CN101342207B - Chinese medicinal composition for treating coronary disease, stenocardia, arrhythmia, hyperlipemia and preparation method thereof - Google Patents
Chinese medicinal composition for treating coronary disease, stenocardia, arrhythmia, hyperlipemia and preparation method thereof Download PDFInfo
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Abstract
The invention provides a Chinese medicine composition used for curing coronary heart disease, angina, arrhythmia and high blood fat and a preparation method thereof. The Chinese medicine composition consists of components as follows: 5 to 20 weight percentage of musk, 12 to 50 weight percentage, 60 to 250 weight percentage of sodium taurocholate, 12 to 50 weight percentage of toad venom, 30 to 120 weight percentage of pearl, 40 to 160 weight percentage of borneol, 1500 to 15000 weight percentage of panax pseudo-ginseng wallich, 150 to 600 weight percentage of ginseng and 50 to 200 weight percentage of the dry extract of buffalo horn. The Chinese medicine composition of the invention can improve blood circulation, dilate coronary arteries, enhance myocardial ischemia, decrease crown arteries resistance, regulate cardiac rate, lower blood pressure, reduce myocardium metabolism, decrease consumed oxygen of myocardium and relieve or eliminate angina via the synergistic and beneficial antagonistic effect of the medicine. As a great amount of the sodium taurochlate is adopted, product cost is reduced while drug effect is ensured as much as possible, thus reducing the economic burden of a patient.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of Chinese medicine composition that is used for the treatment of coronary heart diseases and angina pectoris, arrhythmia, hyperlipidemia and preparation method thereof.
Background technology
The cardiovascular and cerebrovascular diseases such as coronary heart diseases and angina pectoris, arrhythmia, hyperlipidemia are the first killers of harm humans healthy life in the present worldwide, only just there are every year 3000000 people to die from cardiovascular and cerebrovascular disease in China, there was a people dead in average per 10 seconds, makes number one.Cardiovascular and cerebrovascular disease has the characteristics of high incidence, high mortality, high disability rate, high relapse rate, has repeated drug taking, the characteristics of SM for the patient of cardiovascular and cerebrovascular disease.The Chinese and Western patent medicine of a lot for the treatment of cardiovascular and cerebrovascular diseases is arranged in the market, how undesirable, though certain therapeutical effect is arranged mostly, the toxic and side effects that has is larger, the treatment cost that has is too high, and the rear state of an illness of discontinuing medication occurs repeatedly.
Summary of the invention
The object of the present invention is to provide and a kind ofly can effectively treat the cardiovascular and cerebrovascular diseases such as coronary heart diseases and angina pectoris, arrhythmia, hyperlipidemia and Chinese medicine composition with low cost, that toxic and side effects is little and preparation method thereof.
The Chinese medicine composition for the treatment of coronary heart diseases and angina pectoris of the present invention, arrhythmia, hyperlipidemia; made by following component: Moschus 5-20 weight portion; Calculus Bovis 12-50 weight portion; sodium cholate 60-250 weight portion, Venenum Bufonis 12-50 weight portion, Margarita 30-120 weight portion; Borneolum Syntheticum 40-160 weight portion; Radix Notoginseng 1500-15000 weight portion, Radix Ginseng 150-600 weight portion, Cornu Bubali dry extract 50-200 weight portion.
The Chinese medicine composition of the cardiovascular and cerebrovascular diseases such as treatment coronary heart diseases and angina pectoris of the present invention, arrhythmia, hyperlipidemia can be made the dosage form on any pharmaceutics, comprises pill, capsule, tablet, granule, soft capsule or powder.
The preparation method of the various common formulations of Chinese medicine composition of the present invention below is described respectively:
1, the preparation of pill: the 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins; all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively; again with the Radix Notoginseng total arasaponins facing-up; sieve; mixing; with the general ball of ethanol, Radix Glycyrrhizae charcoal coating, cold drying and get final product.
2, the preparation of capsule: the 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins; all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively; again with the Radix Notoginseng total arasaponins facing-up; cold drying; sieve; mixing is filled, and makes capsule.
3, the preparation of tablet: the 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins, and all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively, again with the Radix Notoginseng total arasaponins facing-up; cold drying is sieved, mixing; granulate, be pressed into tablet.
4, the preparation of granule: the 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins, and all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively, again with the Radix Notoginseng total arasaponins facing-up; cold drying; sieve mixing, granulation agent.
5, the preparation of soft capsule: the 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins; all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively; again with the Radix Notoginseng total arasaponins facing-up; sieve; mixing; add an amount of PEG-4000 and a small amount of glycerol, mixing is pressed into soft capsule.
6, the preparation of powder: the 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins, and all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively, again with the Radix Notoginseng total arasaponins facing-up; sieve; mixing, powder is made in cold drying.
Described Radix Notoginseng total arasaponins is to get Radix Notoginseng powder to be broken into coarse powder, uses the 30-90% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.0-6.5 with the 15%-30% hydrochloric acid solution, placement is spent the night, filter, filtrate is extracted with the ether jolting, discards ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol makes at 30-90 ℃ of vacuum drying.
Described Cornu Bubali dry extract is water intaking Cornu Bovis seu Bubali thin slice, adds 6-10 times of water gaging, decocts 1-3 time, and each 5-10 hour, collecting decoction filtered, and filtrate is condensed into thick paste, makes 80 ℃ of lower dryings.
Each is powerful for component of the present invention: pseudo-ginseng blood-circulation-invigovating blood stasis dispelling, reducing swelling and alleviating pain have the power of strengthening by means of tonics concurrently; The Cornu Bubali clearing away heart-fire detoxification, removing heat from blood blood stasis removing dissipating rashes; Moschus, the refreshment of Borneolum Syntheticum causing resuscitation with aromatic drugs, pain relieving spasmolytic; The Venenum Bufonis removing toxic substances and promoting subsidence of swelling, the pain relieving heart tonifying; Sodium cholate can promote digestion and the absorption of fat, activates the pancreas digestive enzyme; Calculus Bovis, Margarita removing heat from the heart to restore the consciousness, tranquilizing mind, spasmolytic; The Radix Ginseng strongly invigorating primordial QI, Yiqi and vein recovery.All medicines share has blood circulation promoting and blood stasis dispelling, invigorates vital energy and reinforce the heart the merit that centering is calmed the nerves.Mutually work in coordination with and useful antagonism by medicine in the prescription of the present invention, can improve blood circulation, coronary artery dilator increases coronary artery blood flow, improves myocardial ischemia; Formation and the progress of energy blood fat reducing or inhibition atheromatous plaque, or regressive effect is arranged, lower coronary resistance, adjust heart rate, reduce blood pressure; Reduce the myocardial metabolism level, lower myocardial oxygen consumption, thereby myocardial ischemia is improved, angina pectoris is eased or eliminates, and cardiac function is improved; And when design component, adopting in a large number sodium cholate, and the ratio of corresponding other component of control has reduced the cost of product as far as possible when not reducing drug effect, the cost performance of product is significantly increased, and has alleviated patient's financial burden.
Below by zoopery, the pharmacological action of Chinese medicine composition of the present invention is described:
1 medicine: " preparation of the present invention " pill for getting by the embodiment of the invention 1 preparation; JIUXIN DAN is that Japan rescues the production of heart Pharmaceutical Co., Ltd, and specification is 15 milligrams/ball.
2 experimental techniques and result
2.1 acute toxicity test
Get 60 of healthy mices, evenly be divided into two groups by sex, body weight, give respectively " preparation of the present invention " and JIUXIN DAN 50mg/10g gavage, observe toxic reaction and death toll.
After " preparation of the present invention " and the Japanese JIUXIN DAN gavage, the poisoning symptom of white mice is different, and JIUXIN DAN main manifestations central excitation phenomenon the clonic spasm type then occurs and faints from fear, and faints from fear because of tetanic type at last and opisthotonus causes death." preparation of the present invention " then main manifestations maincenter suppresses, and animal is quiet, movable to be reduced, and drowsiness phenomenon then occurs, but righting reflex exists still.The mortality rate of JIUXIN DAN, " preparation of the present invention " is respectively 65%, 0%.The toxicity of Japan's JIUXIN DAN is larger than " preparation of the present invention ", and there were significant differences.
2.2 the effect to the Rat Heart of isolated perfusion
Get 7 of the rat of growing up, the male and female dual-purpose, the head of fiercelying attack is cut the thoracic cavity open, takes out rapidly heart, puts in freezing kreb ' the s solution after the washing, inserts sleeve pipe from aorta, passes into continuously O with 37 ℃ of kreb ' s solution Constant pressure perfusions to kreb ' s solution
2And CO
2Gas, and regulate both speed, make PH be constant at 7.4, put two small pieces filter paper at heart surface and connect electrocardio eeg amplifier recording ecg, get a bit of plastic tube, end is pricked a bead with plastic sheeting, put into left ventricle through left atrium, the Bonding pressure transducer links to each other with YL-4 type pressure amplifier, the record left ventricular pressure, and with pressure processor record left ventricular pressure climbing speed, with the MFV-1200 electromagnetic flowmeter record coronary flow of Japanese photoelectricity factory production.Above-mentioned four indexs are all traced continuously with the SJ-42 type 4 passage physiographs of Shanghai Medical Electric Instrument Factory production.Calculate administration front and back coronary flow, left ventricular pressure climbing speed change percentage in arid is with its significance of t test determination.
The result: " preparation of the present invention " increases coronary flow effect highly significant (P＜0.01), and makes left ventricular pressure and left ventricular pressure climbing speed obviously descend (P＜0.05).
Below by the clinical drug development test, therapeutic effect and the safety of medicine of the present invention are described:
1, case is selected:
" preparation of the present invention " clinical verification object is all by " diagnostic criteria for coronary heart disease ", electrocardiogram is ischemic change (ST-T change) case as main during take rest, or there is classical angina to show effect, or myocardial infarction and old myocardial infarction case are arranged, investigate simultaneously fraction arrhythmia and other heart disease case.
Clinical symptoms performance situation: coronary heart disease, classical angina 66 examples, Non-typical angina 56 examples, arrhythmia 1 example, myocardial infarction 1 example, old myocardial infarction 1 example, pulmonary heart disease 1 example.
Follow situation: complicated hypertension 50 examples in 123 examples, merge hyperlipidemia 54 examples, complicated hypertension and hyperlipidemia 32 examples, complicated hypertension and arteriosclerosis 4 examples merge arteriosclerosis 3 examples, complication with diabetes 1 example
2, drug dose and observational technique:
Medicine and consumption: " preparation of the present invention " pill for getting by the embodiment of the invention 1 preparation, every heavy 20mg, each sublingual administration 2 balls, some cases 3 balls, every day 2 times, some cases every day 3 times, withdraw other medicaments for coronary disease during taking this medicine, also withdraw generally speaking blood pressure lowering and blood lipid-lowering medicine with hypertension and hyperlipemic patients.
Observational technique: the record front static electrocardiogram of taking medicine, sublingual administration " preparation of the present invention " 2 balls immediately, take medicine rear 1 hour, 2 hours, 24 hours respectively recording ecg change, be curative effect.Later on each buccal " preparation of the present invention " 2 balls, every day 2 times, two weeks is a course for the treatment of, treats 1-4 the course for the treatment of.Whenever expire a course for the treatment of, the check electrocardiogram once, relatively before and after electrocardiogram change, and measure heart rate, blood pressure situation, symptom variation and the improvement situations such as inquiry angina pectoris, uncomfortable in chest, cardiopalmus, tachypnea, dizzy, perspiration.
Case is carried out the thoracic cavity X-ray examination before beginning to investigate, and observes podiod and lung blood situation, and in case in case of necessity, finish the course for the treatment of, carries out thoracic cavity x-ray check; All being diagnosed as merges the cerebral arteriosclerosis person, carry out the rheoencephalogram inspection; Make a definite diagnosis merging arteriosclerosis person and will carry out examination of ocular fundus; Blood fat the treatment forward and backward check as far as possible serum cholesterol each once, might check simultaneously triglyceride and protein electrophoresis under the condition.
3, efficacy assessment standard:
Efficacy assessment standard is all evaluated according to " coronary heart diseases and angina pectoris and ECG curative effect evaluation criteria ".Arrhythmia is by following standard rating.
The arrhythmia efficacy assessment standard:
Produce effects: the electrocardiogram arrhythmia disappears after the treatment, or premature beat is only arranged, the symptom person of being clearly better.
Effectively: the electrocardiogram arrhythmia obviously reduces (general premature beat reduce to original more than 50%) and the symptom person of taking a favorable turn after the treatment.
Invalid: arrhythmia is without the changer after the treatment.
Hypertension is according to " hypertension efficacy assessment standard " evaluation efficacy of antihypertensive treatment.
4, therapeutic outcome and efficacy analysis:
4.1 curative effect to treat angina pectoris: with classical angina 66 examples, effective 64 examples, effective percentage is 96.97%; Non-typical angina 56 examples, effective 49 examples, effective percentage 87.5%, angina pectoris total effective rate 92.62%, treatment 122 example typical cases all have good curative effect with Non-typical angina.See table 1 for details
Table 1 angina pectoris symptom efficacy analysis
4.2 cardiac function curative effect: the caused various symptoms of Lower cardiac function are all had good therapeutical effect, see (table 2) for details
The doing well,improving situation that table 2 cardiac function descends
4.3 ECG curative effect
Investigate in 123 cases, electrocardiogram has pathological change 122 examples during the front rest for the treatment of, visit check through the treatment observation, produce effects 26 examples account for 21.31%, improve 59 examples, account for 48.36%, total effective rate 69.67%, invalid is 30.33%, and statistical significant difference (P＜0.05) is arranged between effective percentage and the inefficiency.
4.4 blood fat reducing effect:
Follow hyperlipidemia (serum cholesterol〉200mg%) 54 examples, serum cholesterol meansigma methods 247.33mg% before the treatment in 123 examples before the treatment.Meansigma methods is 220.23mg% after the treatment, and 27.1mg% on average descends.Serum cholesterol changes before and after the treatment significant difference (P＜0.05).
4.5 to following the hypertension effect:
50 examples are attended by the hyperpietic in 123 examples, and to begin the rear 24 hours mensuration of taking medicine, produce effects 9 examples account for 13%, improve 13 examples, account for 27%, are 45% to following hyperpietic's total effective rate by " hypertension efficacy assessment standard "." preparation of the present invention " follows the hyperpietic that good hypotensive activity is arranged to coronary heart disease.
5, the observation of side effect
According to the 123 routine clinical investigation results of 5 medical institutions, in therapeutic process, do not find untoward reaction.
The specific embodiment
The present invention will be described in detail by the following examples.
Embodiment 1: the preparation of pill
Get the Radix Notoginseng of 1500 weight portions, be ground into coarse powder, use 80% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.0 with 20% hydrochloric acid solution, placement is spent the night, and filters, and filtrate is extracted with the ether jolting, discard ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol, at 60 ℃ of vacuum dryings, it is for subsequent use to make Radix Notoginseng total arasaponins; Water intaking Cornu Bovis seu Bubali thin slice adds 8 times of water gagings, decocts 2 times, and each 8 hours, collecting decoction filtered, and filtrate is condensed into thick paste, and it is for subsequent use to make Cornu Bubali dry extract 80 ℃ of dryings; Getting Cornu Bubali dry extract 55 weight portions of Radix Notoginseng 1500 weight portions and Moschus 5 weight portions, Calculus Bovis 40 weight portions, sodium cholate 200 weight portions, Venenum Bufonis 30 weight portions, Margarita 50 weight portions, Borneolum Syntheticum 40 weight portions, Radix Ginseng 500 weight portions, above-mentioned preparation pulverizes respectively; again with the Radix Notoginseng total arasaponins facing-up of above-mentioned preparation; sieve; mixing; with the general ball of ethanol; Radix Glycyrrhizae charcoal coating, cold drying and get final product.
Embodiment 2: the preparation of capsule
Get the Radix Notoginseng of 9000 weight portions, be ground into coarse powder, use 50% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.0 with 30% hydrochloric acid solution, placement is spent the night, and filters, and filtrate is extracted with the ether jolting, discard ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol, at 80 ℃ of vacuum dryings, it is for subsequent use to make Radix Notoginseng total arasaponins; Water intaking Cornu Bovis seu Bubali thin slice adds 8 times of water gagings, decocts 2 times, and each 10 hours, collecting decoction filtered, and filtrate is condensed into thick paste, and it is for subsequent use to make Cornu Bubali dry extract 80 ℃ of dryings; Getting Cornu Bubali dry extract 180 weight portions of Radix Notoginseng 6000 weight portions and Moschus 5 weight portions, Calculus Bovis 40 weight portions, sodium cholate 180 weight portions, Venenum Bufonis 30 weight portions, Margarita 50 weight portions, Borneolum Syntheticum 40 weight portions, Radix Ginseng 200 weight portions, above-mentioned preparation pulverizes respectively; again with the Radix Notoginseng total arasaponins facing-up of above-mentioned preparation; cold drying; sieve; mixing; fill, make capsule.
Embodiment 3: the preparation of tablet
Get the Radix Notoginseng of 6000 weight portions, be ground into coarse powder, use 80% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.0 with 20% hydrochloric acid solution, placement is spent the night, and filters, and filtrate is extracted with the ether jolting, discard ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol, at 60 ℃ of vacuum dryings, it is for subsequent use to make Radix Notoginseng total arasaponins; Water intaking Cornu Bovis seu Bubali thin slice adds 8 times of water gagings, decocts 3 times, and each 8 hours, collecting decoction filtered, and filtrate is condensed into thick paste, and it is for subsequent use to make Cornu Bubali dry extract 80 ℃ of dryings; Getting Cornu Bubali dry extract 120 weight portions of Radix Notoginseng 9000 weight portions and Moschus 20 weight portions, Calculus Bovis 40 weight portions, sodium cholate 200 weight portions, Venenum Bufonis 30 weight portions, Margarita 40 weight portions, Borneolum Syntheticum 40 weight portions, Radix Ginseng 500 weight portions, above-mentioned preparation pulverizes respectively; again with the Radix Notoginseng total arasaponins facing-up of above-mentioned preparation; cold drying; sieve; mixing is granulated drying; add magnesium stearate, be pressed into tablet.
Embodiment 4: the preparation of granule
Get the Radix Notoginseng of 3000 weight portions, be ground into coarse powder, use 60% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.2 with 25% hydrochloric acid solution, placement is spent the night, and filters, and filtrate is extracted with the ether jolting, discard ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol, at 60 ℃ of vacuum dryings, it is for subsequent use to make Radix Notoginseng total arasaponins; Water intaking Cornu Bovis seu Bubali thin slice adds 9 times of water gagings, decocts 2 times, and each 6 hours, collecting decoction filtered, and filtrate is condensed into thick paste, and it is for subsequent use to make Cornu Bubali dry extract 80 ℃ of dryings; Getting Cornu Bubali dry extract 60 weight portions of Radix Notoginseng 4000 weight portions and Moschus 8 weight portions, Calculus Bovis 48 weight portions, sodium cholate 80 weight portions, Venenum Bufonis 40 weight portions, Margarita 120 weight portions, Borneolum Syntheticum 130 weight portions, Radix Ginseng 400 weight portions, above-mentioned preparation pulverizes respectively; again with the Radix Notoginseng total arasaponins facing-up of above-mentioned preparation; sieve; mixing; cold drying, the granulation agent
Embodiment 5: the preparation of soft capsule
Get the Radix Notoginseng of 7500 weight portions, be ground into coarse powder, use 90% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.0 with 30% hydrochloric acid solution, placement is spent the night, and filters, and filtrate is extracted with the ether jolting, discard ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol, at 90 ℃ of vacuum dryings, it is for subsequent use to make Radix Notoginseng total arasaponins; Water intaking Cornu Bovis seu Bubali thin slice adds 10 times of water gagings, decocts 3 times, and each 10 hours, collecting decoction filtered, and filtrate is condensed into thick paste, and it is for subsequent use to make Cornu Bubali dry extract 80 ℃ of dryings; Getting Cornu Bubali dry extract 100 weight portions of Radix Notoginseng 7500 weight portions and Moschus 12 weight portions, Calculus Bovis 25 weight portions, sodium cholate 240 weight portions, Venenum Bufonis 45 weight portions, Margarita 110 weight portions, Borneolum Syntheticum 150 weight portions, Radix Ginseng 300 weight portions, above-mentioned preparation pulverizes respectively; again with the Radix Notoginseng total arasaponins facing-up of above-mentioned preparation; sieve; add an amount of PEG-4000 and a small amount of glycerol; mixing is pressed into soft capsule.
Embodiment 6: the preparation of powder
Get the Radix Notoginseng of 9000 weight portions, be ground into coarse powder, use 30% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.5 with 15% hydrochloric acid solution, placement is spent the night, and filters, and filtrate is extracted with the ether jolting, discard ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol, at 30 ℃ of vacuum dryings, it is for subsequent use to make Radix Notoginseng total arasaponins; Water intaking Cornu Bovis seu Bubali thin slice adds 6 times of water gagings, decocts 1 time, and each 5 hours, collecting decoction filtered, and filtrate is condensed into thick paste, and it is for subsequent use to make Cornu Bubali dry extract 60 ℃ of dryings; Getting Cornu Bubali dry extract 200 weight portions of Radix Notoginseng 1000 weight portions and Moschus 20 weight portions, Calculus Bovis 20 weight portions, sodium cholate 70 weight portions, Venenum Bufonis 15 weight portions, Margarita 30 weight portions, Borneolum Syntheticum 80 weight portions, Radix Ginseng 200 weight portions, above-mentioned preparation pulverizes respectively; again with the Radix Notoginseng total arasaponins facing-up of above-mentioned preparation; sieve; mixing; powder is made in cold drying.
Claims (12)
1. a Chinese medicine composition for the treatment of coronary heart diseases and angina pectoris, arrhythmia, hyperlipidemia is characterized in that, makes by the following method:
Get Moschus 5-20 weight portion, Calculus Bovis 12-50 weight portion, sodium cholate 60-250 weight portion, Venenum Bufonis 12-50 weight portion, Margarita 30-120 weight portion, Borneolum Syntheticum 40-160 weight portion, Radix Notoginseng 1500-15000 weight portion, Radix Ginseng 150-600 weight portion, Cornu Bubali dry extract 50-200 weight portion;
The 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins, all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively, again with the Radix Notoginseng total arasaponins facing-up, sieve, mixing, with the general ball of ethanol, Radix Glycyrrhizae charcoal coating, cold drying makes pill;
Described Radix Notoginseng total arasaponins is to get Radix Notoginseng powder to be broken into coarse powder, uses the 30-90% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.0-6.5 with the 15%-30% hydrochloric acid solution, placement is spent the night, filter, filtrate is extracted with the ether jolting, discards ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol makes at 30-90 ℃ of vacuum drying;
Described Cornu Bubali dry extract is water intaking Cornu Bovis seu Bubali thin slice, adds 6-10 times of water gaging, decocts 1-3 time, and each 5-10 hour, collecting decoction filtered, and filtrate is condensed into thick paste, makes 80 ℃ of lower dryings.
2. a Chinese medicine composition for the treatment of coronary heart diseases and angina pectoris, arrhythmia, hyperlipidemia is characterized in that, makes by the following method:
Get Moschus 5-20 weight portion, Calculus Bovis 12-50 weight portion, sodium cholate 60-250 weight portion, Venenum Bufonis 12-50 weight portion, Margarita 30-120 weight portion, Borneolum Syntheticum 40-160 weight portion, Radix Notoginseng 1500-15000 weight portion, Radix Ginseng 150-600 weight portion, Cornu Bubali dry extract 50-200 weight portion;
The 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins, and all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively, again with the Radix Notoginseng total arasaponins facing-up, cold drying is sieved, mixing, fill, make capsule;
Described Radix Notoginseng total arasaponins is to get Radix Notoginseng powder to be broken into coarse powder, uses the 30-90% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.0-6.5 with the 15%-30% hydrochloric acid solution, placement is spent the night, filter, filtrate is extracted with the ether jolting, discards ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol makes at 30-90 ℃ of vacuum drying;
Described Cornu Bubali dry extract is water intaking Cornu Bovis seu Bubali thin slice, adds 6-10 times of water gaging, decocts 1-3 time, and each 5-10 hour, collecting decoction filtered, and filtrate is condensed into thick paste, makes 80 ℃ of lower dryings.
3. a Chinese medicine composition for the treatment of coronary heart diseases and angina pectoris, arrhythmia, hyperlipidemia is characterized in that, makes by the following method:
Get Moschus 5-20 weight portion, Calculus Bovis 12-50 weight portion, sodium cholate 60-250 weight portion, Venenum Bufonis 12-50 weight portion, Margarita 30-120 weight portion, Borneolum Syntheticum 40-160 weight portion, Radix Notoginseng 1500-15000 weight portion, Radix Ginseng 150-600 weight portion, Cornu Bubali dry extract 50-200 weight portion;
The 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins, and all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively, again with the Radix Notoginseng total arasaponins facing-up, cold drying is sieved, mixing, granulate, be pressed into tablet;
Described Radix Notoginseng total arasaponins is to get Radix Notoginseng powder to be broken into coarse powder, uses the 30-90% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.0-6.5 with the 15%-30% hydrochloric acid solution, placement is spent the night, filter, filtrate is extracted with the ether jolting, discards ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol makes at 30-90 ℃ of vacuum drying;
Described Cornu Bubali dry extract is water intaking Cornu Bovis seu Bubali thin slice, adds 6-10 times of water gaging, decocts 1-3 time, and each 5-10 hour, collecting decoction filtered, and filtrate is condensed into thick paste, makes 80 ℃ of lower dryings.
4. a Chinese medicine composition for the treatment of coronary heart diseases and angina pectoris, arrhythmia, hyperlipidemia is characterized in that, makes by the following method:
Get Moschus 5-20 weight portion, Calculus Bovis 12-50 weight portion, sodium cholate 60-250 weight portion, Venenum Bufonis 12-50 weight portion, Margarita 30-120 weight portion, Borneolum Syntheticum 40-160 weight portion, Radix Notoginseng 1500-15000 weight portion, Radix Ginseng 150-600 weight portion, Cornu Bubali dry extract 50-200 weight portion;
The 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins, and all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively, again with the Radix Notoginseng total arasaponins facing-up, cold drying, sieve mixing, granulation agent;
Described Radix Notoginseng total arasaponins is to get Radix Notoginseng powder to be broken into coarse powder, uses the 30-90% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.0-6.5 with the 15%-30% hydrochloric acid solution, placement is spent the night, filter, filtrate is extracted with the ether jolting, discards ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol makes at 30-90 ℃ of vacuum drying;
Described Cornu Bubali dry extract is water intaking Cornu Bovis seu Bubali thin slice, adds 6-10 times of water gaging, decocts 1-3 time, and each 5-10 hour, collecting decoction filtered, and filtrate is condensed into thick paste, makes 80 ℃ of lower dryings.
5. a Chinese medicine composition for the treatment of coronary heart diseases and angina pectoris, arrhythmia, hyperlipidemia is characterized in that, makes by the following method:
Get Moschus 5-20 weight portion, Calculus Bovis 12-50 weight portion, sodium cholate 60-250 weight portion, Venenum Bufonis 12-50 weight portion, Margarita 30-120 weight portion, Borneolum Syntheticum 40-160 weight portion, Radix Notoginseng 1500-15000 weight portion, Radix Ginseng 150-600 weight portion, Cornu Bubali dry extract 50-200 weight portion;
The 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins, all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively, again with the Radix Notoginseng total arasaponins facing-up, sieve, mixing, add an amount of PEG-4000 and a small amount of glycerol, mixing is pressed into soft capsule;
Described Radix Notoginseng total arasaponins is to get Radix Notoginseng powder to be broken into coarse powder, uses the 30-90% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.0-6.5 with the 15%-30% hydrochloric acid solution, placement is spent the night, filter, filtrate is extracted with the ether jolting, discards ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol makes at 30-90 ℃ of vacuum drying;
Described Cornu Bubali dry extract is water intaking Cornu Bovis seu Bubali thin slice, adds 6-10 times of water gaging, decocts 1-3 time, and each 5-10 hour, collecting decoction filtered, and filtrate is condensed into thick paste, makes 80 ℃ of lower dryings.
6. a Chinese medicine composition for the treatment of coronary heart diseases and angina pectoris, arrhythmia, hyperlipidemia is characterized in that, makes by the following method:
Get Moschus 5-20 weight portion, Calculus Bovis 12-50 weight portion, sodium cholate 60-250 weight portion, Venenum Bufonis 12-50 weight portion, Margarita 30-120 weight portion, Borneolum Syntheticum 40-160 weight portion, Radix Notoginseng 1500-15000 weight portion, Radix Ginseng 150-600 weight portion, Cornu Bubali dry extract 50-200 weight portion;
The 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins, and all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively, with the Radix Notoginseng total arasaponins facing-up, sieve again, and mixing, powder is made in cold drying;
Described Radix Notoginseng total arasaponins is to get Radix Notoginseng powder to be broken into coarse powder, uses the 30-90% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.0-6.5 with the 15%-30% hydrochloric acid solution, placement is spent the night, filter, filtrate is extracted with the ether jolting, discards ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol makes at 30-90 ℃ of vacuum drying;
Described Cornu Bubali dry extract is water intaking Cornu Bovis seu Bubali thin slice, adds 6-10 times of water gaging, decocts 1-3 time, and each 5-10 hour, collecting decoction filtered, and filtrate is condensed into thick paste, makes 80 ℃ of lower dryings.
7. the preparation method of Chinese medicine composition as claimed in claim 1 is characterized in that the method is:
Get Moschus 5-20 weight portion, Calculus Bovis 12-50 weight portion, sodium cholate 60-250 weight portion, Venenum Bufonis 12-50 weight portion, Margarita 30-120 weight portion, Borneolum Syntheticum 40-160 weight portion, Radix Notoginseng 1500-15000 weight portion, Radix Ginseng 150-600 weight portion, Cornu Bubali dry extract 50-200 weight portion;
The 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins, all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively, again with the Radix Notoginseng total arasaponins facing-up, sieve, mixing, with the general ball of ethanol, Radix Glycyrrhizae charcoal coating, cold drying makes pill;
Described Radix Notoginseng total arasaponins is to get Radix Notoginseng powder to be broken into coarse powder, uses the 30-90% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.0-6.5 with the 15%-30% hydrochloric acid solution, placement is spent the night, filter, filtrate is extracted with the ether jolting, discards ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol makes at 30-90 ℃ of vacuum drying;
Described Cornu Bubali dry extract is water intaking Cornu Bovis seu Bubali thin slice, adds 6-10 times of water gaging, decocts 1-3 time, and each 5-10 hour, collecting decoction filtered, and filtrate is condensed into thick paste, makes 80 ℃ of lower dryings.
8. the preparation method of Chinese medicine composition as claimed in claim 2 is characterized in that the method is:
Get Moschus 5-20 weight portion, Calculus Bovis 12-50 weight portion, sodium cholate 60-250 weight portion, Venenum Bufonis 12-50 weight portion, Margarita 30-120 weight portion, Borneolum Syntheticum 40-60 weight portion, Radix Notoginseng 1500-15000 weight portion, Radix Ginseng 150-600 weight portion, Cornu Bubali dry extract 50-200 weight portion;
The 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins, and all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively, again with the Radix Notoginseng total arasaponins facing-up, cold drying is sieved, mixing, fill, make capsule;
Described Radix Notoginseng total arasaponins is to get Radix Notoginseng powder to be broken into coarse powder, uses the 30-90% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.0-6.5 with the 15%-30% hydrochloric acid solution, placement is spent the night, filter, filtrate is extracted with the ether jolting, discards ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol makes at 30-90 ℃ of vacuum drying;
Described Cornu Bubali dry extract is water intaking Cornu Bovis seu Bubali thin slice, adds 6-10 times of water gaging, decocts 1-3 time, and each 5-10 hour, collecting decoction filtered, and filtrate is condensed into thick paste, makes 80 ℃ of lower dryings.
9. the preparation method of Chinese medicine composition as claimed in claim 3 is characterized in that the method is:
Get Moschus 5-20 weight portion, Calculus Bovis 12-50 weight portion, sodium cholate 60-250 weight portion, Venenum Bufonis 12-50 weight portion, Margarita 30-120 weight portion, Borneolum Syntheticum 40-160 weight portion, Radix Notoginseng 1500-15000 weight portion, Radix Ginseng 150-600 weight portion, Cornu Bubali dry extract 50-200 weight portion;
The 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins, and all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively, again with the Radix Notoginseng total arasaponins facing-up, cold drying is sieved, mixing, granulate, be pressed into tablet;
Described Radix Notoginseng total arasaponins is to get Radix Notoginseng powder to be broken into coarse powder, uses the 30-90% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.0-6.5 with the 15%-30% hydrochloric acid solution, placement is spent the night, filter, filtrate is extracted with the ether jolting, discards ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol makes at 30-90 ℃ of vacuum drying;
Described Cornu Bubali dry extract is water intaking Cornu Bovis seu Bubali thin slice, adds 6-10 times of water gaging, decocts 1-3 time, and each 5-10 hour, collecting decoction filtered, and filtrate is condensed into thick paste, makes 80 ℃ of lower dryings.
10. the preparation method of Chinese medicine composition as claimed in claim 4 is characterized in that the method is:
Get Moschus 5-20 weight portion, Calculus Bovis 12-50 weight portion, sodium cholate 60-250 weight portion, Venenum Bufonis 12-50 weight portion, Margarita 30-120 weight portion, Borneolum Syntheticum 40-160 weight portion, Radix Notoginseng 1500-15000 weight portion, Radix Ginseng 150-600 weight portion, Cornu Bubali dry extract 50-200 weight portion;
The 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins, and all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively, again with the Radix Notoginseng total arasaponins facing-up, cold drying, sieve mixing, granulation agent;
Described Radix Notoginseng total arasaponins is to get Radix Notoginseng powder to be broken into coarse powder, uses the 30-90% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.0-6.5 with the 15%-30% hydrochloric acid solution, placement is spent the night, filter, filtrate is extracted with the ether jolting, discards ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol makes at 30-90 ℃ of vacuum drying;
Described Cornu Bubali dry extract is water intaking Cornu Bovis seu Bubali thin slice, adds 6-10 times of water gaging, decocts 1-3 time, and each 5-10 hour, collecting decoction filtered, and filtrate is condensed into thick paste, makes 80 ℃ of lower dryings.
11. the preparation method of Chinese medicine composition as claimed in claim 5 is characterized in that the method is:
Get Moschus 5-20 weight portion, Calculus Bovis 12-50 weight portion, sodium cholate 60-250 weight portion, Venenum Bufonis 12-50 weight portion, Margarita 30-120 weight portion, Borneolum Syntheticum 40-160 weight portion, Radix Notoginseng 1500-15000 weight portion, Radix Ginseng 150-600 weight portion, Cornu Bubali dry extract 50-200 weight portion;
The 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins, all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively, again with the Radix Notoginseng total arasaponins facing-up, sieve, mixing, add an amount of PEG-4000 and a small amount of glycerol, mixing is pressed into soft capsule;
Described Radix Notoginseng total arasaponins is to get Radix Notoginseng powder to be broken into coarse powder, uses the 30-90% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.0-6.5 with the 15%-30% hydrochloric acid solution, placement is spent the night, filter, filtrate is extracted with the ether jolting, discards ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol makes at 30-90 ℃ of vacuum drying;
Described Cornu Bubali dry extract is water intaking Cornu Bovis seu Bubali thin slice, adds 6-10 times of water gaging, decocts 1-3 time, and each 5-10 hour, collecting decoction filtered, and filtrate is condensed into thick paste, makes 80 ℃ of lower dryings.
12. the preparation method of Chinese medicine composition as claimed in claim 6 is characterized in that the method is:
Get Moschus 5-20 weight portion, Calculus Bovis 12-50 weight portion, sodium cholate 60-250 weight portion, Venenum Bufonis 12-50 weight portion, Margarita 30-120 weight portion, Borneolum Syntheticum 40-160 weight portion, Radix Notoginseng 1500-15000 weight portion, Radix Ginseng 150-600 weight portion, Cornu Bubali dry extract 50-200 weight portion;
The 20-90% that gets the pseudo-ginseng amount extracts Radix Notoginseng total arasaponins, and all the other Radix Notoginseng and Moschus, Calculus Bovis, sodium cholate, Venenum Bufonis, Margarita, Borneolum Syntheticum, Radix Ginseng, Cornu Bubali dry extract are pulverized respectively, with the Radix Notoginseng total arasaponins facing-up, sieve again, and mixing, powder is made in cold drying;
Described Radix Notoginseng total arasaponins is to get Radix Notoginseng powder to be broken into coarse powder, uses the 30-90% alcohol reflux, filter, filtrate decompression is concentrated into without the ethanol flavor, transfers PH to 6.0-6.5 with the 15%-30% hydrochloric acid solution, placement is spent the night, filter, filtrate is extracted with the ether jolting, discards ether solution, use water saturated n-butanol extraction, merge n-butyl alcohol liquid, the reclaim under reduced pressure n-butyl alcohol makes at 30-90 ℃ of vacuum drying;
Described Cornu Bubali dry extract is water intaking Cornu Bovis seu Bubali thin slice, adds 6-10 times of water gaging, decocts 1-3 time, and each 5-10 hour, collecting decoction filtered, and filtrate is condensed into thick paste, makes 80 ℃ of lower dryings.
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| CN104248695B (en) * | 2013-06-25 | 2018-01-26 | 上海医药集团青岛国风药业股份有限公司 | One kind treats anginal Chinese medicine composition and preparation method thereof, quality determining method |
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| CN1066191A (en) * | 1992-05-20 | 1992-11-18 | 沈阳中药厂 | The reparation technology of medicine for heart-diseases |
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| CN1066191A (en) * | 1992-05-20 | 1992-11-18 | 沈阳中药厂 | The reparation technology of medicine for heart-diseases |
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| Title |
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| 卫生部.通窍益心丸.《WS3-B-3981-98，卫生部颁药品标准（中药成方制剂第二十册）》.1998,z20-303. * |
| 闫彦芳等.猪、熊胆粉主要成分对ECV304 细胞缺氧损伤保护作用的比较.《北京中医药大学学报》.2003,第26卷(第1期),33-35. * |
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Inventor after: Li Zhiyong Inventor after: Zhang Xiqiang Inventor after: Lai Huaien Inventor after: Su Heming Inventor after: Zheng Shaoxin Inventor after: Yang Baoru Inventor after: Wei Jian Inventor before: Li Zhiyong Inventor before: Zhang Xiqiang Inventor before: Lai Huaien Inventor before: Su Heming Inventor before: Zheng Shaoxin |
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