CN106177759A - A kind of compound Chinese medicinal preparation treating angina pectoris and preparation technology thereof - Google Patents
A kind of compound Chinese medicinal preparation treating angina pectoris and preparation technology thereof Download PDFInfo
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Abstract
The present invention provides a kind of compound Chinese medicinal preparation treating angina pectoris and preparation technology thereof, it is made up of Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Curcumae, Radix Salviae Miltiorrhizae, Radix Ginseng, the Radix Astragali, the Radix Aucklandiae, Radix Notoginseng, Borneolum Syntheticum nine traditional Chinese medicines altogether, prescription machine method is flexible, prescription more faithful to traditional Chinese medical science traditional theory, based on clinical practice, with modern scientific research as foundation, pharmacodynamic substances understands, clinical efficacy is notable, all can obtain good curative effect in two months.Capsule formulation is also beneficial to drug absorption, it is easy to carries and takes.Compare with similar drugs, prescription theory of Chinese medical science of the present invention according to fully, mild in medicine property and, compatibility is rigorous, and clinical symptom disappearance is rapid, all can obtain good curative effect in three months.
Description
Technical field
The present invention provides a kind of compound Chinese medicinal preparation treating angina pectoris, and the present invention further discloses in this
The preparation technology of recurrence due to taking drug square preparation, belongs to traditional Chinese medical science pharmaceutical technology field.
Background technology
In China, coronary heart disease is the third-largest causes of death of the mankind after cerebrovascular and malignant tumor.Due to China
Aged tendency of population aggravation, crowd's serum cholesterol level are increased, Prevalence of Hypertension increases, and make the sickness rate of angina pectoris
Still improving constantly, therefore seeking the effective Therapeutic Method to coronary heart disease, improving therapeutic effect, there is great society undoubtedly
Meaning.There is the shortcoming that medical expense is too high, toxic and side effects is big in the treatment to this disease Western medicine;Many is there is on market today
The anginal medicine for the treatment of, but the overwhelming majority has toxic and side effects, untoward reaction is many, unsuitable life-time service.
Summary of the invention
The present invention discloses a kind of compound Chinese medicinal preparation treating angina pectoris, and treatment angina pectoris has clinical treatment significantly
Effect, toxic and side effects is little, takes easy to carry.
Invention further provides the preparation method of a kind of compound Chinese medicinal preparation treating angina pectoris, science is closed
Reason, simple to operate, the maximum effective active composition that ensure that medicine.
A kind of compound Chinese medicinal preparation treating angina pectoris of the present invention, it is characterised in that pressed by following medicine
Ratio of weight and number is made:
Rhizoma Corydalis 5~15, Rhizoma Chuanxiong 5~15, Radix Curcumae 5~15, Radix Salviae Miltiorrhizae 5~15, Radix Ginseng 5~15, the Radix Astragali 5~15, the Radix Aucklandiae 3~10,
Radix Notoginseng 5~15, Borneolum Syntheticum 0.1~1.
A kind of compound Chinese medicinal preparation treating angina pectoris of the present invention, its optimum ratio is;
Rhizoma Corydalis 10, Rhizoma Chuanxiong 9, Radix Curcumae 9, Radix Salviae Miltiorrhizae 10, Radix Ginseng 6, the Radix Astragali 10, the Radix Aucklandiae 5, Radix Notoginseng 6, Borneolum Syntheticum 0.3.
A kind of compound Chinese medicinal preparation treating angina pectoris of the present invention, it is characterised in that include following step
Rapid:
Weigh Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Curcumae, Radix Salviae Miltiorrhizae, Radix Ginseng, the Radix Astragali, the Radix Aucklandiae, Radix Notoginseng, Borneolum Syntheticum altogether nine traditional Chinese medicines, wherein Rhizoma Corydalis,
Rhizoma Chuanxiong, Radix Curcumae, Radix Salviae Miltiorrhizae, Radix Ginseng, the Radix Astragali, the Radix Aucklandiae, (pulverizing 20 mesh) add 70% alcohol reflux 2 times of 6-10 times amount, every time
1.5 hours, filter, merging filtrate, reclaim ethanol, be evaporated to relative density be 1.20~1.25(60 DEG C) extractum, standby
With;Separately take Radix Notoginseng 20 mesh coarse powder, mix with above-mentioned extractum, common dry (70 DEG C), it is ground into fine powder, mixes with Borneolum Syntheticum, load
Capsule, to obtain final product.(easily liquefaction pulverized by Borneolum Syntheticum, should overlap and grind addition).
[usage and dosage] capsule 6-8 grain is each, is administered orally three times a day.90 days courses for the treatment of.
[indication] this compound Chinese medicinal preparation, with theory of Chinese medical science for instructing, based on clinical practice, is ground with modern science
Studying carefully for foundation, with regulating qi to disperse stagnation pain relieving as the rule for the treatment of, for Treating Stable Angina Pectoris of Coronary Artery Disease, Chinese medical discrimination belongs to qi stagnation and blood stasis type.Disease
See that feeling of oppression and pain in the chest, fullness and distention in the chest and hypochondrium, dark tongue quality or purple are dark or have ecchymosis, deep pulse or heavy string.
The pharmacological property (side solves) of the present invention is analyzed as follows:
In prescription, Rhizoma Corydalis processed by wine, arduous and warm, enters the heart, liver, spleen channel, the merit of tool blood-activating and qi-promoting pain relieving, " controlling pained desire extremely "
(Lei Gong's Treatise on Preparation and Broiling of Materia Medica), the stagnation of QI in energy promoting the circulation of blood, the stasis in gas, therefore be monarch drug;Radix Notoginseng sweetness and bitterness and warm, enter liver, stomach two warp, can
Blood stasis dispelling is invigorated blood circulation and analgesic therapy, it is possible to promoting tissue regeneration by removing blood stasis, and blood stasis dispelling is not just being hindered;The pungent temperature of Rhizoma Chuanxiong, enters liver, gallbladder, pericardium channel, blood circulation promoting and blood stasis dispelling, circulation of qi promoting
Pain relieving, for " the gas medicine in blood ", it is possible to sensible QI and blood, makes gas promoting the circulation of blood adjust;Radix Curcumae acrid in the mouth, enters the heart, liver, gallbladder meridian, and Xin Nenghang can dissipate,
Can invigorate blood circulation, again can circulation of qi promoting, can promoting blood circulation and stopping pain, promoting QI circulation for relieving depression.Radix Salviae Miltiorrhizae hardship is slightly cold, and enters the heart, Liver Channel, blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia.
The Radix Aucklandiae is pungent, bitter, temperature, enters spleen, stomach, large intestine, three burnt, gallbladder meridians, promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.The five same use of medicine, help monarch's promoting flow of QI and blood,
Blood-activating analgetic, is ministerial drug altogether;Ginseng sweet temperature, enters the heart, spleen, lung meridian, kind " spasmolytic is throbbed with fear for tonifying five ZANG-organs, peace spirit " (" legendary god of farming's book on Chinese herbal medicine
Warp "), can nourish heart gas by invigorating the spleen to benefit the lung.The sweet tepor of the Radix Astragali, enters to return lung, spleen channel.Tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, promote the production of body fluid and nourish blood, row is stagnant
Blood stasis dispelling.In side Radix Ginseng, the Radix Astragali both can qi-supplementing, blood-engendering, make the prosperous blood of gas raw, power is inexhaustible, again can solid protection healthy energy, anti-monarch, minister all medicines row
The gasification stasis of blood gram penalizes too consumption to hinder healthy energy, and two medicines belong to assistant and help and help the merit of system.Borneolum Syntheticum is arduous to be slightly cold, and GUIXIN, spleen, lung meridian are apt to walk energy
Dissipate, there is scattered fire, scattered gas, scattered blood, dissipate stagnant, sensible, to ward off evil merit, " then gesture of walking alone is weak, helps and makes, gains merit " (amplification on Canon of Materia Medica),
With all medicines phase 5, the happy key of energy, stopping numbness pain, is also adjuvant drug.All medicines share, and play blood circulation promoting and blood stasis dispelling altogether, and the merit of promoting the circulation of QI to relieve pain can make the stasis of blood
Blood must go, and sering must be logical, and the most all diseases are explained by oneself.
The feature of present invention legislation is: prescription machine method is flexible, prescription more faithful to traditional Chinese medical science traditional theory.At traditional prescription
In, have focused solely on blood-activating and qi-promoting pain relieving, do not take into account the card of thoracic obstruction deficiency in origin.And " empty gas stays to the present invention is directed to angina pectoris
Stagnant " pathogenic characteristic, take the literal sense of its " evil contain be difficult to hide deficiency in origin ", take stopgap measures and do not forget to consolidate, just so-called: " kind nourishing YIN person's treating YIN within YANG,
Kind YANG invigorating person's treating YANG within YIN ".While circulation of qi promoting blood circulation promoting and blood stasis dispelling, assistant adds a small amount of Radix Ginseng with reinforcing body resistance, Radix Ginseng energy in we
Qi-supplementing, blood-engendering, makes mechanism of qi power long inexhaustible, " qi being the governor of blood ", makes the gas handsome blood of prosperous energy move, gas row then blood, helps walk help gas
The Chinese medicine of blood circulation promoting and blood stasis dispelling;On the other hand, the thoracic obstruction originally has gas, blood, the card of yin, yang deficiency, the product of application promoting flow of QI and blood blood stasis dispelling easily to consume
Hurt sb.'s feelings the healthy energy of body, make void person more empty.Application Radix Ginseng plays the merit of assistant system with solid protection healthy energy, in case gram penalizing too and consuming and just hindering
Gas.There is promoting flow of QI and blood blood stasis dispelling and just do not hinder, inspire healthy energy not stay the prescription advantage of heresy, clinical practice achieves the best
Good therapeutic effect.The treatment of the present invention, from entirety, emphasizes determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, focuses on individuality, can effectively improve symptom,
Can effect a permanent cure again and untoward reaction is relatively small, there are bright prospects.
Curative effect proves:
One, case selection
Case derives from The Affiliated Hospital to Changchun University of Chinese Medicine's heart internal medicine and is diagnosed as angina pectoris and Chinese medical discrimination genus
In patient 60 example of qi stagnation and blood stasis type, according to random distribution method, with 1:1 ratio mean allocation, treatment group 30 example, matched group 30
Example.Curative is medicine of the present invention, three times on the one, and March is a course for the treatment of.
Two, diagnostic criteria
Western medicine diagnose standard
" ischemic is reported by reference International Society of Cardiology and association and World Health Organization's clinical name standardization associating special topic group
Cardiopathic name and diagnostic criteria ".
1) feature of angina pectoris angina of effort is due to motion or the situation of other increase myocardium requirementing keto quantities
The of short duration episode induced, has a rest or after sublingual administration nitroglycerin, pain often can rapidly disappear.Angina pectoris can
It is divided into 3 classes:
Just hair style angina pectoris: the angina pectoris course of disease is within 1 month;
Stable type angina pectoris: the angina pectoris course of disease stablizes more than 1 month;
Deterioration type angina pectoris: episode number of times, the order of severity and persistent period that equal extent fatigue is induced are prominent
So increase the weight of;
2) feature of spontaneous angina pectoris spontaneous angina pectoris is that the episode increase with myocardium requirementing keto quantity is without obvious relation.
Compared with angina pectoris, this pain general persistence is longer, and degree is heavier, and is difficult to alleviate into nitroglycerin.Not
Seeing enzymic change, electrocardiogram often occurs that some temporary S-T segment forces down or T ripple changes.Spontaneous angina pectoris can individually occur or
Existence is merged with angina pectoris.Panic attacks frequency, persistent period and the pain degree of spontaneous angina pectoris patient can have
Different clinical manifestations, patient can have and continues longer episode sometimes, similar myocardial infarction, but do not has electrocardiogram and enzyme
Characteristic changes.When outbreak, some spontaneous angina pectoris patient occurs that temporary S-T segment is raised, frequently referred to anomaly heart strand
Bitterly.But when myocardial infarction recorded this electrocardiogram pattern in early days, it is impossible to apply this title.
Three, tcm diagnosis standard:
1. TCM syndrome diagnostic criteria (with reference to GB " tcm clinical practice diagnosis and treatment term syndrome part " 1997-0.-04 issue and
Higher medical institution teaching material " Chinese Internal Medicine " Science and Technology of Shanghai publishing house, in October, 1985, the first edition)
2, Syndrome Diagnostic
2.1 syndrome of qi stagnation and blood stasis
Primary symptom: chest pain, uncomfortable in chest.
Secondary disease: fullness and distention in the chest and hypochondrium, breathes hard, and cardiopalmus is insomnia.
Tongue arteries and veins: words are purple dark, hesitant pulse.
3, Syndrome Scale quantifies, and refers to table 1
Table 1 angina pectoris (qi stagnation and blood stasis type) scalar quantization table
4, inclusive criteria
Meet the pain diagnostic criteria and TCM syndrome diagnostic criteria of coronary heart disease heart stricture of vagina, the age 18-65 year between and sign and know the inside story together
Meaning book person, the people that all can receive tests case;
5, exclusion standard
(1) acute myocardial infarction and other heart diseases, severe neurological functional disease, climacteric disease are turned out to be on inspection
The caused chest pain person such as Hou Qun, hyperthyroidism, cervical spondylosis, gallbladder cardiopathia, stomach and esophageal reflux;
(2) severe hypertension, severe pulmonary insufficiency, severe arrhythmia, primary disease, psychotic are merged;
(3 gestation or women breast-feeding their children;
(4) allergic constitution and to multi-medicament allergy sufferers;
Four, observation index
Safety is observed
1, general health check-up item inspection.
2, blood, urine, feces routine examination.
3, the heart, Liver and kidney function inspection.
4, the untoward reaction being likely to occur, such as anaphylaxis, digestive tract reaction, the impact etc. of cardiac hemodynamic.
Above-mentioned detection project typically can in test before and after 1 time for future reference.
Health giving quality is observed
1, angina pectoris
The risk factor of angina pectoris attacks, the size of physical exertion, degree, the number of times of pain, degree, persistent period, nitric acid is sweet
The consumption of oil formulation etc. and related symptoms.Should record weekly 1 time.
2, relevant sign
Such as heart rate, the rhythm of the heart, cardiac murmur, blood pressure, body of the tongue, tongue fur, pulse condition etc., should record weekly 1 time.
3, relevant physico-chemical examination
Blood fat includes cholesterol, TG, high density lipoprotein, low density lipoprotein, LDL, respectively looks into 1 before and after test
Secondary (latter two optional do);
Hemorheology include whole blood senior middle school undercut viscosity, plasma viscosity, packed cell volume, erythrocyte sedimentation rate,
Platelet, plasma fibrinogen mensuration etc..(this can the choosing of bound drug function respectively to look into 1 time before and after test
Do);
Weekly and respectively look into 1 time after test before electrocardiogram test, in test, check when patient has chest pain discomfort to show effect.
Exercise ECG treadmill test or bicycle ergometor exercise, carried out in stable type angina pectoris case,
The change before and after evaluation test is carried out according to the levels of motion completed.It is noted that the contraindication of exercise test and centre of motion electrograph,
Blood pressure, angina pectoris etc. are observed, it is ensured that the safety of exercise test.The case of exercise test should have the sample number of statistical significance.
Five, efficacy determination
Curative effect of disease criterion
1, the cardinal symptom such as effective heart stricture of vagina pain disappears or reaches effective standard, and electrocardiogram recovers to normal ECG or reaches big
Cause normal (i.e. electrocardiogram normal range);
2, the cardinal symptom such as effective angina pectoris alleviates or reaches effective standard, and electrocardiogram improves and reaches effective standard;
3, the cardinal symptom such as invalid angina pectoris is without improving, and electrocardiogram is basic front with treatment identical;
Curative effect of disease criterion
4, increase the weight of to increase the weight of before the cardinal symptoms such as angina pectoris are relatively tested with electrocardiogram;
When comprehensive therapeutic effect judges, if the cardinal symptom curative effects such as angina pectoris are inconsistent with ECG curative effect, should be with curative effect
Low result is comprehensive therapeutic effect.
Therapeutic effect of syndrome criterion
1) effective tcm clinical practice symptom, sign are obviously improved, and syndrome integral reduces >=70%
2) effectively tcm clinical practice symptom, sign all take a favorable turn, and syndrome integral reduces >=30%
3) invalid tcm clinical practice symptom, sign are all not improved, even increase the weight of, syndrome integral reduces deficiency >=30%
4) increasing the weight of tcm clinical practice symptom, sign all to have and increase the weight of, syndrome integral reduces less than < 0.
Statistical procedures
Application SPSS software (13.0 editions) carries out data statistic analysis process, uses t check analysis testing result.
Six, test results and analysis
6.1 patient's ordinary circumstances are analyzed, and are shown in Table 2
Table 2 patient's ordinary circumstance analysis ± s
Sex (example) | N | Mean age (year) | Average course of disease (year) |
Man | 30 | 56.56±3.12 | 7.17±0.42 |
Female | 30 | 51.33±2.81 | 8.63±0.36 |
The improvement situation of 6.2 clinical symptoms, is shown in Table 3
Table 3 patient symptom after treatment improves situation
Symptom | Integration reduces more than 80% | Integration reduces more than 50% | Integration reduces | Integration decreases below 30%; | Effective percentage (%) |
Chest pain | 12 | 18 | 12 | 18 | 70.00 |
Uncomfortable in chest | 12 | 24 | 8 | 16 | 73.33 |
Breathe hard | 7 | 17 | 16 | 20 | 66.67 |
Cardiopalmus | 10 | 17 | 12 | 21 | 65.00 |
It is insomnia | 14 | 15 | 16 | 15 | 75.00 |
The change of 6.3 lipids detection desired values, is shown in Table 4.
The change (± s) of lipids detection desired value before and after table 4 treatment
Project | Before treatment | After treating three months | P value |
TC | 7.60±2.30 | 5.23±1.16 | P<0.05 |
TG | 5.16±2.13 | 2.36±1.12 | P<0.05 |
P value be treatment three months after with treatment before comparison, illustrate that medicine of the present invention significantly reduces cholesterol and triglyceride
Effect.
Before and after 6.4 treatments, angina pectoris attacks situation compares ± s)
It is 81. 2% that two groups of curative effect to treat angina pectoris compare (table 2) treatment group total effective rate, and matched group total effective rate is 43. 3%, controls
Treatment group is evident in efficacy is better than matched group (P < 0. 05).
Table 5 (± s)
Group | Before treatment | After treating three months | P value |
Seizure frequency (secondary/week) | 18.8±2.3 | 6.9±2.0 | P<0.05 |
Persistent period (min/ time) | 9.3±1.8 | 3.1±1.3 | P<0.05 |
P value be after treatment three months with treatment before comparison, illustrate that medicine of the present invention is significantly improved the effect of angina pectoris symptom.
After 6.5 treatments three months, the evaluation situation of curative effect, is shown in Table 6
Table 6 treat three months after the evaluation situation of curative effect
Basic healing | Effective | Effectively | Invalid | Add up to | Effective percentage (%) | |
Curative effect | 16 | 15 | 10 | 19 | 60 | 68.33 |
The positive effect of the present invention is: prescription machine method is flexible, and prescription more faithful to traditional Chinese medical science traditional theory, with clinical practice as base
Plinth, with modern scientific research as foundation, pharmacodynamic substances understands, clinical efficacy is notable, all can obtain good in two months
Curative effect.Capsule formulation is also beneficial to drug absorption, it is easy to carries and takes.Compare with similar drugs, medical knowledge in prescription of the present invention
Opinion according to fully, mild in medicine property and, compatibility is rigorous, and clinical symptom disappearance is rapid, all can obtain good curative effect in three months.
Detailed description of the invention
Illustrated further the description present invention by following example, and limits the present invention never in any form, without departing substantially from
On the premise of the technical solution of the present invention, what those of ordinary skill in the art made for the present invention easily realized any changes
Within dynamic or change falls within scope of the presently claimed invention.
Embodiment 1
Rhizoma Corydalis 5g, Rhizoma Chuanxiong 5 g, Radix Curcumae 5 g, Radix Salviae Miltiorrhizae 5 g, Radix Ginseng 6 g, Radix Astragali 5g, the Radix Aucklandiae 3 g, Radix Notoginseng 6 g, Borneolum Syntheticum 0.3 g
Altogether nine traditional Chinese medicines, wherein Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Curcumae, Radix Ginseng (pulverizing 20 mesh) add 70% alcohol reflux 2 times of 6 times amount,
Each 1.5 hours, filter, merging filtrate, reclaim ethanol, be evaporated to relative density be 1.20~1.25(60 DEG C) leaching
Cream, standby;Separately take Radix Notoginseng 20 mesh coarse powder, mix with above-mentioned extractum, common dry (70 DEG C), it is ground into fine powder, mixes with Borneolum Syntheticum,
Load capsule, obtain (easily liquefaction pulverized by Borneolum Syntheticum, should overlap and grind addition).
Embodiment 2
Rhizoma Corydalis 10 g, Rhizoma Chuanxiong 9g, Radix Curcumae 9g, Radix Salviae Miltiorrhizae 10 g, Radix Ginseng 6 g, the Radix Astragali 10 g, the Radix Aucklandiae 5 g, Radix Notoginseng 6g, Borneolum Syntheticum 0.3
G altogether nine traditional Chinese medicines, wherein Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Curcumae, Radix Ginseng (pulverizing 20 mesh) add 70% alcohol reflux 2 times of 8 times amount,
Each 1.5 hours, filter, merging filtrate, reclaim ethanol, be evaporated to relative density be 1.20~1.25(60 DEG C) leaching
Cream, standby;Separately take Radix Notoginseng 20 mesh coarse powder, mix with above-mentioned extractum, common dry (70 DEG C), it is ground into fine powder, mixes with Borneolum Syntheticum,
Load capsule, obtain (easily liquefaction pulverized by Borneolum Syntheticum, should overlap and grind addition).
Embodiment 3
Rhizoma Corydalis 15 g, Rhizoma Chuanxiong 15 g, Radix Curcumae 15 g, Radix Salviae Miltiorrhizae 15 g, Radix Ginseng 15g, Radix Astragali 15g, the Radix Aucklandiae 10 g, Radix Notoginseng 15 g,
Borneolum Syntheticum 1 g altogether Six-element Chinese medicine, wherein Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Curcumae, Radix Ginseng (pulverizing 20 mesh) add 70% alcohol reflux of 10 times amount
Extracting 2 times, each 1.5 hours, filter, merging filtrate, reclaim ethanol, being evaporated to relative density is 1.20~1.25(60
DEG C) extractum, standby;Separately take Radix Notoginseng 20 mesh coarse powder, mix with above-mentioned extractum, common dry (70 DEG C), it is ground into fine powder, with ice
Sheet mixes, and loads capsule, obtains (easily liquefaction pulverized by Borneolum Syntheticum, should overlap and grind addition).
The medical effect of the present invention is proved further by following model case:
Case 1
Lee, man, 57 years old.Recently panesthesia's anterior pectorial region pain, uncomfortable in chest to shoulder radiation, continue 15-20 minute, take speed throughout the year
Imitate pills for curing heart disease and alleviate.Figure is the most fat, height 160 centimeters, and body weight reaches 90 kilograms, previously has hypertension history, takes multiple medicine
Product, all without positive effect, take one course for the treatment of of the embodiment of the present invention 1 medicine, and symptom is substantially alleviated, and after two courses for the treatment of, angina pectoris stops
Only outbreak.Follow up a case by regular visits to 2 years stablize always, do not recur so far.
Case 2
Grandson, man, 56 years old.Patient has angina pectoris 6 years, and in this year, retrosternal pain outbreak frequently, takes diabetes with polydipsia as the prominent symptom
Bitterly, Radix Salviae Miltiorrhizae drop pill unsatisfactory curative effect.After taking two courses for the treatment of of the embodiment of the present invention 2 medicine, subjective symptoms takes a turn for the better, and continues to take medicine two
The individual course for the treatment of, symptom is wholly absent.Follow up a case by regular visits to 2 years stablize always, do not recur so far.
Case 3
Chen, female, 46 years old, there is precordialgia without obvious inducement before 2 years in patient, uncomfortable in chest, breathe hard, and outbreak is sustainable every time
10-20 minute, electrocardiogram display myocardial ischemia.After taking two courses for the treatment of of the embodiment of the present invention 3 medicine, uncomfortable in chest, symptom of breathing hard is delayed
Solving, Electrocardioscopy is normal.Follow up a case by regular visits to 2 years stablize always, do not recur so far.
Claims (3)
1. the compound Chinese medicinal preparation treating angina pectoris, it is characterised in that be made up by ratio of weight and the number of copies of following medicine
:
Rhizoma Corydalis 5~15, Rhizoma Chuanxiong 5~15, Radix Curcumae 5~15, Radix Salviae Miltiorrhizae 5~15, Radix Ginseng 5~15, the Radix Astragali 5~15, the Radix Aucklandiae 3~10,
Radix Notoginseng 5~15, Borneolum Syntheticum 0.1~1.
2. a kind of compound Chinese medicinal preparation treating angina pectoris described in claim 1, its optimum ratio is:
Rhizoma Corydalis 10, Rhizoma Chuanxiong 9, Radix Curcumae 9, Radix Salviae Miltiorrhizae 10, Radix Ginseng 6, the Radix Astragali 10, the Radix Aucklandiae 5, Radix Notoginseng 6, Borneolum Syntheticum 0.3.
3. a kind of compound Chinese medicinal preparation treating angina pectoris described in claim 1 or 2, comprises the following steps:
Weigh Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Curcumae, Radix Salviae Miltiorrhizae, Radix Ginseng, the Radix Astragali, the Radix Aucklandiae, Radix Notoginseng, Borneolum Syntheticum altogether nine traditional Chinese medicines, wherein Rhizoma Corydalis,
Rhizoma Chuanxiong, Radix Curcumae, Radix Salviae Miltiorrhizae, Radix Ginseng, the Radix Astragali, the Radix Aucklandiae, (pulverizing 20 mesh) add 70% alcohol reflux 2 times of 6-10 times amount, every time
1.5 hours, filter, merging filtrate, reclaim ethanol, be evaporated to relative density be 1.20~1.25(60 DEG C) extractum, standby
With;Separately take Radix Notoginseng 20 mesh coarse powder, mix with above-mentioned extractum, common dry (70 DEG C), it is ground into fine powder, mixes with Borneolum Syntheticum, load
Capsule, to obtain final product.
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CN112806572A (en) * | 2021-01-19 | 2021-05-18 | 胡其勇 | Coarse grain powder for treating coronary heart disease |
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CN1872316A (en) * | 2005-06-01 | 2006-12-06 | 天津天士力制药股份有限公司 | Medication of containing astragalus root in application for treating resistant medication of aspirin |
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CN110548099A (en) * | 2019-10-09 | 2019-12-10 | 辽宁帛道堂药业有限公司 | Traditional Chinese medicine composition for treating coronary heart disease stable angina pectoris and preparation method thereof |
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