CN1456196A - Yunnan Hongyao extractives and application thereof - Google Patents

Abstract

A Yunnan red medicine in the form of tincture, aerosol, tablet, capsule, or oral liquid is prepared by two methods. One method includes such steps as providing all components, respectively pulverizing, sieving, extracting in solvent, collecting extracted liquid, concentrating, drying and proportional mixing. Another method includes such steps as proportioning all components, pulverizing, sieving, mixing, extracting in solvent, collecting the extracted liquid, concentrating and drying. Its application is also disclosed.

Description

A kind of Yunnan hongyao extract and application thereof

Technical field

The present invention relates to YUNNAN HONGYAO, more particularly, the present invention relates to a kind of extract of YUNNAN HONGYAO, the invention still further relates to the application of described Yunnan hongyao extract in multiple dosage form simultaneously.

Background technology

Seven dragons loose in YUNNAN HONGYAO original name Yunnan, feature breed for Yunnan Plant Pharmaceutical Industry Co., Ltd.'s production, main medicine is the Chinese herbal medicine among the people of Yunnan specialty in the prescription, we have effects such as hemostasis, analgesia, removing blood stasis and activating blood flow, expelling wind and removing dampness, hemorrhage effectively with controlling gastrointestinal, uterus, hemorrhoid and cough spitting of blood for many years, the gastric abscess, soft tissue injury, rheumatic arthritis etc. of especially treating stagnation of blood stasis have significant curative effect, through hundreds of routine clinical observations, have affirmed the curative effect to above-mentioned disease.Put on market for many years, significant curative effect has been arranged owing to control various disease conditions such as gastric abscess (stomach, duodenal ulcer and hemorrhage), soft tissue injury, rheumatic arthritis.This kind has gone up ministry standard, and renames YUNNAN HONGYAO as, is the exclusive product of my company, declared to be national Chinese medicine protection kind, after increased Tabules (number of patent application: 03117723.9) again.

But existing capsule and tablet all are crude drug in whole directly to be pulverized back adding adjuvant make, and medicine does not pass through the program of effective component extracting, and wherein the overwhelming majority is the Plant fiber.Therefore, the dosage that existing dosage form need be taken is bigger, and wherein: the YUNNAN HONGYAO tablet amounts is, one time 2～3,3 times on the one, every contains crude drug 0.25g; YUNNANHONGYAOJIAONANG dosage: one time 2～3,3 times on the one, every contains crude drug 0.25g.The dose of medicine is big, and trouble is inconvenient, moreover has strengthened patient's the intestines and stomach burden.The bad people of old people, child or gastrointestinal function particularly, certain difficulty of having taken medicine, this is one and presses for improved problem in addition.

Summary of the invention

The objective of the invention is to overcome deficiency of the prior art, a kind of extract of YUNNAN HONGYAO is provided, be about to the YUNNAN HONGYAO crude drug and extract, propose to be reprocessed into various dosage forms behind its effective ingredient.

Purpose of the present invention is achieved by following technical proposals.

1. the parts by weight of YUNNAN HONGYAO raw material composition are: Radix Notoginseng 20～30, Rhizoma Paridis 55～65, Radix dactylicapni (Radix Dactylicapnotis) 10～15, Radix seu Cortex Heteropanacis 15～20, Radix Psammosilenes 10～15, Pseudostreblus indica Bur. 20～28, Delavay ampelopsis root 20～30, manufacture-yellow Radix Aconiti Kusnezoffii 35～40, Rhizoma Acori Graminei 5～10, southwestern Radix Scutellariae 20～30;

2. Yunnan hongyao extract of the present invention adopts following two kinds of methods to extract respectively:

1. with described YUNNAN HONGYAO each component, pulverize separately is crossed 20～60 mesh sieves, and each adds the solvent of 3～12 times of weight, and described solvent is selected from a kind of in water or the alcohol or their mixture.Extract, collect extracting solution, concentrate, dry, the extract powder mixing that will extract gained more promptly.

2. take by weighing described YUNNAN HONGYAO each component, pulverized 20～60 mesh sieves, mixing adds the solvent extraction of 3～12 times of weight, and described solvent is selected from a kind of in water or the alcohol, or their mixture, collects extracting solution, concentrates, is drying to obtain.

3. the extractum adding adjuvant that makes with above-mentioned two kinds of methods can be made tincture, aerosol, tablet, capsule, oral liquor and other types of formulations respectively.

The toxicological study result

1. acute toxicity testing

17g～20g, the ICR mice, gastric infusion is 3 times in 24 hours, each 0.8/20g, daily dose 15g/kg, behave 400 times of daily dosage, after the administration 7 days, observe the activity of animal hair color, diet and defecation are all normal, the corpse perusal is normal, the ((weight increase of X ± SD) of body weight 20.36 ± 1.17 after the administration of X ± SD) of body weight 18.25 ± 1.07 before the administration.

2. long term toxicity test

1. successive administration is 90 days, the behavior of 3 groups of rat outward appearances, activity, hair color, diet and stool no abnormality seen.

2. to the influence of growth of young rats (body weight), the back body weight gain is slower around the high dose group self administration of medication the, all the other group body weight gain basically identicals.

3. hematological examination result shows, significant difference between each administration group and the matched group, and high low dose group does not have the significance meaning yet, illustrates that administration 90 days do not have obvious influence to rat external hemogram.

4. to the influence of the dirty body ratio of rat, except that high dose group spleen weight/power ratio greater than the matched group, all the other no clear meanings.

Though 5. the red medicine high dose group of blood biochemistry checking results suggest has the trend of rising rat blood serum AST, T-BLL and T-CHO content but compares no significance meaning, meaning that there are no significant between all the other every index groups with blank.

6. zoopery shows, YUNNAN HONGYAO has tangible analgesia, antiinflammatory, hemostasis, promotes the increase of uterine smooth muscle contraction intensity.

3. pharmacological experiments

1. analgesic activity can obviously reduce the mouse writhing number of times that acetic acid causes, the pain that the mice hot plate is caused has analgesic activity.

2. antiinflammatory action, xylol causes that mice auricle swelling has the obvious suppression effect, to mouse peritoneal permeability capillaceous, the agar granuloma, the swelling of wasting time of rat Ovum Gallus domesticus album foot has inhibitory action.

3. anastalsis can shorten clotting time of mice, and can platelet increasing quantity.

4. to the effect of isolated rat uterine smooth muscle, all can promote the increase of intensity of uterine contraction behind the height dosed administration.

Compared with prior art, the present invention has following outstanding advantage:

1. the extract yield that obtains from YUNNAN HONGYAO is 8%～10%, calculate by 8%, from the YUNNANHONG medicated powder of 2.25g, can extract the 0.18g effective ingredient, be only need take the 0.18g Yunnan hongyao extract every day, the administration number of times of dosage form every day of making by this dosage is less greatly, also brings into play the drug action of YUNNAN HONGYAO fully, for example extract tablet and capsule, make the specification that every (grain) contains extract 90mg, just only need take 2 (grains) every day.Reduce administration number of times and accumulated dose, reduce side effect, take also convenient.

2. the capsule of existing YUNNAN HONGYAO and tablet all are after crude drug in whole is directly pulverized, add adjuvant after the sterilization again and make, and Yunnan hongyao extract have been sterilized in leaching process, follow-up processing need not be sterilized again, reduce process procedure, reduced production cost, and met hygienic requirements.

3. utilize the medical material fecula only to be fit to make tablet or capsule, but will can be made into multiple dosage form after the YUNNAN HONGYAO extraction, application and subject range are wider.Extract is inherited and has been strengthened the distinctive medicinal effects of red medicine, and curative effect is more definite.Tablet and the capsule made with extract have strengthened original medicinal effects; Aerosol, tincture and preparation capable of permeating skin are given full play to the external effect of YUNNAN HONGYAO, strengthen the unique effect of treatment soft tissue injury, rheumatic arthritis.The various demands of extensive patients have been made things convenient for.

The specific embodiment

By specific embodiment given below and Application Example, can further be well understood to the present invention.But they are not limitation of the invention.

Embodiment 1

Take by weighing the each component of YUNNAN HONGYAO: Radix Notoginseng 100 grams, Rhizoma Paridis 250 grams, Radix dactylicapni (Radix Dactylicapnotis) 50 grams, Radix seu Cortex Heteropanacis 75 grams, Radix Psammosilenes 50 grams, Pseudostreblus indica Bur. 95 grams, Delavay ampelopsis root 100 grams, manufacture-yellow Radix Aconiti Kusnezoffii 150 grams, Rhizoma Acori Graminei 30 grams, southwestern Radix Scutellariae 100 grams.With described YUNNAN HONGYAO each component, pulverize separately is crossed 20～60 mesh sieves, and each adds the water of 10 times of weight, extracts, and collects extracting solution, concentrates, dry, and the extract powder mixing that will extract gained more promptly.

Embodiment 2

Except the YUNNAN HONGYAO each component after sieving, add respectively outside the ethanol of 4 times of weight, other process is with embodiment 1.

Embodiment 3

Except the YUNNAN HONGYAO each component after sieving, add respectively outside the ethanol water of 6 times of weight 60%, other process is with embodiment 1.

Embodiment 4

Take by weighing described YUNNAN HONGYAO each component, pulverized 20～60 mesh sieves, mixing, the water extraction of 12 times of weight of adding is collected extracting solution, concentrates, is drying to obtain.

Embodiment 5

Except that at extraction step being adds the ethanol of 5 times of weight, other process is with embodiment 4.

Embodiment 6

Except that at extraction step being adds the ethanol water of 8 times of weight 50%, other process is with embodiment 4.

Application Example 1

Yunnan hongyao extract powder 0.1～3kg is got in the preparation of YUNNANHONG tincture, and the ethanol of adding 60%～95% leaves standstill to clear and bright to the 1000ml graduation mark, filters, promptly.This product is external, directly medicine is spread upon the affected part.Promoting blood circulation to remove blood stasis, expelling wind and removing dampness.Be used for soft tissue contusion, rheumatic arthritis, rheumatic lumbago and scelalgia etc.

Application Example 2

The preparation of YUNNAN HONGYAO aerosol is got Yunnan hongyao extract powder 1～20g and vitamin C 0.1～10g and is dissolved in 60%～95% the ethanol, filters, pour in the container of cleaning, drying, load onto valve and tighten, be pressed into propellant in pressing machine, it is operated down and is undertaken by the aerosol for external use preparation method.This product is external, and medicine directly is sprayed at the affected part.Promoting blood circulation to remove blood stasis, expelling wind and removing dampness.Be used for soft tissue contusion, rheumatic arthritis, rheumatic lumbago and scelalgia etc.The YUNNAN HONGYAO aerosol has quick-acting and positioning action, and drug distribution is even, absorbs soon, can avoid gastrointestinal to destroy.

Application Example 3

Consisting of of Yunnan hongyao extract tablet: Yunnan hongyao extract 10～500mg, starch 10～120mg, dextrin 10～100mg, Icing Sugar 10～100mg, microcrystalline Cellulose 10～100mg, 60%～80% ethanol is an amount of, magnesium stearate 0.1～10mg, Pulvis Talci 0.1～10mg

Method for making: take by weighing Yunnan hongyao extract and microcrystalline Cellulose, dextrin, Icing Sugar, starch mix homogeneously, with ethanol system soft material, 12～24 order ferrum sieve series grains, dry under 50 ℃～80 ℃, 12～24 mesh sieve granulate add magnesium stearate and Pulvis Talci in the dried granule, mixing, tabletting are promptly.

Application Example 4

Yunnan hongyao extract is capsular to consist of: Yunnan hongyao extract 10～500mg, and starch 10～120mg, dextrin 10～100mg, microcrystalline Cellulose 10～100mg, 60%～80% ethanol is an amount of, magnesium stearate 0.1～10mg.

Method for making: take by weighing Yunnan hongyao extract, starch, dextrin, microcrystalline Cellulose mix homogeneously, the ethanol system soft material with 60%～80%, 12～24 order ferrum sieve series grains, dry under 50 ℃～80 ℃, 12～24 mesh sieve granulate add magnesium stearate in the dried granule, mixing is filled promptly.

Application Example 5

Consisting of of YUNNAN HONGYAO oral liquid: Yunnan hongyao extract 10～500g, sucrose 10～1000g, antiseptic, flavoring agent, distilled water are an amount of, make 1000ml altogether.

Method for making: get in the sucrose impouring container, behind the adding distil water, feed steam heated, filter with 40 order copper wires after the sucrose dissolved, Yunnan hongyao extract is added in an amount of distilled water, stirring and dissolving is filtered, and filtrate is mixed with above-mentioned liquid syrup, respectively with antiseptic, flavoring agent dissolving, under agitation slowly pour in the above-mentioned mixed liquor, adding distil water to 1000 milliliter, fill is promptly.

The multiple dosage form that the present invention is processed into Yunnan hongyao extract, its route of administration and characteristics see the following form.

Dosage form	Route of administration	Products characteristics	Remarks
				Tablet	For oral administration	Dosage is accurate, uses to make things convenient for volume little, and it is convenient to carry with accumulating; Production mechanization, automaticity height, cost is lower	Comprise coated tablet, Film coated tablets
Capsule	For oral administration	Can cover the abnormal flavour of medicine, attractive in appearance being beneficial to taken, and be easy to carry.Can improve stability of drug.The bioavailability height disperses soon good absorbing in gastrointestinal tract.	Comprise conventional capsule, slow releasing capsule and soft capsule
				Oral liquid	For oral administration	Medicine dispersion height, corresponding solid dosage forms absorbs fast, acts on rapidly, and easily divided dose is fit to child and gerontal patient and takes.
Tincture	External	Directly medicine is spread upon the affected part
				Aerosol	External	Have quick-acting and positioning action, drug distribution is even, absorbs soon, can avoid gastrointestinal to destroy.
Preparation capable of permeating skin	External	Can produce lasting, constant and blood drug level control, prolong action time, reduce administration number of times and accumulated dose, reduce side effect, avoid the medicine gastrointestinal tract to destroy.	Comprise ointment, gel and transdermal patch.

Claims (7)

1. Yunnan hongyao extract, the parts by weight that described YUNNAN HONGYAO raw material is formed are: Radix Notoginseng 20～30, Rhizoma Paridis 55～65, Radix dactylicapni (Radix Dactylicapnotis) 10～15, Radix seu Cortex Heteropanacis 15～20, Radix Psammosilenes 10～15, Pseudostreblus indica Bur. 20～28, Delavay ampelopsis root 20～30, manufacture-yellow Radix Aconiti Kusnezoffii 35～40, Rhizoma Acori Graminei 5～10, southwestern Radix Scutellariae 20～30; Described Yunnan hongyao extract can be prepared by following two kinds of methods respectively:

1. with described YUNNAN HONGYAO each component, pulverize separately is crossed 20～60 mesh sieves, and each adds the solvent of 3～12 times of weight, and described solvent is selected from a kind of in water or the alcohol or their mixture.Extract, collect extracting solution, concentrate, dry, the extract powder mixing that will extract gained more promptly;

2. take by weighing described YUNNAN HONGYAO each component, pulverized 20～60 mesh sieves, mixing adds the solvent extraction of 3～12 times of weight, and described solvent is selected from a kind of in water or the alcohol, or their mixture, collects extracting solution, concentrates, is drying to obtain.

2. the application of the described Yunnan hongyao extract of claim 1 in tablet processing.

3. the application of the described Yunnan hongyao extract of claim 1 in capsule processing.

4. the application of the described Yunnan hongyao extract of claim 1 in oral liquid processing.

5. the application of the described Yunnan hongyao extract of claim 1 in tincture processing.

6. the application of the described Yunnan hongyao extract of claim 1 in aerosol processing.

7. the application of the described Yunnan hongyao extract of claim 1 in preparation capable of permeating skin processing.