CN1498545A - Diet therapy milk powser candy for diabetes and its preparing method - Google Patents
Diet therapy milk powser candy for diabetes and its preparing method Download PDFInfo
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- CN1498545A CN1498545A CNA021395020A CN02139502A CN1498545A CN 1498545 A CN1498545 A CN 1498545A CN A021395020 A CNA021395020 A CN A021395020A CN 02139502 A CN02139502 A CN 02139502A CN 1498545 A CN1498545 A CN 1498545A
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- extraction
- cinnamic aldehyde
- insulin
- polypeptide
- growth factor
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A milk tablet for the dietotherapy of diabetes is prepared through extracting the insulin-like growth factor, protein and polypeptide from formilk of cow, extracting tetramethyl pyrazine from chuan-xiong rhizome, extracting cinnamaldehyde from cinnamon bark, proportionally mixing them with said foremilk and dextrin, and tabletting. Its advnatages are high curative effect and no by-effect.
Description
One, technical field:
The present invention relates to the dietetic therapy product that are used to prevent and treat diabetes that a kind of extract that uses plant and animal is made, is a kind of dietetic therapy milk slice and manufacture method thereof that is used for diabetes specifically.
Two, background technology:
Existing food or the medicine that is used to prevent and treat diabetes, the shortcoming of its existence mainly comprises:
1, the single type of composition wherein, only with single a kind of raw material, effect is not obvious.2, the type of complicated component is wherein only used the total component of Chinese medicine traditional method for extracting, is difficult for accomplishing qualitative, quantitative, and effect is not obvious, and in various degree side effect or untoward reaction are arranged.3, wherein most of raw material is not an integration of edible and medicinal herbs, belongs to the Chinese crude drug class, can not make instant food.
Three, summary of the invention:
The objective of the invention is to overcome the weak point in the above-mentioned background technology, a kind of dietetic therapy milk slice and manufacture method thereof that is used for diabetes is provided, the raw material of this milk slice is an integration of edible and medicinal herbs, the milk slice that uses this method to make, but qualitative, quantitative extracts the known valid chemical constituent respectively, the effective percentage height has no side effect and untoward reaction.
For achieving the above object, technical solution provided by the present invention is:
A kind of dietetic therapy milk slice that is used for diabetes, its special character is to comprise following component: insulin like growth factor that is extracted by cattle colostrums and bonded albumen thereof, polypeptide, the tetramethylpyazine that is extracted by Rhizoma Chuanxiong, the cinnamic aldehyde that is extracted by Cortex Cinnamomi.
Above-mentioned each components contents scope can be: insulin like growth factor and bonded albumen thereof, polypeptide 0.5～2b, tetramethylpyazine 16～20b, cinnamic aldehyde 5～10b (wherein b is a unit of weight).
Above-mentioned each components contents can be: insulin like growth factor and bonded albumen thereof, polypeptide 2b, tetramethylpyazine 16b, cinnamic aldehyde 7b (wherein b is a unit of weight).
A kind of manufacture method that is used for the dietetic therapy milk slice of diabetes, its special character is to comprise following operating procedure:
(1) cattle colostrums is carried out the extraction of insulin like growth factor and bonded albumen thereof, polypeptide, obtain insulin like growth factor and bonded albumen thereof, polypeptide;
(2) Rhizoma Chuanxiong is carried out the extraction of tetramethylpyazine, obtain tetramethylpyazine;
(3) Cortex Cinnamomi is carried out the extraction of cinnamic aldehyde, obtain cinnamic aldehyde;
By the prescription tabletting, make finished product behind the adjuvant mix homogeneously such as three kinds of compositions that (4) above extraction obtained and cattle colostrums powder, dextrin.
In the aforesaid operations step, before tabletting, carry out the cinnamic aldehyde embedding process and handle, the dextrin dry powder during soon cinnamic aldehyde stirs fast with the even injection of high-pressure spray gun, the ratio of cinnamic aldehyde and dextrin dry powder is 4.5～5, form the powdery cinnamic aldehyde, by the prescription tabletting, make finished product then.
In the aforesaid operations step, the extraction process process of insulin like growth factor and bonded albumen thereof, polypeptide is: the lactic acid or the phosphoric acid that cattle colostrums are added an amount of food stage, adjustment acidity is pH4.4～4.6, heating and centrifugation then, get supernatant and carry out clarification filtration, carry out ultrafiltration again,, get insulin like growth factor and bonded albumen thereof, polypeptide the filtrate lyophilization.
In the aforesaid operations step, the extraction process process of Rhizoma Chuanxiong is: Rhizoma Chuanxiong is pulverized, alcohol reflux, the extracting solution concentrating under reduced pressure, desaccharide and oil are removed in the cooling back, reduction vaporization falls residual ethanol, add the hot water dissolving, ether extraction is used in cooling, with extracting solution reuse sulphuric acid extraction, in extracting solution, add saturated sodium carbonate solution and adjust pH9.5～10, with carrying out concentrating under reduced pressure behind the chloroform extraction, once more with in the paste vitriolization, adjust pH9.5～10 with strong aqua ammonia, use chloroform extraction once more, reduction vaporization falls residual chloroform, with the extract Petroleum ether extraction, reduction vaporization falls residual petroleum ether, paste is separated with alkali alumina post layer, add the chloroform eluting with petroleum ether, the reduction vaporization eluent, the crystal that obtains is carried out recrystallization with sublimed method, get tetramethylpyazine.
In the aforesaid operations step, the extraction process process of cinnamic aldehyde is: Cortex Cinnamomi is pulverized, extracted with steam distillation, atmospheric steam distillation Cortex Cinnamomi powder, Jiang Shui cools off with the mixed vapour of oil, carries out oil-water separation then, get cinnamon essential oil, the i.e. cinnamic aldehyde of content 85%～90%.
Compared with prior art, the advantage and the effect that have of the present invention is as follows:
1, the present invention uses modern biochemical technology and extracts wherein known valid chemical constituent, and prescription is simple, definite ingredients, qualitative, quantitative.
2, the present invention all adopts the animal and plant natural food to make raw material, the extract purity height, and consumption is little, and free from extraneous odour can add in the multiple instant food, has no side effect and untoward reaction.
3, the present invention is a food, can make medicine again, is convenient to manufacturer and selects.
4, the finished product made of the present invention meets the alimentary codex of China, Japan, the U.S., European Union.
Four, the specific embodiment:
Contain abundant insulin like growth factor and bonded albumen thereof, polypeptide in the cattle colostrums, main chemical compositions in the Cortex Cinnamomi is a cinnamic aldehyde, be known sugar-lowering components, main chemical compositions tetramethylpyazine in the Rhizoma Chuanxiong (integration of edible and medicinal herbs), be the composition of known energy microcirculation improvement, can prevent and treat diabetic complication.Main component of the present invention is the insulin like growth factor that extracted by cattle colostrums and bonded albumen thereof, polypeptide, the tetramethylpyazine that is extracted by Rhizoma Chuanxiong, the cinnamic aldehyde that is extracted by Cortex Cinnamomi.Manufacture method of the present invention comprises following operating procedure:
(1) cattle colostrums, Cortex Cinnamomi, Rhizoma Chuanxiong are carried out the extraction of three kinds of main components respectively, it comprises:
1, cattle colostrums is carried out the extraction of insulin like growth factor and bonded albumen thereof, polypeptide, get insulin like growth factor and bonded albumen thereof, many skins.
2, Cortex Cinnamomi is carried out the extraction of cinnamic aldehyde, get cinnamic aldehyde.
3, Rhizoma Chuanxiong is carried out the extraction of tetramethylpyazine, get tetramethylpyazine.
(2) batching:
Tabletting behind the adjuvant mix homogeneously such as three kinds of compositions that above extraction is obtained and cattle colostrums powder, before the tabletting, must carry out the cinnamic aldehyde embedding process and handle, it is more stable to make character, and antioxygenic property is the powdery cinnamic aldehyde preferably, its technology is in airtight agitator, dextrin dry powder during evenly injection is stirred fast with high-pressure spray gun with cinnamic aldehyde, cinnamic aldehyde and dextrin dry powder ratio are 1: 4.5～5, form the powdery cinnamic aldehyde, by the prescription tabletting, get the diabetes diet therapy milk slice then.
Embodiment:
A preferred embodiment that below provides test of many times of the present invention and obtain.
(1) insulin like growth factor and bonded albumen thereof, polypeptide in the cattle colostrums, cinnamic aldehyde in the Cortex Cinnamomi, the extraction of tetramethylpyazine in the Rhizoma Chuanxiong, it comprises:
1, the extraction of insulin like growth factor and bonded albumen thereof, polypeptide, its technical process is as follows: will newly gather or the cattle colostrums of cold preservation (4～6 ℃) adds the lactic acid or the phosphoric acid of an amount of food stage, adjustment acidity is pH4.4～4.6,80 ℃ were heated 15 minutes, 4000r/min centrifugation 20 minutes is got supernatant and is carried out clarification filtration, carries out the ultrafiltration of the above material of energy stranded molecule amount 8000 dalton again, with the filtrate lyophilization, get auspicious somatomedin of insulin and bonded albumen thereof, polypeptide.
2, the extraction of cinnamic aldehyde, its technical process is as follows: Cortex Cinnamomi is pulverized, the Cortex Cinnamomi of newly adopting must be placed more than six days, steaming the slide method with steam extracts, atmospheric steam is steamed the slide Cortex Cinnamomi powder, with the mixed vapour cooling of oil with water, carries out oil-water separation, get cinnamon essential oil, wherein cinnamic aldehyde content 85～90%.
3, the extraction of tetramethylpyazine, its technical process is as follows: Rhizoma Chuanxiong is pulverized, use ethanol extraction, the extracting solution concentrating under reduced pressure, desaccharide and oil are removed in the cooling back, reduction vaporization falls residual ethanol, the hot water dissolving who adds 55～60 ℃, ether extraction is used in cooling, with extracting solution reuse 2mol/L sulphuric acid extraction, it is 9.5～10 that extracting solution adds saturated sodium carbonate adjustment pH, with carrying out concentrating under reduced pressure behind the chloroform extraction, once more paste is dissolved in the sulphuric acid of 2mol/L, adjusting pH with strong aqua ammonia is 9.5～10, use chloroform extraction once more, reduction vaporization falls residual chloroform, with extract with 60 ℃ of Petroleum ether extraction, reduction vaporization falls residual petroleum ether, paste is separated with alkali alumina post layer, with 8: 2 petroleum ether, ten chloroform eluting, reduction vaporization eluent, the crystal that obtains is carried out recrystallization with sublimed method, get tetramethylpyazine.
(2) batching:
With above-mentioned auspicious somatomedin of insulin and the bonded albumen thereof that extracts gained respectively, many skins, cinnamic aldehyde, tetramethylpyazine, connecing formula proportion prepares burden, carry out tabletting after adding adjuvants such as cattle colostrums, must carry out the cinnamic aldehyde embedding process before the tabletting handles, it is more stable to make character, antioxygenic property is the powdery cinnamic aldehyde preferably, technology is in the airtight agitator, and cinnamic aldehyde is evenly sprayed dextrin dry powder in stirring fast with high-pressure spray gun, and cinnamic aldehyde and dextrin dry powder ratio are 1: 4.5～5, form the powdery cinnamic aldehyde, connect the prescription tabletting then, promptly make the diabetes diet therapy milk slice, every insulin-containing like growth factor and bonded albumen thereof, polypeptide 2mg, cinnamic aldehyde 7mg, tetramethylpyazine 16mg.
Claims (8)
1, a kind of dietetic therapy milk slice that is used for diabetes is characterized in that comprising following component: insulin like growth factor that is extracted by cattle colostrums and bonded albumen thereof, polypeptide, the tetramethylpyazine that is extracted by Rhizoma Chuanxiong, the cinnamic aldehyde that is extracted by Cortex Cinnamomi.
2, a kind of dietetic therapy milk slice that is used for diabetes according to claim 1, it is characterized in that: described each components contents scope is: insulin like growth factor and bonded albumen thereof, polypeptide 0.5～2b, tetramethylpyazine 16～20b, cinnamic aldehyde 5～10b (wherein b is a unit of weight).
3, a kind of dietetic therapy milk slice that is used for diabetes according to claim 1 and 2, it is characterized in that described each components contents is: insulin like growth factor and bonded albumen thereof, polypeptide 2b, tetramethylpyazine 16b, cinnamic aldehyde 7b (wherein b is a unit of weight).
4, a kind of manufacture method that is used for the dietetic therapy milk slice of diabetes is characterized in that comprising following operating procedure:
(1) cattle colostrums is carried out the extraction of insulin like growth factor and bonded albumen thereof, polypeptide, obtain insulin like growth factor and bonded albumen thereof, polypeptide;
(2) Rhizoma Chuanxiong is carried out the extraction of tetramethylpyazine, obtain tetramethylpyazine;
(3) Cortex Cinnamomi is carried out the extraction of cinnamic aldehyde, obtain cinnamic aldehyde;
By the prescription tabletting, make finished product behind the adjuvant mix homogeneously such as three kinds of compositions that (4) above extraction obtained and cattle colostrums powder, dextrin.
5, a kind of manufacture method that is used for the dietetic therapy milk slice of diabetes according to claim 4, it is characterized in that: before tabletting, carry out the cinnamic aldehyde embedding process and handle, dextrin dry powder during soon cinnamic aldehyde will stir fast with the even injection of high-pressure spray gun, the ratio of cinnamic aldehyde and dextrin dry powder is 4.5～5, form the powdery cinnamic aldehyde, by the prescription tabletting, make finished product then.
6, a kind of manufacture method that is used for the dietetic therapy milk slice of diabetes according to claim 5, it is characterized in that: the extraction process process of described insulin like growth factor and bonded albumen thereof, polypeptide is: the lactic acid or the phosphoric acid that cattle colostrums are added an amount of food stage, adjustment acidity is pH4.4～4.6, heating and centrifugation then, get supernatant and carry out clarification filtration, carry out ultrafiltration again,, get insulin like growth factor and bonded albumen thereof, polypeptide the filtrate lyophilization.
7, a kind of manufacture method that is used for the dietetic therapy milk slice of diabetes according to claim 6, it is characterized in that: the extraction process process of described Rhizoma Chuanxiong is: Rhizoma Chuanxiong is pulverized, alcohol reflux, the extracting solution concentrating under reduced pressure, desaccharide and oil are removed in the cooling back, reduction vaporization falls residual ethanol, add the hot water dissolving, ether extraction is used in cooling, with extracting solution reuse sulphuric acid extraction, in extracting solution, add saturated sodium carbonate solution and adjust pH9.5～10, with carrying out concentrating under reduced pressure behind the chloroform extraction, once more with in the paste vitriolization, adjust pH9.5～10 with strong aqua ammonia, use chloroform extraction once more, reduction vaporization falls residual chloroform, with the extract Petroleum ether extraction, reduction vaporization falls residual petroleum ether, paste is separated with alkali alumina post layer, add the chloroform eluting with petroleum ether, the reduction vaporization eluent, the crystal that obtains is carried out recrystallization with sublimed method, get tetramethylpyazine.
8, a kind of manufacture method that is used for the dietetic therapy milk slice of diabetes according to claim 7, it is characterized in that: the extraction process process of described cinnamic aldehyde is: Cortex Cinnamomi is pulverized, extract with steam distillation, atmospheric steam distillation Cortex Cinnamomi powder, Jiang Shui cools off with the mixed vapour of oil, carry out oil-water separation then, get cinnamon essential oil, the i.e. cinnamic aldehyde of content 85%～90%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA021395020A CN1498545A (en) | 2002-11-04 | 2002-11-04 | Diet therapy milk powser candy for diabetes and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA021395020A CN1498545A (en) | 2002-11-04 | 2002-11-04 | Diet therapy milk powser candy for diabetes and its preparing method |
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| Publication Number | Publication Date |
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| CN1498545A true CN1498545A (en) | 2004-05-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA021395020A Pending CN1498545A (en) | 2002-11-04 | 2002-11-04 | Diet therapy milk powser candy for diabetes and its preparing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006030426A1 (en) * | 2004-09-13 | 2006-03-23 | Amcod Limited | Herbal compositions for treatment of diabetes |
| CN100393225C (en) * | 2006-02-13 | 2008-06-11 | 内蒙古蒙牛乳业（集团）股份有限公司 | Liquid milk |
-
2002
- 2002-11-04 CN CNA021395020A patent/CN1498545A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006030426A1 (en) * | 2004-09-13 | 2006-03-23 | Amcod Limited | Herbal compositions for treatment of diabetes |
| CN100393225C (en) * | 2006-02-13 | 2008-06-11 | 内蒙古蒙牛乳业（集团）股份有限公司 | Liquid milk |
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