CN106177759B - A kind of compound Chinese medicinal preparation and its preparation process for treating coronary disease and angina pectoris - Google Patents
A kind of compound Chinese medicinal preparation and its preparation process for treating coronary disease and angina pectoris Download PDFInfo
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Abstract
The present invention provides a kind of compound Chinese medicinal preparation and its preparation process for treating coronary disease and angina pectoris, it is total to nine traditional Chinese medicines by rhizoma corydalis, Rhizoma Chuanxiong, Radix Curcumae, Radix Salviae Miltiorrhizae, ginseng, Radix Astragali, radix aucklandiae, Radix Notoginseng, borneol and is formed, prescription machine method is flexible, the more faithful to Chinese medicine traditional theory of prescription, based on clinical practice, using modern scientific research as foundation, pharmacodynamic substances understand, clinical efficacy is significant, and good curative effect can be obtained in two months.Capsule formulation is also beneficial to drug absorption, is easy to carry about with one and takes.Compared with similar drugs, prescription theory of traditional Chinese medical science of the present invention is according to sufficiently, and medicinal peace, compatibility is rigorous, and clinical symptoms disappear rapidly, and good curative effect can be obtained in three months.
Description
Technical field
The present invention provides a kind of compound Chinese medicinal preparation for treating coronary disease and angina pectoris, and the present invention further discloses in this
The preparation process of medicine compound preparation belongs to Chinese medicine pharmaceutical technology field.
Background technique
In China, coronary heart disease is the third-largest cause of death of the mankind after cerebrovascular disease and malignant tumour.Due to China
Aging of population aggravation, crowd's serum cholesterol level are increased, Prevalence of Hypertension increases, and make the disease incidence of coronary disease and angina pectoris
It is still being continuously improved, therefore is seeking the effective treatment method to coronary heart disease, improving therapeutic effect, undoubtedly there is great society
Meaning.Have the shortcomings that medical expense is excessively high, toxic side effect is big to the treatment of the disease Western medicine;There is many on market today
The anginal drug for the treatment of, but it is most all there is toxic side effect, adverse reaction is more, should not be used for a long time.
Summary of the invention
The present invention discloses a kind of compound Chinese medicinal preparation for treating coronary disease and angina pectoris, and treatment angina pectoris has significant ground clinical
Medical effect, toxic side effect is small, takes easy to carry.
Invention further provides a kind of preparation method of compound Chinese medicinal preparation for treating coronary disease and angina pectoris, science is closed
Reason, easy to operate, the maximum effective active composition that ensure that drug.
A kind of compound Chinese medicinal preparation for treating coronary disease and angina pectoris of the present invention, it is characterised in that pressed by following drug
Made of weight fraction ratio:
Rhizoma corydalis 5~15, Rhizoma Chuanxiong 5~15, Radix Curcumae 5~15, Radix Salviae Miltiorrhizae 5~15, ginseng 5~15, Radix Astragali 5~15, radix aucklandiae 3~
10, Radix Notoginseng 5~15, borneol 0.1~1.
A kind of compound Chinese medicinal preparation for treating coronary disease and angina pectoris of the present invention, optimum ratio are;
Rhizoma corydalis 10, Rhizoma Chuanxiong 9, Radix Curcumae 9, Radix Salviae Miltiorrhizae 10, ginseng 6, Radix Astragali 10, radix aucklandiae 5, Radix Notoginseng 6, borneol 0.3.
A kind of compound Chinese medicinal preparation for treating coronary disease and angina pectoris of the present invention, it is characterised in that including following step
It is rapid:
It weighs rhizoma corydalis, Rhizoma Chuanxiong, Radix Curcumae, Radix Salviae Miltiorrhizae, ginseng, Radix Astragali, radix aucklandiae, Radix Notoginseng, borneol and is total to nine traditional Chinese medicines, wherein prolonging recklessly
70% alcohol reflux that rope, Rhizoma Chuanxiong, Radix Curcumae, Radix Salviae Miltiorrhizae, ginseng, Radix Astragali, radix aucklandiae, (crushed 20 mesh) plus 6-10 times are measured extracts 2 times,
1.5 hours every time, filtration, merging filtrate, recycle ethyl alcohol, be concentrated under reduced pressure into relative density be 1.20~1.25(60 DEG C) leaching
Cream, it is spare;20 mesh coarse powder of Radix Notoginseng separately is taken, is mixed with above-mentioned medicinal extract, it is common dry (70 DEG C), it is ground into fine powder, is mixed with borneol,
Be packed into capsule to get.(borneol crushes easily liquefaction, should cover and grind addition).
[usage and dosage] capsule 6-8 every time, takes orally 3 times a day.90 days courses for the treatment of.
[indication] Chinese medicine compound preparation is guidance with theory of traditional Chinese medical science, based on clinical practice, is ground with modern science
Study carefully and is used for Treating Stable Angina Pectoris of Coronary Artery Disease, Chinese medical discrimination category qi stagnation and blood stasis type using regulating qi to disperse stagnation analgesic as the rules for the treatment of for foundation.Disease
See feeling of oppression and pain in the chest, fullness in chest and hypochondrium, dark tongue quality or purple dark or have ecchymosis, deeptensepulse or heavy string.
Pharmacological property (side's solution) of the invention is analyzed as follows:
Wine processs rhizoma corydalis in prescription, arduous and warm, enters the heart, liver, the spleen channel, has the function of blood-activating and qi-promoting analgesic, " controls pained desire
Extremely " (Lei Gong's Treatise on Preparation and Broiling of Materia Medica), can the stagnation of the circulation of vital energy in promoting circulation of blood, the stasis in gas, therefore be monarch drug in a prescription;Radix Notoginseng sweetness and bitterness and it is warm, enter liver, stomach two
Through, can stagnation resolvation promoting blood circulation and analgesic therapy, can removing blood stasis for promoting tissue regeneration, stagnation resolvation do not hurt just;Rhizoma Chuanxiong pungent-warm, enters liver, gallbladder, pericardium channel, activating microcirculation and removing stasis medicinal,
Promoting qi circulation and relieving pain, be " the gas medicine in blood ", can sensible qi and blood, make gas promoting circulation of blood tune;Radix Curcumae acrid flavour enters the heart, liver, gallbladder channel, Xin Nenghang
It can dissipate, can invigorate blood circulation and promoting the circulation of qi, it can promoting blood circulation and stopping pain, promoting qi circulation and removing obstruction in the collateral.Radix Salviae Miltiorrhizae hardship is slightly cold, enters the heart, Liver Channel, promoting blood circulation, promoting menstruation
Analgesic.Radix aucklandiae is pungent, bitter, temperature, enters spleen, stomach, large intestine, three burnt, gallbladder channels, promoting qi circulation and relieving pain, reinforcing spleen to promote digestion.Five medicines help monarch's promoting the circulation of qi with using
Promoting blood circulation, blood-activating analgetic is altogether ministerial drug;Ginseng sweet temperature enters the heart, spleen, lung channel, is apt to " tonifying five zang organs, soothe the nerves, stop palpitate with fear " (" legendary god of farming's sheet
Grass warp "), can reinforce the spleen to benefit the lung nourishing heart gas.The sweet tepor of Radix Astragali, enters return lung, the spleen channel.Tonifying Qi and lifting yang, strengthening exterior and reducing sweat, shengjin nourishing, row
Stagnant logical numbness.In side ginseng, Radix Astragali both can qi-supplementing, blood-engendering, keep the prosperous blood of gas raw, power is inexhaustible, and can solid protection healthy tendency, anti-monarch, all medicines of minister
Regulating qi to disperse stagnation gram penalizes too consumption to hurt healthy tendency, and two medicines belong to the function that assistant helped and helped system.Borneol is worked hard slightly cold, and return heart, spleen, lung channel are apt to walk
It can dissipate, have and dissipate fire, air-dispersing, dissipate blood, dissipate function that is stagnant, sensible, warding off evil, " then gesture of walking alone is weak, and assistant makes, active " (" book on Chinese herbal medicine spreads out
Justice "), with all medicine phases 5, the happy key of energy, stopping numbness pain is also adjutant.All medicines share, plays promoting blood circulation altogether, the function of promoting qi circulation and relieving pain,
It can make hemostasis that must go, sering must be logical, then all diseases self solve.
The feature of present invention legislation are as follows: prescription machine method is flexible, the more faithful to Chinese medicine traditional theory of prescription.In traditional prescription
In, blood-activating and qi-promoting analgesic is had focused solely on, does not take into account the card of this void of thoracic obstruction.And " empty gas stays the present invention for coronary disease and angina pectoris
It is stagnant " pathogenic characteristic, take the literal sense of its " heresy contain be difficult to conceal this void ", temporary solution is not forgotten to consolidate, just so-called: " kind tonifying yin person's treating YIN within YANG,
Kind yang-tonifying person's treating YANG within YIN ".While promoting the circulation of qi activating microcirculation and removing stasis medicinal, assistant plus a small amount of ginseng are with building up healthful vital energy, the ginseng energy in we
Qi-supplementing, blood-engendering keeps mechanism of qi power long inexhaustible, " qi being the governor of blood ", make gas it is prosperous can handsome blood and move, gas row then blood, assistant walk help gas
The Chinese medicine of activating microcirculation and removing stasis medicinal;On the other hand, thoracic obstruction originally have gas, blood, yin, yang deficiency card, easily consumed using the product of promoting flow of qi and blood circulation stagnation resolvation
It hurts sb.'s feelings the healthy tendency of body, keeps empty person more empty.The function of assistant system is played with solid protection healthy tendency using ginseng, is penalized to prevent gram and is too consumed and hurt just
Gas.With promoting flow of qi and blood circulation dissolving stasis without hurting just, inspires healthy tendency not stay evil prescription advantage, achieved in clinical application very good
Good therapeutic effect.Treatment of the invention emphasizes diagnosis and treatment from entirety, focuses on individual, can effectively improve symptom,
It can effect a permanent cure again and adverse reaction is relatively small, there are bright prospects.
Curative effect proves:
One, case selection
Case derives from The Affiliated Hospital to Changchun University of Chinese Medicine's heart internal medicine and is diagnosed as coronary disease and angina pectoris and Syndrome Differentiation of Chinese Medicine
Card belongs to patient 60 of qi stagnation and blood stasis type, according to random distribution method, with 1:1 ratio mean allocation, treatment group 30, control group
30.Medicine is drug of the present invention, and three times per day, March is as a treatment course.
Two, diagnostic criteria
Western medicine diagnostic criteria
It " is lacked referring to International Society of Cardiology and association and the standardization joint special topic group report of World Health Organization's clinical name
Hemorrhagic cardiopathic name and diagnostic criteria ".
1) the case where angina pectoris angina of effort is characterized in due to movement or other increase myocardium requirementing keto quantities
The of short duration episode induced, after rest or sublingual administration nitroglycerin, pain can often rapidly disappear.Angina pectoris can
It is divided into 3 classes:
First hair style angina pectoris: the angina pectoris course of disease is within 1 month;
Stable type angina pectoris: the angina pectoris course of disease is stablized 1 month or more;
Deterioration type angina pectoris: equal extent fatigue induced episode number, severity and it is lasting when
Between aggravate suddenly;
2) spontaneous angina pectoris spontaneous angina pectoris is characterized in that the increase of episode and myocardium requirementing keto quantity is closed without obvious
System.Compared with angina pectoris, this pain general persistence is longer, and degree is heavier, and is not easy as nitroglycerin alleviation.
Have no enzymic change, electrocardiogram often occurs that certain temporary S-T segments force down or T wave changes.Spontaneous angina pectoris can individually occur
Or merge presence with angina pectoris.Panic attacks frequency, duration and the pain degree of spontaneous angina pectoris patient can
There is different clinical manifestations, patient there can be persistently longer episode sometimes, similar myocardial infarction, but not have electrocardiogram and enzyme
Characteristic variation.There is temporary S-T segment in breaking-out and raise in certain spontaneous angina pectoris patients, frequently referred to the anomaly heart
Colic pain.But when myocardial infarction early stage this electrocardiogram pattern being recorded, this title cannot be applied.
Three, tcm diagnosis standard:
1. TCM syndrome diagnostic criteria (referring to GB " tcm clinical practice diagnosis and treatment term syndrome part " 1997-0.-04 publication and
Higher medical institution teaching material " Chinese Internal Medicine " Shanghai Scientific & Technical Publishers, in October, 1985, the first edition)
2, Syndrome Diagnostic
2.1 syndrome of qi stagnation and blood stasis
Primary symptom: pectoralgia, it is uncomfortable in chest.
Minor symptom: fullness in chest and hypochondrium, shortness of breath, palpitaition are insomnia.
Tongue vein: words are purple dark, uneven pulse.
3, Syndrome Scale quantifies, and see Table 1 for details
1 coronary disease and angina pectoris of table (qi stagnation and blood stasis type) scalar quantization table
4, it is included in standard
Meet coronary heart disease heart line pain diagnostic criteria and TCM syndrome diagnostic criteria, the age is between 18-65 years old and signature is known
Feelings letter of consent person, the people that can receive test case;
5, exclusion criteria
(1) acute myocardial infarction and other heart diseases, severe neurological functional disease, climacteric are turned out to be on inspection
Pectoralgia person caused by phase syndrome, hyperthyroidism, cervical spondylosis, gallbladder heart trouble, stomach and esophageal reflux etc.;
(2) merge severe hypertension, severe cardiopulmonary insufficiency, severe arrhythmia cordis, primary disease, cyclothymic
Person;
(3 gestation or breast feeding women;
(4) allergic constitution and to a variety of drug allergy persons;
Four, observation index
Safety observation
1, general physical examination item inspection.
2, blood, urine, feces routine inspection.
3, the heart, Liver and kidney function inspection.
4, the adverse reaction being likely to occur, such as allergic reaction, digestive tract reaction, the influence etc. of cardiac hemodynamic.
Above-mentioned detection project generally can be 1 time for future reference in test front and back.
Health giving quality observation
1, angina pectoris
The risk factor of angina pectoris attacks, size, the degree of physical exertion, the number of pain, degree, duration, nitre
Dosage of acid glycerol preparation etc. and related symptoms.It should record weekly 1 time.
2, related sign
Such as heart rate, the rhythm of the heart, heart murmur, blood pressure, tongue nature, tongue fur, pulse condition should record weekly 1 time.
3, relevant physico-chemical examination
Blood lipid includes cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, and test front and back respectively looks into 1
Secondary (latter two optional do);
Hemorheology include whole blood senior middle school undercut viscosity, plasma viscosity, hematocrit, erythrocyte sedimentation rate (ESR),
Platelet, plasma fibrinogen measurement etc..Test front and back respectively looks into 1 time, and (this is in combination with pharmic function
Choosing is done);
It is respectively looked into 1 time weekly and after test before electrocardiogram test, in test, inspection when patient has the breaking-out of pectoralgia discomfort.
Exercise ECG treadmill test or bicycle ergometor exercise carry out in stable type angina pectoris case,
According to the levels of motion of completion come the variation before and after evaluation test.It is noted that the contraindication and centre of motion electrograph of exercise test,
The observation such as blood pressure, angina pectoris, guarantees the safety of exercise test.The case of exercise test should have the sample number of statistical significance.
Five, efficacy determination
Curative effect of disease criterion
1, the cardinal symptoms such as effective heart line pain disappear or reach effective standard, and electrocardiogram restores to normal ECG or reaches
To substantially normal (i.e. normal range (NR) electrocardiogram);
2, the cardinal symptoms such as effective angina pectoris mitigate or reach effective standard, and electrocardiogram improvement reaches effective standard;
3, for the cardinal symptoms such as invalid angina pectoris without improvement, electrocardiogram is substantially identical as before treatment;
Curative effect of disease criterion
4, the cardinal symptoms such as angina pectoris and electrocardiogram are aggravated and relatively tests preceding aggravate;
It, should be with if both the cardinal symptoms such as angina pectoris curative effect and ECG curative effect are inconsistent when comprehensive therapeutic effect judges
The low result of curative effect is comprehensive therapeutic effect.
Therapeutic effect of syndrome criterion
1) effective tcm clinical practice symptom, sign are obviously improved, and syndrome integral reduces >=70%
2) effectively tcm clinical practice symptom, sign take a favorable turn, and syndrome integral reduces >=30%
3) invalid tcm clinical practice symptom, sign are not improved, even aggravating, syndrome integral reduces deficiency >=30%
4) exacerbation tcm clinical practice symptom, sign have exacerbation, and syndrome integral is reduced less than < 0.
Statistical procedures
Using (13.0 editions) the progress data statistic analysis processing of SPSS software, using t check analysis testing result.
Six, test results and analysis
The analysis of 6.1 patient's ordinary circumstances, is shown in Table 2
2 patient's ordinary circumstance analysis ± s of table
Gender (example) | N | Average age (year) | Average course of disease (year) |
Male | 30 | 56.56±3.12 | 7.17±0.42 |
Female | 30 | 51.33±2.81 | 8.63±0.36 |
The improvement situation of 6.2 clinical symptoms, is shown in Table 3
3 patient of table symptom after treating improves situation
Symptom | Integral reduces 80% or more | Integral reduces 50% or more | Integral is reduced | Integral decreases below 30%; | Efficient (%) |
Pectoralgia | 12 | 18 | 12 | 18 | 70.00 |
It is uncomfortable in chest | 12 | 24 | 8 | 16 | 73.33 |
Shortness of breath | 7 | 17 | 16 | 20 | 66.67 |
Palpitaition | 10 | 17 | 12 | 21 | 65.00 |
It is insomnia | 14 | 15 | 16 | 15 | 75.00 |
The variation of 6.3 lipids detection index values, is shown in Table 4.
The variation (± s) of the pretherapy and post-treatment lipids detection index value of table 4
Project | Before treatment | After treatment three months | P value |
TC | 7.60±2.30 | 5.23±1.16 | P<0.05 |
TG | 5.16±2.13 | 2.36±1.12 | P<0.05 |
P value is after treating three months compared with before treatment, and illustrating that drug of the present invention has significantly reduces cholesterol and glycerol
The effect of three esters.
6.4 pretherapy and post-treatment angina pectoris attacks situations compare ± s)
It is 81. 2% that two groups of curative effect to treat angina pectoris, which compare (table 2) treatment group's total effective rate, and control group total effective rate is 43.
3%, treatment group is significant in efficacy to be better than control group (P < 0. 05).
Table 5 (± s)
Group | Before treatment | After treatment three months | P value |
Seizure frequency (times/week) | 18.8±2.3 | 6.9±2.0 | P<0.05 |
Duration (min/ times) | 9.3±1.8 | 3.1±1.3 | P<0.05 |
P value be treatment three months after compared with before treatment, illustrate that drug of the present invention is significantly improved angina pectoris symptom
Effect.
The evaluation situation of curative effect, is shown in Table 6 after 6.5 treatments three months
The evaluation situation of curative effect after table 6 is treated three months
It is basic to cure | It is effective | Effectively | In vain | It is total | Efficient (%) | |
Curative effect | 16 | 15 | 10 | 19 | 60 | 68.33 |
The positive effect of the present invention is: prescription machine method is flexible, the more faithful to Chinese medicine traditional theory of prescription, with clinical practice
Based on, using modern scientific research as foundation, pharmacodynamic substances understand that clinical efficacy is significant, can obtain in two months good
Good curative effect.Capsule formulation is also beneficial to drug absorption, is easy to carry about with one and takes.Compared with similar drugs, in prescription of the present invention
Doctor's theoretical foundation is abundant, and medicinal peace, compatibility is rigorous, and clinical symptoms disappear rapidly, and good treatment can be obtained in three months
Effect.
Specific embodiment
By following embodiment further illustrate description the present invention, do not limit the invention in any way, without departing substantially from
Under the premise of technical solution of the invention, easy to accomplish any of those of ordinary skill in the art made for the present invention changes
Dynamic or change is fallen within scope of the presently claimed invention.
Embodiment 1
Rhizoma corydalis 5g, 5 g of Rhizoma Chuanxiong, 5 g of Radix Curcumae, 5 g of Radix Salviae Miltiorrhizae, 6 g of ginseng, Radix Astragali 5g, 3 g of radix aucklandiae, 6 g of Radix Notoginseng, borneol
0.3 g is total to nine traditional Chinese medicines, and wherein 70% alcohol reflux of rhizoma corydalis, Rhizoma Chuanxiong, Radix Curcumae, ginseng (crushed 20 mesh) plus 6 times of amounts extracts
2 times, 1.5 hours every time, filtration, merging filtrate recycled ethyl alcohol, and being concentrated under reduced pressure into relative density is 1.20~1.25(60 DEG C)
Medicinal extract, it is spare;20 mesh coarse powder of Radix Notoginseng separately is taken, is mixed with above-mentioned medicinal extract, it is common dry (70 DEG C), it is ground into fine powder, it is mixed with borneol
It is even, capsule is packed into get (borneol crushes easily liquefaction, should cover and grind addition).
Embodiment 2
10 g of rhizoma corydalis, Rhizoma Chuanxiong 9g, Radix Curcumae 9g, 10 g of Radix Salviae Miltiorrhizae, 6 g of ginseng, 10 g of Radix Astragali, 5 g of radix aucklandiae, Radix Notoginseng 6g, ice
0.3 g of piece is total to nine traditional Chinese medicines, and wherein 70% alcohol reflux of rhizoma corydalis, Rhizoma Chuanxiong, Radix Curcumae, ginseng (crushed 20 mesh) plus 8 times of amounts mentions
It takes 2 times, 1.5 hours every time, filtration, merging filtrate recycled ethyl alcohol, and being concentrated under reduced pressure into relative density is 1.20~1.25(60 DEG C)
Medicinal extract, it is spare;20 mesh coarse powder of Radix Notoginseng separately is taken, is mixed with above-mentioned medicinal extract, it is common dry (70 DEG C), it is ground into fine powder, with borneol
It mixes, is packed into capsule to get (borneol crushes easily liquefaction, should cover and grind addition).
Embodiment 3
15 g of rhizoma corydalis, 15 g of Rhizoma Chuanxiong, 15 g of Radix Curcumae, 15 g of Radix Salviae Miltiorrhizae, ginseng 15g, Radix Astragali 15g, 10 g of radix aucklandiae, Radix Notoginseng 15
G, 1 g of borneol is total to Six-element Chinese medicine, and wherein 70% ethyl alcohol of rhizoma corydalis, Rhizoma Chuanxiong, Radix Curcumae, ginseng (crushed 20 mesh) plus 10 times of amounts returns
Stream extracts 2 times, and 1.5 hours every time, filtration, merging filtrate recycled ethyl alcohol, and being concentrated under reduced pressure into relative density is 1.20~1.25
The medicinal extract of (60 DEG C), it is spare;20 mesh coarse powder of Radix Notoginseng separately is taken, is mixed with above-mentioned medicinal extract, it is common dry (70 DEG C), it is ground into fine powder,
It is mixed with borneol, is packed into capsule to get (borneol crushes easily liquefaction, should cover and grind addition).
Medical effect of the invention is further proved by following typical case:
Case 1
Lee, male, 57 years old.Recent panesthesia anterior pectorial region pain, it is uncomfortable in chest to be radiated to shoulder, continue 15-20 minutes, takes throughout the year
Alleviated with suxiao jiuxin pills.Posture is partially fat, and 160 centimeters of height, weight previously has hypertension history up to 90 kilograms, takes more
Kind drug takes 1 drug, one course for the treatment of of the embodiment of the present invention without positive effect, and symptom is relieved, and after two courses for the treatment of, the heart is twisted
Pain stops breaking-out.Follow-up 2 years stable always, has not relapsed so far.
Case 2
Sun, male, 56 years old.Patient has coronary disease and angina pectoris 6 years, and in this year, retrosternal pain breaking-out frequently, takes and disappears
Pained, Danshen Root dropping ball unsatisfactory curative effect.After taking 2 drug, two courses for the treatment of of the embodiment of the present invention, subjective symptoms improves, and continues to take medicine
Two courses for the treatment of, symptom completely disappear.Follow-up 2 years stable always, has not relapsed so far.
Case 3
Chen, female, 46 years old, there is precordialgia without obvious inducement in patient's two years ago, and uncomfortable in chest, shortness of breath, breaking-out can be held every time
10-20 minutes continuous, electrocardiogram shows myocardial ischemia.After taking 3 drug, two courses for the treatment of of the embodiment of the present invention, uncomfortable in chest, shortness of breath symptom
Alleviate, ECG examination is normal.Follow-up 2 years stable always, has not relapsed so far.
Claims (1)
1. a kind of compound Chinese medicinal preparation for treating coronary disease and angina pectoris, it is characterised in that be made by ratio of weight and the number of copies of following drug
:
Rhizoma corydalis 5~15, Rhizoma Chuanxiong 5~15, Radix Curcumae 5~15, Radix Salviae Miltiorrhizae 5~15, ginseng 5~15, Radix Astragali 5~15, radix aucklandiae 3~10,
Radix Notoginseng 5~15, borneol 0.1~1;
The preparation method of the compound Chinese medicinal preparation of above-mentioned treatment coronary disease and angina pectoris, comprising the following steps:
Weigh rhizoma corydalis, Rhizoma Chuanxiong, Radix Curcumae, Radix Salviae Miltiorrhizae, ginseng, Radix Astragali, radix aucklandiae, Radix Notoginseng, borneol and be total to nine traditional Chinese medicines, wherein rhizoma corydalis,
Rhizoma Chuanxiong, Radix Curcumae, Radix Salviae Miltiorrhizae, ginseng, Radix Astragali, radix aucklandiae crushed 20 mesh, add 6-10 times of 70% alcohol reflux measured extraction 2 times, every time
1.5 hours, filtration, merging filtrate recycled ethyl alcohol, and the medicinal extract that 60 DEG C are 1.20~1.25 to relative density is concentrated under reduced pressure, spare;
20 mesh coarse powder of Radix Notoginseng separately is taken, is mixed with above-mentioned medicinal extract, 70 DEG C are dried, crushed into fine powder jointly, mix with borneol, it is packed into capsule,
To obtain the final product.
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CN104042797A (en) * | 2014-07-09 | 2014-09-17 | 新疆维吾尔医学专科学校 | Aiweixin oral solution for treating cardiovascular diseases and preparation method thereof |
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CN1872316A (en) * | 2005-06-01 | 2006-12-06 | 天津天士力制药股份有限公司 | Medication of containing astragalus root in application for treating resistant medication of aspirin |
CN104042797A (en) * | 2014-07-09 | 2014-09-17 | 新疆维吾尔医学专科学校 | Aiweixin oral solution for treating cardiovascular diseases and preparation method thereof |
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