CN1440781A - Chinese medicine Xinxuening for treating cardiac and cerebral vascular diseases - Google Patents
Chinese medicine Xinxuening for treating cardiac and cerebral vascular diseases Download PDFInfo
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- CN1440781A CN1440781A CN 03111057 CN03111057A CN1440781A CN 1440781 A CN1440781 A CN 1440781A CN 03111057 CN03111057 CN 03111057 CN 03111057 A CN03111057 A CN 03111057A CN 1440781 A CN1440781 A CN 1440781A
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Abstract
The present invention relates to the medicine technology and is a kind of Chinese medicine, named Xincuening, for treating cardiac and cerebral vascular diseases. The medicine is prepared with Chinese medicinal materials kudzu vine root and haw and through mixing the kudzu vine root extractive and haw extractive in the weight ratio of 4-10 to 1-5. The medicine has the functions of improving coronary artery circulation, reducing myocardial infarction range, preventing and treating hyperlipemia, changing rheological effect of blood, resisting platelet congregation, etc. The medicine is a safe and reliable medicine with high curative effect on coronary heart disease, angina pectoris and other cardiac and cerebral vascular diseases.
Description
Technical field the present invention is a field of pharmaceutical technology, and it is peaceful to relate to a kind of Chinese patent medicine painstaking effort for the treatment of cardiovascular and cerebrovascular disease.
Background technology coronary heart disease, angina pectoris are a kind of common diseases of middle-aged and elderly people, are one of three big diseases that are detrimental to health.Along with quickening, the market competition of growth in the living standard, rhythm of life is growing more intense, people's cerebral cortex high-pressure, the increase of stress, morbidity has younger trend, and its prevalence height, mortality rate height account for first of the various diseases.Although the continuous development and the exploitation of Western medicine, interventional medicine in the ascendant, tradition is continued to use the Therapeutic Method of Western medicine, and certain toxic and side effects and untoward reaction are all arranged.At present, adopt clinically both at home and abroad as: cerebrolysin, XUESHUANXINMAINING, BUCHANG NAOXINTONG, FUFANG DANSHEN PIAN etc., its therapeutic effect is not ideal.It is the hope that medical circle is seek assiduously that the Chinese medicine of inquiring into a kind of high effect nontoxic side effect is treated this type of disease.Chinese patent 94115820.9 is disclosed by retrieval is its logical and manufacture method of a kind of treatment cardiovascular diseases compound recipe ant, by Hirudo, Eupolyphaga Seu Steleophaga is that raw material of Chinese medicine is made, and diseases such as treatment coronary heart disease, myocardial infarction, cerebral infarction, apoplexy sequela, angina pectoris are had significant curative effect.
Summary of the invention the objective of the invention is to be cardiovascular and cerebrovascular diseases such as treatment coronary heart disease, angina pectoris, provides a kind of Chinese patent medicine preparation painstaking effort that have more curative effect peaceful.
A kind of peaceful content Description of Chinese patent medicine painstaking effort for the treatment of cardiovascular and cerebrovascular disease of the present invention:
The present invention is a kind of, and to treat the Chinese patent medicine painstaking effort of cardiovascular and cerebrovascular disease peaceful, and it is characterized in that: the prescription of the peaceful ingredient of Chinese patent medicine painstaking effort is: adopt Chinese crude drug Radix Puerariae and Fructus Crataegi to make;
The Chinese patent medicine painstaking effort are the extract of Radix Puerariae and Fructus Crataegi rather, and be by weight (4～10): the ratio of (5～1) is carried out mix preparation.
Chinese patent medicine painstaking effort of the present invention are peaceful, and experiment showed, that according to modern pharmacology this medicine has eight big pharmacological actions: (1) improves coronary circulation, dwindles the heart infarction scope; (2) hyperlipidemia had prevention and therapeutical effect; (3) good change hemorheology effect; (4) antiplatelet aggregation, the prevention thrombotic disease; (5) improve myocardial ischemia, anoxia functions; (6) continual and steady hypotensive effect (7) myocardial contraction is significantly strengthened, and prevents ventricular fibrillation; (8) free radical resisting damage, antioxidation.Clinical drug trial of the present invention is finished, and 589 routine coronary heart disease, anginal patient are carried out clinical practice.
Hyperlipemia, hypertension, arrhythmia patient are carried out clinical practice.
| Produce effects (rate) | Effectively (rate) | Invalid (rate) | Total effectively (rate) | |
| The treatment group | 160 examples (51.4%) | 128 examples 944.4%) | 21 examples (6.8%) | 288 examples (93.2%) |
| Matched group | 114 examples (40.1%) | 116 examples (41.5%) | 50 examples (18.4%) | 230 examples (81.6%) |
| The P value | ＜0.01 | ＜0.01 |
| The treatment group | Matched group | |
| Merge arrhythmia example number | 186 examples | 104 examples |
| Total effectively (rate) | 106 examples (57%) | 32 examples (30.7%) |
| The P value | ????＜0.01 | ????＜0.01 |
| Merge hyperlipemia example number | 206 examples | 84 examples |
| Total effectively (rate) | 132 examples (64.7%) | 28 examples (30%) |
| The P value | ????＜0.01 | ????＜0.01 |
| The complicated hypertension case load | 188 examples | 96 examples |
| Total effectively (rate) | 102 examples (54.3%) | 38 examples (39.5%) |
| The P value | ????＜0.01 | ????＜0.01 |
Above-mentioned clinical practice proves, the coronary heart disease of treatment group, angina pectoris obvious effective rate and total effective rate are all apparently higher than matched group, there were significant differences in P value＜0.01, and merge hyperlipemia, complicated hypertension disease in the treatment group, merge ARR total effective rate also apparently higher than matched group, there were significant differences in P value＜0.01, and blood, routine urinalysis, liver, renal function are not had obvious adverse reaction.
This medicine is looked into total effective rate more than 90% to the patients with coronary heart disease systematic perspective, and blood fat reducing total effective rate 64.7% can reduce patient's cholesterolemia, triglyceride, improves high density lipoprotein, and for the difference curative effect zero difference of course of disease length, age size.The total effective rate 54.3% that brings high blood pressure down, this medicine can reduce systolic pressure and diastolic pressure simultaneously.All effective for angina pectoris treatment in various degree, the frequency of angina pectoris attacks and the shortening of persistent period there are significant curative effect, be applicable to preliminary angina of effort and stablize angina of effort.To the Electrocardiographic effective percentage that improves is more than 49%, can improve the electrocardiogram ischemia.Said preparation is obvious to the improvement of symptom, particularly to dizziness, chest pain, breast suppress, the treatment total effective rate of backache is more than 90%, along with the improvement of clinical symptoms, picture of the tongue, pulse condition make moderate progress.Do not find that by observing this preparation has bad and toxic and side effects, patient's hematuria routine, serum creatinine, the more no abnormal variation of hepatic and renal function before and after the treatment.The present invention has more curative effect to cardiovascular and cerebrovascular diseases such as treatment coronary heart disease, angina pectoriss, is a kind of safe and reliable medicine.
The specific embodiment
Embodiment 1
Zhang, the man, 68 years old, the cadre, admission number 30347 is because of ictal precordialgia, dizzy 5 years, increase the weight of a week, be admitted to hospital November 3 calendar year 2001, whenever after activity or anxious state of mind, above-mentioned symptom can bring out this trouble, and each painful area is fixing not to be moved, surplus each outbreak 10 minute, the buccal nitroglycerine tablets are effective, and the cardiopalmus tachypnea of the tired back of companion is after one all preceding Changes in weather, last disease is increased the weight of, look into BP:180/100mmHg when being admitted to hospital, P:98 time/minute, R:24 time/minute, die Blausucht, purplish tongue has petechia, deep and hesitant pulse, heart circle enlarges slightly to left down, apex is heard and 2 grades of systolic murmurs, audible premature beat 8-10 time/minute, A2＞P2, electrocardiogram prompting sinus rate, chamber early (10 times/minute) takes place frequently, I, avl, the V4-6T ripple is inverted, and ST section declivity type moves down and reaches 0.1mFV, and microcirculation checks that suggest severe is unusual, hemorheology is learned the prompting blood high viscosity syndrome, hyperlipemia (cholesterolemia 7.2mmol/L, triglyceride 2.8mmol/L, HDL0.85mmol/L), tcm diagnosis: thoracic obstruction type of obstruction of heart-blood, Western medicine diagnose: angina pectoris, hypertension III level, arrhythmia (chamber of taking place frequently is early), heart merit II level.
Treatment: oral the present invention is by the extract of the prescription Chinese crude drug Radix Puerariae of said medicine composition and Fructus Crataegi (4～10) by weight: the ratio of (5～1) is carried out the Chinese patent medicine preparation tablet for coronary heart disease and hypertension of mix preparation, every day 3 times is oral, one upward disease alleviation of week back, the chest pain attack times reduces, and pain degree alleviates, and the cardiopalmus tachypnea is alleviated, continue one week of treatment, precordialgia and cardiopalmus tachypnea transference cure are had a medical check-up: die Blausucht, purplish tongue, disappear with petechia, deep and hesitant pulse disappears, and P:70 time/minute, BP:130/80mmH1～, R:18 time/minute, cardiac auscultation premature beat disappears, the electrocardiogram prompting: hole blood rule chamber early disappears, and it is normal that ST-T recovers; Microcirculation is checked: the nail fold microcirculation blood flow is normal substantially; Hemorheology learn to be checked: blood high viscosity syndrome disappears, blood fat normal (cholesterolemia reduce to 3.8mmol/L, triglyceride reduce to 1.6mmol/L, HDL rises to 1.55mmol/L), and stable disease is left hospital.
Embodiment 2
The king * *, the woman, 60 years old, coronary heart disease before 3 years was with hyperlipidemia, chest pain often occurs, feel suffocated 4, increase the weight of recently, angor 3-4 time behind the breastbone/day, continuing 4-5 minute at every turn. the companion breathes hard, backache, dizziness, fatigue and weak, sleepy drowsiness, light red tongue yellow and thin fur, rolling pulse.Have a blood test and press 105/75mmHg, the electrocardio diagram: II, III, VI, S-T section change, and look into whole blood fat TC223mg%, TG151mg%, HDL-ch54%.
Treatment: oral Chinese patent medicine preparation tablet for coronary heart disease and hypertension of the present invention, a week back further consultation, tell the three days breastbones of taking medicine after angor do not had outbreak, sense slightly uncomfortable in chest, conscious fatigue and weak, the clothes tablet for coronary heart disease and hypertension continues.Examined angina pectoris attacks after January again, dizzy, breathe hard pain pain, fatigue and weak and sleepy drowsiness transference cure.Look into BP:92/70mmhg, it is normal that electrocardiogram has recovered.Whole blood fat TC217mg%, TG123mg%, HDL-ch59mg% all return to normal range.
Embodiment 3
The king * *, woman, 64 years old, angina pectoris outbreak, companion's hyperlipidemia.Show effect 5-6 time, continue 2 minutes at every turn, complexion is turned white, sweating, malaise, pale tongue with thin fur Huang, deep and stringy pulse and puckery.Have a blood test and press BP126/72mmhg, suddenly look into the electrocardio diagram: III, V3, the V5 ST section of leading obviously descends, and is diagnosed as the angina pectoris outbreak.Look into whole blood fat FC254mg%, TG231mg%, HDL-ch41.4mg% all raise to some extent.
Treatment: oral Chinese patent medicine preparation tablet for coronary heart disease and hypertension of the present invention, every day three times, each four.The back further consultation of one week, the back pain of taking medicine during patient's angina pectoris attacks is gradually alleviated, and only have pain every day 1-2 time after the 3rd day, continues about 1 minute, and spirit is clearly better, and continues the clothes tablet for coronary heart disease and hypertension, examines the releasing of all diseases after January again.Look into ECG ST-T and change, whole blood fat TC232mg%, TG186mg% all descend to some extent, and it is normal that HDL-ch48mg% has recovered.
Claims (2)
1, a kind of Chinese patent medicine painstaking effort for the treatment of cardiovascular and cerebrovascular disease are peaceful, and it is characterized in that: the prescription of the peaceful ingredient of Chinese patent medicine painstaking effort is: adopt Chinese crude drug Radix Puerariae and Fructus Crataegi to make.
2, the Chinese patent medicine painstaking effort of treatment cardiovascular and cerebrovascular disease according to claim 1 are peaceful, it is characterized in that: the Chinese patent medicine painstaking effort rather are the extract of Radix Puerariae and Fructus Crataegi, and be by weight (4～10): the ratio of (5～1) is carried out mix preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03111057 CN1440781A (en) | 2003-02-26 | 2003-02-26 | Chinese medicine Xinxuening for treating cardiac and cerebral vascular diseases |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03111057 CN1440781A (en) | 2003-02-26 | 2003-02-26 | Chinese medicine Xinxuening for treating cardiac and cerebral vascular diseases |
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| CN1440781A true CN1440781A (en) | 2003-09-10 |
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| CN 03111057 Pending CN1440781A (en) | 2003-02-26 | 2003-02-26 | Chinese medicine Xinxuening for treating cardiac and cerebral vascular diseases |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102217770A (en) * | 2010-08-11 | 2011-10-19 | 马欣宏 | Formula for promoting micro circulation and alleviating dizziness, tinnitus and limb numbness |
| CN101461523B (en) * | 2007-12-18 | 2013-08-14 | 广西壮族自治区花红药业股份有限公司 | Health-care food oral liquid assistant for reducing blood fat and technique for preparing the same |
| CN104105496A (en) * | 2012-02-10 | 2014-10-15 | 雀巢产品技术援助有限公司 | Hawthorn and kudzu and their effect on cardiovascular diseases |
| CN107080771A (en) * | 2017-04-12 | 2017-08-22 | 吉林省德葆康医药科技股份有限公司 | Treat Chinese medicine composition of hyperlipidemia and fatty liver and preparation method thereof |
| CN112205557A (en) * | 2020-09-11 | 2021-01-12 | 坤承丰源(重庆)生物科技有限公司 | Hypolipidemic solid food beverage and preparation method thereof |
-
2003
- 2003-02-26 CN CN 03111057 patent/CN1440781A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461523B (en) * | 2007-12-18 | 2013-08-14 | 广西壮族自治区花红药业股份有限公司 | Health-care food oral liquid assistant for reducing blood fat and technique for preparing the same |
| CN102217770A (en) * | 2010-08-11 | 2011-10-19 | 马欣宏 | Formula for promoting micro circulation and alleviating dizziness, tinnitus and limb numbness |
| CN104105496A (en) * | 2012-02-10 | 2014-10-15 | 雀巢产品技术援助有限公司 | Hawthorn and kudzu and their effect on cardiovascular diseases |
| CN107080771A (en) * | 2017-04-12 | 2017-08-22 | 吉林省德葆康医药科技股份有限公司 | Treat Chinese medicine composition of hyperlipidemia and fatty liver and preparation method thereof |
| CN112205557A (en) * | 2020-09-11 | 2021-01-12 | 坤承丰源(重庆)生物科技有限公司 | Hypolipidemic solid food beverage and preparation method thereof |
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