA200309099B (https=)

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US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
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Also Published As

Publication number Publication date
US20030039686A1 (en) 2003-02-27
EP1399153A2 (en) 2004-03-24
JP2004532272A (ja) 2004-10-21
DE60222898D1 (de) 2007-11-22
ES2292782T3 (es) 2008-03-16
AU2002319189B2 (en) 2005-08-18
CN1514726A (zh) 2004-07-21
PE20030262A1 (es) 2003-03-19
PT1399153E (pt) 2007-12-31
CA2448035A1 (en) 2002-12-12
UY27320A1 (es) 2003-02-28
MXPA03011041A (es) 2004-03-19
EP1399153B1 (en) 2007-10-10
WO2002098413A2 (en) 2002-12-12
BR0210267A (pt) 2004-07-20
JP4558313B2 (ja) 2010-10-06
WO2002098413A3 (en) 2003-02-27
GT200200105A (es) 2003-02-26
KR20040010681A (ko) 2004-01-31
ZA200309099B (en) 2005-05-25
ATE375155T1 (de) 2007-10-15
DE60222898T2 (de) 2008-07-24
CA2448035C (en) 2009-11-03
UY3901U (es) 2002-07-31
KR100613946B1 (ko) 2006-08-18
US6730319B2 (en) 2004-05-04
PA8546501A1 (es) 2003-01-24
AR037490A1 (es) 2004-11-17
DK1399153T3 (da) 2008-01-07

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Effective date of registration: 20180731

Address after: Greifswald, Germany

Patentee after: Koplar Pharmaceutical Pharmaceutical Company Limited

Address before: Basel

Patentee before: F. Hoffmann-La Roche AG

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20101006