CN1500525A - Medical dressing and its producing method - Google Patents
Medical dressing and its producing method Download PDFInfo
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- CN1500525A CN1500525A CNA021519684A CN02151968A CN1500525A CN 1500525 A CN1500525 A CN 1500525A CN A021519684 A CNA021519684 A CN A021519684A CN 02151968 A CN02151968 A CN 02151968A CN 1500525 A CN1500525 A CN 1500525A
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- medical dressing
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Abstract
The medical dressing consists of solid component and water, and features that the solid component contains quasi-cationic water soluble chitin derivative in 5-100 wt%. The production process of the medical dressing is to dissolve quasi-cationic water soluble chitin derivative in pure water to form water solution. Owing to that the quasi-cationic water soluble chitin derivative is water soluble, water maintainable, antibiotic, biocompatible and biodegradable and can promote heal of wound, it is easy to change without adhesion, less likely to form scar, high in antiseptic and antiphlogistic effect and high in promoting heal. The medical dressing has obvious curative effect on cut, burn and scald wound, traumatic wound, external ulcer surface, etc.
Description
Technical field:
The present invention relates to a kind of medical dressing and production method thereof, relate in particular to a kind of medical dressing and production method thereof for the treatment of skin injury.
Background technology:
The skin injury of medical circle treatment at present typically uses Plant fiber's gauze (as cotton cloth) as drug administration carrier, is covered in the method for wound surface behind the band medicine.This method is because the easy adhesion wound site of Plant fiber's gauze (as cotton cloth) causes when changing dressings repeated trauma skin.Simultaneously, Plant fiber's gauze itself does not have antibiotic property, need be in the advance pedestrian worker sterilization of band medicine; Biocompatibility and degradability are poor, must remove clean.
Summary of the invention:
Purpose of the present invention is exactly to provide a kind of medical dressing and production method thereof in order to overcome the above problems, it obviously quicken wound surface healing, reduce cicatrization, anti-inflammation, be easy to change clothes and anti fully.
The scheme that the present invention achieves the above object is: a kind of medical dressing, comprise solid composition and water, it is characterized in that: include Zhunyang ion-type water-solubility chitin derivative in the solid composition, the percentage by weight that described Zhunyang ion-type water-solubility chitin derivative accounts for all solids composition is 5%-100%.
The scheme that the present invention achieves the above object also comprises a kind of production method of medical dressing, it is characterized in that: Zhunyang ion-type water-solubility chitin derivative is dissolved in the pure water, be made into aqueous solution, wherein to account for the percentage by weight of whole solutes be 5%-100% to water-solubility chitin derivative, and all the other are filler.
Because Zhunyang ion-type water-solubility chitin derivative has characteristics such as good water-solubility, water-retaining property, antibiotic property, promotion skin healing, biocompatibility and biodegradability, therefore be easy to change clothes and complete anti, be difficult for to form cicatrix, anti-inflammation also has good therapeutic effect to wound healing.Through experiment confirm, this dressing is to various operative incisions, empyrosis wound surface, and various traumatic wound surface, the ulcer in body surface wound surface, and various healing property of difficulty chronic ulcers etc. all have the curative effect of highly significant.
Description of drawings:
Fig. 1 is a medical dressing production method flow chart of the present invention.
The specific embodiment:
Medical dressing proposed by the invention includes Zhunyang ion-type (band is amino) water-solubility chitin derivative, also can compositely can promote epidermal growth or/and the medicine of organized renewing or/and other fillers such as medicine that can anti-inflammation, and adds pure water.It can be aqueous solution or makes the film type product.
No matter be aqueous solution or make the film type product, the percentage by weight that Zhunyang ion-type water-solubility chitin derivative accounts for whole solid contents is 5%-100%, and all the other are filler or composite medicine.Filler can be harmless objects such as starch, also can be compound medicine itself.Compound medicine can select to strengthen the medicine of its effect, such as beta-interferon with antivirus action, again such as the epidermal growth factor interest that can promote skin growth because of peptide etc.
Described Zhunyang ion-type water-solubility chitin derivative is that amino reservation amount (containing the percentage ratio that amino repetitive quantity accounts for whole repetitive quantity) is the water-solubility chitin derivative more than 50%.The amino Cationic functional groups that is as the criterion has excellent chemical functional and gives birth to the body function, and as absorption and antibiotic, so amino reservation amount is that water-solubility chitin derivative effect more than 50% is more remarkable.
The production method of this medical dressing as shown in Figure 1, with water-solubility chitin derivative with the medicine that can promote epidermal growth or/and promote the medicine of organized renewing or/and other fillers such as medicine that can anti-inflammation are mutually composite and be dissolved in the pure water, be made into aqueous solution; The direct tinning of composite aqueous solution is become spray-type products.Also composite aqueous solution can be made the film type product under the dry aseptic environments of low temperature (being lower than 35 degrees centigrade).Film forming process is that common process utilizes existing equipment just can realize, for example can adopt plane pouring method, is rotated into embrane method, vacuum film formation method etc.
Provide an object lesson below: (O6CMCH is a kind of in the water-solubility chitin derivative with the water-soluble carboxymethyl chitin O6CMCH of deacetylation 85%, substitution value 10%, molecular weight 300,000, full name is " 6 substituted carboxymethyl chitins of hydroxyl of carbon ", produce by the road biomaterial Science and Technology Ltd. of Shenzhen's sunlight) composite and be dissolved in the pure water with epidermal growth factor rhEGF (producing) by the Shenzhen City HuaShengYuan Gene Engineering Development Co., Ltd, be made into O6CMCH content and be 1% aqueous solution (percentage by weight).This aqueous solution directly tinning becomes spray-type products, also can become the film type product under the cold drying aseptic environments.Film size is 50mm*100mm, and thick is 0.2mm, and this film contains 2 approximately, the rhEGF of 000IU.RhEGF in the spray-type products doubles the consumption of O6CMCH by rhEGF in the film type product.
Claims (10)
1. a medical dressing comprises solid composition and water, it is characterized in that: include Zhunyang ion-type water-solubility chitin derivative in the solid composition, the percentage by weight that described Zhunyang ion-type water-solubility chitin derivative accounts for all solids composition is 5%-100%.
2. medical dressing as claimed in claim 1 is characterized in that: described Zhunyang ion-type water-solubility chitin derivative is that amino reservation amount is the water-solubility chitin derivative more than 50%.
3. medical dressing as claimed in claim 1 is characterized in that: also composite have can promote epidermal growth or/and the medicine of organized renewing or/and medicine that can anti-inflammation.
4. medical dressing as claimed in claim 1 or 2 is characterized in that: described medical dressing is an aqueous solution.
5. medical dressing as claimed in claim 1 or 2 is characterized in that: described medical dressing is a thin film.
6. the production method of a medical dressing is characterized in that: Zhunyang ion-type water-solubility chitin derivative is dissolved in the pure water, is made into aqueous solution, wherein to account for the percentage by weight of whole solutes be 5%-100% to water-solubility chitin derivative, and all the other are filler.
7. medical dressing production method as claimed in claim 6, its feature also comprises the steps: above-mentioned solution with the medicine that can promote epidermal growth the direct tinning of composite aqueous solution to be become spray-type products or/and promote the medicine of organized renewing or/and medicine that can anti-inflammation is mutually composite.
8. medical dressing production method as claimed in claim 6, its feature also comprises the steps: above-mentioned solution with the medicine that can promote epidermal growth composite aqueous solution to be made the film type product or/and promote the medicine of organized renewing or/and medicine that can anti-inflammation is mutually composite under less than 35 degrees centigrade cold drying aseptic environments.
9. medical dressing production method as claimed in claim 6, it is characterized in that: described chitin derivativ is that deacetylation is more than 50%, substitution value is below 30%, molecular weight is about 300,000 the substituted carboxymethyl chitin O6CMCH of 6 hydroxyls of carbon, promote that the medicine of epidermal growth and organized renewing is epidermal growth factor rhEGF, the chitin derivativ O6CMCH content 0.1%-10% that is weight percentage in the described aqueous solution.
10. medical dressing production method as claimed in claim 9 is characterized in that: making film size is 50mm*100mm, and thick is 0.2mm, contains 2, the rhEGF of 000IU.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021519684A CN100453121C (en) | 2002-11-12 | 2002-11-12 | Medical dressing and its producing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021519684A CN100453121C (en) | 2002-11-12 | 2002-11-12 | Medical dressing and its producing method |
Publications (2)
| Publication Number | Publication Date |
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| CN1500525A true CN1500525A (en) | 2004-06-02 |
| CN100453121C CN100453121C (en) | 2009-01-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB021519684A Expired - Lifetime CN100453121C (en) | 2002-11-12 | 2002-11-12 | Medical dressing and its producing method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101053669B (en) * | 2007-05-22 | 2010-05-26 | 中国海洋大学 | Water soluble chitosan-based hemostatic wound-healing marine sponge and its preparation method and application |
| CN102198293A (en) * | 2011-05-27 | 2011-09-28 | 缪泽年 | Compound type chitin artificial skin and preparation method thereof |
| CN102302797A (en) * | 2011-09-15 | 2012-01-04 | 德州海利安生物科技股份有限公司 | Medical colloid dressing and application thereof |
| WO2012136082A1 (en) | 2011-04-02 | 2012-10-11 | 佛山市优特医疗科技有限公司 | A chitosan wound dressing and its method of manufacturing |
| CN102824308A (en) * | 2012-08-31 | 2012-12-19 | 广州润虹医药科技有限公司 | Chitosan antibacterial filming sprayer and preparation method |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4956350A (en) * | 1988-08-18 | 1990-09-11 | Minnesota Mining And Manufacturing Company | Wound filling compositions |
| JPH0469235A (en) * | 1990-07-11 | 1992-03-04 | Taiyo Kagaku Kogyo Kk | Preparation of bacteriaproof packaging material and bacteriaproof packaging material |
| CN1079909A (en) * | 1991-10-31 | 1993-12-29 | 中国人民解放军军事医学科学院卫生装置研究所 | The prescription of biologic dressing for burns and processing technique |
| SE9604610D0 (en) * | 1996-12-16 | 1996-12-16 | Noviscens Ab | Medical composition |
| US6128977A (en) * | 1997-04-09 | 2000-10-10 | Emerson Electric Co. | Shock-absorbing claw hammer |
| US6350336B1 (en) * | 1999-06-22 | 2002-02-26 | Albany International Corp. | Method of manufacturing a press fabric by spirally attaching a top laminate layer with a heat-activated adhesive |
| CN1297957A (en) * | 1999-12-01 | 2001-06-06 | 武汉大学 | Preparation and use of intermingled film or fiber of carboxymethyl chitosan and alginic acid |
| CN1164336C (en) * | 2002-01-21 | 2004-09-01 | 徐云龙 | Biological dressing and its preparing method |
-
2002
- 2002-11-12 CN CNB021519684A patent/CN100453121C/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101053669B (en) * | 2007-05-22 | 2010-05-26 | 中国海洋大学 | Water soluble chitosan-based hemostatic wound-healing marine sponge and its preparation method and application |
| WO2012136082A1 (en) | 2011-04-02 | 2012-10-11 | 佛山市优特医疗科技有限公司 | A chitosan wound dressing and its method of manufacturing |
| CN102198293A (en) * | 2011-05-27 | 2011-09-28 | 缪泽年 | Compound type chitin artificial skin and preparation method thereof |
| CN102302797A (en) * | 2011-09-15 | 2012-01-04 | 德州海利安生物科技股份有限公司 | Medical colloid dressing and application thereof |
| CN102302797B (en) * | 2011-09-15 | 2013-11-20 | 德州海利安生物科技股份有限公司 | Medical colloid dressing and application thereof |
| CN102824308A (en) * | 2012-08-31 | 2012-12-19 | 广州润虹医药科技有限公司 | Chitosan antibacterial filming sprayer and preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100453121C (en) | 2009-01-21 |
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Assignee: SHENZHEN BRIGHT WAY NOVEL BIO-MATERIALS TECH. Co.,Ltd. Assignor: Wu Yiguang Contract record no.: 2010440020063 Denomination of invention: Medical dressing and its producing method Granted publication date: 20090121 License type: Exclusive License Open date: 20040602 Record date: 20100524 |
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Owner name: SHENZHEN BRIGHT WAY NOVEL BIO-MATERIAL TECH. CO., Free format text: FORMER OWNER: WU YIGUANG Effective date: 20100827 |
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Free format text: CORRECT: ADDRESS; FROM: 518049 ROOM 402, BUILDING 13, MEILIN VILLAGE 1, FUTIAN DISTRICT, SHENZHEN CITY, GUANGDONG PROVINCE TO: 518055 A, 8/F, BUILDING 2, CHAGUANGCUN INDUSTRIAL PARK, SHAHE WEST ROAD, NANSHAN DISTRICT, SHENZHEN CITY, GUANGDONG PROVINCE |
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Effective date of registration: 20100827 Address after: 518055, 8 floor A, 2 Industrial Zone, tea garden, Shahe West Road, Shenzhen, Guangdong, Nanshan District Patentee after: SHENZHEN BRIGHT WAY NOVEL BIO-MATERIALS TECH. Co.,Ltd. Address before: 518049 room 13, building 402, Meilin Village, Futian District, Guangdong, Shenzhen Patentee before: Wu Yiguang |
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