CN1445242A - 人源化抗血管内皮生长因子单克隆抗体及其制法和药物组合物 - Google Patents
人源化抗血管内皮生长因子单克隆抗体及其制法和药物组合物 Download PDFInfo
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Abstract
Description
试验内容 | 终浓度(微克/毫升) | |||||||
0 | 200 | 400 | 800 | 1600 | 3200 | 6400 | 12800 | |
阴性对照(抗CD20单克隆抗体) | 0.34 | 0.71 | 0.67 | 0.33 | 0.46 | 0.53 | 0.73 | 0.29 |
阳性对照(RhuFab,V2) | 3341.2 | 3432.9 | 2891.3 | 1983.4 | 1508.2 | 935.6 | 300.3 | 6.67 |
本发明6A6 | 3548.7 | 2083.2 | 1564.9 | 210.0 | 5.71 | 6.44 | 0.33 | 0.32 |
组别 | 肿瘤体积(cm3) | 与灌注前相比肿瘤增长率(倍数) | 与对照相比增长率降低的百分数 | |
灌注前 | 灌注后 | |||
阴性对照组 | 0.06l±0.012 | 0.937±0.331 | 15.36 | --- |
治疗组 | 0.059±0.027 | 0.277±0.161 | 4.69 | 69.46 |
组别 | 体积(cm3) | 与灌注前相比肿瘤增长率(倍数) | 与对照相比增长率降低的百分数 | |
治疗前 | 治疗后 | |||
阴性对照 | 0.086±0.032 | 2.612±0.871 | 30.37 | --- |
治疗组 | 0.089±0.037 | 0.132±0.052 | 1.48 | 95.13 |
Claims (10)
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CNB02111093XA CN1187373C (zh) | 2002-03-20 | 2002-03-20 | 人源化抗血管内皮生长因子单克隆抗体及其制法和药物组合物 |
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CNB02111093XA CN1187373C (zh) | 2002-03-20 | 2002-03-20 | 人源化抗血管内皮生长因子单克隆抗体及其制法和药物组合物 |
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Publication Number | Publication Date |
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CN1445242A true CN1445242A (zh) | 2003-10-01 |
CN1187373C CN1187373C (zh) | 2005-02-02 |
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Cited By (9)
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EP1648939A2 (en) * | 2003-08-01 | 2006-04-26 | Genentech, Inc. | Anti-vegf antibodies |
US7622115B2 (en) | 2003-05-30 | 2009-11-24 | Genentech, Inc. | Treatment with anti-VEGF antibodies |
WO2011023130A1 (zh) * | 2009-08-28 | 2011-03-03 | 江苏先声药物研究有限公司 | 一种抗vegf的单克隆抗体及含有该抗体的药物组合物 |
CN102167740A (zh) * | 2010-02-25 | 2011-08-31 | 百迈博药业有限公司 | 一种全人源抗vegf单克隆抗体、其制备方法及用途 |
CN102344926A (zh) * | 2011-09-16 | 2012-02-08 | 江苏普罗赛生物技术有限公司 | 真核表达并纯化人源化抗血管内皮生长因子单克隆重组抗体(Anti-VEGF)的简便化工业技术 |
CN102397542A (zh) * | 2004-11-18 | 2012-04-04 | 英克隆有限责任公司 | 抗血管内皮生长因子受体-1的抗体 |
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US10072075B2 (en) | 2015-09-23 | 2018-09-11 | Genentech, Inc. | Optimized variants of anti-VEGF antibodies and methods of treatment thereof by reducing or inhibiting angiogenesis |
CN110372792A (zh) * | 2008-06-25 | 2019-10-25 | 艾斯巴技术-诺华有限责任公司 | 抑制vegf的稳定和可溶的抗体 |
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KR100883430B1 (ko) * | 2007-06-13 | 2009-02-12 | 한국생명공학연구원 | 혈관내피성장인자 수용체를 중화하는 인간 단클론항체 및그 용도 |
CN101575379B (zh) * | 2008-05-09 | 2012-05-30 | 上海抗体药物国家工程研究中心有限公司 | 可溶性vegfr双功能融合受体、其制备方法及用途 |
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US10072075B2 (en) | 2015-09-23 | 2018-09-11 | Genentech, Inc. | Optimized variants of anti-VEGF antibodies and methods of treatment thereof by reducing or inhibiting angiogenesis |
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