CN1432278A - Niclosamide colloidal suspension - Google Patents
Niclosamide colloidal suspension Download PDFInfo
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- CN1432278A CN1432278A CN 02100059 CN02100059A CN1432278A CN 1432278 A CN1432278 A CN 1432278A CN 02100059 CN02100059 CN 02100059 CN 02100059 A CN02100059 A CN 02100059A CN 1432278 A CN1432278 A CN 1432278A
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- niclosamidum
- niclosamide
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Abstract
The present invention relates to niclosamide colloidal suspension and its preparation process. The niclosamide colloidal suspension is ropy fluid comprising solid niclosamide, water and several assistants. It is used for killing rice field snail, Fushou snail and schistosome. It has high pesticidal effect and is superior to oil emulsion, wettable powder and other conventional forms.
Description
The technical field of the invention
The present invention relates to new compositions as a kind of niclosamidum of invertebrate poison.More specifically, the present invention relates to a kind of niclosamide colloidal suspension.Above-mentioned colloidal suspending agent has good Environmental compatibility, and consumption is suitable, and drug effect is better than the conventional formulations of pesticide.
Background technology
The chemistry of niclosamidum is by name 2 ', 5-two chloro-4 '-nitro-salicylic acid for aniline (2 ', 5-dichloro-4 '-nitrosalicylanilide).Niclosamidum can be used as invertebrate poison on agricultural, by killing its parasitic mollusk, as oncomelania, snail also is used as the medicament of prevention and cure of schistosomiasis.Mainly contain two kinds of formulations in the prior art: missible oil and wetting powder.Missible oil since work in-process with an organic solvent, unfavorable environmental protection, and eyes are had strong and stimulating; Although the wetting powder Environmental compatibility is better than missible oil, its drug effect is not ideal enough, and usage amount is big.In order to overcome the defective of above-mentioned formulation, the inventor has carried out a large amount of research, has developed the application's colloidal suspending agent.
Summary of the invention
Niclosamide colloidal suspension of the present invention is characterised in that in per 100 parts of preparation compositions, comprises former medicine 10-50 part of niclosamidum.Niclosamide colloidal suspension further of the present invention is characterised in that, in per 100 parts of preparation compositions, the former medicine 10-50 part that comprises niclosamidum, dispersant 1-3 part, thickening agents 0.5-2 part, wetting agent 2-10 part, stabilizing agent 1-3 part, antifreezing agent 0.5-1 part, defoamer 0.1-1 part, preservative 0.1-1 part, water are supplied 100 parts.Preferably comprise 20-45 part niclosamidum active component in the colloidal suspending agent of the present invention.
Above-mentioned dispersant for example is: NNO (methylene dinaphthalene sodium disulfonate), sulfonated lignin sodium salt, bentonite, ore clay or alkylsulfonate; Above-mentioned thickener for example is: polyethylene glycol, xanthans, gelatin or the methylcellulose that contracts; Above-mentioned wetting agent for example is: one or more in alkylphenol polyoxyethylene, aliphatic alcohol polyethenoxy sulphate, sorbitan stearate, Chinese honey locust or the alkylbenzenesulfonate; Detergent for example is: stabilizing agent for example is 3-oleoyl amino-2-methoxy benzenesulfonic acid sodium; Antifreezing agent for example is: ethylene glycol, ethanol, sodium chloride or calcium chloride; Defoamer for example is: polyoxypropylene glycerin ether, vegetable oil, silicone oil, lauric acid, stearic acid or bubble enemy; Preservative for example is: benzoic acid or formaldehyde.
The compound method of colloidal suspending agent of the present invention is: before preparation former medicine of solid and solid additive are crushed to the 5-10 micron with cracker, reinforced according to said ratio then, mixing are stirred in mixing still, prepare through homogenize technology mixing.
In order to satisfy preparation at pourability (residue), initiatively dispersed, the premium properties of product specification aspects such as wet screening test and suspensibility and bin stability, the inventor has carried out a large amount of research, and the pourability (residue) of finding the present composition unexpectedly is smaller or equal to 1.0%; Automatically dispersed more than or equal to 70.0%: wet screening test (by 325 mesh sieves) is more than or equal to 98%; After 0 ℃ and 54 ℃ of storages, pourability (54 ℃), dispersed automatically, wet screening test and suspensibility meet above requirement, and content (after the heat-storage stability test with heat-storage stability test before relatively) is more than or equal to 97%.
The characteristics of niclosamidum suspension concentrates of the present invention are: (1) fine size, and the suspensibility height, drug effect is higher than wetting powder, can save dose more than 20%; (2) not with an organic solvent.Exempted the excitant of organic solvent to people and animals; (3) agricultural chemicals is a disperse phase, and water is continuous phase.Suppressed the volatilization of agricultural chemicals steam, the preparation substantially tasteless; (4) no explosion danger, the storing peace is individual; (5) reduced the percutaneous toxicity of preparation; (6) easy to use.Stoste is thin up and be directly used in the ground ultra low volume spraying not, but also thin up is used for the control of constant and low-gallonage spraying.
Embodiment
The present invention will be described in detail with specific embodiment below.Following embodiment does not constitute any limitation of the invention.
1. example of formulations
With 250 gram/liter niclosamide colloidal suspensions is example:
25 parts of niclosamidums
2 parts of bentonites
1 part of polyethylene glycol
15 parts of the hard ester acid esters of sorbierite
2.5 parts in alkylphenol-polyethenoxy (8) ether
2 parts of 3-oleoyl amino-2-methoxy benzenesulfonic acid sodium
0.5 part of ethylene glycol
0.5 part of polypropylene glycerin ether
0.5 part in benzoic acid
Water is supplied 100 parts
2. drug effect embodiment
Adopt following test method, compared suspension concentrates of the present invention, and conventional missible oil and wetting powder are to the drug effect of snail.Rearing-box: 20 centimetres of 40 cm x, 25 cm x (length * wide * height), uncovered, cover with gauze in case snail climbs out of.Raising condition: dark moist environment.Place about 2 cm thick fine earths at the bottom of the case; 27 ± 2 ℃ of temperature; Humidity: 70-80% (soil
Earth and air).Feed: fresh Chinese cabbage.Snail: 4 monthly ages golden apple snail (golden apple snail), raise a week, get healthy snail as subjects.
By above-mentioned condition, in each case, put and spread 2-3 sheet Chinese cabbage, the snail at 20 4 monthly ages is placed on the Chinese cabbage, soup dilutes with ordinary tap water.Evenly spray 5 milliliters of the good soups of dilution with atomizer, cover with gauze.Three parallel tests are carried out simultaneously.Write down lethality after 48 hours.Described in biological activity determination result such as the following table 1:
Table 1: various formulation comparative trials
*: field working concentration niclosamidum 25% colloidal suspending agent of recommendation: former medicine is a niclosamidum; Niclosamidum 25% missible oil: former medicine is a niclosamidum; But niclosamidum 50% wet-milling: former medicine is a bayluscid
| Quantity | Concentration (gram/liter) | Average death toll (average mortality, %) | ||
| Niclosamidum 25% colloidal suspending agent | Contrast | |||
| Niclosamidum 25% missible oil | But niclosamidum 50% wet-milling | |||
| ??20 | ????1.0 | ????8.0(40.0) | ????8.0(40.0) | ????6.3(31.6) |
| ??20 | ????1.2 | ????11.3(56.7) | ????11.7(58.3) | ????8.3(41.6) |
| ??20 | ????1.4 | ????16.3(81.7) | ????16.7(83.3) | ????12.6(63.3) |
| ??20 | ????1.6 * | ????18.3(91.7) | ????19.0(95.0) | ????15.3(76.6) |
| ??20 | ????1.8 | ????19.0(95.0) | ????19.3(96.7) | ????15.6(78.3) |
| ??20 | ????2.0 | ????19.7(98.3) | ????19.7(98.3) | ????17.3(86.7) |
| ??20 | 0 (blank, water) | ????0.6(3.3) | ????0.6(3.3) | ????0.3(1.7) |
From above-mentioned result of the test as can be known, under the field working concentration of recommending (1.6 gram/liter), to the control rate of snail, niclosamidum 25% colloidal suspending agent, under laboratory condition, control efficiency is suitable with niclosamidum 25% missible oil, but apparently higher than niclosamidum 50% wetting powder.
Claims (4)
1. a niclosamide colloidal suspension is characterized in that in per 100 parts of preparation compositions, comprises former medicine 20-50 part of niclosamidum.
2. according to the niclosamidum suspension concentrates of claim 1, it is characterized in that in per 100 parts of preparation compositions, the former medicine 10-50 part that comprises niclosamidum, dispersant 1-3 part, thickening agents 0.5-2 part, wetting agent 2-10 part, stabilizing agent 1-3 part, antifreezing agent 0.5-1 part, defoamer 0.1-1 part, preservative 0.1-1 part, water are supplied 100 parts.
3. according to the niclosamidum suspension concentrates of claim 2, dispersant wherein is NNO (methylene dinaphthalene sodium disulfonate), sulfonated lignin sodium salt, bentonite, ore clay or alkylsulfonate; Thickener is polyethylene glycol, xanthans, gelatin or the methylcellulose that contracts; Wetting agent is one or more in alkylphenol polyoxyethylene, aliphatic alcohol polyethenoxy sulphate, sorbitan stearate, Chinese honey locust or the alkylbenzenesulfonate; Stabilizing agent is 3-oleoyl amino-2-methoxy benzenesulfonic acid sodium; Antifreezing agent is: ethylene glycol, ethanol, sodium chloride or calcium chloride; Defoamer is: polyoxypropylene glycerin ether, vegetable oil, silicone oil, lauric acid, stearic acid or bubble enemy; Preservative is: benzoic acid or formaldehyde.
4. according to the compound method of the niclosamidum suspension concentrates of claim 1, it is characterized in that before the preparation former medicine of solid and solid additive being crushed to the 5-10 micron with cracker, reinforced by proportioning then, mixing are stirred in stirred tank, and mixing is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB02100059XA CN1181737C (en) | 2002-01-14 | 2002-01-14 | Niclosamide colloidal suspension |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB02100059XA CN1181737C (en) | 2002-01-14 | 2002-01-14 | Niclosamide colloidal suspension |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1432278A true CN1432278A (en) | 2003-07-30 |
| CN1181737C CN1181737C (en) | 2004-12-29 |
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ID=27626968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB02100059XA Expired - Fee Related CN1181737C (en) | 2002-01-14 | 2002-01-14 | Niclosamide colloidal suspension |
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| Country | Link |
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| CN (1) | CN1181737C (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1313438C (en) * | 2004-12-24 | 2007-05-02 | 仲恺农业技术学院 | Preparation method of snail killing agent crude medicine niclosamide |
| WO2007095842A1 (en) * | 2006-02-21 | 2007-08-30 | Fudan University | Use of ginkgolic acids in preparing biotic pesticide for killing snails and preventing schistomiasis |
| CN1985813B (en) * | 2006-12-07 | 2010-10-06 | 江苏省血吸虫病防治研究所 | Metronidazole ethanolamine spray as blood flukedisease preventing and treating medicine for farm cattle and its preparing method |
| CN101366376B (en) * | 2008-09-22 | 2011-04-27 | 扬州绿源生物化工有限公司 | Niclosamide controlled release dispersing agent for killing blood fluke cercaria and preparation method thereof |
| US20110287475A1 (en) * | 2010-05-20 | 2011-11-24 | Azer Scientific, Inc. | Tissue Fixative Having Increased Viscosity |
| CN101088339B (en) * | 2006-06-12 | 2012-05-23 | 复旦大学 | Composite molluscacide containing ginkgolic acid and its preparation process |
| CN107094775A (en) * | 2017-04-25 | 2017-08-29 | 中国农业科学院植物保护研究所 | A kind of composition for preventing and treating agricultural disease and the spiral shell that goes out |
-
2002
- 2002-01-14 CN CNB02100059XA patent/CN1181737C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1313438C (en) * | 2004-12-24 | 2007-05-02 | 仲恺农业技术学院 | Preparation method of snail killing agent crude medicine niclosamide |
| WO2007095842A1 (en) * | 2006-02-21 | 2007-08-30 | Fudan University | Use of ginkgolic acids in preparing biotic pesticide for killing snails and preventing schistomiasis |
| CN101088339B (en) * | 2006-06-12 | 2012-05-23 | 复旦大学 | Composite molluscacide containing ginkgolic acid and its preparation process |
| CN1985813B (en) * | 2006-12-07 | 2010-10-06 | 江苏省血吸虫病防治研究所 | Metronidazole ethanolamine spray as blood flukedisease preventing and treating medicine for farm cattle and its preparing method |
| CN101366376B (en) * | 2008-09-22 | 2011-04-27 | 扬州绿源生物化工有限公司 | Niclosamide controlled release dispersing agent for killing blood fluke cercaria and preparation method thereof |
| US20110287475A1 (en) * | 2010-05-20 | 2011-11-24 | Azer Scientific, Inc. | Tissue Fixative Having Increased Viscosity |
| CN107094775A (en) * | 2017-04-25 | 2017-08-29 | 中国农业科学院植物保护研究所 | A kind of composition for preventing and treating agricultural disease and the spiral shell that goes out |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1181737C (en) | 2004-12-29 |
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