CN1429594A - Raw material in plant for regulating blood sugar extracted by using super critical CO2 extraction method and its preparation method - Google Patents
Raw material in plant for regulating blood sugar extracted by using super critical CO2 extraction method and its preparation method Download PDFInfo
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- CN1429594A CN1429594A CN 01145563 CN01145563A CN1429594A CN 1429594 A CN1429594 A CN 1429594A CN 01145563 CN01145563 CN 01145563 CN 01145563 A CN01145563 A CN 01145563A CN 1429594 A CN1429594 A CN 1429594A
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Abstract
A process for extracting the active components from raw plant materials by the supercritical Co2 extraction method in order to regulate blood sugar and treat II-type diabetes is disclosed, and it features that the said raw plant materials are mulberry leaf 33-34 wt.%, tuckahoe 33-34 wt.% and yam 34-35 wt.%.
Description
Technical field:
The invention belongs to field of medicaments and nutritional health food field, specifically raw material of a kind of blood sugar regulation and preparation method thereof.
Background technology:
China diabetes association adds up domestic diabetics to have reached 40,000,000 in November, 2000, and patient is also constantly increasing every year, though antidiabetic drug is large in the variety in the market, but the Rezulin product that domestic and international diabetic is taken only play blood sugar lowering basically and keep the effect of symptom, cure far from, and the product that reaches ideal treatment does not almost have.
Technology contents:
The object of the present invention is to provide a kind of supercritical CO of using
2Extraction extracts raw material of blood sugar regulation in the plant and preparation method thereof.
Technical scheme of the present invention is achieved in that uses supercritical CO
2Extraction extracts the raw material of blood sugar regulation in the plant, and it is characterized in that: described raw material is Powdered and is made up of Folium Mori, Poria, Rhizoma Dioscoreae, and their weight percentages of components is Folium Mori 33～34%, Poria 33～34%, Rhizoma Dioscoreae 34～35%.
Use supercritical CO
2Extraction extracts the preparation method of the raw material of blood sugar regulation in the plant, it is characterized in that:
A. Folium Mori, Poria, Rhizoma Dioscoreae 3 flavor Chinese medicines are cleaned up section, section back natural drying, crushed after being dried becomes 65～70 order powder;
B. adopt supercritical CO
2Fluid extraction technology extracts, and is specially: Folium Mori, Poria, 3 kinds of Chinese medicinal powder of Rhizoma Dioscoreae are placed extractor, begin to supply with supercritical CO
2Extraction, condition is pressure 38～46MPa, 38～45 ℃ of temperature, supercritical CO
2The extractor of from bottom to top flowing through, extracting solution flows to first separator after the air relief valve decompression, contain the glycoside product and be insoluble to CO under the pressure about 7MPa
2Be deposited in the separator bottom, extracting solution flows into second separator by first separator after reducing pressure, contain polysaccharide material and be insoluble to CO under the pressure about 2MPa
2, this moment, temperature was controlled at 18～21 ℃, the required bottom that polysaccharide material is deposited in separator, the CO of containing
2Reclaim through second separator, the semi-finished product after secondary separates are the extractum shape, all take out;
C. the fast household freezer that extractum shape semi-finished product are taken out through-183 ℃ is frozen into lyophilized powder;
D. pulverize dry powder at least 100 purpose powder and sieve.
The present invention is owing to be smart powder to the extraction of wild plant extract, effect with treatment diabetes, main treatment target is the type ii diabetes patient, reach and control the effect that table effects a permanent cure, show through experimental result, this prescription significantly blood sugar lowering, urine is sick, the balance endocrine, improves the function of islets of langerhans, makes it recover normal.Though antidiabetic drug is large in the variety on the market now, but the product that reaches therapeutic effect does not almost have, now the eutherapeutic product of therapeutical effect is badly in need of having in the domestic and international market, carries the powder compatibility to together because our new product Main Ingredients and Appearance is wild plant Folium Mori, Poria, Rhizoma Dioscoreae essence.Played the balance endocrine, reached and control the table effect of effecting a permanent cure, with to put into practice curative effect good, these product all had the curative effect of uniqueness to type ii diabetes through the scientific researches in 3 years.The method of medicinal supercritical extraction is extracted in its prescription, improved drug quality, few consumption just plays better curative effect, than also 3～5 days in advance common Chinese antihypelipidemic preparation onset time, this product compares with domestic and international similar drug, effect is remarkable, and following table 1 is for taking the inhibiting statistical table of different pharmaceutical to hyperglycemia.
Table 1
| Medicine | Example number n | Different time blood sugar increasing percentage rate X ± SE | The place of production | |
| 1 hour | 2 hours | |||
| Diamicron 0.5g | ????120 | ????132.9±19.7 | ??141.0±22.4 | Germany |
| This product 0.5g | ????120 | ????52.5±11.7 | ??68.8±18.8 | Our company |
| This product 1.0g | ????120 | ????31.6±12.9 | ??26.8±19.9 | Our company |
Table 2 sample is to the influence of the anti-blood glucose value of zoic model with hyperglycemia (X ± SD)
*(through variance analysis) compared with the hyperglycemia model group in P＜0.05
| Group | Number of animals (only) | Blood glucose difference (mmol/L) | |
| 0.5-0 (hour) | 2-0.5 (hour) | ||
| Hyperglycemia model | ????10 | ????8.2±2.8 | ????-8.7±3.3 |
| Low dosage | ????10 | ????8.2±2.9 | ????-10.7±5.7 |
| Middle dosage | ????10 | ????9.0±3.3 | ????-12.3±4.9 |
| High dose | ????10 | ????8.5±3.8 | ????-17.6±4.8 * |
This product has the effect of remarkable inhibition hyperglycemia as can be seen from Table 1, and experimental group is taken 1.0g, can significantly suppress blood sugar increasing, takes for a long time to have no side effect, and cure rate reaches 30～35%, and table 1 explanation this product has more superiority than commercially available antihypelipidemic product.
By table 2 as seen, the blood glucose difference of sample high dose phase in the time of 2-0.5 hour is compared with the hyperglycemia model group, and significant difference is arranged.
Description of drawings:
Fig. 1 is the preparation method sketch map of one embodiment of the invention
The specific embodiment:
Below the invention will be further described, and provide embodiment.
The present invention is for using supercritical CO
2Extraction extracts the raw material of blood sugar regulation in the plant, it is different from prior art and is: raw material is that powder is made up of Folium Mori, Poria, Rhizoma Dioscoreae, their weight percentages of components is, Folium Mori 33～34%, Poria 33～34%, Rhizoma Dioscoreae 34～35%, component in this raw material powder contains Folium Mori, globulariacitrin, polypeptide, Poria-pachyman, polysaccharide, Rhizoma Dioscoreae, dioscin, can make the islets of langerhans restore funcitons, reach the purpose of radical cure.Folium Mori function dispelling wind and heat pathogens in the raw material powder, liver heat removing and eyesight improving, the effect of polypeptide can stimulate insulin secretion, and slows down the degraded deactivation of insulin in peripheral tissues, thus rising insulinemia concentration and blood sugar lowering; The Poria function: spleen invigorating and in, mind tranquilizing and the heart calming, promoting diuresis to eliminate damp pathogen, quench the thirst; The pachyman pachymic acid has blood sugar reducing function, Rhizoma Dioscoreae function tonifying the spleen and stomach, lung benefiting kidney; Polysaccharide C, D all have the function of hypoglycemic activity.
Use supercritical CO
2Extraction extracts the preparation method of the raw material of blood sugar regulation in the plant, it is characterized in that:
A. press the percentage by weight of Folium Mori 33～34%, Poria 33～34%, Rhizoma Dioscoreae 34～35%, Folium Mori and other 2 flavor Chinese medicine are cleaned up section, section back natural drying, crushed after being dried becomes 65～70 order powder;
B. adopt supercritical CO
2Fluid extraction technology extracts, and is specially: the powder of Folium Mori, Poria, Rhizoma Dioscoreae is placed extractor, begin to supply with supercritical CO
2Extraction, condition is pressure 38～46MPa, 38～45 ℃ of temperature, supercritical CO
2The extractor of from bottom to top flowing through, extracting solution flows to first separator after the air relief valve decompression, contain the glycoside material and be insoluble to CO under the pressure about 7MPa
2Be deposited in the separator bottom, extracting solution flows into second separator by first separator after reducing pressure, contain polysaccharide material and be insoluble to CO under the pressure about 2MPa
2, this moment, temperature was controlled at 18～21 ℃, and desired substance is deposited in the bottom of separator, CO
2Reclaim through second separator, the semi-finished product after secondary separates are the extractum shape, all take out;
C. the fast household freezer that extractum shape semi-finished product are taken out through negative 183 ℃ is frozen into lyophilized powder;
D. pulverize dry powder at least 100 purpose powder and sieve;
E. the powder that will sieve again is filled to through between the sterile working in No. 0 soft gelatin capsule, and every heavy 0.5g can adorn the box seal, packaging and warehousing.
The supercritical CO of Cai Yonging in force
2Fluid extraction technology extracts and is mature technique comparatively, and the parameter difference of some temperature of physics of the present invention, pressure is specially: 3 kinds of Chinese medicinal powder such as Folium Mori and Poria are placed extractor, begin to carry out supercritical CO
2Extraction, condition is pressure 38～46MPa, 38～45 ℃ of temperature, supercritical CO
2The extractor of from bottom to top flowing through, extracting solution flows to first separator after the air relief valve decompression, contain the glycoside product and be insoluble to CO under the pressure about 7MPa
2Be deposited in the separator bottom.Extracting solution flows into second separator by first separator after reducing pressure, contain polysaccharide product class product and be insoluble to CO under the pressure about 2MPa
2, this moment, temperature was controlled at 18～21 ℃, and required product is deposited in the bottom of separator, CO
2The semi-finished product that extract through the second separator recycling use are the extractum shape, and the fast household freezer that extractum shape semi-finished product are taken out through negative 183 ℃ is frozen into lyophilized powder.
The purity of carbon dioxide is 95～98% when implementing, and required capital equipment is a supercritical CO
2Extraction equipment, disintegrating apparatus and cryotherapy equipment.
Embodiment 1
A. Chinese medicines such as Folium Mori, Poria, Rhizoma Dioscoreae are cleaned up section, section back natural drying, crushed after being dried becomes 65 order powder;
B. adopt supercritical CO
2Fluid extraction technology extracts, and is specially: 3 kinds of Chinese medicinal powder such as Folium Mori and Poria are placed extractor, and their percentage by weight is Folium Mori 32.5%, Poria 33%, Rhizoma Dioscoreae 34.5%.Begin to supply with supercritical CO
2Extraction, CO
2Purity be 95%., condition is pressure 35MPa, 36 ℃ of temperature, supercritical CO
2The extractor of from bottom to top flowing through, extracting solution flows to first separator after the air relief valve decompression, contain the glycoside product and be insoluble to CO under the pressure about 7MPa
2Be deposited in the separator bottom, extracting solution flows into second separator by first separator after reducing pressure, contain the polysaccharide product and be insoluble to CO under the pressure about 2MPa
2, this moment, temperature was controlled at about 20 ℃, and required product is deposited in the bottom of separator, CO
2The semi-finished product that extract through the second separator recycling use are the extractum shape.
C. the fast household freezer that extractum shape semi-finished product are taken out through negative 183 ℃ is frozen into lyophilized powder.
D. pulverize dry powder at least 100 purpose powder and sieve.
Embodiment 2
Production method is pressed example 1, only is that some physical parameters change, and is specially:
A. Folium Mori, Poria, Rhizoma Dioscoreae 3 flavor Chinese medicines are cleaned up section, section back natural drying, crushed after being dried becomes 70 order powder;
B. adopt supercritical CO
2Fluid extraction technology extracts, and is specially: Folium Mori and Poria 3 flavor Chinese medicinal powder are placed extractor, and their percentage by weight is Folium Mori 32%, Poria 33.5%, Rhizoma Dioscoreae 34.5%.Begin to supply with supercritical CO
2Extraction, CO
2Purity be 96%., condition is pressure 45MPa, 42 ℃ of temperature, supercritical CO
2The extractor of from bottom to top flowing through, extracting solution flows to first separator after the air relief valve decompression, contain the glycoside product and be insoluble to CO under the pressure about 7MPa
2Be deposited in the separator bottom, extracting solution flows into second separator by first separator after reducing pressure, contain the polysaccharide product and be insoluble to CO under the pressure about 2MPa
2, this moment, temperature was controlled at about 19 ℃, and required product is deposited in the bottom of separator, CO
2The semi-finished product that extract through the second separator recycling use are the extractum shape.
C. the fast household freezer that extractum shape semi-finished product are taken out through negative 183 ℃ is frozen into lyophilized powder.
D. pulverize dry powder at least 120 purpose powder and sieve.
Embodiment 3
A. Folium Mori, Poria, Rhizoma Dioscoreae 3 flavor Chinese medicines are cleaned up section, section back natural drying, crushed after being dried becomes 80 order powder;
B. adopt supercritical CO
2Fluid extraction technology extracts, and is specially: 3 kinds of Chinese medicinal powder such as Folium Mori and Poria are placed extractor, and their percentage by weight is Folium Mori 33.5%, Poria 32%, and Rhizoma Dioscoreae 34.5% begins to supply with supercritical CO
2Extraction, CO
2Purity be 97%., condition is pressure 35MPa, 36 ℃ of temperature, supercritical CO
2The extractor of from bottom to top flowing through, extracting solution flows to first separator after the air relief valve decompression, contain the glycoside product and be insoluble to CO under the pressure about 7MPa
2Be deposited in the separator bottom, extracting solution flows into second separator by first separator after reducing pressure, contain the polysaccharide product and be insoluble to CO under the pressure about 2MPa
2, this moment, temperature was controlled at about 20 ℃, and required product is deposited in the bottom of separator, CO
2The semi-finished product that extract through the second separator recycling use are the extractum shape.
C. the fast household freezer that extractum shape semi-finished product are taken out through negative 183 ℃ is frozen into lyophilized powder.
D. pulverize dry powder at least 100 purpose powder and sieve.
Claims (3)
1. use supercritical CO
2Extraction extracts the raw material of blood sugar regulation in the plant, and it is characterized in that: described raw material is Powdered and is made up of Folium Mori, Poria, Rhizoma Dioscoreae, and their weight percentages of components is Folium Mori 33～34%, Poria 33～34%, Rhizoma Dioscoreae 34～35%.
2. by the described supercritical CO of using of claim 1
2Extraction extracts the preparation method of the raw material of blood sugar regulation in the plant, it is characterized in that:
A. Folium Mori, Poria, Rhizoma Dioscoreae 3 flavor Chinese medicines are cleaned up section, section back natural drying, crushed after being dried becomes 65～70 order powder;
B. adopt supercritical CO
2Fluid extraction technology extracts, and is specially: Folium Mori, Poria, 3 kinds of Chinese medicinal powder of Rhizoma Dioscoreae are placed extractor, begin to supply with supercritical CO
2Extraction, condition is pressure 38～46MPa, 38～45 ℃ of temperature, supercritical CO
2The extractor of from bottom to top flowing through, extracting solution flows to first separator after the air relief valve decompression, contain the glycoside product and be insoluble to CO under the pressure about 7MPa
2Be deposited in the separator bottom, extracting solution flows into second separator by first separator after reducing pressure, contain polysaccharide material and be insoluble to CO under the pressure about 2MPa
2, this moment, temperature was controlled at 18～21 ℃, the required bottom that polysaccharide material is deposited in separator, the CO of containing
2Reclaim through second separator, the semi-finished product after secondary separates are the extractum shape, all take out;
C. the fast household freezer that extractum shape semi-finished product are taken out through-183 ℃ is frozen into lyophilized powder;
D. pulverize dry powder at least 100 purpose powder and sieve.
3. by the described supercritical CO of using of claim 2
2Extraction extracts the preparation method of the raw material of blood sugar regulation in the plant, and it is characterized in that: the purity of carbon dioxide is 95～98%, and required capital equipment is a supercritical CO
2Extraction equipment, disintegrating apparatus and cryotherapy equipment.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01145563 CN1429594A (en) | 2001-12-29 | 2001-12-29 | Raw material in plant for regulating blood sugar extracted by using super critical CO2 extraction method and its preparation method |
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| CN 01145563 CN1429594A (en) | 2001-12-29 | 2001-12-29 | Raw material in plant for regulating blood sugar extracted by using super critical CO2 extraction method and its preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103518910A (en) * | 2012-06-13 | 2014-01-22 | 福州万丰和生物科技有限公司 | Pine needle tea drink |
| CN107041558A (en) * | 2017-06-20 | 2017-08-15 | 慧谷生命科技湖北有限公司 | A kind of Poria cocos radix polygonati officinalis meal replacement powder suitable for diabetes |
| CN113017092A (en) * | 2021-04-01 | 2021-06-25 | 吉林省特医食品生物科技有限公司 | Fermentation type small molecule peptide mixed solution for regulating blood sugar and preparation method and application thereof |
-
2001
- 2001-12-29 CN CN 01145563 patent/CN1429594A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103518910A (en) * | 2012-06-13 | 2014-01-22 | 福州万丰和生物科技有限公司 | Pine needle tea drink |
| CN103518910B (en) * | 2012-06-13 | 2015-02-25 | 福州万丰和生物科技有限公司 | Pine needle tea drink |
| CN107041558A (en) * | 2017-06-20 | 2017-08-15 | 慧谷生命科技湖北有限公司 | A kind of Poria cocos radix polygonati officinalis meal replacement powder suitable for diabetes |
| CN113017092A (en) * | 2021-04-01 | 2021-06-25 | 吉林省特医食品生物科技有限公司 | Fermentation type small molecule peptide mixed solution for regulating blood sugar and preparation method and application thereof |
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