CN114392250A - In-situ rapid-forming hydrogel skin patch and preparation method thereof - Google Patents

In-situ rapid-forming hydrogel skin patch and preparation method thereof Download PDF

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CN114392250A
CN114392250A CN202111343927.1A CN202111343927A CN114392250A CN 114392250 A CN114392250 A CN 114392250A CN 202111343927 A CN202111343927 A CN 202111343927A CN 114392250 A CN114392250 A CN 114392250A
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沙前坤
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Chongqing Yangdu Biological Research Institute Co ltd
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Abstract

The invention relates to the technical field of hydrogel, in particular to an in-situ fast forming hydrogel skin patch, which comprises a patch base formula, a patch base formula and a patch base formula, wherein the patch base formula comprises a component A and a component B, the component A comprises 0.5-4% (w/v) sodium alginate and 0-5% (w/v) adhesive film-forming material, and the balance is deionized water; the component B comprises 0.5-10% (w/v) of polyvalent metal ions, 0-70% (w/v) of ethanol and 0-5% (w/v) of a viscous film forming material, and the balance is deionized water, and according to the use purpose, auxiliary medicines and auxiliary materials are added into the component A and the component B or the component AB in the basic formula to replace the equivalent deionized water in the corresponding components; also relates to a preparation method of the hydrogel skin patch for in-situ rapid prototyping, which comprises the following steps: after the component A and the component B are prepared, the solution in the component A is sprayed or brushed on a target area, then the solution in the component B is sprayed or brushed on the same position, and after the spraying or brushing is finished, the hydrogel patch can be generated in situ after waiting for a certain time.

Description

In-situ rapid-forming hydrogel skin patch and preparation method thereof
Technical Field
The invention relates to the technical field of hydrogel, in particular to an in-situ rapid-forming hydrogel skin patch and a preparation method thereof.
Background
The skin is the largest organ in the human body, is directly contacted with the external environment, and has the functions of protection, feeling, breathing, excretion and the like. In daily work and life, people often suffer from small-scale skin injuries such as incised wounds, abrasions, scalds and the like, and if the skin injuries are not treated in time, serious consequences are possibly caused; in addition, various sports injuries, sprains, soft tissue injuries, joint pain and itching, and skin diseases such as leprosy, scabies, mycosis, skin bacterial infections, etc. are usually treated by skin-assisted drug delivery. At present, a plurality of transdermal drug delivery modes, such as a wound dressing, have the effect of dressing wounds and transdermal drug delivery, but have poor joint activity and skin attachment degree; the cream has larger dosage and better slow release performance, but the cream is inconvenient to use and often causes discomfort to patients; the liniment volatilizes fast and has poor slow release performance; in addition, film-spraying agent and plaster can be added.
The film spraying agent is a novel preparation for local external use, which is prepared by taking a biological high molecular material as a carrier and dissolving and dispersing a medicine in the carrier. When in use, the water-soluble bio-membrane is sprayed on the surface of skin injury or the affected part of skin to form a layer of soluble bio-membrane, so that the evaporation of water on the surface of the skin is reduced, the hydration and the dissolution of cutin are promoted, the medicine penetrates through the cutin to slowly release the medicine, the retention time of the medicine on the affected part is prolonged, the medicine effect is improved, and other auxiliary materials are saved. The film spraying agent has wide application and development prospect in the aspects of bacteriostasis, diminishing inflammation, stopping bleeding, relieving pain and promoting wound healing as an external preparation with simple preparation, convenient application and obvious curative effect, and has been widely concerned at home and abroad in recent years, such as Chinese patent 'an anti-dermatitis film forming spraying agent and a preparation method thereof' (CN 1093811449A '), Chinese patent' a film spraying agent for traumatic wounds containing rhubarb superfine powder and a preparation method thereof '(CN 108261447A'), and Chinese patent 'a traditional Chinese medicine film spraying agent for promoting blood circulation, stopping bleeding, removing necrotic tissue and promoting tissue regeneration and a base preparation method thereof' (CN 110680879A).
The film spraying agent is a hydrated film which is usually used, and the film forming time is long, and some film forming time is even about one hour. In order to shorten the film forming time, ethanol is added to assist water evaporation, but too high ethanol can cause burning feeling to the skin and has flammable risk, and the film forming time is generally more than 5min even if ethanol is added to assist drying. The formed film is thin, so that the moisturizing and drug slow-release effects are poor.
The plaster is generally made of non-woven fabrics as a surface material, and the ointment medicine is smeared on the non-woven fabrics and is pasted on the affected part of a patient, so that the medicine effect is exerted through the absorption effect of the skin, and the pain of the patient is relieved. The plaster has large drug loading and good transdermal effect, but the commonly used plaster is adhered to the skin by using a rubber adhesive, so that the skin is easily red and swollen, allergic and the like, and the comfort is poor. The hydrogel is a gel taking water as a dispersion medium, is a polymer network system, has the characteristics of large water absorption amount, good moist healing environment for wounds, good air permeability, skin irritation and the like, and becomes an ideal drug delivery carrier for the patch. However, most of the hydrogel products currently used as patches are prepared into finished products, for example, the Chinese patent 'a sodium polyacrylate hydrogel patch' (CN 211301230U), the Chinese patent 'a chitosan hydrogel patch' (206508117U) and the Chinese patent 'a hydrogel-based cold application and preparation method thereof' (CN 105078645A) are not hydrogel patches quickly formed in situ, which results in that the hydrogel patches cannot be changed according to the actual size and shape during use, and are inconvenient to use and waste greatly.
Therefore, those skilled in the art have been devoted to the development of an in situ rapidly forming hydrogel skin patch and a method for preparing the same.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides an in-situ rapid forming hydrogel skin patch and a preparation method thereof, and aims to provide the hydrogel skin patch which can be rapidly formed in situ according to actual size and shape changes and has good air permeability and small skin irritation. The patch can be added with different medicinal materials for different purposes, and has high medicinal content, good sustained release performance, and low irritation to skin. The interpenetrating network hydrogel patch is formed by crosslinking sodium alginate and polyvalent metal ions and assisting with a high-molecular viscous film forming material in situ on the skin, so that the interpenetrating network hydrogel patch has the double advantages of both a film spraying agent and a patch.
In order to achieve the aim, the invention provides an in-situ quick-forming hydrogel skin application, which comprises a component A and a component B, wherein the component A comprises: 0.5-4% (w/v) of sodium alginate, 0-5% (w/v) of a viscous film forming material and the balance of deionized water; the component B comprises: 0.5-10% (w/v) polyvalent metal ion, 0-70% (w/v) ethanol, 0-5% (w/v) viscous film forming material, and the balance of deionized water. According to the use purpose, auxiliary medicines and auxiliary materials are added into the component A and the component B or the component AB in the basic formula to replace the equivalent deionized water in the corresponding components. In use, repeatedly applying component A and component B to a target area in sequence and waiting for a specified time to form a hydrogel skin patch.
Preferably, the solutions in the A component and the B component can be respectively arranged in the existing two spray bottles with the same size, so that the A bottle and the B bottle are formed, in order to avoid mixing between the A component and the B component, a user can make corresponding marks on the outer surfaces of the two spray bottles to distinguish the A component from the B component, and then the ethanol is the existing medical ethanol, and the user can selectively and properly add the ethanol according to the application of the patch, so that the patch can be applied to different types of skin symptoms, and then the target area is any part of the surface of human skin.
When the spraying or brushing is carried out on the affected part of the skin, the using amount ratio of the component A to the component B is 1: 1-1: 0.5.
As optimization, the components A and B can be sprayed or brushed on any part of the surface of human skin according to the dosage ratio.
Wherein the component A and the component B in the formed hydrogel skin application are alternately and repeatedly sprayed or brushed for 1-3 times, and the formed hydrogel skin application waits for a specific time of 5-30 s.
As optimization, when the spraying or brushing of the component A and the component B is finished, the more times of the spraying or brushing are, the larger the thickness of the hydrogel film is, the more the drug content is, and the longer the slow release time is.
Wherein the sodium alginate in the component A is formed by connecting beta-D-mannuronic acid and alpha-L-guluronic acid through glycosidic bonds, and two alpha-L-guluronic acid monomers can generate a cross-linking reaction with a polyvalent metal ion.
As optimization, sodium alginate is an anionic polysaccharide, and has the advantages of allergy resistance, strong hydrophilicity, low immunogenicity, biological inertia and the like. Wherein two alpha-L-guluronic acid monomers can generate a crosslinking reaction with a polyvalent metal ion, the crosslinking reaction speed and the mechanical strength of the hydrogel are determined by the concentrations of sodium alginate and the polyvalent metal ion, the higher the concentration is, the faster the reaction speed is, the higher the mechanical strength of the hydrogel is, and the higher the speed of generating the hydrogel by crosslinking with the polyvalent ion when the concentration of the sodium alginate is 1.25% (w/v), and the moderate mechanical strength.
Wherein the adhesive film-forming material in the component A is one or a mixture of polyvinyl alcohol, hydroxypropyl methyl cellulose sodium, sodium carboxymethyl cellulose, sodium carboxyethyl cellulose and polyacrylamide.
The adhesive film forming material is selected from polyvinyl alcohol 17-88 or hydroxypropyl methyl cellulose with 10 ten thousand molecular weight as optimization;
the polyvinyl alcohol is white particles, flaky or flocculent solids in appearance, is prepared by partially or completely hydrolyzing polyvinyl acetate, is a water-soluble high polymer with quite wide application, and has physical properties mainly influenced by the polymerization degree and the alcoholysis degree, and various types can be obtained according to the difference of the alcoholysis degree and the polymerization degree;
hydroxypropyl methyl cellulose is an important variety in non-ionic cellulose mixed ether, is odorless, tasteless and nontoxic, and the finished product is white powder or loose fiber, has a granularity of 80 meshes, does not react with heavy metals, has different proportions of methoxyl content and hydroxypropyl content and different viscosities, and becomes a variety with different properties.
Wherein the polyvalent metal ion in the component B is Ca2+、Mg2+、Zn2+、Cu2+And Co2+One or a mixture of several of them.
Optimally, Ca is selected from polyvalent metal ions2+、Mg2+And Zn2+At concentrations of 2.7% (w/v), 1.6% (w/v) and 4.4% (w/v), respectively, and Ca2+、Mg2+And Zn2+Respectively made of CaCl2、MgSO4And ZnSO4Preparing;
Ca2+is an ion indispensable to various physiological activities of the body, an important substance of the skeleton, Ca2+Is also a coagulation factor, is involved in the coagulation process, and in addition, Ca2+The muscle is involved in synthesis and release of neurotransmitters and synthesis and secretion of hormones, including: the contraction process of skeletal muscle and smooth muscle, calcium ion plays a role in triggering and regulating in the contraction process of skeletal muscle, and the concentration of calcium ion influences the speed and strength of contraction;
Mg2+is one of the most abundant cations in the body, Mg2+The magnesium is an activator of various enzymes, such as alkaline and acid phosphatase, phosphoglucomutase, pyrophosphatase, creatine kinase, hexokinase, leucine aminopeptidase and carboxylase, and the like, the catalytic action of the magnesium is required to be activated by magnesium ions, and magnesium is also an element necessary for forming DNA, RNA and a ribosome macromolecular structure and is also an important element for maintaining normal nerve functions and muscles;
Zn2+it is important to maintain normal repair of epithelial cells, fibroblast proliferation, collagen and epithelialization, etc.
Wherein the auxiliary medicine is one of tiger yellow, benzalkonium bromide and terbinafine hydrochloride, and the concentration of the auxiliary medicine is 0.5-4% (w/v).
As optimization, the tiger yellow has the functions of purging fire, detoxifying, cooling blood, activating blood, reducing swelling, eliminating dampness and healing sores;
benzalkonium bromide is a mixture of dimethyl benzyl ammonium bromide, is a yellow-white waxy solid or colloid, and is mainly used for disinfecting skin, mucous membrane, wound, surface of articles and indoor environment;
terbinafine hydrochloride is terbinafine hydrochloride solution, and its main component is terbinafine hydrochloride, and can be used for treating dermatoses such as tinea manuum, tinea pedis, tinea cruris, tinea corporis, and tinea versicolor.
The auxiliary material comprises an auxiliary film forming material and an auxiliary medicine dissolving and stabilizing material, the auxiliary film forming material is one or a mixture of more of carboxymethyl chitosan, polyvinylpyrrolidone and a plasticizer, and the concentration of the auxiliary film forming material is 0-5% (w/v).
As optimization, the carboxymethyl chitosan is an important water-soluble chitosan derivative and has medical effects of promoting wound healing, stopping bleeding, inhibiting scars, relieving pain, inhibiting bacteria and the like;
polyvinylpyrrolidone is a non-ionic polymer compound, and has excellent physiological inertia, no participation in human metabolism, excellent biocompatibility and no stimulation to skin, mucous membrane, eye and the like;
plasticizers are generally referred to as plasticizers, the primary function of which is to add to the polymeric material, which may increase the plasticity of the polymer.
Wherein the auxiliary drug dissolution and stabilization substance is one or a mixture of more of an active agent, a dispersing agent and an antifoaming agent, and the concentration of the auxiliary drug dissolution and stabilization substance is 0-4% (w/v).
As optimization, the surfactant can change the surface strength of the liquid surface, the liquid-liquid interface and the liquid-solid interface, increase the solubility of hydrophobic drugs and make solid particles in the solution more stable;
the dispersing agent is a surfactant with two opposite properties of lipophilicity and hydrophilcity in a molecule, can uniformly disperse solid and liquid particles of inorganic and organic pigments which are difficult to dissolve in liquid, and can prevent the particles from settling and coagulating to form an amphiphilic agent required by stable suspension;
an antifoaming agent is a substance that reduces the surface tension of water, solutions, suspensions, etc., prevents the formation of foam, or reduces or eliminates the original foam.
Also discloses a preparation method of the in-situ rapid prototyping hydrogel skin patch, which comprises the following steps: according to the hydrogel skin patch capable of being rapidly formed in situ, after the component A and the component B are mixed, the solution in the component A is sprayed or brushed on a target area, then the solution in the component B is sprayed or brushed on the same position, and after the spraying or brushing is finished, the hydrogel patch can be generated in situ after waiting for a certain time.
The hydrogel patch can be sprayed or brushed on any part of the skin surface of a user, and the wound surface of the skin can be repaired after the hydrogel patch is generated.
Compared with the prior art, the in-situ rapid-forming hydrogel skin application has the following advantages and remarkable progress:
(1) the hydrogel skin patch can be sprayed or brushed to form the hydrogel skin patch according to the size and the position of a wound surface, the use is convenient and quick, and a user can adjust the thickness of the whole patch according to the requirement of the user, so that the use of the user is facilitated;
(2) the hydrogel skin patch has high forming speed, can be formed almost instantly, overcomes the problem of low forming speed of a film spraying agent, and avoids the condition that a wound is exposed to the outside for a long time and is easily infected by bacteria;
(3) the hydrogel skin patch can be well attached and formed on any part of the skin surface, including fingers, elbow joints and the like, has good ductility, and overcomes the problem that the adhesive bandage is not ideal for being attached on certain parts;
(4) the hydrogel skin patch has high moisture content, is beneficial to improving the release of the medicine, improving the medicine-loading rate, prolonging the slow release time and is more convenient to use;
(5) the hydrogel skin patch can be added with various transdermal drug delivery medicines according to the use purpose and the prior art, thereby being capable of treating different diseases and having wide use range;
(6) the hydrogel skin patch has good biocompatibility, generates a porous structure after the surface is dried, has good air permeability, and does not generate allergic and uncomfortable reactions such as red swelling, pruritus and the like on the skin.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a photograph of a hydrogel skin patch formed from a base formulation at the wrist of an embodiment of the present invention;
FIG. 2 is a scanning electron microscope image of the benzalkonium bromide hydrogel-loaded skin application of the present invention.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the invention and are not to be construed as limiting the invention.
In order to make the technical solutions and principles of the present invention more apparent to those skilled in the art, the following detailed description is provided for the purpose of:
the invention provides a preparation method of an in-situ rapid-forming hydrogel skin patch, which comprises the following steps:
1. preparing two spray bottles with the same model size, and marking the outer surfaces of the spray bottles to separate a bottle A and a bottle B;
2. when the spraying or brushing liquid medicine bottle is used, a user can prepare liquid medicine according to the needs of the user, the liquid medicine is placed in the bottle A and the bottle B respectively, and then the component A and the component B are prepared, when the preparation is completed, the water solution in the bottle A is sprayed or brushed on the required skin affected part, then the water solution in the bottle B is sprayed or brushed on the same position according to the ratio A/B ═ 1: 1-1: 0.5, and the spraying or brushing liquid medicine is sprayed or brushed alternately and repeatedly for 1-3 times;
3. after spraying or brushing accomplished, can generate aquogel in the normal position after about 5 ~ 30s and apply ointment or plaster, this aquogel skin is applied ointment or plaster, and the shaping is fast, and the gas permeability is good, and convenient to use is swift, and is good with the skin adhesion nature, can coat in the different positions of health, can control the thickness of applying ointment or plaster according to the demand of oneself simultaneously, can not produce the discomfort reactions such as irritability such as red swelling pruritus to skin simultaneously.
The following detailed description is made with reference to the accompanying figures 1-2 and specific embodiments. The teachings of the present invention are not limited to any particular embodiment nor represent the best embodiment, and general alternatives known to those skilled in the art are also encompassed within the scope of the present invention.
Example 1
Hydrogel skin patch matrix preparation: preparing a bottle A and a bottle B with a nozzle, wherein the bottle A is filled with an aqueous solution containing 0.75% (w/v) of sodium alginate and 1.5% (w/v) of polyvinyl alcohol 17-88; bottle B is filled with CaCl containing 5% (w/v)2And 2% (w/v) aqueous polyvinyl alcohol 17-88;
when the hydrogel patch matrix is used, the solution in the bottle A is sprayed on the required skin of a patient, and then the solution in the bottle B is sprayed at the same position according to A: B ═ 1: 0.5, and the hydrogel patch matrix can be generated in situ after about 25 seconds.
Example 2
Hydrogel skin patch matrix preparation: preparing a bottle A and a bottle B with a nozzle, wherein the bottle A is filled with an aqueous solution containing 1.25% (w/v) of sodium alginate and 2% (w/v) of polyvinyl alcohol 17-88; bottle B is filled with CaCl containing 7.5% (w/v)2And 2% (w/v) aqueous polyvinyl alcohol 17-88;
when the hydrogel patch matrix is used, the solution in the bottle A is sprayed on the required skin, and then the solution in the bottle B is sprayed at the same position according to the A: B ═ 1: 0.75, and the hydrogel patch matrix can be generated in situ after about 15 seconds.
Example 3
Hydrogel skin patch matrix preparation: preparing a bottle A and a bottle B, wherein the bottle A is filled with an aqueous solution containing 2% (w/v) sodium alginate and 2.5% (w/v) polyvinyl alcohol 17-88; bottle B was filled with a composition containing 9.5% (w/v) MgSO4And 2% (w/v) aqueous polyvinyl alcohol 17-88;
when the hydrogel patch matrix is used, the solution in the bottle A is brushed on the required skin, then the solution in the bottle B is brushed on the same position according to A: B ═ 1: 1, and the hydrogel patch matrix can be generated in situ after about 7 seconds.
Example 4
Preparing the burn and scald wound hydrogel skin patch: preparing a bottle A and a bottle B with a nozzle, wherein the bottle A is filled with a solution containing 0.75% (w/v) sodium alginate, 1.5% (w/v) polyvinyl alcohol 17-88, 0.5% (w/v) saxifraga extract and 1% (w/v) OP-10 aqueous solution; bottle B is filled with CaCl containing 5% (w/v)22% (w/v) polyvinyl alcohol 17-88 and 20% (w/v) ethanol water solution;
when in use, the solution in the bottle A is sprayed on the required skin, and then the solution in the bottle B is sprayed at the same position according to the A: B ═ 1: 0.5, and the hydrogel patch carrying the tiger yellow can be generated in situ after about 20 seconds.
Example 5
Preparing the cut and bruise wound hydrogel skin dressing: preparing a bottle A and a bottle B with nozzles, wherein the bottle A is filled with an aqueous solution containing 1.25% (w/v) sodium alginate, 2% (w/v) polyvinyl alcohol 17-88, 0.05% (w/v) carboxymethyl chitosan, 1% (w/v) benzalkonium bromide and 5% (w/v) OP-10; bottle B was filled with a composition containing 5.7% (w/v) MgSO42% (w/v) polyvinyl alcohol 17-88 aqueous solution;
when in use, the solution in the bottle A is sprayed on the required skin, and then the solution in the bottle B is sprayed at the same position according to the A: B ═ 1: 0.75, and the benzalkonium bromide-loaded hydrogel patch can be generated in situ after about 20 seconds.
Example 6
Preparation of hydrogel skin application for tinea corporis: preparing a bottle A and a bottle B, wherein the bottle A contains 2% (w/v) sodium alginate, 2.5% (w/v) polyvinyl alcohol 17-88, 5% (w/v) OP-10 and 4% (w/v) hydrochloric acid specific bitAn aqueous solution of naftifine; bottle B is filled with 10% (w/v) CaCl2And 2% polyvinyl alcohol 17-88 aqueous solution;
when in use, the solution in the bottle A is firstly brushed on the required skin, and then the solution in the bottle B is brushed on the same position according to A: B ═ 1: 1, and after about 10 seconds, the in-situ generated terbinafine hydrochloride-loaded hydrogel patch can be used.
As shown in FIG. 1, the skin application substrates also performed well at the skin joints according to examples 1 to 6; as can be seen from FIG. 2, the hydrogel skin patch matrix has a porous structure therein and is highly breathable.
While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (10)

1. An in-situ rapid-forming hydrogel skin patch comprises a basic formula, a component A and a component B, wherein the component A comprises 0.5-4% (w/v) of sodium alginate, 0-5% (w/v) of a viscous film-forming material and the balance of deionized water; the component B comprises 0.5-10% (w/v) of polyvalent metal ions, 0-70% (w/v) of ethanol and 0-5% (w/v) of viscous film-forming material, and the balance of deionized water; according to the use purpose, auxiliary medicines and auxiliary materials are added into the component A or the component B or the component AB in the basic formula to replace the equivalent deionized water in the corresponding components. In application, the hydrogel skin patch is formed by repeatedly applying component A and component B to the target area in sequence and waiting for a certain time.
2. The in situ rapid prototyping hydrogel patch of claim 1 wherein the ratio of component a to component B in the hydrogel patch is from 1: 1 to 1: 0.5.
3. The in situ rapid prototyping hydrogel dermal patch of claim 1 wherein the hydrogel dermal patch is formed by alternately and repeatedly spraying or brushing the A component and the B component for 1-3 times and the hydrogel dermal patch is formed by waiting for a specified time of 5-30 seconds.
4. The in situ rapid prototyping hydrogel patch as set forth in claim 1, wherein the sodium alginate in component a is formed by β -D-mannuronic acid and α -L-guluronic acid through glycosidic linkages, and two α -L-guluronic acid monomers can undergo a cross-linking reaction with a polyvalent metal ion.
5. The in situ rapid prototyping hydrogel skin patch of claim 1 wherein the adhesive film-forming material of component a is one or a mixture of polyvinyl alcohol, sodium hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, sodium carboxyethyl cellulose, and polyacrylamide.
6. The in situ rapid prototyping hydrogel skin patch of claim 1 wherein the polyvalent metal ion of component B is Ca2+、Mg2+、Zn2+、Cu2+And Co2+One or a mixture of several of them.
7. The in situ rapid prototyping hydrogel dermal patch of claim 1 wherein the adjuvant drug is one of tiger yellow, benzalkonium bromide, terbinafine hydrochloride, and the adjuvant drug concentration is 0.5-4% (w/v).
8. The in situ rapid prototyping hydrogel skin patch as set forth in claim 1, wherein the auxiliary material comprises an auxiliary film forming material and an auxiliary drug dissolving and stabilizing material, the auxiliary film forming material is one or more of carboxymethyl chitosan, polyvinylpyrrolidone and plasticizer, and the concentration of the auxiliary film forming material is 0-5% (w/v).
9. The in situ rapid prototyping hydrogel skin patch of claim 8 wherein the dissolution aid and the stabilizer are one or more of a combination of an active agent, a dispersant and an antifoaming agent, and the concentration of the dissolution aid and the stabilizer is 0-4% (w/v).
10. A method for preparing an in-situ rapid prototyping hydrogel skin application comprises the following steps: a component a and a component B according to any one of claims 1 to 9; after the component A and the component B are blended, firstly spraying or brushing the solution in the component A on a target area, then spraying or brushing the solution in the component B on the same position, and after the spraying or brushing is finished, waiting for a specific time, and then generating the hydrogel patch in situ.
CN202111343927.1A 2021-11-14 2021-11-14 In-situ rapid-forming hydrogel skin patch and preparation method thereof Pending CN114392250A (en)

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CN115554279A (en) * 2022-11-18 2023-01-03 长春工业大学 Method for preparing film-forming spray

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CN110694102A (en) * 2019-11-13 2020-01-17 中国矿业大学 3D printing hydrogel wound dressing with long-acting antibacterial effect
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