CN1504089A - Chlorsalicylamide cholamine salt suspension formulation - Google Patents
Chlorsalicylamide cholamine salt suspension formulation Download PDFInfo
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- CN1504089A CN1504089A CNA021539103A CN02153910A CN1504089A CN 1504089 A CN1504089 A CN 1504089A CN A021539103 A CNA021539103 A CN A021539103A CN 02153910 A CN02153910 A CN 02153910A CN 1504089 A CN1504089 A CN 1504089A
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Abstract
The invention relates to a novel niclosamide ethanolamine salt suspending agent and method for making same, which is in the form of homogeneous flow viscous agent comprising solid original liquid medicine, water and multiple auxiliary agents for eradication of rice field snail, spiro and schistosomiasis prevention and cure. The suspending agent according to the invention has satisfactory effect in killing mollusk, and it overcomes the drawbacks of the conventional wettable powders.
Description
The technical field of the invention
The present invention relates to new compositions as a kind of bayluscid of invertebrate poison.More specifically, the present invention relates to a kind of bayluscid suspending agent.Above-mentioned suspending agent has good Environmental compatibility, and consumption is suitable, and drug effect is better than the conventional formulations of pesticide.
Background technology
The chemistry of bayluscid is called 2 ', and 5-two chloro-4 '-nitro-salicylic acid is for aniline ethanolamine salt (Niclosamide-olamine).Bayluscid can be used as invertebrate poison on agricultural, by killing its parasitic mollusk, as oncomelania, snail also is used as the medicament of prevention and cure of schistosomiasis.Mainly contain a kind of formulation in the prior art: wetting powder.Because the drug effect of wetting powder is not ideal enough, usage amount is big.In order to overcome the defective of above-mentioned formulation, the inventor has carried out a large amount of research, has developed the application's suspending agent.
Summary of the invention
Bayluscid suspending agent of the present invention is characterised in that in per 100 parts of preparation compositions, comprises niclosamidum active ingredient (Niclosamide) 10-60 part, then is 12.11-72.66 part in bayluscid 98% former medicine.Bayluscid suspending agent further of the present invention is characterised in that, in per 100 parts of preparation compositions, the former medicine 12.11-60.55 part that comprises bayluscid, dispersant 1-15 part, thickener 0.5-5 part, wetting agent 2-20 part, stabilizing agent 1-5 part, antifreezing agent 0.5-10, defoamer 0.1-3 part, preservative 0.1-2 part, water are supplied 100 parts.
Above-mentioned wetting dispersing agent for example is: NNO (methylene dinaphthalene sodium disulfonate), sodium lignin sulfonate, aliphatic alcohol polyethenoxy base ether, alkylaryl polyoxyethylene groups ether sodium sulfate etc.; Above-mentioned thickener and suspension stabilizer for example are: xanthan gum, carboxymethyl cellulose, bentonite, Magnesiumaluminumsilicate etc.; Antifreezing agent for example is: ethylene glycol, glycerine, propane diols etc.; Defoamer for example is: vegetable oil, silicone oil, lauric acid, stearic acid or bubble enemy etc.; Preservative for example is: benzoic acid or formaldehyde.
The former medicine of solid, water and above-mentioned various auxiliary agent are evenly mixed, get final product preparation cost invention preparation, in order to satisfy preparation at pourability (residue), automatically dispersed, the high request of product specification aspects such as wet screening test and suspensibility and bin stability, screen a large amount of auxiliary agents, just obtained satisfied result: pourability (residue)≤1.0%; Automatic dispersiveness 〉=70.0%; Wet screening test (by 325 order testing sieves) 〉=98%; Suspensibility 〉=95%; After 0 ℃ and 54 ℃ of storages, pourability (54 ℃), dispersed automatically, dispersed automatically, wet screening test and suspensibility meet above requirement, content (heat storage stability test back with heat storage stability test before relatively) 〉=97%.
The characteristics of bayluscid suspending agent of the present invention are: (1) fine size, and the suspensibility height, drug effect is higher than wetting powder, can save dose more than 20%; (2) not with an organic solvent.Exempted the excitant of organic solvent to people and animals; (3) agricultural chemicals is a disperse phase, and water is continuous phase.Suppressed the volatilization of agricultural chemicals steam, the preparation substantially tasteless; (4) no explosion danger, storing safety; (5) reduced the percutaneous toxicity of preparation; (6) easy to use.Stoste is thin up and be directly used in the ground ultra low volume spraying not, but also thin up is used for the control of constant and low-gallonage spraying.
Embodiment
The present invention will be described in detail with specific embodiment below.Following embodiment does not constitute any limitation of the invention.
1. example of formulations
1.1 120 gram/liter bayluscid suspending agents
Bayluscid active ingredient: 12 parts
5.0 parts of sodium lignin sulfonates
Draw back 7.0 parts in powder
3.0 parts of carboxymethyl celluloses
5.5 parts of Magnesiumaluminumsilicates
0.5 part of ethylene glycol
0.5 part of lauric acid
0.5 part in benzoic acid
Water: supply 100 parts
1.2 300 gram/liter bayluscid suspending agents:
Bayluscid active ingredient: 30 parts
5.5 parts of sodium lignin sulfonates
6.5 parts of NNO (methylene dinaphthalene sodium disulfonate)
1 part of xanthan gum
1.5 parts of bentonites
0.5 part of ethylene glycol
0.5 part of lauric acid
0.5 part in benzoic acid
Water: supply 100 parts
1.3 580 gram/liter bayluscid suspending agents
Bayluscid active ingredient: 58 parts
7.0 parts of sodium lignin sulfonates
5.8 parts of NNO (methylene dinaphthalene sodium disulfonate)
0.5 part of xanthan gum
1.2 parts of carboxymethyl celluloses
2.0 parts of bentonites
0.5 part of ethylene glycol
0.5 part of lauric acid
0.5 part in benzoic acid
Water: supply 100 parts
2. drug effect embodiment
Adopt following test method, compared suspending agent of the present invention, and conventional wetting powder is to the drug effect of snail.
Rearing-box: 20 centimetres of 40 cm x, 25 cm x (length * wide * height), uncovered, cover with gauze in case snail climbs out of.
Raising condition: dark moist environment.Place the fine earth of about 2 cm thicks at the bottom of the case; Temperature 27 ± 2; Humidity: 70-80% (soil
Earth and air).
Feed: fresh Chinese cabbage.
Snail: 4 monthly ages golden apple snail (golden apple snail), raise a week, it is right as test to get healthy snail
Resemble.
By above-mentioned condition, in each case, spread 2-3 sheet Chinese cabbage, the snail at 20 4 monthly ages is placed on the Chinese cabbage, soup dilutes with ordinary tap water.Evenly spray 5 milliliters of the good soups of dilution with atomizer, cover with gauze.Three parallel tests are carried out simultaneously.Write down lethality after 72 hours.Described in biological activity determination result such as the following table 1:
Table 1: various formulation comparative trials
| Quantity | Concentration (gram niclosamidum/liter) | Average death toll (average mortality, %) | |
| Bayluscid 30% suspending agent ** | But bayluscid 70% wet-milling ***(contrast) | ||
| ??20 | ???1.0 | ??9.3(46.5) | ??7.3(36.5) |
| ??20 | ???1.2 | ??11.3(56.7) | ??9.3(46.5) |
| ??20 | ???1.4 | ??16.3(81.7) | ??14.6(73.0) |
| ??20 | ???1.6 * | ??18.6(93.0) | ??16.6(83.0) |
| ??20 | ???1.8 | ??19.0(95.0) | ??18.0(90.0) |
| ??20 | ???2.0 | ??19.7(98.3) | ??19.0(95.0) |
| ??20 | 0 (blank, water) | ??0.6(3.3) | ??0.3(1.7) |
*: the field working concentration of recommendation
*: in bayluscid, then be 250 gram/liters in niclosamidum
* *: in niclosamidum, then be 830.8 gram/kilograms in bayluscid
Bayluscid 30% suspending agent: former medicine is 98% bayluscid;
But bayluscid 70% wet-milling: former medicine is 98% bayluscid
As can be known, under the field working concentration of recommending (1.6 gram/liter), to the control rate of snail, bayluscid 30% suspending agent is under laboratory condition, apparently higher than bayluscid 70% wetting powder from above-mentioned result of the test.
Claims (4)
1. a bayluscid suspending agent is characterized in that in per 100 parts of preparation compositions, comprises niclosamidum (Niclosamide) active ingredient 10-60 part.
2. according to the bayluscid suspending agent of claim 1, it is characterized in that in per 100 parts of preparation compositions, the 98% former medicine 24.22-60.55 part that comprises bayluscid, dispersant 1-15 part, thickener 0.5-5 part, wetting agent 2-20 part, stabilizing agent 1-5 part, antifreezing agent 0.5-10 part, defoamer 0.1-3 part, preservative 0.1-2 part, water are supplied 100 parts.
3. according to the bayluscid suspending agent of claim 2, Ricinate wherein comprises anionic surfactant, comprise naphthalene or Fluhyzon formaldehyde condensation products, fatty alcohol ethylene oxide adduct sulfonate, the alkylaryl sulfonates of alkylphenol-polyethenoxy base ether sulfonate, lignin and derivative sulfonate thereof, polymerization, polycarboxylate, fatty acid ethane addition product phosphate, alkylphenol-polyethenoxy based phosphates, alkyl phenol polyoxy acetate ether formaldehyde condensation products sulphate; Nonionic surface active agent comprises polyoxyethylene polyoxypropylene base ether block copolymers, alkylphenol-polyethenoxy base phosphate; Water-soluble high-molecular substance comprises starch, gelatin, gum Arabic, lecithin, carboxymethyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, Sodium Polyacrylate, vinylpyrrolidone/vinyl acetate co-polymer, polyethylene glycol; And inorganic dispersant, condensed phosphate; Thickener and suspension stabilizer are: the gum Arabic of organic class, arm protein, xanthan gum, methylcellulose, carboxymethyl cellulose, hydroxyethylcellulose, the bright basic cellulose of hydroxyl, PAA, Sodium Polyacrylate, polyethylene sodium acetate, the dispersed silicic acid of mineral-type, gaseous state silica, bentonite, mineral clay and Magnesiumaluminumsilicate; Antifreezing agent is ethylene glycol, propane diols, glycerine, glycerine-ether diglycol, methyl trimethylene diglycol, urea; Defoamer comprises organic silicone, C
8-10Fatty alcohol, C
10-20Representative examples of saturated aliphatic carboxylic and ester thereof are built, ester-ether type compound; Preservative: Sodium Benzoate, formaldehyde.
4. according to the compound method of the bayluscid suspending agent of claim 1, it is characterized in that by proportioning reinforced after, batch mixes is even, be crushed to particle diameter 70-80 μ m through just, carry out ultramicro grinding then to particle diameter 3-10 μ m, again through the homogeneous mixing preparation, get final product finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02153910 CN1225973C (en) | 2002-12-05 | 2002-12-05 | Chlorsalicylamide cholamine salt suspension formulation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02153910 CN1225973C (en) | 2002-12-05 | 2002-12-05 | Chlorsalicylamide cholamine salt suspension formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1504089A true CN1504089A (en) | 2004-06-16 |
| CN1225973C CN1225973C (en) | 2005-11-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02153910 Expired - Fee Related CN1225973C (en) | 2002-12-05 | 2002-12-05 | Chlorsalicylamide cholamine salt suspension formulation |
Country Status (1)
| Country | Link |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985813B (en) * | 2006-12-07 | 2010-10-06 | 江苏省血吸虫病防治研究所 | Metronidazole ethanolamine spray as blood flukedisease preventing and treating medicine for farm cattle and its preparing method |
| CN103583513A (en) * | 2013-12-03 | 2014-02-19 | 四川省化学工业研究设计院 | Suspending agent of chlorosalicylamide as snail control drug and preparation method thereof |
| CN106070190A (en) * | 2016-06-17 | 2016-11-09 | 杨美玲 | Two-in-one " Lac Bovis seu Bubali shape " pesticide of a kind of efficient stable and the preparation of compounding suspending agent thereof |
-
2002
- 2002-12-05 CN CN 02153910 patent/CN1225973C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985813B (en) * | 2006-12-07 | 2010-10-06 | 江苏省血吸虫病防治研究所 | Metronidazole ethanolamine spray as blood flukedisease preventing and treating medicine for farm cattle and its preparing method |
| CN103583513A (en) * | 2013-12-03 | 2014-02-19 | 四川省化学工业研究设计院 | Suspending agent of chlorosalicylamide as snail control drug and preparation method thereof |
| CN106070190A (en) * | 2016-06-17 | 2016-11-09 | 杨美玲 | Two-in-one " Lac Bovis seu Bubali shape " pesticide of a kind of efficient stable and the preparation of compounding suspending agent thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1225973C (en) | 2005-11-09 |
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Granted publication date: 20051109 Termination date: 20111205 |