CN107007689A - A kind of Chinese medicine preparation of temperature compensation heart kidney and its production and use - Google Patents
A kind of Chinese medicine preparation of temperature compensation heart kidney and its production and use Download PDFInfo
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Abstract
The present invention provides a kind of Chinese medicine preparation of temperature compensation heart kidney, includes the preparing raw material of following mass percent：2.1% 4.3% datura flowers, 0.8% 2.5% ginsengs, 1% 4% pilose antlers, 16% 28% Chinese cassia trees, 52% 60% monkshoods, 6% 10.2% pseudo-ginseng, 0.08% 0.15% borneols, 0.1% 0.25% Moschus, 0.1% 0.18% dried venoms of toads.The invention belongs to technical field of traditional Chinese medicine preparation, the Chinese medicine preparation that the present invention is provided significantly reduces ginseng consumption, reduces cost, and drug effect is significantly increased.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, more particularly to a kind of Chinese medicine preparation of temperature compensation heart kidney and preparation method thereof
And purposes.
Background technology
Arrhythmia cordis：Refer to any one or the multinomial exceptions such as rhythm of the heart origin position, cardiac frequency and the rhythm and pace of moving things and impulse conduction
Disease.Arrhythmia cordis belongs to the categories such as the traditional Chinese medical science " palpitaition ", " palpitation ", " palpitation with fear ", " obstruction of qi in the chest ", " pained ", more due to internal organs gas
The reciprocations such as blood negative and positive are deficient, the resistance of internal damage by the excessive seven emotions, qi depression to blood stasis, wet hot phlegm cause the heart to become homeless, and foster, the mistake of heart arteries and veins is smooth and causes.Mental and physical efforts
Exhaustion：For the serious of various heart diseases and whole last stage, incidence of disease height, survival rate is suitable with tumour within 5 years, is current most important
One of cardiovascular disease, but its treatment still faces problems.When guide is defined to heart failure, cardiac structure is highlighted
With the importance of dysfunction, it is indicated that heart failure is a kind of clinical syndrome, patient has typical H F symptoms and typical
The features such as H F signs.Myocardial ischemia：" obstruction of qi in the chest ", " chest impediment and cardialgia ", " angina pectoris " equivalent to the traditional Chinese medical science etc., due to myocardial ischemia,
The pareordia that myocardial muscle load is overweight and produces is uncomfortable, and angina pectoris and arrhythmia cordis are the most common indications of cardiomyopathy.Sick sinus is comprehensive
Simulator sickness：It is that sinoatrial node and surrounding tissue lesion or dysfunction cause pace-making and conduction function not normal, so as to cause the devices such as heart and brain
Official's blood supply insufficiency and cause palpitaition, shortness of breath, uncomfortable in chest, a series of clinical symptoms such as faint syndromes.It is comprehensive according to diseased sinus node
The performance of simulator sickness, can belong to the categories such as the traditional Chinese medical science " palpitaition ", " obstruction of qi in the chest ", " dizziness ", " fainting de- ", " retarded pulse disease ", " consumptive disease ".The chronic heart
Insufficiency：It is various heart diseases and the most common syndrome caused by aged patients with heart diseases retrogression.
" heart treasure pill " is achievement of the Guangdong Prov. Inst. of Materia Medica according to the traditional Chinese medical science " heart kidney is related " theoretical research and development, has been listed many
Year, recorded in《Drug Standard of Ministry of Public Health of the Peoples Republic of China》Traditional Chinese medicine historical preparation the 18th." heart treasure pill " is by foreign gold
The Chinese medicines such as flower, monkshood, Chinese cassia tree and the dried venom of toads are made, tool temperature compensation heart kidney, benefiting qi and supporting yang, effect of blood circulation and channel invigorating, for treating heart kidney
Chronic cardiac insufficiency caused by the deficiency of yang, heart arteries and veins stasis blocking, bradycardia caused by sinus node dysfunction, sick sinus syndrome and
Angina pectoris caused by ischemic heart disease and electrocardiogram ischemic change.Although having when datura flower, monkshood and dried venom of toads exclusive use
Have certain toxicity, but through there is good security with obtained heart treasure pill after the prescription such as pseudo-ginseng, Chinese cassia tree, to arrhythmia cordis,
The angiocardiopathy such as myocardial ischemia and sick sinus syndrome has good curative effect, particularly to heart function of patients with chronic heart failure
And prognosis has preferable curative effect, the accreditation of many patients is obtained.
Chinese patent application CN 1033567 discloses a kind of manufacture method of " heart is precious " pill, by datura flower, monkshood, meat
More than 93% medicinal material is by leaching solvent effective component extracting in the Chinese medicinal materials such as osmanthus, about 6% medicinal material be directly ground to fine powder,
Less than 1% medicinal material is prefabricated into decoction, and condensed pill, but the consumption and technique of undisclosed each preparing raw material is then made, also not right
The dregs of a decoction after solvent is extracted are studied and utilized.
Chinese patent application CN 1891266 discloses a kind of precious preparation (oral disnitegration tablet) of the heart, active ingredient therein by
Datura flower, monkshood extract, ginseng, pseudo-ginseng, deer antler extract crush obtained fine powder, and cinnamon oil, Moschus extract, toad
The Hp- beta-CD inclusions composition of crisp extract, borneol；The handling process of bulk drug includes：Datura flower and monkshood are through 80-90% second
Alcohol extracting, ginseng, pseudo-ginseng and pilose antler are extracted through 40-60% ethanol, and Chinese cassia tree is through extraction by steam distillation, and Moschus is through 60-75%
Ethanol is extracted, and the dried venom of toads is through 75% alcohol extracting, and handling process is more complicated, and the dregs of a decoction after extraction are not studied and utilized.This
Outside, the large usage quantity of the expensive medicinal material such as dried venom of toads and ginseng in bulk drug, causes cost higher.
Chinese patent application CN 102114127 discloses a kind of Multifunctional good medicine for heart, by the original of following weight percents
Material medicine is prepared from：Chinese ephedra 0-20%, datura flower 2.0%-8.0%, dried venom of toads 0.1%-0.3%, Chinese cassia tree 4.0%-22%, borneol
0-0.3%, pilose antler 0-4%, monkshood 45.0%-60%, ginseng 4.0%-22%, Moschus 0-0.3%, pseudo-ginseng 0-10% and asarum
0-15%；The handling process of bulk drug includes：The part (40-70% of total pseudo-ginseng amount) of pseudo-ginseng and ginseng 50%-95% second
Alcohol extracting, Chinese cassia tree with water after vapor removing volatile oil with live part is extracted, and Moschus, borneol and the dried venom of toads are through 50%-95% second
Alcohol extracting, pilose antler and remaining pseudo-ginseng, which are crushed, is used as medicine, with preferable security, to heart failure, chronic cardiac insufficiency and sick sinus
The heart diseases such as syndrome have good curative effect, but the dregs of a decoction after extraction are not utilized rationally, also undisclosed heart disease
Disease treatment purposes or efficacy data beyond disease.
Chinese patent application CN 105641203, which is disclosed, a kind of treats chronic cardiac insufficiency caused by heart arteries and veins stasis blocking
Chinese medicine composition, each component and its mass parts are than as follows：0.3~0.6g of datura flower, 2.5~16g of ginseng, radix pseudostellariae 10
~16g, 2.5~7.5g of Chinese cassia tree, 7.5~15g of Radix Angelicae Sinensis, 5~12g of monkshood, 1~3g of pilose antler, 0.15~0.35g of borneol, artificial musk deer
0.18~0.3g of perfume, 3~10g of pseudo-ginseng, 0.015~0.03g of the dried venom of toads；On the basis of the precious taste medicinal material of preparation 9 of the heart, crown prince is added
Ginseng and Radix Angelicae Sinensis, undisclosed specific preparation technology, cost are higher.
The content of the invention
For solve problems of the prior art (handling process is more complicated, be not implemented the dregs of a decoction reasonable utilization, cost compared with
It is high), inventor is screened and compounded to the prescription of the precious preparation of the heart by lot of experiments, is found surprisingly that：By inciting somebody to action whole three
Seven and ginseng crush after alcohol extracting, medicinal extract is together used as medicine with the dregs of a decoction, the consumption of increase Chinese cassia tree, and technique is simpler, is significantly reducing people
While joining consumption, the drug effect of Chinese medicine preparation is enhanced.Based on above-mentioned discovery, so as to complete the present invention.
The purpose of the present invention will be further described in detail below reflect and description.
A kind of Chinese medicine preparation of temperature compensation heart kidney, includes the preparing raw material of following mass percent：2.1%-4.3% oceans gold
Flower, 0.8%-2.5% ginsengs, 1%-4% pilose antlers, 16%-28% Chinese cassia trees, 52%-60% monkshoods, 6%-10.2% pseudo-ginseng,
0.08%-0.15% borneols, 0.1%-0.25% Moschus, the 0.1%-0.18% dried venoms of toads.
Datura flower contains hyoscine and hyoscyamine, and role includes：A) a1 acceptors and m acceptors are blocked；B) increase thin
After birth mobility；C) improving microcirculation opens valnllae vasorum, and vascular wall diastole, VPV is accelerated, and blood flow is by block rheology
Granular flow, reduces the viscosity of blood；D) antagonism catecholamine is acted on, so that the blood that endogenous catecholamine increase causes
Pipe spasm releases vasodilation and reduces cardiac load；E) heart rate is increased；F) blood viscosity is reduced；G) myocardial contractive power is strengthened
And suppress the effect of dystopy excitement.Moschus, borneol and Chinese cassia tree have synergy, can improve microcirculation, expand blood vessel, increase
Coronary flow, protection cardiac muscle.Monkshood and ginseng, which have, strengthens myocardial contractive power, the effect of excited sinoatrial node, going contained by monkshood
First coclaurine can improve heart rate, increase coronary blood flow, improve Atrioventricular Conduction, hence it is evident that shorten SACT and sinoatrial node recovers
Time, improve sinoatrial node frequency and improve sinoatrial node conduction function；Ginsenoside contained by ginseng and pseudo-ginseng has cardiotonic,
Can coronary artery dilator, improvement myocardial ischemia, the impaired sinoatrial node of excitement.Pilose antler, which has, accelerates sino-atrial sconduction system conduction speed
Degree, increases the effect of myocardial contractive power.The toxicity of dried venom of toads energy antagonism datura flower, enables the excessive cardioacceleration of datura flower
Relax and retain its cardiotonic, while being also a kind of strong cardiac stimulant material, make the big heart rate of ventricle amplitude change slack-off, with people
Ginseng, monkshood have synergy, the dried venom of toads can be avoided to cause intoxicating phenomenon with the collective effect of datura flower.
Using above-mentioned technical proposal, on the basis of the precious preparation of the existing heart, the consumption of Chinese cassia tree is mainly added, people is reduced
The dregs of a decoction are rationally utilized by the consumption of ginseng, while cost is significantly reduced, and enhance the drug effect of Chinese medicine preparation.Wherein, it is attached
Son, pilose antler are monarch drug in a prescription, and inverse effect is rescued with the sun of temperature compensation heart kidney, eliminating cold to stop pain, cardiac stimulant；Ginseng reinforces vital energy, Yiqi and vein recovery,
Chinese cassia tree warming and tonifying primordial YANG is ministerial drug altogether；Datura flower cardiac stimulant, analgesic, pseudo-ginseng blood-circulation-invigovating stagnation resolvation are promoted blood circulation, and the pungent perfume (or spice) of Moschus is had one's ideas straightened out, warming meridians and promoting circulation of qi,
Dried venom of toads analgesic is had one's ideas straightened out, and is altogether adjutant；The pungent perfume (or spice) of borneol enters the heart channel of Hang-Shaoyin, helps the efficacy of a drug to guide drugs to illness station, to make medicine.All medicines share, plays temperature compensation altogether
Heart kidney, qi and activate blood circulation, the work(of Qiangxin Fumai.
According to theory of traditional Chinese medical science, in the vital movement of human body, yang-energy plays leading role, and kidney yang is human life activity
Motive power, kidney yang is sufficient, rising kidney yin；Kidney yin rises, and subsidizes the heart-yin；The heart-yin is sufficient, restricts heart-yang, declines heart-yang, to help
Kidney yang.If the insufficiency of the kidney yang, or because powerless rising kidney yin rises, the asthenic yin of heart kidney, it is impossible to restrict internal heat and cause flaring up of heart fire, or
Because of heart-kidney yang deficiency, it is short of power and function is weak.It is all the pathological change of the breakdown of the normal physiological coordination between the heart and the kidney of heart kidney imbalance between YIN and YANG.From
In qi-blood relationship, the deficiency of vital energy is then powerless to agitate, i.e., so-called gas row then blood, the stagnation of the circulation of vital energy then blood stasis；Blood obtains Wen Zehang, meets to tremble with fear and then coagulates,
Insufficiency of YANG bringing about cold syndrome, heart-kidney yang deficiency causes blood clotting not all right.Above mechanism changes, and while causing qi and blood not smooth, will necessarily also influence
Gains in depth of comprehension function, and influencing each other therebetween, then yang-energy is obstructed for blood clotting, the deficiency of yang then qi and blood stagnation.Therefore, the present invention is provided
Chinese medicine preparation composition QI invigorating, Wen Yang, qi-regulating, have one's ideas straightened out and be used in combination.
Preferably, the Chinese medicine preparation of described temperature compensation heart kidney, includes the preparing raw material of following mass percent：2.8%-
4.0% datura flower, 1%-2.5% ginsengs, 2%-3% pilose antlers, 22%-28% Chinese cassia trees, 55%-60% monkshoods, 8%-10% tri-
7th, 0.1%-0.14% borneols, 0.12%-0.2% Moschus, the 0.12%-0.18% dried venoms of toads.
Preferably, the Chinese medicine preparation of described temperature compensation heart kidney, includes the preparing raw material of following mass percent：3.4% ocean
Golden flower, 2.2% ginseng, 2.2% pilose antler, 25% Chinese cassia tree, 58% monkshood, 8.8% pseudo-ginseng, 0.11% borneol, 0.14% Moschus,
0.15% dried venom of toads.
Preferably, the Chinese medicine preparation of described temperature compensation heart kidney, includes the preparing raw material of following mass percent：3.8% ocean
Golden flower, 1.8% ginseng, 2% pilose antler, 26% Chinese cassia tree, 57% monkshood, 9% pseudo-ginseng, 0.10% borneol, 0.14% Moschus, 0.16%
The dried venom of toads.
Preferably, the Moschus is muscone.
Preferably, the preparation method of the Chinese medicine preparation of described temperature compensation heart kidney comprises the following steps：
1) pseudo-ginseng and ginseng are weighed, is crushed, 65%-90% ethanol is added and extracts secondary, each 1-3h, filtration collects the
One extract solution, dregs of a decoction drying for standby；Datura flower is weighed, 65%-90% ethanol is added and extracts secondary, each 1-3h, filter, collect
Second extract solution, merges first extract solution and second extract solution, is condensed into medicinal extract, and drying obtains dried cream powder；
2) monkshood is weighed, is crushed, water is added and carries out water extract-alcohol precipitation, drying obtains monkshood extract；Chinese cassia tree is weighed, is steamed with water
Steam distillation method is extracted and collects volatile oil, obtains cinnamomum cassia extract；
3) pilose antler, borneol, Moschus and the dried venom of toads are weighed, the dregs of a decoction are added, fine powder is ground into, the dried cream powder, institute is added
Monkshood extract and the cinnamomum cassia extract are stated, is mixed, pharmaceutically acceptable auxiliary material is added, the Chinese medicine system of temperature compensation heart kidney is made
Agent.
The quality of pseudo-ginseng and ginseng is hard, and especially pseudo-ginseng has the title of " copper sheet gagger ", though it is used as medicine using pseudo-ginseng milling
The content of pseudo-ginseng activity composition can be increased to a certain extent, but be difficult to fully absorbing for intestines and stomach, cause availability not
It is high；In addition, inventor has found that after pseudo-ginseng and ginseng crushing after 1-3h alcohol extracting, the pseudo-ginseng dregs of a decoction and the ginseng dregs of a decoction are also containing more
Active component (Panax Notoginseng saponin R1, notoginseng polysaccharide, radix notoginseng flavones, ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1, people
Gracilis polysaccharide etc.).By the way that whole pseudo-ginseng and ginseng are crushed after alcohol extracting, medicinal extract is together used as medicine with the dregs of a decoction, increases the consumption of Chinese cassia tree, can
Acted synergistically with the other compositions such as monkshood extract, so as to while cost is reduced, improve ginseng and pseudo-ginseng activity
The utilization ratio of composition, enhances the drug effect of Chinese medicine preparation.The price of ginseng is about 400-600 members/kg, and the price of Chinese cassia tree is big
About 18-35 members/kg, the Chinese medicine preparation that provides of the present invention and prior art the precious preparation of the heart (large usage quantity of ginseng, ginseng and
The pseudo-ginseng dregs of a decoction, which are not backfilled, to be used as medicine, and Chinese cassia tree consumption is not very high) compare, cost reduction by 10%~20%, for heart failure, chronic heart work(
It can not significantly mitigate economic pressures entirely and for the longer heart disease patients for the treatment of cycle such as sick sinus syndrome.
In addition, by carrying out water extraction to monkshood, diester-type Aconitum is reduced while effective component extracting biological
The extraction of the toxic components such as alkali composition, improves security performance.Water extract-alcohol precipitation, the steam distillation being related in the present invention be
The common process of this area.
Preferably, the step 1) in, it is extracted as ultrasonic extraction, Soakage extraction, seepage pressure effects or Microwave Extraction；Medicinal extract
Relative density is 1.08-1.38.
Preferably, the step 1) in, pseudo-ginseng and ginseng are weighed, is crushed, 75% ethanol is added and extracts secondary, for the first time
2.5h, second of 2.5h, filtration merge filtrate twice, collect the first extract solution, and the loss of active component is few, are conducive to improving
The availability of active component.
Preferably, the step 3) in, crush as ultramicro grinding or freeze low-temperature grinding, active component distribution area is big,
Loss is few, is conducive to improving the availability of active component.
Preferably, the preparation is pill, capsule or tablet；The pharmaceutically acceptable auxiliary material include talcum powder,
One or more in medical charcoal, starch, carboxyrnethyl starch sodium, microcrystalline cellulose and magnesium stearate.
Correspondingly, the present invention also provides the preparation method of the Chinese medicine preparation of temperature compensation heart kidney, comprises the following steps：
S1 weighs pseudo-ginseng and ginseng, crushes, and adds 65%-90% ethanol and extracts secondary, each 1-3h, filtration, collects the
One extract solution, the dregs of a decoction are standby；Datura flower is weighed, 65%-90% ethanol is added and extracts secondary, each 1-3h, filtration collects second
Extract solution, merges first extract solution and second extract solution, is condensed into medicinal extract, and drying obtains dried cream powder；
S2 weighs monkshood, crushes, and adds water and carries out water extract-alcohol precipitation, drying obtains monkshood extract；Chinese cassia tree is weighed, is steamed with water
Steam distillation method is extracted and collects volatile oil, obtains cinnamomum cassia extract；
S3 weighs pilose antler, borneol, Moschus and the dried venom of toads, adds the dregs of a decoction, is ground into fine powder, adds the dried cream powder, institute
Monkshood extract and the cinnamomum cassia extract are stated, is mixed, pharmaceutically acceptable auxiliary material is added, the Chinese medicine system of temperature compensation heart kidney is made
Agent.
Preferably, in the step S1, ultrasonic extraction, Soakage extraction, seepage pressure effects or Microwave Extraction are extracted as；Medicinal extract
Relative density is 1.08-1.38.
Preferably, in the step S1, pseudo-ginseng and ginseng are weighed, is crushed, 75% ethanol is added and extracts secondary, for the first time
2.5h, second of 2.5h, filtration merge filtrate twice, collect the first extract solution, and the dregs of a decoction are standby.
Preferably, the preparation is pill, capsule or tablet；The pharmaceutically acceptable auxiliary material include talcum powder,
One or more in medical charcoal, starch, carboxyrnethyl starch sodium, microcrystalline cellulose and magnesium stearate.
In addition, the Chinese medicine preparation that the present invention also provides temperature compensation heart kidney is preparing preventing and treating sick sinus syndrome, chronic heart function not
Entirely, the purposes in angina pectoris, myocardial ischemia and arrhythmia cordis medicine.
Compared with prior art, beneficial effects of the present invention include：(1) present invention is by the way that whole pseudo-ginseng and ginseng are crushed
After alcohol extracting, medicinal extract is together used as medicine with the dregs of a decoction, increases the consumption of Chinese cassia tree, can cooperate with work with the other compositions such as monkshood extract
With enhancing the drug effect of Chinese medicine preparation；(2) by carrying out water extraction to monkshood, reduced while effective component extracting double
The extraction of the toxic components such as ester type aconite alkaloids composition, improves security performance；(3) obtained twice by 1-3h alcohol extractings
The pseudo-ginseng dregs of a decoction and the ginseng dregs of a decoction backfill be used as medicine, realize the reasonable utilization of the dregs of a decoction, reduce pollution, significantly reduce ginseng
Consumption, reduces cost, economic benefit and obvious environment benefit；(4) preparation method that the present invention is provided is simpler, manufacturing cycle
It is shorter, improve production efficiency.
Embodiment
Below by specific embodiment, the present invention is described in further detail.
In the present invention, involved component and raw material is conventional commercial product, or can pass through the ordinary skill in the art
Means are obtained.
The Chinese medicine preparation of the temperature compensation heart kidney of embodiment one
The Chinese medicine preparation of temperature compensation heart kidney, includes the preparing raw material of following mass percent：3.4% datura flower, 2.2% people
Ginseng, 2.2% pilose antler, 25% Chinese cassia tree, 58% monkshood, 8.8% pseudo-ginseng, 0.11% borneol, 0.14% Moschus, 0.15% dried venom of toads.
The preparation method of the Chinese medicine preparation of temperature compensation heart kidney comprises the following steps：
S1 weighs pseudo-ginseng and ginseng, crushes, and adds 75% alcohol dipping and extracts secondary, first time 2.5h, second of 2.5h,
Filtration, merges filtrate twice, collects the first extract solution, and the dregs of a decoction are standby；Datura flower is weighed, 75% alcohol dipping is added and extracts two
Secondary, first time 2.5h, second of 2.5h, filtration merges filtrate twice, collects the second extract solution, merges first extract solution
With second extract solution, the medicinal extract that relative density is 1.25 is condensed into, drying obtains dried cream powder；
S2 weighs monkshood, crushes, and adds water and carries out water extract-alcohol precipitation, drying obtains monkshood extract；Chinese cassia tree is weighed, is steamed with water
Steam distillation method is extracted and collects volatile oil, obtains cinnamomum cassia extract；
S3 weighs pilose antler, borneol, Moschus and the dried venom of toads, adds the dregs of a decoction, is ground into fine powder, adds the dried cream powder, institute
Monkshood extract and the cinnamomum cassia extract are stated, is mixed, pharmaceutically acceptable auxiliary material is added and condensed pill is made, then use appropriate medicine
It is coated with charcoal and talcum powder, the Chinese medicine preparation of temperature compensation heart kidney is made.
The Chinese medicine preparation of the temperature compensation heart kidney of embodiment two
The Chinese medicine preparation of temperature compensation heart kidney, includes the preparing raw material of following mass percent：3.8% datura flower, 1.8% people
Ginseng, 2% pilose antler, 26% Chinese cassia tree, 57% monkshood, 9% pseudo-ginseng, 0.10% borneol, 0.14% Moschus, 0.16% dried venom of toads.
The preparation method of embodiment two is similar with embodiment one.
The Chinese medicine preparation of the temperature compensation heart kidney of embodiment three
The Chinese medicine preparation of temperature compensation heart kidney, includes the preparing raw material of following mass percent：3% datura flower, 2% ginseng,
2.2% pilose antler, 25.4% Chinese cassia tree, 58.2% monkshood, 8.8% pseudo-ginseng, 0.12% borneol, 0.14% Moschus, 0.14% dried venom of toads.
The preparation method of embodiment three is similar with embodiment one.
Comparative example 1
Chinese medicine preparation includes the preparing raw material of following mass percent：3.4% datura flower, 7.2% ginseng, 2.2% pilose antler,
15% Chinese cassia tree, 58% monkshood, 13.8% pseudo-ginseng, 0.11% borneol, 0.14% Moschus, 0.15% dried venom of toads.
The preparation method of Chinese medicine preparation comprises the following steps：
S1 weighs part pseudo-ginseng (account for pseudo-ginseng consumption 50%) and ginseng, crushes, and adds 75% ethanol and extracts secondary, and first
Secondary 2.5h, second of 2.5h, filtration merge filtrate twice, collect the first extract solution；Datura flower is weighed, 75% ethanol is added and carries
Secondary, first time 2.5h is taken, second of 2.5h, filtration merges filtrate twice, collects the second extract solution, merges described first and carries
Liquid and second extract solution are taken, the medicinal extract that relative density is 1.25 is condensed into, drying obtains dried cream powder；
S2 weighs monkshood, crushes, and adds water and carries out water extract-alcohol precipitation, drying obtains monkshood extract；Chinese cassia tree is weighed, is steamed with water
Steam distillation method is extracted and collects volatile oil, obtains cinnamomum cassia extract；
S3 weighs pilose antler, borneol, Moschus, the dried venom of toads and remaining pseudo-ginseng, is ground into fine powder, adds the dried cream powder, described
Monkshood extract and the cinnamomum cassia extract, are mixed, and are added pharmaceutically acceptable auxiliary material and are made condensed pill, then with appropriate medicinal
Charcoal and talcum powder are coated, and Chinese medicine preparation is made.
The difference of comparative example 1 and embodiment one is：Ginseng and the increase of the consumption of pseudo-ginseng, the consumption of Chinese cassia tree are reduced, part
Pseudo-ginseng milling is used as medicine, and the dregs of a decoction after pseudo-ginseng and ginseng alcohol extracting, which are not backfilled, to be used as medicine.
Comparative example 2
Chinese medicine preparation includes the preparing raw material of following mass percent：3.4% datura flower, 2.2% ginseng, 2.2% pilose antler,
25% Chinese cassia tree, 58% monkshood, 8.8% pseudo-ginseng, 0.11% borneol, 0.14% Moschus, 0.15% dried venom of toads.
The preparation method of Chinese medicine preparation comprises the following steps：
S1 weighs pseudo-ginseng and ginseng, crushes, and adds 75% ethanol and extracts secondary, first time 2.5h, second of 2.5h, filter
Cross, merge filtrate twice, collect the first extract solution；Datura flower is weighed, 75% ethanol is added and extracts secondary, first time 2.5h, the
Secondary 2.5h, filtration merges filtrate twice, collects the second extract solution, merges first extract solution and second extract solution,
The medicinal extract that relative density is 1.25 is condensed into, drying obtains dried cream powder；
S2 weighs monkshood, crushes, and adds water and carries out water extract-alcohol precipitation, drying obtains monkshood extract；Chinese cassia tree is weighed, is steamed with water
Steam distillation method is extracted and collects volatile oil, obtains cinnamomum cassia extract；
S3 weighs pilose antler, borneol, Moschus and the dried venom of toads, is ground into fine powder, add the dried cream powder, the monkshood extract and
The cinnamomum cassia extract, is mixed, and adds pharmaceutically acceptable auxiliary material and condensed pill is made, then entered with appropriate medical charcoal and talcum powder
Row is coated, and Chinese medicine preparation is made.
The difference of comparative example 2 and embodiment one is：The dregs of a decoction after pseudo-ginseng and ginseng alcohol extracting, which are not backfilled, to be used as medicine.
Comparative example 3
Chinese medicine preparation includes the preparing raw material of following mass percent：3.4% datura flower, 2.2% ginseng, 2.2% pilose antler,
25% Chinese cassia tree, 58% monkshood, 8.8% pseudo-ginseng, 0.11% borneol, 0.14% Moschus, 0.15% dried venom of toads.
The preparation method of Chinese medicine preparation comprises the following steps：
S1 weighs pseudo-ginseng and ginseng, crushes, and adds 75% ethanol and extracts secondary, first time 2.5h, second of 2.5h, filter
Cross, merge filtrate twice, collect the first extract solution, the dregs of a decoction are standby；Datura flower is weighed, 75% ethanol is added and extracts secondary, first
Secondary 2.5h, second of 2.5h, filtration merge filtrate twice, collect the second extract solution, merge first extract solution and described the
Two extract solutions, are condensed into the medicinal extract that relative density is 1.25, and drying obtains dried cream powder；
S2 weighs monkshood, crushes, and adds water and carries out water extract-alcohol precipitation, drying obtains monkshood extract；Chinese cassia tree is weighed, is steamed with water
Steam distillation method removes volatile oil, and extracting in water obtains cinnamomum cassia extract；
S3 weighs pilose antler, borneol, Moschus and the dried venom of toads, adds the dregs of a decoction, is ground into fine powder, adds the dried cream powder, institute
Monkshood extract and the cinnamomum cassia extract are stated, is mixed, pharmaceutically acceptable auxiliary material is added and condensed pill is made, then use appropriate medicine
It is coated with charcoal and talcum powder, Chinese medicine preparation is made.
The difference of comparative example 3 and embodiment one is：Cinnamomum cassia extract is water extract, and volatile oil component is removed.Meat
Osmanthus volatile oil includes the compositions such as cinnamic acid, cinnamic acid, o-methoxy cinnamic aldehyde.
The analysis of the dregs of a decoction of test example one
Respectively to the dregs of a decoction after the dregs of a decoction after pseudo-ginseng alcohol extracting, ginseng alcohol extracting, the dregs of a decoction after datura flower alcohol extracting, the Chinese cassia tree way of distillation
The detection and backfill that the dregs of a decoction after the dregs of a decoction, monkshood water extraction after extraction carry out active component are used as medicine investigation.As a result find：Pseudo-ginseng
With in the ginseng dregs of a decoction contain more notoginsenoside, ginsenoside isoreactivity composition, through the test of pesticide effectiveness find with pseudo-ginseng and ginseng
The function of alcohol extracting active component is approached, and can strengthen drug effect after backfill, and will not cause safety issue；And it is the datura flower dregs of a decoction, attached
Contained tropane alkaloidses, aconite alkaloids content are higher in the sub- dregs of a decoction, alkaloid can be caused too high after backfill
Trigger toxicity；Though, can not after backfill containing composition close with Cortex Cinnamomi volatile oil active component function on a small quantity in the Chinese cassia tree dregs of a decoction
Strengthen drug effect.It can be seen that, the backfill of the dregs of a decoction is not intended to certainly or it will be apparent that final screening is determined pseudo-ginseng and ginseng alcohol extracting
Dregs of a decoction backfill afterwards is used as medicine.
The safety testing of test example two
Respectively to embodiment one to embodiment three, the Chinese medicine preparation of comparative example 1 to comparative example 3 carries out acute toxicity and long-term
Toxicity test.By 18g/kg dosage (equivalent to 1000 times or so of people's conventional amount used) gavage mouse, observe 7 days, it is as a result small
Mouse normally survives, and anatomical results and Main Biochemical are normal, illustrates the Chinese medicine preparation of the invention provided without acute toxicity；
By 1.8g/kg dosage (equivalent to 100 times or so of people's conventional amount used) continuous gavage mouse 6 months, observe and detect respectively
1 month after gavage, the mouse situation of 3 months and 6 months, as a result mouse normally survives, and anatomical results and main biochemical refer to
Mark is normal, illustrates that the Chinese medicine preparation of the invention provided, without long term toxicity, adapts to long-term taking.
The heart disease of test example three correlation clinical tests
Respectively by the embodiment of the present invention one to embodiment three, and the Chinese medicine preparation of comparative example 1 to comparative example 3 carries out normal pressure
Resist oxygen lack is tested, while using commercially available heart treasure pill and commercially available inderal as control group, as a result as shown in table 1.As known from Table 1, this hair
Bright embodiment one is to embodiment three, and the Chinese medicine preparation of comparative example 1 to comparative example 3 is when can significantly extend the survival of mouse
Between, improve the ability of small white mouse resist oxygen lack；The time-to-live that one group of embodiment is slightly longer than other groups, but difference is without statistics
Learn meaning；The time-to-live that 2 groups of comparative example is relatively short, illustrates after ginseng and the consumption of pseudo-ginseng, and pseudo-ginseng and ginseng alcohol extracting
The dregs of a decoction backfill certain influence is all generated to resist oxygen lack effect.
Influence of the Chinese medicine preparation of table 1 to mouse oxygen deficit tolerance
Note：Compared with distilled water group, P<0.01 indicates pole significant difference.
Chinese medicine preparation to investigate the embodiment of the present invention one, comparative example 1, comparative example 3 is convened to the curative effect of sick sinus syndrome
200 meet into group condition patient volunteer (male 108 people, the people of female 92, the range of age be 26~65 years old, wherein 36 patients
Also there is the indication of chronic cardiac insufficiency), it is randomly divided into 4 groups of carry out clinical tests, i.e. one group of embodiment, 1 group of comparative example, right
Between 3 groups of ratio and positive controls (commercially available heart treasure pill), every group of 50 people, each group at sex, age, symptom, be in a bad way journey
Do not have significant difference in terms of degree.Given 180-300mg/ times respectively depending on coincident with severity degree of condition, 3 times a day, be with 30 days
One course for the treatment of, patient is not taken during clinical test to the medicable other drugs of sick sinus syndrome.
Efficacy assessment standard is as follows：
Recovery from illness：Symptom disappears, 24 hours electrocardiogram (sinus rule) more than 60 beats/min, electrocardiogram recovers normal, and atropine is tried
The positive is tested to turn negative；SNRT or SACT are normal.
It is effective：Cardinal symptom disappears, 24 hours electrocardiogram average heart rate (sinus rule) raising ＞s 10 beat/min more preceding than treatment, the heart
Electrograph is substantially normal, and the atropine test positive is turned negative or SACT, recovery time are obviously improved.
Effectively：Cardinal symptom partial disappearance, 24 hours electrocardiogram average heart rates before treatment than improving 5 beats/min of ＞, electrocardiogram
It is substantially normal.
It is invalid：Every Index for examination is without improvement.
24h dynamic ecg monitoring results are as shown in table 2.As known from Table 2,24h after medication, one group of embodiment, comparative example 1
Group, 3 groups of comparative example and positive controls it is awake when highest HR, minimum HR when waking up, minimum HR when sleeping, highest HR and the average heart when sleeping
Rate is significantly improved, and the increase rate of wherein 1 group of comparative example is relatively low.
The patient volunteer of table 2 takes the Holter monitoring results after the Chinese medicine preparation 24h that the present invention is provided
Patient volunteer is taken after 1 course for the treatment of, and the curative effect of Chinese medicine preparation is as shown in table 3.As known from Table 2, medication 1 month
Afterwards, the total effective rate of one group of embodiment is up to 94%, is significantly higher than comparative example 1, comparative example 3 and positive controls, patient's aspiration
The symptom such as the chest screen of person, weak is obviously improved, and is taken.In addition, the continuous Chinese medicine preparation for taking one group of embodiment is fullyed recover from an illness after 2 months
More rate is up to 28%.
The patient volunteer of table 3 takes clinical efficacy of the Chinese medicine preparation of the invention provided after 1 month
| Group | Total number of cases | Recovery from illness | It is effective | Effectively | It is invalid | Total effective rate |
| Embodiment one | 50 | 0 | 19 | 28 | 3 | 94% |
| Comparative example 1 | 50 | 0 | 13 | 25 | 12 | 76% |
| Comparative example 3 | 50 | 0 | 17 | 24 | 9 | 82% |
| Positive control | 50 | 0 | 16 | 26 | 8 | 84% |
Use 300 patient volunteers' of Chinese medicine preparation treatment made from embodiment one (some patientss have a variety of indications)
Clinical efficacy result is as shown in table 4.As known from Table 4, Chinese medicine preparation treatment sick sinus syndrome 175 made from embodiment one, always
Effective percentage is 89.7%；Chronic cardiac insufficiency 206 (wherein I grade 16, II grade 139, III grade 51) is treated, it is total effective
Rate is 93.2%；Treat electrocardiogram in ischemic ST-T to change or myocardium fatigue person 213, total effective rate is 77.0%；Treatment
Patient with angina pectoris 98, total effective rate is 92.8%.As a result show：Chinese medicine preparation made from the embodiment of the present invention one is multi-functional
Cardiac drug, with excited sinoatrial node, shorten sinoatrial reentry tachycardia, improve disease Dou Xinlv, reduction electrocardiogram V1 is led
Join P ripple Ptfv1s (Ptfv1) negative value, heart function is improved, improves symptoms of heart failure, adjustment cardiac insufficiency causes heart rate of overrunning,
Resist myocardial ischemia, eliminate angina pectoris, anti-arrhythmia cordis etc. is acted on.
4 300 patient volunteers of table take clinical efficacy of the Chinese medicine preparation of the invention provided after 1 month
| Indication | Total number of cases | It is effective | Effectively | It is invalid | Aggravate | Total effective rate |
| Sick sinus syndrome | 175 | 65 | 92 | 18 | 0 | 89.7% |
| Chronic cardiac insufficiency | 206 | 77 | 115 | 14 | 0 | 93.2% |
| Myocardial ischemia (ECG) | 213 | 63 | 101 | 48 | 1 | 77.0% |
| Angina pectoris | 98 | 54 | 37 | 7 | 0 | 92.8% |
| Ptfv1Determine | 147 | 59 | 75 | 13 | 0 | 91.2% |
Above content is to combine specific preferred embodiment further description made for the present invention, it is impossible to assert
The specific implementation of the present invention is confined to these explanations.For general technical staff of the technical field of the invention,
On the premise of not departing from present inventive concept, some simple deduction or replace can also be made, should all be considered as belonging to the present invention's
Protection domain.
Claims (10)
1. a kind of Chinese medicine preparation of temperature compensation heart kidney, it is characterised in that：Include the preparing raw material of following mass percent：2.1%-
4.3% datura flower, 0.8%-2.5% ginsengs, 1%-4% pilose antlers, 16%-28% Chinese cassia trees, 52%-60% monkshoods, 6%-
10.2% pseudo-ginseng, 0.08%-0.15% borneols, 0.1%-0.25% Moschus, the 0.1%-0.18% dried venoms of toads.
2. the Chinese medicine preparation of temperature compensation heart kidney according to claim 1, it is characterised in that：Include the system of following mass percent
Standby raw material：2.8%-4.0% datura flowers, 1%-2.5% ginsengs, 2%-3% pilose antlers, 22%-28% Chinese cassia trees, 55%-60% are attached
Son, 8%-10% pseudo-ginseng, 0.1%-0.14% borneols, 0.12-0.2% Moschus, the 0.12-0.18% dried venoms of toads.
3. the Chinese medicine preparation of temperature compensation heart kidney according to claim 2, it is characterised in that：Include the system of following mass percent
Standby raw material：3.4% datura flower, 2.2% ginseng, 2.2% pilose antler, 25% Chinese cassia tree, 58% monkshood, 8.8% pseudo-ginseng, 0.11% ice
Piece, 0.14% Moschus, 0.15% dried venom of toads.
4. the Chinese medicine preparation of temperature compensation heart kidney according to claim 2, it is characterised in that：Include the system of following mass percent
Standby raw material：3.8% datura flower, 1.8% ginseng, 2% pilose antler, 26% Chinese cassia tree, 57% monkshood, 9% pseudo-ginseng, 0.10% borneol,
0.14% Moschus, 0.16% dried venom of toads.
5. the Chinese medicine preparation of temperature compensation heart kidney according to any one of claim 1 to 4, it is characterised in that：Its preparation method
Comprise the following steps：
1) pseudo-ginseng and ginseng are weighed, is crushed, 65%-90% ethanol is added and extracts secondary, each 1-3h, filtration is collected first and carried
Liquid is taken, the dregs of a decoction are standby；Datura flower is weighed, 65%-90% ethanol is added and extracts secondary, each 1-3h, filtration is collected second and extracted
Liquid, merges first extract solution and second extract solution, is condensed into medicinal extract, and drying obtains dried cream powder；
2) monkshood is weighed, is crushed, water is added and carries out water extract-alcohol precipitation, drying obtains monkshood extract；Chinese cassia tree is weighed, is steamed with water vapour
The method of evaporating is extracted and collects volatile oil, obtains cinnamomum cassia extract；
3) weigh pilose antler, borneol, Moschus and the dried venom of toads, add the dregs of a decoction, be ground into fine powder, add the dried cream powder, described attached
Seed extract and the cinnamomum cassia extract, are mixed, and add pharmaceutically acceptable auxiliary material, and the Chinese medicine preparation of temperature compensation heart kidney is made.
6. the Chinese medicine preparation of temperature compensation heart kidney according to claim 5, it is characterised in that：The step 1) in, it is extracted as surpassing
Sound extraction, Soakage extraction, seepage pressure effects or Microwave Extraction；The relative density of medicinal extract is 1.08-1.38.
7. the Chinese medicine preparation of temperature compensation heart kidney according to any one of claim 1 to 6, it is characterised in that：The preparation is
Pill, capsule or tablet；The pharmaceutically acceptable auxiliary material includes talcum powder, medical charcoal, starch, carboxyrnethyl starch sodium, micro-
One or more in crystalline cellulose and magnesium stearate.
8. the preparation method of the Chinese medicine preparation of temperature compensation heart kidney according to claim 1, it is characterised in that：Including following step
Suddenly：
S1 weighs pseudo-ginseng and ginseng, crushes, and adds 65%-90% ethanol and extracts secondary, each 1-3h, filtration is collected first and carried
Liquid is taken, the dregs of a decoction are standby；Datura flower is weighed, 65%-90% ethanol is added and extracts secondary, each 1-3h, filtration is collected second and extracted
Liquid, merges first extract solution and second extract solution, is condensed into medicinal extract, and drying obtains dried cream powder；
S2 weighs monkshood, crushes, and adds water and carries out water extract-alcohol precipitation, drying obtains monkshood extract；Chinese cassia tree is weighed, is steamed with water vapour
The method of evaporating is extracted and collects volatile oil, obtains cinnamomum cassia extract；
S3 weighs pilose antler, borneol, Moschus and the dried venom of toads, adds the dregs of a decoction, is ground into fine powder, adds the dried cream powder, described attached
Seed extract and the cinnamomum cassia extract, are mixed, and add pharmaceutically acceptable auxiliary material, and the Chinese medicine preparation of temperature compensation heart kidney is made.
9. the preparation method of the Chinese medicine preparation of temperature compensation heart kidney according to claim 8, it is characterised in that：The step 1)
In, it is extracted as ultrasonic extraction, Soakage extraction, seepage pressure effects or Microwave Extraction；The relative density of medicinal extract is 1.08-1.38.
10. the Chinese medicine preparation of temperature compensation heart kidney according to any one of claim 1 to 9 prepare preventing and treating sick sinus syndrome,
Purposes in chronic cardiac insufficiency, angina pectoris, myocardial ischemia and arrhythmia cordis medicine.
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