CN1454602A - High water-soluble povidone-iodine cream - Google Patents
High water-soluble povidone-iodine cream Download PDFInfo
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- CN1454602A CN1454602A CN 03117635 CN03117635A CN1454602A CN 1454602 A CN1454602 A CN 1454602A CN 03117635 CN03117635 CN 03117635 CN 03117635 A CN03117635 A CN 03117635A CN 1454602 A CN1454602 A CN 1454602A
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- water
- povidone iodine
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- polyvinyl alcohol
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Abstract
The invention is a kind of high water-solubility povidone iodine film agent, it is made from povidone iodine and high water-solubility filming material polyethylene alcohol, the weight ratio is 1:1-1:100, the polyethylene alcohol is selected from the first class polyethylene alcohol by which the film agent is made up, the film agent can be dissolved in half an hour at 37 deg.C, such as polyethylene alcohol 05-88, 04-88, and the compound of them at any rate. The manufacturing method is: the povidone iodine is added to the water and heated to 40-100 deg.C, after it is dissolved, the polyethylene alcohol and plasticizer are added and heated under 80-100 deg.C for an hour, they are dissolved evenly; they are cooled to 40-70% and are mixed to remove bubbles, then they are placed on the board, they are dried under 60-100 deg.C for 30-60 minutes, removes the film and slices them into pieces.
Description
Technical field
The invention belongs to the disinfectant technical field that contains iodine, be specifically related to a kind ofly to be used for the treatment of burn and scald, skin ulcer, gynaecopathia, prevent the povidone iodine membrane agent of spread of sexually transmitted diseases and contraception during in particular for sexual intercourse.
Technical background
Povidone iodine is the disinfectant of a kind of wide spectrum, efficient, low toxicity, safety.For antibacterial, fungus, virus, protozoon etc. good killing action is arranged all, can be used for treating burn and scald, skin ulcer, gynaecopathia, prevention and auxiliary treatment sexually transmitted disease (STD).At present, the dosage form about povidone iodine has solution, suppository, ointment, gel.But the solution poor stability easily runs off the drug level that can not remain valid for a long time; Ointment, this two classes dosage form drug loading of gel are little, use inconvenience; And suppository is unstable more than 40 ℃, and easily fusion, inconvenience are preserved, and easily flow out after the medication.
Once relevant for the povidone iodine membrane agent report of treatment oral ulcer, the method that is adopted was: povidone iodine, polyvinyl alcohol 17-88, sodium carboxymethyl cellulose, G ﹠ W are made membrane.Because the filmogen polyvinyl alcohol 17-88 poorly water-soluble that is adopted, need under higher temperature, as could in water, dissolving in 80 ℃ of-90 ℃ of water-baths, so the above-mentioned membrane poorly water-soluble that makes, can't be suitable for the demanding applied environment of water solublity, range of application is restricted.Therefore, though povidone iodine has wide spectrum, low toxicity, efficient, safe characteristics, because the shortcomings such as use inconvenience, poor stability or poorly water-soluble of product at present, its application is subjected to certain limitation.
Summary of the invention
The objective of the invention is to the problem that exists at prior art, a kind of good stability, long shelf-life, curative effect height, good water solubility, high water capacity povidone iodine membrane agent easy to use are provided.
The present invention is a kind of highly-water-soluble povidone iodine membrane agent, and it is that principal agent is formulated with povidone iodine and highly-water-soluble filmogen polyvinyl alcohol, and povidone iodine and filmogen polyvinyl alcohol weight ratio are 1: 1-1: 100.
The membrane that described highly-water-soluble filmogen polyvinyl alcohol is made in room temperature to 37 ℃ scope can dissolve in half an hour in water, and is optional from polyvinyl alcohol 05-88 or 04-88, or the mixture of being made with arbitrary proportion by 05-88 and 04-88.
Described povidone iodine membrane agent, the weight ratio of its component is preferably 1: 1-1: 4.
Preparation method of the present invention is:
In water, add povidone iodine PVP-I, agitating heating 40-100 ℃, make its dissolving, add polyvinyl alcohol and plasticizer, in 80-100 ℃ of agitating heating 1 hour, the dissolving mixing; Be cooled to 40 ℃-70 ℃ and slowly stir the aerofluxuss bubble, bed board while hot advanced to dry by the fire 30-60 minute in 60-100 ℃, and optimum temperature is 90 ℃ and advances baking 30 minutes.Skinning cuts into every film that contains iodine 50mg, also can adopt film-making machine device system film.Wherein plasticizer is glycerol, sorbitol etc.
Advantage of the present invention is:
(1) steady quality because povidone iodine has been made membrane, makes available iodine wherein not volatile, is beneficial to keep its curative effect.
(2) the povidone iodine membrane agent volume is little, and drug loading is big, and it is convenient to use, store.
(3) owing to adopted filmogen soluble in water such as polyvinyl alcohol 05-88 or 04-88, the povidone iodine membrane agent water solublity that makes is good.By following contrast experiment as can be seen: get the membrane A that makes by PVAC polyvinylalcohol 05-88 or 04-88 and each two of the membrane B that make by the lower PVAC polyvinylalcohol 17-88 of water solublity, shred, place the 50ml beaker respectively, add water 20ml, in 25 ℃ of stirrings of room temperature, observe, all dissolvings in membrane A5 minute, and membrane B is almost not molten in 5 minutes.Get membrane B separately and still according to said method measure its dissolubility respectively in 50 ℃, 60 ℃, 70 ℃, 80 ℃, 90 ℃, the result only could be dissolved in 5 minutes at membrane B more than 80 ℃.
(4) curative effect height because it can dissolve rapidly in water the time, is distributed in the affected part, and medicine can be not excessive, and can keep sufficient dose.Can progressively discharge the iodine of valid density after the dissolving and bring into play antibacterial action.
The characteristics that the present invention gives prominence to are to have adopted good filmogen of water solublity such as polyvinyl alcohol 05-88 or 04-88 to make this membrane; make membrane have extraordinary water solublity; in the time of 25 ℃, just can be dissolved in the water rapidly; can bring into play bactericidal action fast in the use; be specially adapted to practise contraception when sexual intercourse or prevent spread of sexually transmitted diseases, it can dissolve rapidly in intravaginal, forms protecting film; thereby prevent spread of sexually transmitted diseases such as gonorrhea, syphilis, acquired immune deficiency syndrome (AIDS), have easy to use, act on characteristics rapidly.
The specific embodiment
Embodiment 1: povidone iodine (the PVP-I amount of iodine is 22.57%) 27g polyvinyl alcohol 05-88 (PVA) 61g glycerol 13g water 300ml
PVAC polyvinylalcohol 05-88, glycerol are added in the suitable quantity of water, and stirring in water bath is heated to 85 ℃, makes it dissolving, adds povidone iodine (PVP-I) again, in 85 ℃ of agitating heating 1 hour, dissolves mixing fully.Be cooled to 50-60 ℃ and drain bubble.Bed board is made film while hot, advances baking 30 minutes, skinning in 90 ℃.Cut into every film that contains iodine 50mg.
Embodiment 2: povidone iodine (the PVP-I amount of iodine is 22.57%) 27g polyvinyl alcohol 04-88 (PVA) 61g glycerol 13g water 300ml
Add povidone iodine (PVP-I) in water, about 60 ℃ of agitating heating makes its dissolving, adds polyvinyl alcohol 04-88 (PVA), glycerol, in 90 ℃ of agitating heating 1 hour, and the dissolving mixing.Be cooled to 50 ℃-60 ℃ and slowly stir the aerofluxuss bubble, bed board while hot advances baking 30 minutes in 90 ℃, and skinning cuts into every film that contains iodine 50mg.
Embodiment 3: povidone iodine (the PVP-I amount of iodine is 22.57%) 27g polyvinyl alcohol 04-88 (PVA) 30g polyvinyl alcohol 05-88 (PVA) 30g glycerol 13g water 300ml
Preparation changes the mixture with polyvinyl alcohol 05-88 (PVA) for polyvinyl alcohol 04-88 (PVA) with embodiment 1 with polyvinyl alcohol 05-88 (PVA).
Claims (7)
1. a highly-water-soluble povidone iodine membrane agent is characterized in that with povidone iodine and highly-water-soluble filmogen polyvinyl alcohol be that principal agent is formulated, and weight ratio is 1: 1-1: 100.
2, highly-water-soluble povidone iodine membrane agent according to claim 1, it is characterized in that highly-water-soluble filmogen polyvinyl alcohol be selected from the membrane in room temperature to 37 ℃ scope, made can be in water a dissolved quasi-polyethylene alcohol in half an hour.
3,, it is characterized in that highly-water-soluble filmogen polyvinyl alcohol is the arbitrary proportion mixture of polyvinyl alcohol 05-88, polyvinyl alcohol 04-88 or polyvinyl alcohol 05-88 and polyvinyl alcohol 04-88 according to the described highly-water-soluble povidone iodine membrane agent of claim 2.
4, according to claim 1,2 or 3 described highly-water-soluble povidone iodine membrane agents, the weight ratio that it is characterized in that its principal agent is 1: 1-1: 4.
5, the preparation method of claim 1,2 or 3 described highly-water-soluble povidone iodine membrane agents, it is characterized in that: in water, add povidone iodine PVP-I, agitating heating 40-100 ℃, make its dissolving, add highly-water-soluble filmogen polyvinyl alcohol and plasticizer, in 80-100 ℃ of agitating heating 1 hour, the dissolving mixing; Be cooled to 40 ℃-70 ℃ and slowly stir the aerofluxuss bubble, bed board while hot advanced to dry by the fire 30-60 minute in 60-100 ℃, and skinning cuts into diaphragm.
6. highly-water-soluble povidone iodine membrane agent preparation method according to claim 5 is characterized in that plasticizer is glycerol, sorbitol etc.
7. highly-water-soluble povidone iodine membrane agent preparation method according to claim 5, the optimum temperature that it is characterized in that into baking is 90 ℃, Best Times is 30 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03117635 CN1454602A (en) | 2003-04-06 | 2003-04-06 | High water-soluble povidone-iodine cream |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03117635 CN1454602A (en) | 2003-04-06 | 2003-04-06 | High water-soluble povidone-iodine cream |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1454602A true CN1454602A (en) | 2003-11-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03117635 Pending CN1454602A (en) | 2003-04-06 | 2003-04-06 | High water-soluble povidone-iodine cream |
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| CN (1) | CN1454602A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016109344A1 (en) * | 2014-12-30 | 2016-07-07 | 3M Innovative Properties Company | Bactericidal composition |
| CN108403671A (en) * | 2018-06-11 | 2018-08-17 | 佛山市南海东方澳龙制药有限公司 | Betagen Solution and preparation method thereof |
| CN108836951A (en) * | 2018-06-20 | 2018-11-20 | 中山万汉制药有限公司 | A kind of povidone iodine slow-release medicine-membrane and preparation method thereof |
-
2003
- 2003-04-06 CN CN 03117635 patent/CN1454602A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016109344A1 (en) * | 2014-12-30 | 2016-07-07 | 3M Innovative Properties Company | Bactericidal composition |
| CN108403671A (en) * | 2018-06-11 | 2018-08-17 | 佛山市南海东方澳龙制药有限公司 | Betagen Solution and preparation method thereof |
| CN108403671B (en) * | 2018-06-11 | 2021-04-27 | 佛山市南海东方澳龙制药有限公司 | Povidone-iodine solution and preparation method thereof |
| CN108836951A (en) * | 2018-06-20 | 2018-11-20 | 中山万汉制药有限公司 | A kind of povidone iodine slow-release medicine-membrane and preparation method thereof |
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