CN1985813B - Metronidazole ethanolamine spray as blood flukedisease preventing and treating medicine for farm cattle and its preparing method - Google Patents
Metronidazole ethanolamine spray as blood flukedisease preventing and treating medicine for farm cattle and its preparing method Download PDFInfo
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- CN1985813B CN1985813B CN 200610098192 CN200610098192A CN1985813B CN 1985813 B CN1985813 B CN 1985813B CN 200610098192 CN200610098192 CN 200610098192 CN 200610098192 A CN200610098192 A CN 200610098192A CN 1985813 B CN1985813 B CN 1985813B
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- clonitrilide
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- farm cattle
- schistosomicide
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Abstract
The present invention is niclosamide ethanolamine spray as blood fluke disease preventing and treat medicine for farm cattle and its preparation process. The present invention prepares the niclosamide ethanolamine spray through dissolving niclosamide ethanolamine in 0.5-5 weight portions in cosolvent in 5-10 weight portions, adding penetant in 0.5-2 weight portions and emulsifier in 1-5 weight portions, adding anhydrous alcohol via stirring to 100 weight portions and obtain the niclosamide ethanolamine spray. The niclosamide ethanolamine spray is sprayed to the skin of farm cattle to form one lipophilic protecting medicine layer capable of preventing farm cattle against blood fluke disease in 15-30 days.
Description
Technical field
A kind of metronidazole ethanolamine spray as blood flukedisease preventing and treating medicine for farm cattle and preparation method thereof belongs to the medical protection agent and prevents that farm cattle from infecting the technical field of schistosomicide.
Background technology
Schistosomiasis japanica is the great infectious disease of a kind of serious harm China people's health, and is zoonosis.Farm cattle are the topmost sources of infection of schistosomiasis endemic, still lack at present the method for preventing and treating that effective control farm cattle infect schistosomicide, are difficult to carry out for the measure such as herd of cattle and taboo with machine.Schistosomiasis of farm cattle protective agent technology is to utilize efficient, low toxicity, low-cost Clonitrilide to have good schistosomicide cercaria effect; it is dissolved in makes spray in the cosolvent; be sprayed at the epidermis of cattle; under the effect of short penetrating agent etc.; form the protective layer of a close ester in the epidermal area of cattle; reach the drug effect of long-term maintenance Clonitrilide, prevent that farm cattle from infecting schistosomicide, the control schistosomiasis endemic.
Summary of the invention
The purpose of this invention is to provide a kind of metronidazole ethanolamine spray as blood flukedisease preventing and treating medicine for farm cattle and preparation method thereof, be mixed with the Clonitrilide spray.Spray is sprayed onto the epidermis of cattle, forms the medicament protection layer of an esterphilic type, can prevent effectively that farm cattle from infecting schistosomicide, the protection farm cattle promote to produce, the source of infection of control schistosomicide, protection people health.
Technical scheme of the present invention:
A kind of metronidazole ethanolamine spray as blood flukedisease preventing and treating medicine for farm cattle, the mass content of its solvent is: Clonitrilide 0.5%-5%, cosolvent 5%-10%, penetrating agent 0.5%-2%, emulsifying agent 1%-5%, all the other are dehydrated alcohol.Described cosolvent is a kind of in dimethyl sulfoxide, ethylenediamine or the acetone; Penetrating agent is a kind of in propylene glycol or the azone; Emulsifying agent is a kind of in sorbester p18 or the sorbester p17.
The compound method of Clonitrilide spray, with the quality percentage is that the Clonitrilide of 0.5-5 part is dissolved in the cosolvent of 5-10 part, the penetrating agent that adds 0.5-2 part, the emulsifying agent of 1-5 part, add again under the stirring condition and be mixed with solution in the dehydrated alcohol, solution quality adds up to 100 parts, obtains the Clonitrilide spray.
The application of Clonitrilide spray, after farm cattle are had a blood test the fluke infection situation, use earlier praziquantel treatment, promptly spray the farm cattle whole body after the treatment with the Clonitrilide spray, sprayed 1 time the Clonitrilide spray of the sprinkling dosage average out to 100g that every cattle is each every 15-30 days.
Beneficial effect of the present invention: with the Clonitrilide is raw material, Clonitrilide is dissolved in the cosolvent of 5%-10%, add penetrating agent, emulsifying agent, add again under the stirring condition and be mixed with solution in the dehydrated alcohol, obtain the Clonitrilide spray.Spray is sprayed onto the epidermis of cattle, forms the medicament protection layer of an esterphilic type, can effectively prevent the schistosomicide of farm cattle, the protection farm cattle promote to produce, the source of infection of control schistosomicide, protection people health.This spray preparation method is simple, easy to use, in the protection farm cattle, can control the popular of schistosomicide.
Specific implementation method
Embodiment 1: the preparation of Clonitrilide spray
In the quality percentage, 5 parts of Clonitrilides are dissolved in 10 parts ethylenediamine, add 2 parts of azones and 1 part of sorbester p18, stir in the dehydrated alcohol that joins 82 parts and obtain the Clonitrilide spray.
Embodiment 2: the preparation of Clonitrilide spray
In the quality percentage, 5 parts of Clonitrilides are dissolved in 5 parts ethylenediamine, add 2 parts azone and 2 parts sorbester p18, stir in the dehydrated alcohol that joins 86 parts and obtain the Clonitrilide spray.
Embodiment 3: the preparation of Clonitrilide spray
In the quality percentage, 0.5 part of Clonitrilide is dissolved in 10 parts of dimethyl sulfoxide, adds 0.5 part of azone and 1 part of sorbester p18, stirs in the dehydrated alcohol that is added to 88 parts and obtains the Clonitrilide spray.
Embodiment 4: the preparation of Clonitrilide spray
In the quality percentage, 0.5 part of Clonitrilide is dissolved in 10 parts acetone, adds 1 part of azone and 5 parts of sorbester p17s, stirs in the dehydrated alcohol that joins 83.5 parts and obtains the Clonitrilide spray.
Embodiment 5: the preparation of Clonitrilide spray
In the quality percentage, 0.5 part of Clonitrilide is dissolved in 5 parts acetone, adds 2 parts of propylene glycol and 1 part of sorbester p17, stirs in the dehydrated alcohol that joins 91.5 parts and obtains the Clonitrilide spray.
Embodiment 6: the test of laboratory schistosomicide cercaria
It is 0.5 * 10 that 25 ℃ of laboratorys are mixed with Clonitrilide valid density with embodiment 1
-5, 10
-6, 0.5 * 10
-6, 10
-7, 0.5 * 10
-7, 10
-8Medicinal liquid, hang with suspension ring and to get some schistosomulumes, drop into the death condition of cercaria when observing medicinal liquid effect 20min in the above-mentioned medicinal liquid, the results are shown in Table 1.
Table 1 laboratory protective agent kills larva of a tapeworm or the cercaria of a schistosome result of the test
Embodiment 7: the test of laboratory schistosomicide cercaria
It is 0.5 * 10 that 25 ℃ of laboratorys are mixed with Clonitrilide valid density with embodiment 2
-5, 10
-6, 0.5 * 10
-6, 10
-7, 0.5 * 10
-7, 10
-8Medicinal liquid, hang with suspension ring and to get some schistosomulumes, drop into the death condition of cercaria when observing medicinal liquid effect 20min in the above-mentioned medicinal liquid, the results are shown in Table 2.
Table 2 laboratory protective agent kills larva of a tapeworm or the cercaria of a schistosome result of the test
Embodiment 8: the test of laboratory schistosomicide cercaria
It is 0.5 * 10 that 25 ℃ of laboratorys are mixed with Clonitrilide valid density with embodiment 3
-5, 10
-6, 0.5 * 10
-6, 10
-7, 0.5 * 10
-7, 10
-8Medicinal liquid, hang with suspension ring and to get some schistosomulumes, drop into the death condition of cercaria when observing medicinal liquid effect 20min in the above-mentioned medicinal liquid, the results are shown in Table 3.
Table 3 laboratory protective agent kills larva of a tapeworm or the cercaria of a schistosome result of the test
Embodiment 9: the test of laboratory schistosomicide cercaria
It is 0.5 * 10 that 25 ℃ of laboratorys are mixed with Clonitrilide valid density with embodiment 4
-5, 10
-6, 0.5 * 10
-6, 10
-7, 0.5 * 10
-7, 10
-8Medicinal liquid, hang with suspension ring and to get some schistosomulumes, drop into the death condition of cercaria when observing medicinal liquid effect 20min in the above-mentioned medicinal liquid, the results are shown in Table 4.
Table 4 laboratory protective agent kills larva of a tapeworm or the cercaria of a schistosome result of the test
Embodiment 10: the test of laboratory schistosomicide cercaria
It is 0.5 * 10 that 25 ℃ of laboratorys are mixed with Clonitrilide valid density with embodiment 5
-5, 10
-6, 0.5 * 10
-6, 10
-7, 0.5 * 10
-7, 10
-8Medicinal liquid, hang with suspension ring and to get some schistosomulumes, drop into the death condition of cercaria when observing medicinal liquid effect 20min in the above-mentioned medicinal liquid, the results are shown in Table 5.
Table 5 laboratory protective agent kills larva of a tapeworm or the cercaria of a schistosome result of the test
Embodiment 11: laboratory prevents the mouse infection test with the Clonitrilide spray
It is 0.5 * 10 that 25 ℃ of laboratorys are mixed with valid density with the Clonitrilide spray
-5, 10
-6, 0.5 * 10
-6, 10
-7, 0.5 * 10
-7, 10
-8Medicinal liquid, the variable concentrations medicinal liquid is sprayed on mice cuts plucked abdominal part, treat airing after; hang with suspension ring and to get 45 infection by cercariae of schistosoma mices, every concentration group infects 10 mices, infects and dissects mice after 45 days; observe its infection rate, protective rate and worm load condition, the results are shown in Table 6.
Table 6 laboratory protective agent prevents the mouse infection result of the test
Embodiment 12: laboratory prevents the mouse infection test with the Clonitrilide spray
25 ℃ of laboratorys are sprayed on mouse skin with Clonitrilide spray medicinal liquid; after treating airing; hang with suspension ring respectively at 1d, 5d, 10d, 20d and 30d behind the spray medicine and to get 45 schistosomulumes through the abdominal infection mice; every group is infected 10 mices; infect and dissect mice after 45 days, observe its infection rate and protective rate, respectively organizing the mouse infection rate as a result in the 30d is 0; protective rate is 100%, and protective action is preferably arranged.
Embodiment 13: on-the-spot Clonitrilide spray prevents that farm cattle from infecting the schistosomicide test
Select 160 farm cattle in Wu cities and towns, Yongxiu County, Jiangxi Province to be divided into totally 3 groups of A (53), B (54), C (53), with the top jar hatching method fluke infection situation of having a blood test, the number that A, B, C respectively organize farm cattle infection schistosomicide is respectively 11,8 and 11.Farm cattle are looked into and all use praziquantel treatment after being ill, and check is 1 time after 1 month, and positive person treats again.In the 1st treatment back of farm cattle farm cattle are carried out protection test, promptly spray the farm cattle whole body with the Clonitrilide spray, A group cattle is sprayed Niu Quanshen 1 time with the every 15d of Clonitrilide spray, B group cattle is sprayed Niu Quanshen 1 time with the every 30d of Clonitrilide spray, the every 15d of C group cattle used additives spray sprays Niu Quanshen 1 time, and the spray value of average every cattle is the Clonitrilide spray of 100g.Spray behind the protective agent and with a top jar hatching method 3 groups of farm cattle to be looked into disease in every month, A, B, C respectively organize the number that farm cattle infect schistosomicide and are respectively 2,1 and 8.The results are shown in Table 7, the Clonitrilide spray has the effect that prevents farm cattle infection schistosomicide preferably.
The on-the-spot farm cattle Protection Results of table 7
Claims (1)
1. metronidazole ethanolamine spray as blood flukedisease preventing and treating medicine for farm cattle and preparation method thereof belongs to the medical protection agent and prevents that farm cattle from infecting the technical field of schistosomicide.The present invention is that the Clonitrilide of 0.5-5 part is dissolved in the cosolvent of 5-10 part with the quality percentage, the penetrating agent that adds 0.5-2 part, the emulsifying agent of 1-5 part, add again under the stirring condition and be mixed with solution in the dehydrated alcohol, solution quality adds up to 100 parts, obtains the Clonitrilide spray.This spray is sprayed onto the epidermis of cattle, forms the medicament protection layer of an esterphilic type, can prevent effectively that in 15-30 days farm cattle from infecting schistosomicide, the protection farm cattle promote to produce, the source of infection of control schistosomicide, protection people health.This Clonitrilide spray preparing process is simple, easy to use, when the protection farm cattle are not subjected to schistosomicide, can prevent and control crowd's schistosomiasis endemic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610098192 CN1985813B (en) | 2006-12-07 | 2006-12-07 | Metronidazole ethanolamine spray as blood flukedisease preventing and treating medicine for farm cattle and its preparing method |
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| CN 200610098192 CN1985813B (en) | 2006-12-07 | 2006-12-07 | Metronidazole ethanolamine spray as blood flukedisease preventing and treating medicine for farm cattle and its preparing method |
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| CN1985813A CN1985813A (en) | 2007-06-27 |
| CN1985813B true CN1985813B (en) | 2010-10-06 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102247323A (en) * | 2011-07-07 | 2011-11-23 | 江苏省血吸虫病防治研究所 | Schistosomiasis protective agent used for cattle, namely niclosamide spraying agent and preparation method thereof |
| CN102860981A (en) * | 2012-10-26 | 2013-01-09 | 天津必佳药业集团有限公司 | Schistosomiasis resistant praziquantel transdermal solution for flocks and herds and preparation method |
| CN114272307A (en) * | 2021-06-24 | 2022-04-05 | 岳阳市宇峰血防科技开发有限公司 | Spray for preventing schistosomiasis and preparation method thereof |
Citations (7)
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|---|---|---|---|---|
| GB2213722A (en) * | 1988-01-15 | 1989-08-23 | Ancare Distributors | Anthelmintic niclosamide compositions. |
| EP0487973A1 (en) * | 1990-11-26 | 1992-06-03 | Bayer Corporation | Topical lotion containing Niclosamide |
| CN1124621A (en) * | 1994-08-19 | 1996-06-19 | 中国预防医学科学院寄生虫病研究所 | Wettable powder of niclosamide salt |
| CN1389112A (en) * | 2002-07-11 | 2003-01-08 | 江苏省农药研究所 | Niclosamide insecticide and molluscacide suspension and its prepn. process |
| CN1432278A (en) * | 2002-01-14 | 2003-07-30 | 珠海市侨基海外贸易有限公司 | Niclosamide colloidal suspension |
| CN1504089A (en) * | 2002-12-05 | 2004-06-16 | 珠海市侨基海外贸易有限公司 | Chlorsalicylamide cholamine salt suspension formulation |
| CN1620867A (en) * | 2004-10-16 | 2005-06-01 | 江苏省血吸虫病防治研究所 | Niclosamide ethanolamine salt powder and its preparation method |
-
2006
- 2006-12-07 CN CN 200610098192 patent/CN1985813B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2213722A (en) * | 1988-01-15 | 1989-08-23 | Ancare Distributors | Anthelmintic niclosamide compositions. |
| EP0487973A1 (en) * | 1990-11-26 | 1992-06-03 | Bayer Corporation | Topical lotion containing Niclosamide |
| CN1124621A (en) * | 1994-08-19 | 1996-06-19 | 中国预防医学科学院寄生虫病研究所 | Wettable powder of niclosamide salt |
| CN1432278A (en) * | 2002-01-14 | 2003-07-30 | 珠海市侨基海外贸易有限公司 | Niclosamide colloidal suspension |
| CN1389112A (en) * | 2002-07-11 | 2003-01-08 | 江苏省农药研究所 | Niclosamide insecticide and molluscacide suspension and its prepn. process |
| CN1504089A (en) * | 2002-12-05 | 2004-06-16 | 珠海市侨基海外贸易有限公司 | Chlorsalicylamide cholamine salt suspension formulation |
| CN1620867A (en) * | 2004-10-16 | 2005-06-01 | 江苏省血吸虫病防治研究所 | Niclosamide ethanolamine salt powder and its preparation method |
Non-Patent Citations (1)
| Title |
|---|
| CN 1389112 A,全文. |
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