CN104147346B - It is a kind of to treat the anginal Chinese medicine compound prescription of coronary artery diffusivity lesion - Google Patents

Abstract

The present invention is a kind of to treat the anginal Chinese medicine compound prescription of coronary artery diffusivity lesion, the raw material including following component, by weight for：15~45g of Radix Astragali, 10~30g of Radix Ophiopogonis, 9~15g of Rhizoma Chuanxiong, 6~9g of leech, 15~30g of Radix Puerariae, 9~18g of Fructus Forsythiae, 9~15g of the coptis, 6~18g of cape jasmine, 6~12g of 9~27g of cassia twig, 9~27g of Radix Paeoniae Alba and Radix Glycyrrhizae；It can also further comprise any one or the combination of several of them in following raw materials according：6~15g of Schisandra chinensis, 6~15g of radix scutellariae, 12~30g of 10~30g of corydalis tuber, 2~6g of Radix Notoginseng powder and Radix Codonopsis.For treating coronary artery diffusivity lesion, can apparent patient's myocardial ischemia and angina pectoris symptom, solve the problems, such as clinical doctor trained in Western medicine at present to this disease cannot row coronary blood flow Reconstruction it is awkward, therapy is simple and easy to do, has no adverse reaction, curative for effect.

Description

It is a kind of to treat the anginal Chinese medicine compound prescription of coronary artery diffusivity lesion

Technical field

The invention belongs to the field of Chinese medicines, it is related to and a kind of treats the anginal Chinese medicine compound prescription of coronary artery diffusivity lesion.

Background technology

Coronary artery diffusivity lesion refer to coronary stenosis length be more than 20mm, be coronary artery pathological changes complicated type it One, patient is present with angina pectoris and heart function declines, percutaneous coronary intervention（PCI）Operating difficulty is big, intraoperative compliaction hair Raw rate is high, its postoperative restenosis rate is high while is also the independent hazard factor of PCI postoperative restenosis.Narrow remote end diffuses venereal disease Become or diameter is meticulous can limit bypass operation of coronary artery（CABG）Grafting vessel and previous anastomotic distal end native blood vessel blood flow afterwards, cause The generation of major adverse cardiovascular events, therefore, some coronary artery blood vessel diffusivity lesion patients for these reasons, can not be preced with into percutaneous Shape arterial intervention（PCI）And coronary artery bypass grafting（CABG）Based on coronary artery revascularization.Studies have reported that：It is mostly height to diffuse patch Endanger patient, and atherosclerosis is extensive, and calcification is apparent, and the death rate is high.Traditional Chinese medicine has in terms of angiocardiopathy is treated and can not replace The effect in generation, Chinese medicine treatment coronary artery diffusivity lesion obtain many achievements in clinical studies.

The content of the invention

The purpose of the present invention：It is diffused mainly for the coronary artery that can not clinically carry out PCI or CABG coronary artery revascularizations Venereal disease becomes patient, and by being inquired into its interpretation of the cause, onset and process of an illness, invention is a kind of to treat the anginal Chinese medicine compound prescription of coronary artery diffusivity lesion, and takes The effect of good was obtained, a kind of new method is provided for the solution of the clinical problem.

Chinese medicine compound prescription technical solution of the present invention is：

It is a kind of to treat the anginal Chinese medicine compound prescription of coronary artery diffusivity lesion, the raw material including following component, by weight for：It is yellow 15~45g of stilbene, 10~30g of Radix Ophiopogonis, 9~15g of Rhizoma Chuanxiong, 6~9g of leech, 15~30g of Radix Puerariae, 9~18g of Fructus Forsythiae, the coptis 9~ 15g, 6~18g of cape jasmine, 6~12g of 9~27g of cassia twig, 9~27g of Radix Paeoniae Alba and Radix Glycyrrhizae.

Wherein, preferably：Radix Astragali 45g, Radix Ophiopogonis 30g, Rhizoma Chuanxiong 15g, leech 6g, Radix Puerariae 15g, Fructus Forsythiae 15g, coptis 9g, Cape jasmine Sub- 9g, cassia twig 12g, Radix Paeoniae Alba 12g and Radix Glycyrrhizae 6g.

Chinese medicine compound prescription of the present invention on the basis of said components, can also further comprise any one in following raw materials according or several Kind combination, by weight for：6~15g of Schisandra chinensis, 6~15g of radix scutellariae, 10~30g of corydalis tuber, 2~6g of Radix Notoginseng powder and Radix Codonopsis 12~ 30g。

Major function：Chinese medicine compound prescription of the present invention has effects that qi and activate blood circulation removing toxic substances, harmonizing yingfen and weifen；For treating coronary artery more Unrestrained venereal disease becomes, and improves and delay coronary stenosis disease progression.The coronary artery diffusivity of primary treatment clinically qi deficiency to blood stasis heat toxin syndrome Lesion and should not row PCI or CABG coronary artery revascularization patient, can allevating angina pectoris symptom, improve patient's myocardial ischemia It state and improves the quality of living.

Usage and dosage：It is decocted in water for oral dose；Warm water impregnates 30-50 minutes, and water is added not have about 1-2 centimetres of a drug, drug decocting 2 times, First decocts after boiling about 30 minutes, and second decocts after boiling about 20 minutes, merges the common 400ml of liquid twice, adds in Radix Notoginseng powder, point It is warmly taken when 1 is small after early, dinner, each 200ml, one dose per day.

The prescription foundation of Chinese medicine compound prescription of the present invention：

Tonifying Qi is the method effected a permanent cure of this disease, promoting blood circulation and removing blood stasis, clearing heat and detoxicating, harmonizing yingfen and weifen treatment worry big method.In coronary disease During sick disease progression, the local inflammatory response of damaged coronary inner membrance is to induce the startup factor of restenosis, and its pathology Phlegm-blood stasis knot blocks in the process, and the stasis of blood is changed heat, accumulate in heat toxin, stagnation of blood stasis and heat long, damages train of thought.

Battalion is defended with middle coke is gone out, and it is similar that qi and blood with battalion defends different name.Battalion belongs to cloudy, nutritious and metaplasia blood function；Category sun is defended, " person that defends gas, so warm boundary between muscles, fills skin, fertile space between skin and muscles, entire person is closed in department." defend gas and there is defence to leak invasion, admittedly take the photograph regulation and control blood, Tianjin The operation of liquid and defeated cloth, skin nutrition space between skin and muscles regulate and control the effect of thermostasis.Heart governing blood and vessels runs qi and blood, dirty with nutrition whole body Internal organs, joint, muscle etc., the function and qi and blood of heart are closely related.Heart runing adjustment qi and blood, nutrition whole body；Qi and blood also nutrition Heart, qi and blood dysfunction cause cardiac function to be damaged, all flourish all damages of the two.With the passing of time worry necessarily causes heart negative and positive of qi and blood to lose Void causes deficient property disease,《Hardly possible warp》Cloud " damages its heart person, its battalion is adjusted to defend ", this is that the treatment of the treatment deficient property disease of heart is big Method.This disease state of an illness is complicated, is in a bad way, it is necessary to treat both principal and secondary aspect of disease, detoxify with qi and activate blood circulation, harmonizing yingfen and weifen therapy treats coronary artery Diffusivity lesion alleviates the progress of coronary stenosis disease.

（One）Prescription analysis：

It is monarch that we, which reuse Radix Astragali,《Book on Chinese herbal medicine is looked for the truth》It says：" Radix Astragali ... for all medicines of tonifying Qi most, to there is the title of over sixty years of age ".This Place has three using Radix Astragali, purpose：First, Radix Astragali work(mends three cokes and can provide and mend congenital vigour, obstruction of qi in the chest patient's middle age vigour is easily lost.Two That Radix Astragali can mend pectoral qi, pectoral qi is air in the heart, " pectoral qi product in the heart, for throat, to pass through heart arteries and veins, and go breathing here.” （《The evil visitor of Ling Shu Miraculous Pivot or Divine Axis》）.Third, Radix Astragali specially leads to battalion Wei Zhiqi, the meaning of " damaging its heart person, its battalion is adjusted to defend " is taken.Furthermore " people crosses 40, Half of YIN QI consumed ", therefore patients with coronary heart disease has the performance of the deficiency of Yin more on the basis of the deficiency of vital energy, it is also related with underlying cause：One merges It quenches one's thirst, then more deficiency of Yin are scorching；The two " yang-energy person, bothers, and opens ", bothers excessively, liver-kidney irritation, and flaring up of heart fire consumes impairment of yin gas； Three merges hepatopyretic vertigo (high blood pressure), long consumption impairment of yin liquid.Therefore on the basis of tonifying Qi, clinical practice also adds in nourishing Yin and promoting production of body fluid Product.Radix Ophiopogonis sweet and slightly bitter taste enters the heart, lung two passes through, sweet Han Zhirun, nourishing heart the moon, relieving restlessness of promoting the production of body fluid tranquilizing the mind, for ministerial drug.

Also product promoting blood circulation and removing blood stasis are mostly used in side, Rhizoma Chuanxiong has the title of " gas medicine in blood ", blood-activating and qi-promoting, analgesic, row the whole body vim and vigour； The in love product of leech flesh and blood, promoting blood circulation and removing obstruction in channels, Zhu Yu Xiao Disorder；Appropriate Radix Puerariae, heat-clearing except it is dry, promote the production of body fluid to quench thirst；Corydalis tuber blood-activating and qi-promoting Analgesic；Radix Notoginseng powder is taken after mixing it with water, can stagnation resolvation promoting blood circulation analgesic therapy, there is stagnation resolvation not hinder strong point just.Many blood-activating drugs and the Radix Astragali compatibility of QI invigorating There are two big benefits：First, the stasis of blood is dispelled, blood work hinders healthy tendency without consuming；Second is that gas blood work certainly enough.Therefore " gas leads to without stagnant, blood work without The stasis of blood, gas lead to blood work, what, which is suffered from the disease, does not remove ".

Fructus Forsythiae, the coptis, cape jasmine are clearing heat and detoxicating, also to for minister.Fructus Forsythiae bitter is cold in nature, it is main enter the heart channel of Hang-Shaoyin, can removing summer-heat internal heat, Again can removing summer-heat it is hot and suffocating.The coptis have let out the work(of monarch fire clearly, cape jasmine has the clear fire for rushing down three cokes, the school of heat conduction downlink, such compatibility application There is the meaning of " huanglian jiedu decoction " in fact, bitter cold is directly rolled over, clearing heat and detoxicating.

Ministerial drug cassia twig, Radix Paeoniae Alba purpose abide by osmanthus, Chinese herbaceous peony in purport Guizhi decoction, and cassia twig is pungent sweet, warm-natured, can help heart-yang, promoting blood circulation；Radix Paeoniae Alba It is sour, there is the work(that the moon is held back in blood-nourishing, used together with cassia twig, monoyang and monoyin, amount to the work(of harmonizing yingfen and weifen.Radix Glycyrrhizae coordinating the drug actions of a prescription makes for assistant, And Radix Glycyrrhizae and cassia twig acridness and sweetness activating yang, Radix Glycyrrhizae Radix Paeoniae Alba sour-sweet herbs nourishing yin, help osmanthus spoon harmonizing yingfen and weifen.

The plus-minus application of Chinese medicine compound prescription of the present invention：The plus-minus application of Chinese medicine is Chinese medicine compound prescription energy Mutiple Targets regulation and control body The practical application basis of pathophysiological process, extends the popularity of compound of Chinese herbal medicine disease and the property taken into account, also adds The flexibility of compound of Chinese herbal medicine disease.

Optional material composition pharmacological research in prescription

Schisandra chinensis：Schisanhenol has protective effect to isolated rat heart, can protect cardiac structure and function, reduces Myocardial oxygen consumption extends the holding time for body-centered.Schisandra chinensis lignanoid can inhibit neutrophil infiltration, and it is anti-to reduce inflammatory Should, so as to mitigate myocardial damage.There is expansion coronary artery and increase coronary flow effect, so as to allevating angina pectoris symptom.

Radix scutellariae：Scutelloside can significantly reduce the malondialdehyde (MDA) of ischemia-reperfusion injury model rat heart muscle Content, raise tissue in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity, carry Show that scutelloside has the cardiac muscle of reperfusion injury protective effect, mechanism may be anti-with lipid peroxidation caused by antioxidant radical It should be related.Intracellular Calcium overload is both damage as a result, and causing cell during another aspect ischemical reperfusion injury The major reason further damaged.It is found in the research of glioma rat model, scutelloside can be substantially reduced by going first High-calcium ionic concentration level in the neuroglial cytoma of adrenaline (NE) induction, and there are effect doses for the power acted on Relation.Further research also found, the drop calcium mechanism of scutelloside may be related with reducing the activity of cell membrane phospholipid enzyme C.Right During rat myocardial ischemia and reperfusion, scutelloside can protect Ischemia Reperfusion by inhibiting cardiac muscle cell apoptosis and inflammatory cell infiltration Note cardiac muscle.

Corydalis tuber：1. function of resisting myocardial ischemia：The treating myocardial ischemia damage of Induced By Isoprenaline causes lipid with oxygen radical Peroxidating is related with cytosolic free calcium concentration in cardiomyocyte excess load.Tetrahydropalmatine has stronger inhibition of lipid peroxidation, there is Ca²⁺Antagonism Effect.Also play the role of viewpoint think corydalis tuber resist myocardial ischemia damage with its contained by tetrahydropalmatine, dehydrocorydaline, the coptis Element is related to the direct protective action of cardiac muscle cell with palmatine, and not by anti-oxidative damage mechanism.2. anti thrombotic action： Tetrahydropalmatine levo form（(-)-THP）There is apparent inhibitory action to Rat Experimental cerebral thrombosis, (-)-THP can inhibit ADP, arachidonic acid and collagen-induced platelet aggregation.In addition, (-)-THP can significantly reduce red blood cell, blood plasma and whole blood Specific viscosity, hence it is evident that inhibit rats in vitro thrombosis and platelet adhesion reaction, reduce the rat suppository death rate caused by ADP.3. Improving micro_circulation effect：(-)-THP can reduce erythrocyte aggregation, improve the deformability of red blood cell, so that blood is interior Frictional force is reduced, and blood viscosity declines, and red blood cell passes through capillary, keeps normal microcirculatory perfusion.Xing Shuhua etc. Anesthetized dog is injected intravenously with (-)-THP10 mg/kg, as a result observes that dog coronary blood flow increases in 10min after being injected intravenously, It may be the complex effect to α 1 and alpha-2 receptor retardation that (-)-THP, which improves coronary blood flow effect,.

Radix Notoginseng powder：Radix Notoginseng powder active ingredient Ginsenoside Rg1, can be with the formation of Inhibition test thrombus and thrombin induction Platelet aggregation, the mechanism of action may with reduce blood platelet Ca2+i it is related.Arasaponin can also raise blood plasma egg White C activity, and PROTEIN C is a kind of cellulose dependence protein matter synthesized by liver, after being activated in human body, is had anti- Solidifying activity and rush fibrinolytic, therefore notoginsenoside has apparent anti-freezing, inhibits platelet aggregation, promotes fibrinolysis Effect, so as to play inhibitory action to patch formation in coronary artery.Ginsenoside Rg1 can promote blood vessel by Fibrinolytic System Endothelial cell discharge NO and play antithrombotic effect, NO have the function of expand blood vessel, can Green Tea Extract damage, mitigation endothelium it is thin Fibrinolytic caused by cellular damage is disorderly.NO also has antiplatelet adhesion and aggregation function simultaneously, this is the adherency of blood vessel endothelium antiplatelet The main reason for.

Radix Codonopsis：Reduce presphygmic period（PEPI）Left room ejection time（LVET）Ratio enhances left heart function, inhibits blood platelet Adherency and aggregation；Inhibit synthesis of the thromboxane B2 synthesis without influencing 6-Keto-PGF1a.Prompting this product is comparatively ideal prevention The Chinese medicine of coronary heart disease has certain effect for anginal treatment.

A kind of anginal Chinese medicine compound prescription of coronary artery diffusivity lesion for the treatment of provided by the invention has the beneficial effect that：

1）Solve the problems, such as clinical doctor trained in Western medicine at present to this disease cannot row coronary blood flow Reconstruction it is awkward, solve and be determined for patient Angina disease, therapy is simple and easy to do, has no adverse reaction, curative for effect, and unique diagnosis and treatment system makes treatment means Implementation more individuation；

2）Coronary artery diffusivity lesion is treated, angina pectoris symptom and tcm symptom can be obviously improved, improve cardiac ejection Fraction and electrocardiogram；

3）Improve coronary artery diffusivity lesion patient's myocardial ischemia, improve its heart function and quality of life.

Specific embodiment

Below by clinical testing data and specific embodiment, to further illustrate the present invention the beneficial effect of Chinese medicine compound prescription Fruit.

Clinical test

First, diagnostic criteria

Western medicine diagnostic criteria is with reference to International Society of Cardiology and association and World Health Organization's clinical name standardization joint Special topic group is reported《The name of ischemic heart disease and diagnostic criteria》The coronary disease and angina pectoris diagnostic criteria and coronary artery of formulation CT angiographic results show that coronary artery diffusivity is narrow, are controlled with hypertension, glycosuria patient by drug in normal range (NR). Syndrome Differentiation of Traditional Chinese Medicine standard reference《New Chinese medicine guideline of clinical investigations》The middle obstruction of qi in the chest (coronary disease and angina pectoris) standard, country Department of Medical Administration of State Administration of Traditional Chinese Medicines obstruction of qi in the chest acute disease cooperative groups on《Chest impediment and cardialgia（Coronary disease and angina pectoris）Acute disease diagnosis and treatment specification》It is and complete State's higher institutions of Chinese medicine programming textbook《Chinese Internal Medicine》And the qi deficiency to blood stasis that clinical experience is formulated, heat toxin hinder network Syndrome Diagnostic Standard, main symptom：Pectoralgia, uncomfortable in chest, palpitaition, shortness of breath.Minor symptom：Lassitude and weak, dry, bitter taste, dysphoria in chestpalms-soles, constipation.Tongue vein：Tongue is purple It is dark or dark red, thick,yellow and greasy fur, wiry and rolling pulse or sliding number.Possess primary symptom 2, minor symptom 3, with reference to tongue vein.

2nd, case selection and grouping

Meet above-mentioned coronary disease and angina pectoris diagnostic criteria and coronary artery CT angiographic results show coronary artery diffusivity it is narrow and Syndrome Differentiation of Traditional Chinese Medicine standard person；Age 18-75 Sui；Voluntarily receive the patient of clinical observation and sign informed consent form.

Exclusion criteria：Pectoralgia person caused by excluding acute myocardial infarction and other heart diseases, non-cardiac disease, It excludes to merge severe hypertension, severe cardiopulmonary insufficiency, severe arrhythmia cordis.

60 are to meet 2 months in October, 2013 in 2012 to include mark in Hospital Attached to Shandong Chinese Medical Univ.'s Cardiological Accurate patient.Control group and treatment group are divided into using random digits table.Control group 30, wherein male 16, women 14, Average age (61.67 ± 6.56) year, the course of disease（7.50±6.36）Year；Treatment group 30, wherein male 15, women 15, Average age（64.00±9.57）Year, the course of disease（8.25±6.71）Year.Two groups of Genders, average age, average course of disease, hearts Angina Syndrome Scale, coronary artery pathological changes situation etc. compare, no significant difference (P ＞ 0.05).

12 groups of angina pectoris Syndrome Scale distribution situations of table compare

22 groups of patient's coronary artery pathological changes situations of table compare

32 groups of patient's diffusivity lesion vessels distribution situations of table compare

3rd, therapy

Two groups are given diet control, ACEI or ARB, beta-blocker, statins, low molecular weight heparin, low dose The treatments such as enteric coated aspirin, nitric acid lipid drug.

Control group adds Tongxinluo medicinal capsule on basis of conventional therapy（Shijiazhuang Yi Ling medicine companies pharmaceutcal corporation, Ltd, traditional Chinese medicines are accurate Word Z19980015）, 4, Tid, PO；

Treatment group states the Chinese medicine compound prescription of the present invention for being formulated one in suitable for reading take of basis of conventional therapy, is decocted in water for oral dose, 2 times a day, Each 200ml.Nitroglycerin can be given during angina pectoris attacks（Beijing Yimin Pharmaceutical Co., Ltd. produces Chinese medicines quasi-word H11021022）, every 0.5mg, sublingual administration.

Formula one：Radix Astragali 45g, Radix Ophiopogonis 30g, Rhizoma Chuanxiong 15g, leech 6g, Radix Puerariae 15g, Fructus Forsythiae 15g, coptis 9g, cape jasmine 9g, cassia twig 12g, Radix Paeoniae Alba 12g and Radix Glycyrrhizae 6g.

Two groups of courses for the treatment of are 4 weeks, and during the patient for participating in research treats observation, two groups of cases must not add other treatment again Western medicine, the Chinese patent drug of coronary disease and angina pectoris.Blood, urine, hepatic and renal function are detected before and after treatment and record adverse events.

4th, research contents and method

（1）Observation index and method

Observe the primary symptoms such as two groups of pretherapy and post-treatment pectoralgias, uncomfortable in chest, palpitaition, shortness of breath and lassitude and weak, dry, bitter taste, five vexed The variation of the minor symptoms such as heat, constipation, primary symptom by it is light, in, again respectively based on 2,4,6 points, minor symptom by it is light, in, again respectively based on 1,2,3 point, Tongue vein according to without, have respectively count 0,1 point.The variations such as Ecg ST-T variations and arrhythmia cordis, conventional cardiac ultrasonic measurement Diastasis left ventricular internal diameter, end-systole Left atrial size, Siopsons methods measurement left ventricular ejection fraction（LVEF）.

（2）Efficacy assessment standard：1. angina pectoris symptom curative effect determinate standard, ECG curative effect criterion and tcm syndrome Curative effect determinate standard：It is write with reference to National Drug Administration's tissue in 2002《New Chinese medicine clinical research guidance is former Then》；2. Chinese medicine syndrome integral reference《New Chinese medicine guideline of clinical investigations》And make suitably modified, primary symptom：Pectoralgia, it is uncomfortable in chest, Palpitaition, shortness of breath；Minor symptom：By lassitude and weak, dry, bitter taste, dysphoria in chestpalms-soles, constipation.

（3）Statistical method

Data carry out statistical procedures, measurement data mean ± standard deviation using SPSS18.0 softwares

（x±s）

It represents, is examined using t, enumeration data uses x²It examines, P ＜ 0.05 are statistically significant for difference.

5th, efficacy analysis

（1）The pretherapy and post-treatment angina pectoris symptom curative effect of two groups of patients compares：Effective 22 for the treatment of group（73.3%）, effective 8 （26.7%）, invalid 0, total effective rate 100%；Effective 10 of control group（33.3%）, effective 18（60%）, invalid 2 （6.7%）, total effective rate 93.3%；Through ridit analytical controls, two groups of angina pectoris symptom curative effect comparing differences are statistically significant（P ＜ 0.05）, treatment group is better than control group.

（2）The comparison of two groups of pretherapy and post-treatment ECG curative effects：Effective 11 for the treatment of group（36.7%）, effective 15（50%）, Invalid 4（13.3%）, total effective rate 86.7%；Effective 5 of control group（16.7%）, effective 7（23.3%）, invalid 18 （60%）, total effective rate 40%；Through ridit analytical controls, two groups of ECG curative effect comparing differences are statistically significant（P＜ 0.05）, treatment group is better than control group.

（3）The comparison of two groups of pretherapy and post-treatment tcm syndrome comprehensive therapeutic effects：Effective 28 for the treatment of group（93.3%）, effective 2 （6.7%）, total effective rate 100%；Control group effective 0, effective 30（100%）, total effective rate 100%, through ridit analysis inspections It tests, two groups of tcm syndrome comprehensive therapeutic effect comparing differences are statistically significant（P ＜ 0.01）, treatment group is better than control group.

（4）Two groups of pretherapy and post-treatment LVEF and Chinese medicine syndrome integral compare：Left Ventricular Ejection Fraction increases after two groups of treatments, with Comparing difference is statistically significant before treatment（* P ＜ 0.05）；Treatment group's ejection fraction is poor apparently higher than control group after treatment It is different statistically significant（Δ P ＜ 0.05）.Two groups of Chinese medicine syndrome integrals decline after treatment, have system with comparing difference before treatment Meter learns meaning（* P ＜ 0.05）；Treatment group's Chinese medicine syndrome integral is significantly lower than treatment group's group after treatment, and two groups of comparing differences have system Meter learns meaning（Δ P ＜ 0.05）.

4 two groups of pretherapy and post-treatment LVEF of table and Chinese medicine syndrome integral compare

Note：With this group before treatment, * P<0.05；Compared with after control group treatment, Δ P<0.O5.

（5）Two groups of adverse reactions are compared

Adverse reaction is not found in two groups of patient treatment procedures.It is pretherapy and post-treatment two groups of patient's hepatic and renal functions, blood, urine, big Just it is conventional no abnormal.

The conditions of patients complicated and severe of coronary artery diffusivity lesion, coronary intervention or anesthesia about coronary artery bypass grafting difficulty are big, Poor prognosis.By above-mentioned statistics as it can be seen that Chinese medicine compound prescription of the present invention can improve coronary artery more by qi and activate blood circulation method of dissipating heat and detoxifying Unrestrained venereal disease becomes patient's myocardial ischemia, improves its heart function and quality of life.

It chooses model case below and Chinese medicine compound prescription of the present invention is specifically described in optimization formula.

Embodiment 1

It is high certain, man, 56 years old, because of pectoralgia, uncomfortable in chest in local hospital hospitalization, row coronary artery CT showed Coronary Artery in patients within 2010 Diffusivity calcification, the main branch diffusivity of 3 coronary arterys are narrow.Coronary heart disease is diagnosed as, internal medicine conservative treatment gives antiplatelet, expansion hat Arteries and veins blood vessel adjusts the symptomatic treatments such as blood fat, leaves hospital after improvement.Patient's the past hypertension 8 years, blood pressure 160/90mmHg does not give weight Depending on.Patient is interrupted oral Betaloc sustained release tablets control heart rate usually, reduces myocardial oxygen consumption, the depressor such as benazepril, Valsartan Blood pressure is controlled, aspirin antiplatelet to fit adjustable blood fat, delays artery plaque to be in progress.

September is examined for 4 days one within 2012：There is pectoralgia, uncomfortable in chest, shortness of breath because of fatigue recently in patient, and tired postemphasis, breaking-out is earlier above Frequently, pain is more violent, takes nitroglycerin weak curative effect, with malaise, has palpitation, dizzy, occasionally there is abdominal distension, and dormancy of receiving is poor, no It easily falls asleep, because waking up with a start, purplish tongue tongue fur is yellow thick, wiry and rolling pulse number.Auxiliary examination：Coronary artery CT shows that coronary artery diffusivity lesion diffuses Property calcification, 3 coronary stenosis are serious, the narrow ＞ 75% of narrowest position descending anterior branch.Tcm diagnosis：The obstruction of qi in the chest（Deficiency of both qi and yin, stagnant heat are mutual Knot）Doctor trained in Western medicine diagnoses：1. 2. hypertension of coronary heart disease（2 grades, high danger）.

With promoting blood circulation and removing blood stasis in treatment, clearing heat and detoxicating, harmonizing yingfen and weifen is principle, takes two Chinese medicine compound prescription of inventive formulation.

Formula two：Radix Astragali 30g, Radix Ophiopogonis 15g, Rhizoma Chuanxiong 15g, leech 6g, Radix Puerariae 30g, Fructus Forsythiae 12g, coptis 12g, cape jasmine 12g, 12 g of cassia twig, 12 g of Radix Paeoniae Alba, Schisandra chinensis 9g, 12 g of radix scutellariae, corydalis tuber 30g, Radix Notoginseng powder 3g and Radix Glycyrrhizae 9g.

It is decocted in water for oral dose, one dose per day, a point morning and evening warmly takes twice, takes 7 days.

September is examined for 11 days two within 2012：Patient's readme pectoralgia, alleviation uncomfortable in chest, pain degree decline, break out 2 times during medication, Each left and right for 20 seconds, rest can be alleviated.The symptoms such as shortness of breath, weak, dizzy also mitigate, and dormancy of receiving improves, two times can, tongue nature is purple Dark tongue fur is yellow, deep wiry pulse.Continue to take three Chinese medicine compound prescription of inventive formulation.

Formula three：Radix Astragali 45g, Radix Ophiopogonis 15g, Rhizoma Chuanxiong 15g, leech 6g, Radix Puerariae 30g, Fructus Forsythiae 12g, coptis 12g, cape jasmine 9g, cassia twig 15g, 15 g of Radix Paeoniae Alba, Schisandra chinensis 9g, 9 g of radix scutellariae, corydalis tuber 30g, Radix Notoginseng powder 3g, Radix Codonopsis 12g and Radix Glycyrrhizae 9g.

It is decocted in water for oral dose, one dose per day, a point morning and evening warmly takes twice, takes 7 days.

September is examined for 18 days three within 2012：Patient's readme pectoralgia is relieved, and angina pectoris, chest are not caused under general physical exertion Bored, shortness of breath, weak symptom are clearly better, receive dormancy can, two times tune, the dark tongue of tongue is thin, veins string.Continue to take four Chinese medicine of inventive formulation Compound.

Formula four：Radix Astragali 30g, Radix Ophiopogonis 15g, Rhizoma Chuanxiong 15g, leech 6g, Radix Puerariae 30g, Fructus Forsythiae 12g, coptis 12g, cape jasmine 9g, cassia twig 15g, 15 g of Radix Paeoniae Alba, Schisandra chinensis 6g, corydalis tuber 30g, Radix Notoginseng powder 3g, Radix Codonopsis 12g and Radix Glycyrrhizae 9g.

It is decocted in water for oral dose, one dose per day, a point morning and evening warmly takes twice, and following the service 14 days consolidates curative effect.Effect of follow-up visit by telephone after half a month, situation Well.

Embodiment 2

Zhang, female, 62 years old, 2006 because pectoralgia, it is uncomfortable in chest in local hospital treat, be diagnosed as coronary heart disease, row coronary artery CT shows, Coronary artery diffusivity calcification, diffusivity is narrow, LM stenosis ＞ 50%.Patient's hypertension history 10 years, maximal blood pressure 180/ 100mmHg, diabetes 3 years.Patient takes orally Betaloc control heart rate, nifedipine, Valsartan control blood pressure, melbine tune usually Section blood glucose, aspirin platelet aggregation-against, Morbidity control are fine.

September is examined for 27 days one within 2012

There is uncomfortable in chest, pectoralgia without apparent inducement recently in patient, and when rest also may occur in which, dizzy with shortness of breath, weak, even There is cough, abdominal distension, appetite is fine, sleeps few, easily wakes up with a start, and small, stool is partially dry, the purple dark thin Huang of tongue fur, wiry and frequent pulse.Auxiliary inspection It looks into：Coronary artery CT shows that coronary artery diffusivity calcified plaque, coronary artery diffusivity is narrow, most narrow place ＞ 70%.Tcm diagnosis：The obstruction of qi in the chest（Gas Yin bivacuity, stagnation of blood stasis and heat）Doctor trained in Western medicine diagnoses：1. 2. hypertension of coronary heart disease（3 grades, high danger）3. diabetes.

With promoting blood circulation and removing blood stasis in treatment, clearing heat and detoxicating, harmonizing yingfen and weifen is therapy, takes five Chinese medicine compound prescription of inventive formulation.

Formula five：Radix Astragali 30g, Radix Ophiopogonis 15g, Rhizoma Chuanxiong 15g, leech 6g, Radix Puerariae 30g, Fructus Forsythiae 12g, coptis 12g, cape jasmine 12g, 12 g of cassia twig, 12 g of Radix Paeoniae Alba, Schisandra chinensis 9g, 12 g of radix scutellariae, corydalis tuber 30g, Radix Notoginseng powder 3g, Radix Codonopsis 12g and Radix Glycyrrhizae 9g.

It is decocted in water for oral dose, one dose per day, a point morning and evening warmly takes twice, takes 7 days.

4 days two October in 2012 examines

Patient's readme is uncomfortable in chest, pectoralgia remission, and sharp ache degree and attack times are reduced, and has palpitation, is shortness of breath, weak Symptom is obviously improved, receive dormancy can, two times can, purplish tongue thin lingual fur is yellow, veins string.Continue to take six Chinese medicine of inventive formulation and answer Side.

Formula six：Radix Astragali 30g, Radix Ophiopogonis 15g, Rhizoma Chuanxiong 15g, leech 6g, Radix Puerariae 30g, Fructus Forsythiae 12g, coptis 12g, cape jasmine 6g, 15 g of cassia twig, Radix Paeoniae Alba 15g, Schisandra chinensis 9g, 12 g of radix scutellariae, corydalis tuber 30g, Radix Notoginseng powder 3g, Radix Codonopsis 12g and Radix Glycyrrhizae 9g.

It is decocted in water for oral dose, one dose per day, a point morning and evening warmly takes twice, takes 7 days.

11 days three October in 2012 examines

Patient's readme occasionally has uncomfortable in chest, pectoralgia symptom, and angina pectoris is not caused under general activity, and angina pectoris attacks number substantially subtracts Less and pain degree declines, and has palpitation, and shortness of breath symptom is obviously improved, no dizzy, headache, receive dormancy can, two times tune, the dark tongue of tongue fur is thin In vain, veins string.Continue to take seven Chinese medicine compound prescription of inventive formulation.

Formula seven：Radix Astragali 30g, Radix Ophiopogonis 15g, Rhizoma Chuanxiong 15g, leech 6g, Radix Puerariae 30g, Fructus Forsythiae 12g, coptis 12g, cape jasmine 6g, 15 g of cassia twig, Radix Paeoniae Alba 15g, Schisandra chinensis 9g, 12 g of radix scutellariae, corydalis tuber 30g, Radix Notoginseng powder 3g and Radix Glycyrrhizae 9g.

It is decocted in water for oral dose, one dose per day, a point morning and evening warmly takes twice, and following the service 14 days consolidates curative effect.

Effect of follow-up visit by telephone after half a month, patient's readme state of an illness recover good, satisfactory effect.

More than 2 cases, show that Chinese medicine compound prescription of the present invention can be obviously improved coronary artery diffusivity lesion patient's myocardial ischemia shape State improves its heart function and quality of life.

Claims (6)

1. a kind of treat the anginal Chinese medicine of coronary artery diffusivity lesion, which is characterized in that is made of, presses the bulk pharmaceutical chemicals of following component Weight is：15~45g of Radix Astragali, 10~30g of Radix Ophiopogonis, 9~15g of Rhizoma Chuanxiong, 6~9g of leech, 15~30g of Radix Puerariae, 9~18g of Fructus Forsythiae, 9~15g of the coptis, 6~18g of cape jasmine, 6~12g of 9~27g of cassia twig, 9~27g of Radix Paeoniae Alba and Radix Glycyrrhizae.

2. Chinese medicine according to claim 1, which is characterized in that be made of the bulk pharmaceutical chemicals of following component, by weight for：Radix Astragali 45g, Radix Ophiopogonis 30g, Rhizoma Chuanxiong 15g, leech 6g, Radix Puerariae 15g, Fructus Forsythiae 15g, coptis 9g, cape jasmine 9g, cassia twig 12g, Radix Paeoniae Alba 12g and Radix Glycyrrhizae 6g.

3. a kind of treat the anginal Chinese medicine of coronary artery diffusivity lesion, which is characterized in that is formed in bulk pharmaceutical chemicals described in claim 1 On the basis of, further increase following raw material medicaments, by weight for：6~15g of Schisandra chinensis, 6~15g of radix scutellariae, 10~30g of corydalis tuber, Radix Notoginseng 12~30g of 2~6g of powder and Radix Codonopsis.

4. Chinese medicine according to claim 3, which is characterized in that be made of the bulk pharmaceutical chemicals of following component, by weight for：Radix Astragali 45g, Radix Ophiopogonis 15g, Rhizoma Chuanxiong 15g, leech 6g, Radix Puerariae 30g, Fructus Forsythiae 12g, coptis 12g, cape jasmine 9g, cassia twig 15g, 15 g of Radix Paeoniae Alba, Schisandra chinensis 9g, 9 g of radix scutellariae, corydalis tuber 30g, Radix Notoginseng powder 3g, Radix Codonopsis 12g and Radix Glycyrrhizae 9g.

5. Chinese medicine according to claim 3, which is characterized in that be made of the bulk pharmaceutical chemicals of following component, by weight for：Radix Astragali 30g, Radix Ophiopogonis 15g, Rhizoma Chuanxiong 15g, leech 6g, Radix Puerariae 30g, Fructus Forsythiae 12g, coptis 12g, cape jasmine 12g, 12 g of cassia twig, Radix Paeoniae Alba 12 G, Schisandra chinensis 9g, 12 g of radix scutellariae, corydalis tuber 30g, Radix Notoginseng powder 3g, Radix Codonopsis 12g and Radix Glycyrrhizae 9g.

6. Chinese medicine according to claim 3, which is characterized in that be made of the bulk pharmaceutical chemicals of following component, by weight for：Radix Astragali 30g, Radix Ophiopogonis 15g, Rhizoma Chuanxiong 15g, leech 6g, Radix Puerariae 30g, Fructus Forsythiae 12g, coptis 12g, cape jasmine 6g, 15 g of cassia twig, Radix Paeoniae Alba 15g, Schisandra chinensis 9g, 12 g of radix scutellariae, corydalis tuber 30g, Radix Notoginseng powder 3g, Radix Codonopsis 12g and Radix Glycyrrhizae 9g.