CN1432380A - Bone setting pills for promoting fracture healing and its prepn process - Google Patents
Bone setting pills for promoting fracture healing and its prepn process Download PDFInfo
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- CN1432380A CN1432380A CN 02109040 CN02109040A CN1432380A CN 1432380 A CN1432380 A CN 1432380A CN 02109040 CN02109040 CN 02109040 CN 02109040 A CN02109040 A CN 02109040A CN 1432380 A CN1432380 A CN 1432380A
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Abstract
The bone setting pills for promoting fracture healing is prepared with drynaria rhizome, myrrh, astragalus root, Dangshen, pilose antler, angelica, ground beetle and safflower as material. It can promote the healing of fracture and has the features of obvious treating effect, quick swelling eliminating and pain relieving effect, forming well osteotylus, low cost, etc.
Description
One, affiliated technical field
The present invention relates to a kind of bone setting pills that promotes union of fracture, is the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.
Two, technical background
Clinical treatment union of fracture at present has traditional external splint, interior steel plate of employing to fix or modes such as planter cast, traction, takes the bone-setting medicament partner treatment again; Interior steel plate fixing means is because conduction stress by fixed position, stimulates the osteohalsiteresis physiological stress, exists indolence, rehabilitation duration length, osteoporosis, easy problem such as generation fracture once more; As adopt surgery synthetism operation easily to bring very big misery and operation sequela to the patient.
Three, summary of the invention
The purpose of this invention is to provide the bone setting pills that a kind of short treating period, curative effect significantly promote union of fracture.
Another object of the present invention provides the preparation method of the bone setting pills medicine that promotes union of fracture.
Solution of the present invention is based on pathogeny understanding and the Therapeutic Principle of motherland's medical science to bone fracture disease, achieve with reference to modern pharmacological research, from motherland's medicine treasure-house, filter out the kidney tonifying essence, fill blood, the natural edible-plant medicine of reducing swelling and alleviating pain, benefit bone tissue regeneration promoting, by the theory of Chinese medical science prescription, skim the cream off milk, make it give play to the promotion inostosis, improve local microcirculation, regulate calcium balance in the animal body, thereby reach the purpose that promotes union of fracture, rapid healing.
Medicine of the present invention is made up of following flavour of a drug: (consumption is a weight portion)
Cornu Cervi Pantotrichum 2～6 Radix Angelicae Sinensis 16～32 Radixs Astragali 25～45 Radix Codonopsis 15～20
Eupolyphage sece steleophaga 11～15 Flos Carthamis 10～15 Myrrhas 5～15 Rhizoma Drynariae 15～20
Formula optimization weight (part) ratio range of preparation medicine of the present invention is:
Cornu Cervi Pantotrichum 3～5 Radix Angelicae Sinensis 20～30 Radixs Astragali 30～40 Radix Codonopsis 16～19
Eupolyphage sece steleophaga 12～14 Flos Carthamis 11～14 Myrrhas 6～12 Rhizoma Drynariae 16～19
The optimum weight of medicine of the present invention (part) proportioning is:
Cornu Cervi Pantotrichum 3 Radix Angelicae Sinensis 20 Radixs Astragali 32 Radix Codonopsis 16
Eupolyphage sece steleophaga 12 Flos Carthamis 11 Myrrhas 9 Rhizoma Drynariae 17
Radix Angelicae Sinensis contains vitamin B in above-mentioned each composition
12And folic acid class material, the effect of anti-pernicious anemia is arranged, the liver protecting prevents liver glycogen minimizing, analgesia, calm, vitamin antagonist E shortage; Promote local blood circulation.The Flos Carthami low dose has slight excitation to heart; Cornu Cervi Pantotrichum contains calcium phosphate, colloid albumen, energy physical strength reinforcing, improving appetite and sleep, promotes the new life of cell protein, skein cell; Promote trauma fracture and ulcer healing.Radix Codonopsis contains protein, vitamin B
1B
2, sucrose, alkaloid etc. have excitation to nervous system, can strengthen the phagocytic function of reticuloendothelial system, improve the resistance against diseases of body, the expansion peripheral vessels, suppress the adrenal gland and have tangible hypotensive effect.The Radix Astragali contains saccharide, choline, folic acid and several amino acids, and stimulating central nervous system is arranged, and strengthens the phagocytic function of reticuloendothelial system, and disease resistance enhancemen has the heart tonifying blood vessel dilating, an effect of bringing high blood pressure down, and multiple pathogenic bacterias such as staphylococcus are had inhibitory action.
Above-mentioned each component is made medicine production method of the present invention is:
1, raw material is prepared according to the above ratio, crushed after being dried is to fine powder;
2, cross 100 mesh sieve, add proper honey then and mix stirring, send into the pellet processing machine pill;
3,, put shady and cool dry place with 60 ℃ of dry for standby of water-honeyed pill of making.
An important feature of the present invention is by promoting the growth of fracture site blood capillary, improve blood circulation, promotion bone trabecula hypertrophy and the callus formation of fracture, improve calcium balance in the animal body, the absorption of regulating calcium and storage such as stay at approach, shortening healing time; Can reduce whole blood viscosity and plasma viscosity simultaneously, improve blood supply promotion blood capillary proliferation, blood vessel is grown into, improve the macrophage phagocytic ability, absorb downright bad sclerotin, thereby be beneficial to sclerotin reparation and regeneration.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, selecting the natural edible-plant medicine for use is raw material, and each component meets the regulation of pharmaceutical control law.Utilize the comprehensive function of the Chinese medicine of respectively distinguishing the flavor of to promote the fracture healing and human body is had no side effect.
2, the present invention need not decoct, and no bitterness sense, nutritious, taking convenience meet the regulation of national drug health legislation.
3, heavy, light patient is all suitable, and therapeutic effect is obvious.Medical expense is low, short treating period, patient's no pain, is easy to promote.
The present invention reaches Orthopaedics Clinic from being in hospital and selects 180 cases to carry out system's clinical observation, set up the paired observation group at random, treatment group " bone setting pills " group (A) 100 examples, contrast groups " powder for fracture and trauma " is organized (B) 80 examples and is carried out paired observations such as the clinical symptoms in 1-6 week, sign, X-ray film variation.Wherein clavicular fracture 25 examples, humeral fracture 28 examples, forearm fracture 26 examples, lumbar vertebra fracture 25 examples, fracture of femoral neck 24 examples, fracture of shaft of femur 25 examples, fracture of tibia and fibula 27 examples, basic condition sees Table 1.The group n men and women age course of disease (year) A organizes 100 53 47 54.1 ± 10.06 2.83 ± 4.41B and organizes 80 52 28 54.3 ± 11.3 2.72 ± 3.12P value＞0.05＞0.05＞0.05
The clinical physical data of table 1 relatively
Above-mentioned 180 routine patients are implemented Drug therapy of the present invention, instructions of taking: 10 grams/time, day three warm yellow wine of clothes are taken after mixing it with water, diet Chinese liquor and congee with mung beans, and two weeks were a course of treatment, totally 3 courses of treatment; After the patient takes this medicine, carry out the X line and take the photograph the sheet inspection, the results are shown in Table 2.
(1) clinical healing: clinical symptoms, sign disappear, the X ray examination recovers normal.
(2) produce effects: clinical symptoms, sign obviously alleviate
The X line is taken the photograph sheet callus formation index 80%.
(3) effective: clinical symptoms, sign alleviate
The X line is taken the photograph sheet callus formation index 40%-60%.
(4) invalid: symptom, sign and X line are taken the photograph the sheet index after 6 weeks of treatment is not had the improver.All numbers are made fine distinctions between routine number efficacy evaluation result
Recovery from illness example (%) produce effects example (%) effectively example (%) invalid example (%) 2 treatments organizes 100 25 (25.0) 41 (41.0) 34 (34.0) 0 (0)
Contrast groups 80 0 (0) 0 (0) 20 (25.0) 60 (75.0) 4 treatments organize 75 49 (65.33) 22 (29.34) 4 (5.33) 0 (0)
Contrast groups 80 9 (11.25) 25 (31.25) 31 (38.5) 15 (18.75) 6 treatments organize 26 26 (100.0) 0 (0) 0 (0) 0 (0)
Contrast groups 71 34 (47.88) 18 (25.36) 8 (11.25) 11 (15.47) general comment treatments organize 100 100 (100) 0 (0) 0 (0) 0 (0)
Contrast groups 80 43 (53.75) 18 (22.5) 8 (10.0) 11 (13.75)
After the table 2 liang different curative effects of group are organized 180 treatments of routine patient through 6 weeks more entirely, bone setting pills group 100 examples, 100 examples of fully recovering, clinical cure rate is 100%; Contrast groups 80 examples, the recovery from illness example, cure rate is 53.75%.2 weeks of grouping, 4 week, 6 all A 4.17 ± 0.41 9.67 ± 0.82 11.67 ± 0.83B 2.11 ± 0.23 3.81 ± 0.32 6.33 ± 0.55P value＜0.001＜0.001＜0.001
The table 3 radiological examination appraisal result variance analysis (N=6 of X ± S)
Test of homogeneity according to the digital a plurality of variances of going ahead of the rest of test and appraisal in the table, the result variance of 2 groups of data is neat for this reason, variance analysis between above-mentioned at once a plurality of sample averages, the result shows the radiological examination appraisal result in 2 groups of each periods, and all there were significant differences, but treatment group area of new bone amount is apparently higher than matched group.Therefore, have therapeutic effect significantly, the characteristics of instant effect, short treating period.
Four, the specific embodiment
Take by weighing raw material (kilogram) by following proportioning
Cornu Cervi Pantotrichum 3 Radix Angelicae Sinensis 20 Radixs Astragali 32 Radix Codonopsis 16
Eupolyphage sece steleophaga 12 Flos Carthamis 11 Myrrhas 9 Rhizoma Drynariae 17
Production method is as follows:
1, raw materials such as Cornu Cervi Pantotrichum, Radix Angelicae Sinensis, the Radix Astragali, Radix Codonopsis, eupolyphage sece steleophaga, Flos Carthami, Myrrha, Rhizoma Drynariae are prepared according to the above ratio, crushed after being dried is to fine powder;
2, cross 100 mesh sieve, add proper honey then and mix stirring, send into the pellet processing machine pill;
3,, put shady and cool dry place with 60 ℃ of dry for standby of water-honeyed pill of making.
Claims (6)
1, a kind of bone setting pills that promotes union of fracture is characterized in that it is the medicament of being made by the following weight proportion raw material
Cornu Cervi Pantotrichum 2～6 Radix Angelicae Sinensis 16～32 Radixs Astragali 25～45 Radix Codonopsis 15～20
Eupolyphage sece steleophaga 11～15 Flos Carthamis 10～15 Myrrhas 5～15 Rhizoma Drynariae 15～20
2, the bone setting pills of promotion union of fracture according to claim 1, wherein the weight proportion of each raw material is:
Cornu Cervi Pantotrichum 3～5 Radix Angelicae Sinensis 20～30 Radixs Astragali 30～40 Radix Codonopsis 16～19
Eupolyphage sece steleophaga 12～14 Flos Carthamis 11～14 Myrrhas 6～12 Rhizoma Drynariae 16～19
3, the bone setting pills of promotion union of fracture according to claim 1, wherein the weight proportion of each raw material is:
Cornu Cervi Pantotrichum 3 Radix Angelicae Sinensis 20 Radixs Astragali 32 Radix Codonopsis 16
Eupolyphage sece steleophaga 12 Flos Carthamis 11 Myrrhas 9 Rhizoma Drynariae 17
4,, it is characterized in that said is said dosage form on any pharmaceutics according to the bone setting pills of claim 1 or 2 or 3 described promotion union of fracture.
5, the bone setting pills of promotion union of fracture according to claim 4 is characterized in that said medicament is powder or pill.
6, the preparation method of the bone setting pills of the described promotion union of fracture of claim 5 is characterized in that raw material is prepared according to the above ratio, and crushed after being dried is to fine powder; Cross 100 mesh sieve, add proper honey then and mix stirring, send into the pellet processing machine pill; With 60 ℃ of dry for standby of water-honeyed pill of making, put shady and cool dry place.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02109040 CN1208071C (en) | 2002-01-12 | 2002-01-12 | Bone setting pills for promoting fracture healing and its prepn process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02109040 CN1208071C (en) | 2002-01-12 | 2002-01-12 | Bone setting pills for promoting fracture healing and its prepn process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1432380A true CN1432380A (en) | 2003-07-30 |
| CN1208071C CN1208071C (en) | 2005-06-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02109040 Expired - Fee Related CN1208071C (en) | 2002-01-12 | 2002-01-12 | Bone setting pills for promoting fracture healing and its prepn process |
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| CN (1) | CN1208071C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751301A (en) * | 2014-01-20 | 2014-04-30 | 程宪福 | Product for patients with aseptic necrosis of femoral head |
-
2002
- 2002-01-12 CN CN 02109040 patent/CN1208071C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751301A (en) * | 2014-01-20 | 2014-04-30 | 程宪福 | Product for patients with aseptic necrosis of femoral head |
| CN103751301B (en) * | 2014-01-20 | 2016-03-30 | 程宪福 | For the goods of aseptic necrosis of femoral head patient |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1208071C (en) | 2005-06-29 |
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Granted publication date: 20050629 Termination date: 20110112 |