CN100404051C - Chinese medicinal composition for treating coronary heart disease, stenocardia and its preparation method - Google Patents
Chinese medicinal composition for treating coronary heart disease, stenocardia and its preparation method Download PDFInfo
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- CN100404051C CN100404051C CNB2004100969702A CN200410096970A CN100404051C CN 100404051 C CN100404051 C CN 100404051C CN B2004100969702 A CNB2004100969702 A CN B2004100969702A CN 200410096970 A CN200410096970 A CN 200410096970A CN 100404051 C CN100404051 C CN 100404051C
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Abstract
The present invention discloses a traditional Chinese medicine composition and a preparation method thereof. The composition is composed of dragon blood and musk. The preparation method for the composition of the present invention comprises: the dragon blood and the musk are ground into fine powder which is sieved by 100 meshes; vaseline is added to the sieved fine powder which evenly is mixed, and the vaseline and the fine powder are blended evenly; ointment is formed by closing. The medicine composition of the present invention has obvious effects on treating coronary disease and angina pectoris. The present invention has no toxic or side effect.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of treatment coronary heart disease, anginal Chinese medicine composition and preparation method thereof.
Technical background:
China is at present to enter aging society, the rejuvenation day by day and coronary atherosclerotic heart disease is fallen ill, become one of lethal the fourth-largest killer in the whole world, high surprising of myocardial infarction mortality rate brought out in angina pectoris, hard to guard against, acute heart soldier is dead, the basic time that does not have rescue, coronary heart disease, for seeing, doctor trained in Western medicine adopts nitric acid lipid more more with unstable angina pectoris in angina pectoris, calcium antagonist, beta-blocker, aspirin, Low molecular heparin, Drug therapy such as Statins but a few patients through the said medicine therapeutic alliance after, outbreak that still can not allevating angina pectoris, motherland's medical science thinks that primary disease belongs to traditional Chinese medical science thoracic obstruction category, is the card of deficiency in origin and excess in superficiality.Empty support, wait in fact for cold coagulation, the stagnation of QI, blood stasis, stagnation of phlegm, many simulataneous insufficiency and excessive occur, how morbidity stage patient mainly shows as the mark excess syndrome for the heart, spleen, liver, deficiency of the kidney void, heart arteries and veins lose.
Summary of the invention:
The object of the invention is providing a kind of treatment coronary heart disease, anginal Chinese medicine composition.
Another object of the present invention is to provide a kind of preparation method for the treatment of coronary heart disease, anginal Chinese medicine composition
The present invention is achieved through the following technical solutions: choose crude drug
Sanguis Draxonis 25-75 weight portion Moschus 2-8 weight portion
Optimum ratio of the present invention is: choose crude drug
Sanguis Draxonis 50 weight portion Moschus 5 weight portions
Preparation method of the present invention for will be above-mentioned two flavor Chinese medicines, be ground into fine powder cross 80-120 mesh sieve 1-3 all over after, mix homogeneously adds vaseline 120-380 weight portion, blending is evenly sealed and is made ointment.
Pharmaceutical composition of the present invention is remarkable to treatment coronary heart disease and angina pectoris effect, has no side effect.
Following experimental example is used to further specify the present invention:
One, clinical data
This clinical diagnosis foundation: with reference to " medicine for cardiovascular system clinical research guideline " standard of Ministry of Public Health formulation.Ministry of Public Health medicine for cardiovascular system clinical research guideline (J), Chinese clinical pharmacology magazine 1998.4 (4): 251.
Select:
1, coronary heart disease unstable angina angina pectoris attacks every day once more than.
When 2, ischemia occurring during normal, the angina pectoris attacks of resting electrocardiogram, ST changes or be ischemic electrocardiogram person during tranquillization.
3, more than seven days, can not reduce attack times, degree person through pernitric acid lipid, calcium antagonist, beta receptor antagonist, aspirin, heparin, statins and the therapeutic alliance of dead point FUFANG DANSHEN ZHUSHEYE.Angina pectoris after the eliminating acute myocardial infarction, cardiac function 3-4 level, serious hepatic and kidney function obstacle and whole body function status difference person.
Two, physical data:
This method treatment case 132 examples are inpatient, male 82 examples, women 50 examples, course of disease 5-6.Wherein, 13 examples of the property sent out angina pectoris just; Pernicious angina pectoris 7 examples; Clinostatism angina pectoris 24 examples; Ariant angina 85 examples; PTCA adds stenting angor 3 examples of making up one's mind again later six months.Complicated hypertension 76 examples; Complication with diabetes 21 examples; Hyperlipemia 77 examples.
Three, Therapeutic Method
The patient gets 1.5 cun places, the outside that XINYU acupoint, position recess between back the 5th and sixth dorsal vertebra spinous process are got in the ventricumbent position.Tu shu cave: 1.5 cun places, the recess outside between back the 6th and seventh dorsal vertebra spinous process.Do local routine disinfection, generally with iodine fluorine cotton balls, outwards twice of sterilization from the lining, the reuse cotton ball soaked in alcohol takes off iodine, partial cover sterilization hole towel, provoke 2-3 time and get final product with the band handle three edged needle that disinfects in advance, the about 2-3 millimeters deep in straight thrust acupuncture point, behind sterilized cotton ball pressure cleared-out blood, be about to about about 0.5 gram of Chinese medicine ointment, landfill is in the acupuncture point of teasing, stroke gently flat after, the external application adhesive bandage gets final product.Can according to circumstances change a medicine treatment after seven days, general seven days was 1 course of treatment, and promptly fully recover 2-3 the course of treatment.Noninductive hair dyeing is given birth to, 2-4 days fruits that promptly take effect in therapeutic process, and decrement generally has other double disease gradually, can join other Yu cave, but based on Hsinshu (acupoint), tu shu.
Three, observation index:
Write down angina pectoris attacks frequency, position, degree, radiation every day, persistent period, routine electrocardiogram.(Hsinshu (acupoint), tu shu are that master point buries Chinese medicine ointment of the present invention and looks into electrocardiogram after second day, and 1-7 days was 1 course of treatment, and general 2-3 takes a turn for the better, fully recovers the course of treatment.)
Four, criterion of therapeutical effect:
1, ECG curative effect index:
Produce effects: electrocardio recovers normal.
Effectively: ischemic ST descends, and more than the treatment back rise 15mm, but the end is normal.Or the T ripple that mainly leads shoals and reaches more than 50%, or the T ripple by smooth transfer to upright.
Invalid: with basic identical or increase the weight of before the treatment.
2, curative effect to treat angina pectoris standard:
Produce effects: tired program of the same race, do not cause angina pectoris, or the angina pectoris attacks number of times reduces＞80%.
Effectively: angina pectoris attacks number of times minimizing＜50%-80%.
Invalid: angina pectoris attacks number of times＜50%.
Five, therapeutic outcome:
ECG curative effect: treatment back produce effects 29 examples are 29%, effective 66 examples 50%, invalid 7 examples 28.1%.Total effective rate 71.9%.
Curative effect to treat angina pectoris: treatment back produce effects 54 examples (40.6%), effective percentage 62 examples (47.44%), invalid 13 examples (9.4%) increase the weight of 2 examples (2.64%).Total effective rate is 87.5%.
Six, discuss
Modern medicine is thought unstable angina pectoris and coronary artery atheromatous plaque instability, and speckle enlarges or breaks and forms ulcer and local blood is fastened formation, and the coronary artery convulsion is twin relevant.Unstable angina pectoris shows as vexed pain in anterior pectorial region or squeezing property pain more, has palpitation, breathes hard, spiritlessness and weakness, dizziness, movingly then increase the weight of, even also above-mentioned symptom can appear under the quiet situation, thin and delicate or the stringy and thready pulse of pulsation, during outbreak in addition can not touch, dark tongue quality or ecchymosis is arranged, hear sounds is low blunt unable, TCM Syndrome Type is that the motive is lost void, obstruction of collaterals by blood stasis.The inventor according to Chinese medical discrimination, serves as that the intractable unstable angina pectoris of treatment is buried in main other Yu cave of joining with Hsinshu (acupoint), tu shu two caves on the treatment basis of doctor trained in Western medicine, the angina pectoris attacks frequency is reduced or disappearance.Nitric acid lipid and other oral drugs consumption obviously reduce.
Before and after the treatment relatively: difference has the significance meaning, and symptom total effective rate 87.5%, electrocardiogram effective percentage are 71.9%, and can significantly improve electrocardiogram ischemia scope and degree, shows as NST, ∑ ST, STmax, NT and significantly alleviates.
Seven, model case:
Case I: journey XX, the male, 53 years old, the cadre suffered from coronary heart disease 6 years, through province, city and region's tertiary hospitals, was diagnosed as coronary atherosclerotic heart disease, angina pectoris, unstable angina pectoris.Once the treatment of oral nitric acid lipid drug, irregularly dead point compound Salviae Miltiorrhizae or SHUXUENING ZHUSHEYE, the conventional amount used treatment, angina pectoris attacks is irregular, but the bad or tired feelings will of having a rest is when happy, easily outbreak.In on June 27th, 99 at my institute's hospitalization, be diagnosed as angina pectoris.Have a blood test and press 155/120mm
HG, heart rate 90 times/minute.
Readme: pareordia, dull pain, have palpitation, breathe hard, moving then more so, companion's dizziness, headache, limbs fatigue are looked into electrocardio and are shown that the ST section moves down 1.0mm.Through six days (convention amount) oral nitric acid lipid drugs of dead point compound Salviae Miltiorrhizae, poor effect, promptly confer with the patient, agree to bury Chinese medicinal ointment treatment of the present invention with Yu cave, promptly divide and give Hsinshu (acupoint) at 99 on JIUYUE 9:40 in the 7 ,-morning, the tu shu cave is the main bl of joining, Pishu, shen shu, bury Chinese medicinal ointment of the present invention behind the routine disinfection, drug withdrawal in the 3rd day is observed, readme chest pareordia dull pain, the nervous remission of breathing hard, the energy autonomic activities, no angina pectoris outbreak, sb.'s illness took a favorable turn after observing three days, changed dressings once in above-mentioned Yu cave again by the 6th day, look into electrocardio diagram ST section rise 0.5mm simultaneously, electrocardiogram is normal after being in hospital seven, pareordia dull pain, nervous breathing hard, the spiritlessness and weakness transference cure, blood pressure 120/80mm
HG, recovery from illness is left hospital.
Case II: Gong XX, the male, 56 years old, the teacher, coronary heart disease, in year surplus the angina pectoris sick ten, on April 21st, 2002, do the operation of heart coronary artery branch vessel inner support in Mudanjiang City's cardiovascular section hospital, the nearly one-year age of postoperative angina pectoris symptom does not have outbreak, but last in April, 2003 because activity is bigger, and precordialgia appears, chest pain radiating to the back, oral at short notice spasmolytic, the coronary dilating medicine is slightly alleviated, afternoon on April 28th, 2003 is conscious, uncomfortable in chest, nervous, breathe hard, chest pain, promptly my institute's hospitalization promptly is diagnosed as coronary heart disease, the postoperative angina pectoris is had a blood test and is pressed 155/110mm
HG, heart rate 96 times/minute, 37 ℃ of body temperature, electrocardio diagram ST section decline 1.0mm, oral nitric acid lipid drug, cooperate compound Salviae Miltiorrhizae, Radix Et Caulis Acanthopanacis Senticosi injection treatment after three days symptom take a turn for the better not obvious, promptly solicit patient and family members and agree that doing Yu cave buries Drug therapy of the present invention, core Yu, tu shu, bl, Pishu, SHENYU point buries Chinese medicine ointment of the present invention, medication conscious pareordia dull pain on the same day is alleviated, is breathed steadily, the energy autonomic activities, and diet, two is just normal, look into heart diagram ST section and carry on 0.5mm, angina pectoris symptom disappears.Observe after five days, the electrocardio diagram is normal, after a week is observed in the drug withdrawal of being in hospital, and no angina pectoris outbreak, recovery from illness is left hospital.
Following embodiment is used to further specify the present invention:
Embodiment 1:
Sanguis Draxonis 50kg Moschus 5kg
With above-mentioned two flavor Chinese medicines, be ground into after fine powder crosses twice of 100 mesh sieve, mix homogeneously adds white vaseline 250kg, blending evenly, ointment is made in sealing.In each medication 0.5g left side, changed dressings once in 5-7 days.
Embodiment 2:
Sanguis Draxonis 30kg Moschus 7kg
With above-mentioned two flavor Chinese medicines, be ground into after fine powder crosses twice of 100 mesh sieve, mix homogeneously adds white vaseline 200kg, blending evenly, ointment is made in sealing.In each medication 0.5g left side, changed dressings once in 5-7 days.
Embodiment 3
Sanguis Draxonis 70kg Moschus 3kg
With above-mentioned two flavor Chinese medicines, be ground into after fine powder crosses twice of 100 mesh sieve, mix homogeneously adds white vaseline 300kg, blending evenly, ointment is made in sealing.In each medication 0.5g left side, changed dressings once in 5-7 days.
Embodiment 4
Sanguis Draxonis 40kg Moschus 6kg
Said medicine technology is routinely made spray.
Embodiment 5
Sanguis Draxonis 60kg Moschus 4kg
Said medicine technology is routinely made spray.
Claims (9)
1. a treatment coronary heart disease, anginal Chinese medicine composition is characterized in that said composition made by following crude drug:
Sanguis Draxonis 25-75 weight portion Moschus 2-8 weight portion.
2. Chinese medicine composition according to claim 1 is characterized in that said composition made by following crude drug:
Sanguis Draxonis 50 weight portion Moschus 5 weight portions.
3. Chinese medicine composition according to claim 1 is characterized in that said composition made by following crude drug:
Sanguis Draxonis 30 weight portion Moschus 7 weight portions.
4. Chinese medicine composition according to claim 1 is characterized in that said composition made by following crude drug:
Sanguis Draxonis 70 weight portion Moschus 3 weight portions.
5. according to claim 1,2,3 or 4 described Chinese medicine compositions, it is characterized in that said composition adds pharmaceutically conventional adjuvant and makes the clinical dosage form of accepting.
6. Chinese medicine composition according to claim 5 is characterized in that described dosage form is tablet, capsule, granule, spray, ointment, emplastrum or ointment.
7. according to the preparation method of claim 1,2,3 or 4 described Chinese medicine compositions, it is characterized in that this method is: with Sanguis Draxonis, Moschus be ground into fine powder cross 80-120 mesh sieve 1-3 all over after, mix homogeneously adds vaseline 120-380 weight portion, and blending is evenly sealed and made ointment.
8. the preparation method of Chinese medicine composition according to claim 7 is characterized in that this method is: Sanguis Draxonis, Moschus are ground into after fine powder crosses 100 mesh sieves 2 times, and mix homogeneously adds white vaseline 250 weight portions, blending evenly, ointment is made in sealing.
9. according to claim 1,2, the application of 3 or 4 described Chinese medicine compositions in preparation treatment coronary heart disease and anginal medicine.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100969702A CN100404051C (en) | 2004-12-07 | 2004-12-07 | Chinese medicinal composition for treating coronary heart disease, stenocardia and its preparation method |
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| CNB2004100969702A CN100404051C (en) | 2004-12-07 | 2004-12-07 | Chinese medicinal composition for treating coronary heart disease, stenocardia and its preparation method |
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| CN1785334A CN1785334A (en) | 2006-06-14 |
| CN100404051C true CN100404051C (en) | 2008-07-23 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1358544A (en) * | 2000-09-25 | 2002-07-17 | 瓦里安医疗系统公司 | Radiation medical inplantation article and making method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1358544A (en) * | 2000-09-25 | 2002-07-17 | 瓦里安医疗系统公司 | Radiation medical inplantation article and making method thereof |
Non-Patent Citations (8)
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| 人工麝香抗心绞痛的初步临床观察. 中津药厂.广东医学，第3期. 1976 |
| 人工麝香抗心绞痛的初步临床观察. 中津药厂.广东医学，第3期. 1976 * |
| 血竭治疗冠心病临床资料分析. 李春生.云南中医中药杂志，第17卷第6期. 1996 |
| 血竭治疗冠心病临床资料分析. 李春生.云南中医中药杂志，第17卷第6期. 1996 * |
| 麝香的药理作用及临床应用研究. 黄正良.中成药研究，第5期. 1987 |
| 麝香的药理作用及临床应用研究. 黄正良.中成药研究，第5期. 1987 * |
| 麝香酮制剂治疗冠心病患者71例疗效观察. 上海市麝香酮临床科研协作组.中成药研究，第6期. 1982 |
| 麝香酮制剂治疗冠心病患者71例疗效观察. 上海市麝香酮临床科研协作组.中成药研究，第6期. 1982 * |
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