CN1443546A - Medicine for curing postpartum subinvolution of uterus and its preparation method - Google Patents
Medicine for curing postpartum subinvolution of uterus and its preparation method Download PDFInfo
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Abstract
The present invention relates to a Chinese medicine for curing puerperal subinvolution of uterus and its preparation method. It is made up by using 10 Chinese medicinal materials of cuscuta seed, lycium berry, glehnia root, Chinese angelica root, white peony root and others as raw material through a certain preparation process. Said invention Chinese medicine has the advantages of improving subinvolution of uterus, promoting contraction of uterine smooth muscle, raising endogenous hormone level, resisting inflammation, stopping pain, arresting hemorrhage and accelerating involution of uterus, etc.
Description
Technical field:
The present invention relates to a kind of medicine for the treatment of gynaecopathia, particularly relating to a kind of is the medicine of the treatment postpartum subinvolution of uterus disease of feedstock production with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Technical background:
Postpartum women through trimester of pregnancy, stages of labor phase, produce the influence in succession of Yong phase, though be human deutero-naturally physiological process because the influence of body constitution and extraneous factor, unhealthful easily with stay obstinate disease.From clinical practice, the clinical incidence rate of illness in puerperal accounts for 5.1-7.2% according to Epidemiological study, infects, hemorrhage, hypertension is maternal death three big main causes.The commonly encountered diseases kind has lochiorrhea, difficulty in defecation, spontaneous perspiration, general pain, hypogalactia, spasm syndrome, bruise etc.Wherein lochiorrhea belongs to subinvolution of uterus in the puerperal disease Chinese and western medicine, is the one of the main reasons that causes postpartum hemorrhage, adopts uterotonic treatment, the dilatation and curettage more.Even consider when bleeding profusely to hysterectomize.Untimely treatment easily causes multiple chronic diseases such as endometritis, pelvic inflammatory disease, menoxenia, and protracted course of disease is a kind of frequently-occurring disease in puerperal of serious harm WomanHealth.
To the treatment of primary disease, following clinical difficult problem puzzlement is arranged at present:
1, uterotonic such as oxytocin, ergometrine can make uterus tetanic property contraction, and effect continues a few hours, and anastalsis is arranged.But can produce side effect such as temporary serious hypertension, water intoxication, unsuitable conventional the application.
2, the employing of operative therapy such as dilatation and curettage more should be prudent, and certain indication is arranged.The antibiotics itself that postoperative must add usefulness has outside the side effect, also can influence suckling.
3, the Chinese patent medicine of present less treatment primary disease, only several not fairly obvious as effects such as motherwort formulation, SHENGHUATANG plus-minus sides, can not satisfy the clinical treatment needs.
Summary of the invention:
The object of the present invention is to provide a kind of comprehensive subinvolution of uterus symptom of improving that has, promote uterine smooth muscle to shrink, improve endogenous hormone level, antiinflammatory, analgesia, hemostasis, the quickening involution of uterus, thereby also help the medicine of the treatment postpartum subinvolution of uterus disease of postpartum women build recovery.
Another object of the present invention provides the preparation method of this medicine.
Solution of the present invention is based on motherland's medical science to pathogenetic understanding of subinvolution of uterus disease and Therapeutic Principle, with reference to modern medicinal agents, pharmaceutical research achievement and form.
The composition principle of medicine of the present invention is: in motherland's medical science, to women's warp, produce, have comparatively maturation and scientific understanding, formed the theoretical system of complete uniqueness.Think CHONG meridian being the blood pool, appoint main uterus, lochia is bloodization, and blood comes from internal organs, annotates in dashing times.If internal organs are subjected to disease, especially owing to modern women's work anxiety, the diet savoury is excessively nourished, the exhaustion due to sexual indulgence overfrequency, very easily interior volt asthenic fire, pregnant in addition cloudy blood fetus nourishing, stages of labor consumption impairment of QI Tianjin causes virtuous empty anemia in puerperal, stagnation of blood stasis, the debility of CHONG and REN meridians causes lochia, and it is dripping to produce lochia, and the vagoue pain of lumbus and abdomen, soreness of the waist and knees, Mian Se Koushi is white, the light red tongue tongue is dim, deep pulse such as counts accurately at clinical manifestation, and smelting is mended when training and is method, and kidney tonifying nourishes blood, work as blood circulation promoting and blood stasis dispelling again, blood stasis does not go, and fresh blood is had no way of with life.We form with ten flavor medicines such as Semen Cuscutae, Colla Corii Asini, Radix Angelicae Sinensis, Pollen Typhae, refine through science, be used to control the anemia of suffering from a deficiency of the kidney, the lochia that stops in the blood stasis is incomplete, promote uterine smooth muscle to shrink, improve endogenous hormone level, antiinflammatory, analgesia, hemostasis, the quickening involution of uterus, thereby also help the recovery of postpartum women build.
The medicine that the present invention treats the postpartum subinvolution of uterus disease is the medicament of being made by the following weight proportion raw material:
8～20 parts of 8～20 portions of Radix Glehniaes of 8～20 parts of Fructus Lycii of Semen Cuscutae
5～15 parts in Radix Angelicae Sinensis 5～15 parts of Colla Corii Asini of 8～20 portions of Radix Paeoniae Albas (stir-fry)
8～20 parts of Cortex Lycii 8～20 parts of Herba Schizonepetaes of 5～15 parts of Herba Leonuris (parch to black)
8～20 parts of Pollen Typhaes (parch to black)
The formula optimization weight proportion scope of medicine of the present invention is:
8～15 parts of 8～15 portions of Radix Glehniaes of 8～15 parts of Fructus Lycii of Semen Cuscutae
5～10 parts in Radix Angelicae Sinensis 5～10 parts of Colla Corii Asini of 8～15 portions of Radix Paeoniae Albas (stir-fry)
8～15 parts of Cortex Lycii 8～15 parts of Herba Schizonepetaes of 5～10 parts of Herba Leonuris (parch to black)
8～15 parts of Pollen Typhaes (parch to black)
The optimum weight proportioning of medicine of the present invention is:
10 parts of 10 portions of Radix Glehniaes of 10 parts of Fructus Lycii of Semen Cuscutae
6 parts in Radix Angelicae Sinensis 6 parts of Colla Corii Asini of 10 portions of Radix Paeoniae Albas (stir-fry)
10 parts of Cortex Lycii 10 parts of Herba Schizonepetaes of 5 parts of Herba Leonuris (parch to black)
10 parts of Pollen Typhaes (parch to black)
Said medicament is the dosage form on any pharmaceutics.
Said medicament is a granule.
The method for preparing the medicine of above-mentioned treatment postpartum subinvolution of uterus disease is to be that elder generation with behind the Colla Corii Asini stir-baked in powder of CONCHA MERETRICIS SEU CYCLINAE, is ground into 120 order fine powders; Radix Glehniae, Pollen Typhae, Semen Cuscutae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Herba Schizonepetae discard residue with Diluted Alcohol solution reflux, extract,, and extracting solution is standby; Herba Leonuri, Fructus Lycii, Cortex Lycii decoct with water, discard residue, decoction liquor concentrates and adds 95% ethanol sedimentation, extract supernatant, merge backflow such as above-mentioned Radix Glehniae, reclaim ethanol, aqueous solution concentrates back residue drying, be ground into fine powder, make granule by described mixed after evenly with the Colla Corii Asini powder.
The concrete grammar of preparation medicine of the present invention is:
1, earlier with Colla Corii Asini with stir-baked in powder of CONCHA MERETRICIS SEU CYCLINAE after, be ground into 120 order fine powders;
2, Radix Adenophorae (Radix Glehniae), Pollen Typhae, Semen Cuscutae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Herba Schizonepetae discard residue with Diluted Alcohol solution reflux, extract,, and extracting solution is standby;
3, Herba Leonuri, Fructus Lycii, Cortex Lycii decoct with water, and discard residue, and decoction liquor concentrates and adds 95% ethanol, sedimentation, extracts supernatant, merges extracting solution in above-mentioned 2, reclaims ethanol, and aqueous solution concentrates back residue drying, is ground into fine powder;
4, add suitable adjuvant with the Colla Corii Asini powder by the even back of described mixed and make granule with dry pressing or boiling granulation method.
An important feature of medicine of the present invention is
1, presses the Chinese medical theory prescription, and in conjunction with the pure Chinese medicinal preparation that the modern scientific research achievement is made, have short treating period clinically, the characteristics of instant effect.At commonly encountered diseases, frequently-occurring disease, a sick medicine, outstanding Chinese medicine characteristic.
2, the prescription Chinese crude drug through science extract, purification, improve active constituent content, reduce dose, confirm evident in efficacyly through pharmacodynamics, toxicological experiment, do not see toxicity.Reached purpose safe, effective, taking convenience.
3, each step of pharmaceutical preparation of the present invention all has preparation laboratory data and the support of pharmacodynamics preference data, and has formulated two content of effective testing indexs, thereby guarantees product quality.
4, treat the medicine and the medical procedure of primary disease at present, can not satisfy the clinical treatment needs.Medicine of the present invention provides a kind of new efficient medicine, increases a kind of powerful mean for clinical with the card medication.
Another important feature of medicine of the present invention is
1, contains large number of biological alkali in the medicament, comprise leonurine, stachydrine, graveoline etc., have, the contraction of uterine smooth muscle is significantly strengthened the isolated uterine excitation.
2, also contain a large amount of glycoside compositions in the medicament, comprise Quercitroside, peoniflorin and saponins, various pathogens, virus are had inhibitory action, uterine smooth muscle effect and tangible antiinflammatory action.
3, also contain a large amount of flavones ingredients in the medicament, total content reaches 1.2～2.0%, comprises ligustilide, Quercetin, rutin etc., and the isolated uterine excitation is arranged; Early pregnancy placental villi nurse tissue is cultivated, promoting sexual gland hormone-chorionic-gonadotropin hormone HCG secretory volume is increased.Also contain polysaccharide and several amino acids constituents.
The clinical use result of medicine of the present invention shows that following advantage is arranged:
1, to select natural plant for use be raw material in the present invention, and each component all meets Pharmacopoeia of the People's Republic of China regulation, press the comprehensive function of Chinese medical theory prescription and treat postpartum subinvolution of uterus disease, no chemical substance.
2, medicine of the present invention through extract, purification, active constituent content height, dose are little, and the strict quality index is arranged, and reach safe and effective, and be quality controllable, the taking convenience requirement.Meet national medical rules.
3, medicine of the present invention provides a kind of new treatment means for the postpartum subinvolution of uterus treatment for diseases, replaces Western medicine and operative therapy, avoids its side effect.And its comprehensive function treatment postpartum subinvolution of uterus disease is replenished the blank of such disease treatment.
Therefore, the medicine that the present invention treats the postpartum subinvolution of uterus disease has the comprehensive subinvolution of uterus symptom of improving, promote uterine smooth muscle to shrink, improve endogenous hormone level, antiinflammatory, analgesia, hemostasis, the quickening involution of uterus, thus the advantage that also helps the postpartum women build to recover.
For showing the effect of Drug therapy postpartum subinvolution of uterus disease of the present invention, medicine of the present invention is through the clinical observation of 90 routine systems, according to " new Chinese medicine clinical research guideline " version in 1993 draft in, the postpartum subinvolution of uterus disease patient that makes a definite diagnosis of Western medicine diagnose, dialectical standard.
Differential diagnosis in tcm standard (syndrome of yin deficiency and blood stasis)
Postpartum lochiorrhea: lochia continues more than 20 days still dripping urine endlessly.Inferior card: (1) lochia amount is many, and color is red, and is muddy or with the smelly gas that moves; (2) stomachache or lower abdomen weigh down and expand; (3) hyperhidrosis, thirsty, limbs fatigue; (4) light red tongue or purple dark spottiness; (5) moderate pulse or string are puckery.Main symptom indispensability is wherein doublely seen three of time cards, and is promptly diagnosable.
Puerperal disease main symptom: postpartum lochiorrhea, postpartum hemorrhage.Inferior card: (1) vagoue pain of lumbus and abdomen; (2) lose heart, hyperhidrosis; (3) difficulty in defecation; (4) lower abdomen tenesmus, the waistline chap.
The Western medicine diagnose standard
Subinvolution of uterus: the lochia rubra persistent period prolongs.(1) reposition of the womb: three weeks of puerperal are at the bottom of the palace still can be touched in the pubic symphysis position; (2) size, position: check that the uterus is normal big and soft, and be the retroversioflexion position; (3) pain: tenderness; (4) the soft and many palaces mouth of cervix uteri is not closed.
Instructions of taking: medicine of the present invention (trial-production of Liaoyang City's natural drug institute), the more than or postpartum hemorrhage of lochia in 21 days puerperal or promptly begin puerperal to take, each 1 bag, every day 3 times, warm boiled water.Serve on for two weeks.
The course of treatment: two weeks were a course of treatment, took two courses of treatment.Follow up a case by regular visits to two courses of treatment after the drug withdrawal.
Result of the test (one), efficacy assessment standard and foundation: the efficacy assessment standard in the clinical research guideline of postpartum lochiorrhea " new Chinese medicine treatment " issued with reference to Ministry of Health of the People's Republic of China and drafting.
The symptom integral method
The natural law that lochia occurs: 20 days 0 minute; 22 days 2 minutes; 25 days 4 minutes; More than 30 days 6 minutes.
The late postpartum hemorrhage that subinvolution of uterus causes: 14 days puerperal is show lochia 0 minute not; Have puerperal and bleed 2 fens on a small quantity; Have on a small quantity puerperal and bleed, continue unclean 4 minutes; Amount is bled in having puerperal, continues unclean 6 minutes.
Lochia color: normal 0 minute; Dark red 1 minute; Purple 2 minutes of color; Purple dim or dark purple 3 minutes.
Lochia quality: normal 0 minute; Thick partially, but do not have clot 1 minute; Thick, a small amount of little clot 2 minutes; Thickness, volume clot 3 minutes;
Lochia abnormal smells from the patient: normal 0 minute; Light abnormal flavour 1 minute is arranged; Frowziness 2 minutes; Smelly oxious gas flavor 3 minutes are arranged.
Lower abdomen pain: painless 0 minute; Sagging distention in the smaller abdomen 1 minute; The vagoue pain of lumbus and abdomen, constant 2 minutes; Lower abdomen pain was difficult to stand 3 fens.
The hyperhidrosis of losing heart: normal 0 minute; Little sense is felt oppressed, and hands, the sufficient heart often had sweating 1 minute; Out of breath uncomfortable in chest, sweating while acting 2 minutes; Rapid breathing was from dropping sweat 3 minutes.
Difficulty in defecation: defecated normal 0 minute; Be hard and dry 1 fen; Constipation due to dry stool was difficult to resolve 2 fens; Constipation due to dry stool needs just can solve 3 fens with medicine.
Abdominal circumference: normal 0 minute; Lower abdomen projection 1 minute; Following ventral tubercle 2 minutes; Lower abdomen tenesmus 3 minutes.
Tongue fur: normal 0 minute; Body of the tongue is red partially, few Tianjin of yellow and thin fur 1 minute; The few tongue of red tongue 2 minutes; Red and uncoated tongue 3 minutes.
Efficacy assessment standard
Recovery from illness: treatment back lochia is clean, stopped bleeding, and other symptom disappears substantially, and drug withdrawal is not recurrence after 15 days, and integrated value is below 3 minutes.
Produce effects: treatment back lochia or amount of bleeding have reduced more than 1/3 before than treatment, other transference cure or alleviate, and drug withdrawal is recurrence after 15 days, and integrated value has reduced more than 2/3 before than treatment.
Effectively: treatment back lochia or amount of bleeding are improved than treatment is preceding, and also than alleviating before the treatment, drug withdrawal is not recurrence after 15 days for other symptom, and integrated value has reduced more than 1/3 before treating.
Invalid: treatment back lochia or amount of bleeding do not have and improve or increase the weight of, integrated value than treatment before no change or than reducing less than 1/3 before the treatment.
Efficacy analysis: the detailed results of this clinical observation, see the following table general curative effect for details
Group n recovery from illness produce effects enabledisable
Observation group's 90 examples, 48 examples (53.33%) 21 example (23.33%) 15 example (16.67%) 6 example (6.67%)
As can be seen from the above table: the cure rate of Drug therapy subinvolution of uterus of the present invention reaches 55.33%, obvious effective rate 23.33%, effective percentage 16.67%, inefficiency 6.67%, total obvious effective rate 76.67%, total effective rate 93.33%.
The curative effect of state of an illness integration relatively before and after the treatment
Before the group n treatment (x ± s) treat afterwards (x ± s)
Observation group's 90 examples 15.07 ± 4.04 15.07 ± 4.04
※ ※
Annotate: with relatively use before the treatment
※ ※Expression P＜0.01.
As can be seen from the above table: the curative effect of state of an illness integration relatively has utmost point significant difference, P＜0.01 before and after the treatment of Drug therapy subinvolution of uterus of the present invention.
The curative effect that symptom and sign changes before and after the treatment relatively
From following table as can be seen: the curative effect that symptom and sign changes before and after the treatment of Drug therapy subinvolution of uterus of the present invention relatively has utmost point significant difference, P＜0.01.
Sign n u p in treatment back before the treatment
++++++-++++++-the lose heart comparison of hidrosis 90 examples 16 27 45 203 21 66 6.3206＜0.01 difficulty in defecation 90 examples 06 57 27 03 15 72 3.2870＜0.01 abdominal circumference 90 examples 18 25 35 12 09 15 66 4.1442＜0.01 tongue fur 90 examples 0 27 48 15 066 78 4.9044＜0.011, the state of an illness and curative effect of lochia color 90 examples 0 18 45 27 00 15 75 3.8013＜0.01 lochia quality 90 examples 30 48 12 003 21 66 6.3206＜0.01 lochia smell 90 examples 18 36 33 309 24 57 4.8970＜0.01 underbelly pain 90 examples 9 18 57 600 18 72 4.8970＜0.01
State of an illness n recovery from illness produce effects enabledisable x
2p
Light 15 examples 15 000
In 69 examples 33 21 15 0 8.5217＜0.05
Weigh 6 examples 0006
As can be seen from the above table: the state of an illness and curative effect compare before and after the treatment of Drug therapy subinvolution of uterus of the present invention, x
2=8.5217, there is significant difference p＜0.05.
Model case: Wang, woman, 25 years old, workman, No. 9, case numbering.
This patient is in primiparity in October, 2,000 one girl baby, and 27 days puerperal, lochia was more than, and color is purple dark, and clot is arranged, sagging distention in the smaller abdomen, pain, the hyperhidrosis of breathing hard, red tongue, few tongue, thready and rapid pulse.Blood, routine urinalysis, electrocardiogram, liver, renal function procuratorial work are normal.Through with 1 bag of medicine of the present invention a time, 2 times on the one, lochia was promptly ended on 5th, and other symptom has improvement, continues to take to the course of treatment and finishes, and the light gas of conscious body is refreshing, and build recovers, and simultaneous phenomenon all disappears, electrocardiogram, and liver, renal function are examined all normal again, clinical cure.Do not find untoward reaction during the medication.
The clinical efficacy of medicine of the present invention
Test statistics shows: the clinical efficacy of Drug therapy subinvolution of uterus patient 90 examples of the present invention is satisfied, its cure rate reaches 53.33% (48/90), and obvious effective rate reaches 23.33% (21/90), and effective percentage reaches 16.67% (15/90), cure-remarkable-effectiveness rate reaches 76.67%, and total effective rate reaches 93.33%.
Embodiment
Take by weighing raw material by following proportioning
Semen Cuscutae 8,10,20kg Fructus Lycii 8,10,20 kg Radix Glehniaes 8,10,20kg
Radix Angelicae Sinensis 8,10, the 20kg Radix Paeoniae Alba 5,6,15 kg Colla Corii Asini (stir-fry) 5,6,15kg
Cortex Lycii 5,5,15kg Herba Leonuri 8,10,20kg Herba Schizonepetae (parch to black) 8,10,20kg
Pollen Typhae (parch to black) 8,10,20kg
Production method is as follows;
Earlier with Colla Corii Asini with stir-baked in powder of CONCHA MERETRICIS SEU CYCLINAE after, be ground into 120 order fine powders; Radix Adenophorae (Radix Glehniae), Pollen Typhae, Semen Cuscutae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Herba Schizonepetae discard residue with Diluted Alcohol solution reflux, extract,, and extracting solution is standby; Herba Leonuri, Fructus Lycii, Cortex Lycii decoct with water, and discard residue, and decoction liquor concentrates and adds 95% ethanol, sedimentation, extracts supernatant, merges extracting solution in above-mentioned 2, reclaims ethanol, and aqueous solution concentrates back residue drying, is ground into fine powder; Add suitable adjuvant with the Colla Corii Asini powder by the even back of described mixed and make granule with dry pressing or boiling granulation method.
Claims (6)
1, a kind of medicine for the treatment of the postpartum subinvolution of uterus disease is characterized in that the medicament of being made by the following weight proportion raw material
8～20 parts of 8～20 portions of Radix Glehniaes of 8～20 parts of Fructus Lycii of Semen Cuscutae
5～15 parts in Radix Angelicae Sinensis 5～15 parts of Colla Corii Asini of 8～20 portions of Radix Paeoniae Albas (stir-fry)
8～20 parts of Cortex Lycii 8～20 parts of Herba Schizonepetaes of 5～15 parts of Herba Leonuris (parch to black)
8～20 parts of Pollen Typhaes (parch to black)
2, the medicine of treatment postpartum subinvolution of uterus disease according to claim 1 is characterized in that the weight proportion of described raw material is
8～15 parts of 8～15 portions of Radix Glehniaes of 8～15 parts of Fructus Lycii of Semen Cuscutae
5～10 parts in Radix Angelicae Sinensis 5～10 parts of Colla Corii Asini of 8～15 portions of Radix Paeoniae Albas (stir-fry)
8～15 parts of Cortex Lycii 8～15 parts of Herba Schizonepetaes of 5～10 parts of Herba Leonuris (parch to black)
8～15 parts of Pollen Typhaes (parch to black)
3, the medicine of treatment postpartum subinvolution of uterus disease according to claim 2 is characterized in that the weight proportion of described raw material is
10 parts of 10 portions of Radix Glehniaes of 10 parts of Fructus Lycii of Semen Cuscutae
6 parts in Radix Angelicae Sinensis 6 parts of Colla Corii Asini of 10 portions of Radix Paeoniae Albas (stir-fry)
10 parts of Cortex Lycii 10 parts of Herba Schizonepetaes of 5 parts of Herba Leonuris (parch to black)
10 parts of Pollen Typhaes (parch to black)
4,, it is characterized in that said medicament is the dosage form on any pharmaceutics according to the medicine of claim 1,2 or 3 described treatment postpartum subinvolution of uterus diseases.
5, the medicine of treatment postpartum subinvolution of uterus disease according to claim 4 is characterized in that said medicament is a granule.
6, a kind of method for preparing the medicine of above-mentioned treatment postpartum subinvolution of uterus disease, it is characterized in that earlier with Colla Corii Asini with stir-baked in powder of CONCHA MERETRICIS SEU CYCLINAE after, be ground into 120 order fine powders; Radix Glehniae, Pollen Typhae, Semen Cuscutae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Herba Schizonepetae discard residue with Diluted Alcohol solution reflux, extract,, and extracting solution is standby; Herba Leonuri, Fructus Lycii, Cortex Lycii decoct with water, discard residue, decoction liquor concentrates and adds 95% ethanol sedimentation, extract supernatant, merge backflow such as above-mentioned Radix Glehniae, reclaim ethanol, aqueous solution concentrates back residue drying, be ground into fine powder, make granule by described mixed after evenly with the Colla Corii Asini powder.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102379913A (en) * | 2011-10-26 | 2012-03-21 | 吉泰安（四川）药业有限公司 | Pharmaceutical composition for treating subinvolution of uterus, and preparation method and use thereof |
| CN105248763A (en) * | 2015-10-22 | 2016-01-20 | 上海裕家农业科技发展有限公司 | Uterine contraction drink |
| CN105343784A (en) * | 2015-12-02 | 2016-02-24 | 杨慧丽 | Traditional Chinese medicine decoction for treating puerperal subinvolution of uterus |
| CN106924459A (en) * | 2015-12-29 | 2017-07-07 | 印骏 | A kind of herbal composite and its preparation method for woman postpartum disease conditioning |
-
2002
- 2002-03-07 CN CN 02104047 patent/CN1203876C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102379913A (en) * | 2011-10-26 | 2012-03-21 | 吉泰安（四川）药业有限公司 | Pharmaceutical composition for treating subinvolution of uterus, and preparation method and use thereof |
| CN105248763A (en) * | 2015-10-22 | 2016-01-20 | 上海裕家农业科技发展有限公司 | Uterine contraction drink |
| CN105343784A (en) * | 2015-12-02 | 2016-02-24 | 杨慧丽 | Traditional Chinese medicine decoction for treating puerperal subinvolution of uterus |
| CN106924459A (en) * | 2015-12-29 | 2017-07-07 | 印骏 | A kind of herbal composite and its preparation method for woman postpartum disease conditioning |
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| Publication number | Publication date |
|---|---|
| CN1203876C (en) | 2005-06-01 |
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