CN108324746A - A kind of medicine materical crude slice and preparation method thereof that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower - Google Patents
A kind of medicine materical crude slice and preparation method thereof that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower Download PDFInfo
- Publication number
- CN108324746A CN108324746A CN201810409009.6A CN201810409009A CN108324746A CN 108324746 A CN108324746 A CN 108324746A CN 201810409009 A CN201810409009 A CN 201810409009A CN 108324746 A CN108324746 A CN 108324746A
- Authority
- CN
- China
- Prior art keywords
- cordyceps militaris
- male flower
- eucommia bark
- bark male
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/424—Gynostemma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to medical compounds fields, more particularly to a kind of medicine materical crude slice that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower, it is after extracting concentration with root of Dahurain angelica extracting solution using the mixture of Cordyceps militaris and eucommia Bark male flower, gynostemma pentaphylla is added in concentrate, the gynostemma pentaphylla used, which need to once extract, can reach gynosaponin content for 75% or more high-quality gynostemma pentaphylla, then using soy milk protein and vitamin as the tablet of auxiliary material.Cost of manufacture of the present invention is relatively low, and ingredient is simple, comparatively very safe, Cordyceps militaris and eucommia Bark male flower synergistic function can also be performed to maximum, and applying with can not ignore in terms of preventing or treating bone class disease, hydrarthrosis class disease, internal growth of cancer cells, increment and infiltration metastasis, in the drug of the nourishing and health preserving of the weak crowd of resistance simultaneously.
Description
Technical field
The present invention relates to medical compounds fields, and in particular to a kind of drink that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower
Piece and preparation method thereof.
Background technology
It preventives treatment of disease, is exactly to raise constitution by many kinds of measures such as daily life, the conditioning of feelings will, kinesiatrics and Chinese herbal medicines,
Body yang blood and qi isoequilibrium is improved, human disease resistance is enhanced, makes human body few sick, not sick, it also can be as early as possible even if falling ill
Recovery from illness, recurs less after recovery from illness.
Cordyceps militaris also known as northern Chinese caterpillar Fungus, Cordceps militaris etc., worldwide distribution natural resources quantity are seldom；Cordyceps sinensis is
It refers in particular to Qinghai-Tibet Platean be the main place of production, the distinctive cordyceps sinensis of China.Cordyceps sinensis is a kind of Chinese medicine of traditional rare nourishing and health preserving
Material has multiple efficacies, the Chinese medicine such as adjusting function of immune system, antitumor, antifatigue to think that cordyceps sinensis sweet in flavor and neutral in nature enters lung kidney two
Through, can tonifying lung is cloudy and kidney-replenishing, adjust viscera function, strong qi-restoratives and balance conditioning, strengthening the essence gas, the benefit gate of vitality controls all void
Hundred damages, more disease, diseases prevention, prolong life, and cure mainly kidney deficiency, impotence and seminal emission, soreness of waist and knee joint, eak after being ill, chronic cough is weak, phthisical cough phlegm
Blood, spontaneous sweating etc. are a kind of unique Chinese medicine that can balance, adjust negative and positive simultaneously.
Eucommia Bark male flower, eucommia Bark male flower are the flowers that Cortex Eucommiae Xiong Shu is opened, and Cortex Eucommiae is the tree of the double strains of male and female, and eucommia Bark male flower is that China is only
The medicinal pollen resource having, it is precious, it is known as the good reputation of " among hundred grass, Cortex Eucommiae is expensive, and above and below Cortex Eucommiae, male flower is honor ", tool
There is strengthening the bones and muscles, antifatigue, liver protection, kidney tonifying, defaecation, relieving mental strain and helping sleep, lower hyperlipidemia, hypertension, hyperglycemia (hyperlipidemia, hyperglycemia, hypertension), exclude poison
Element, the effect of climacteric syndrome are especially pronounced.
It has been reported that cordyceps sinensis and eucommia Bark male flower have the function of good synergy, it is immune slowing down aging, adjusting
Power, nourishing and health preserving, treat or prevent cardiovascular and cerebrovascular disease drug in have good application prospect.But in process of production,
In order to increase the synergistic function of cordyceps sinensis and eucommia Bark male flower, generally require to increase a large amount of auxiliary material as carrier, such as China
Patent CN 104274509A, ingredient is complex, and cost of manufacture is higher.
Invention content
It is an object of the present invention to overcome the above-mentioned technical problems, and to provide a kind of to control made of Cordyceps militaris and eucommia Bark male flower
Not sick medicine materical crude slice and preparation method thereof, ingredient is single, and manufacturing process is simple, the significant effect in terms for the treatment of not disease.
The technical solution for solving above-mentioned technical problem is as follows：
A kind of medicine materical crude slice that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower is used using the mixture of Cordyceps militaris and eucommia Bark male flower
After the extraction concentration of root of Dahurain angelica extracting solution, gynostemma pentaphylla is added in concentrate, the gynostemma pentaphylla of use, which need to once extract, can reach strand
The high-quality gynostemma pentaphylla that blue saponin content is 75% or more, then using soy milk protein and vitamin as the tablet of auxiliary material.
Judge whether the gynostemma pentaphylla of selection meets the requirements using following methods：
As reference by the amount of taking-up 1/10th in the new fresh gynostemma pentaphylla of same a batch picking, gynostemma pentaphylla is crushed, then puts
Enter in pressure pan, the deionized water of identical weight is added, adds organic silicon modified by polyether, the organic silicon modified by polyether
Addition is the 0.5-0.8% of gynostemma pentaphylla aqueous solution total weight, is forced into 5kgf/cm2, 20min is kept, mistake after normal pressure is restored
Filter, obtains extracting solution；Gynostemma pentaphyllum Makino carries out aqueous two-phase extraction, obtains the upper phase of extraction and the lower phase of extraction, and aqueous two-phase extraction is used
Double-aqueous phase system be made of polyethylene glycol, sodium hydroxide and water, quality percentage of the polyethylene glycol in the double-aqueous phase system
Than for 15-25%, mass percent of the sodium hydroxide in the double-aqueous phase system is 10-15%, and surplus is water, described is poly-
The weight average molecular weight of diethanol is 5000-6000, will extraction is upper mutually uses dialysis desalination, that is, use molecular cut off for
The bag filter desalination of 1000-100000 is concentrated and dried, and by the lower phase of extraction, sodium hydroxide is added and is adopted using ultrafiltration desalination
The ultrafiltration membrane desalination for being 1000-100000 with molecular cut off is concentrated and dried, and addition amount of sodium hydroxide is phase quality hundred under extraction
Divide the 5-10% of ratio, merges dried object twice and obtain gynosaponin, detected with HPLC, content reaches 75% or more, that is, illustrates
The gynostemma pentaphylla of selection meets the requirements, and changes the period conversely, needing to rechange place and goes to pick another batch of gynostemma pentaphylla.
It further says, it is 0.1~0.5 that both the mixture of the Cordyceps militaris and eucommia Bark male flower, which is, according to mass ratio:5
~8.
It further says, the extracting solution that the root of Dahurain angelica extracting solution is 85~110 DEG C.
It further says, the addition of the gynostemma pentaphylla is 3.5-3.8 times of Cordyceps militaris addition.
It further says, the vitamin is the mixture of vitamin B and vitamin C or vitamin E, wherein dimension life
The content of vitamin B is no less than 70% in element.
It preventives treatment of disease the preparation method of medicine materical crude slice, includes the following steps made of Cordyceps militaris and eucommia Bark male flower：
(1) it chooses Natural C.militaris and eucommia Bark male flower piece is pulverized and mixed uniformly, cross 600 mesh sieve；By satisfactory strand
Indigo plant smashes it through 80 mesh sieve；
(2) root of Dahurain angelica is crushed granulating, with the clean water heating and refluxing extraction 1 hour of ten times of quality, be repeated 3 times, filter off medicine
Slag obtains filtrate；
(3) filtrate obtained to step (2) is added in Cordyceps militaris and eucommia Bark male flower piece mixture after step (1) being sieved
In, it is extracted in ice bath by the way of ultrasonic oscillation, leaching process continues 3-4 hours；
(4) the extraction mixture obtained to step (3) by the way of evaporation is concentrated, during concentration, side
Concentrate is slowly stirred, gynostemma pentaphyllum powder is added in side, until when solid content is 65-70%, soy milk protein and Wei Sheng is added
Plain auxiliary material, the soy milk protein quality are the 65-75% of auxiliary material gross mass, and the preparation method of the soy milk protein is to press
According to mass ratio 1:2:1:1 takes the mixture of broad bean, soya bean, black soya bean, red bean, and after impregnating 4 hours, beans are worn under the conditions of 65 DEG C
Filter residue is abandoned in slurry, filtering；It is slow added into vitamin powder, water content is concentrated to and is no more than 15%, be placed in sterilizing oven, 40 DEG C
It dries 2-2.5 hours, takes out cooling, tabletting is made.
It further says, hawthorn can be added in leaching process.
It further says, the addition of the hawthorn is the 1/5~1/4 of Cordyceps militaris quality.
It further says, sucrose can also be used to replace vitamin as auxiliary material.
The application of the medicine materical crude slice that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower is preventing or is treating bone class disease, closing
In terms of saving ponding class disease, internal growth of cancer cells, increment and infiltration metastasis, the drug of the nourishing and health preserving of the weak crowd of resistance
In application.
The beneficial effects of the invention are as follows：
The present invention provides a kind of medicine materical crude slice and preparation method thereof that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower, are fabricated to
This is relatively low, and ingredient is single, comparatively very safe, while assisting Cordyceps militaris and eucommia Bark male flower under the action of gynosaponin
Maximum is performed to synergistic effect, or even kills tumour cell, inhibits the demutation rate of tumour cell, and preventing or treating bone
In terms of bone class disease, hydrarthrosis class disease, internal growth of cancer cells, increment and infiltration metastasis, the taste of the weak crowd of resistance
Take a tonic or nourishing food to build up one's health applying with can not ignore in raw drug.In addition, under the effect of the auxiliary material of soy milk protein and vitamin or sucrose,
So that there is the tablet preferable mouthfeel, universal for the tablet to have established positive basis.
Specific implementation mode
The present invention will be further described in detail with reference to the specific embodiments.
Embodiment 1：
A kind of medicine materical crude slice that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower is used using the mixture of Cordyceps militaris and eucommia Bark male flower
After the extraction concentration of root of Dahurain angelica extracting solution, gynostemma pentaphylla is added in concentrate, the gynostemma pentaphylla of use, which need to once extract, can reach strand
The high-quality gynostemma pentaphylla that blue saponin content is 75% or more, then using soy milk protein and vitamin as the tablet of auxiliary material.
Judge whether the gynostemma pentaphylla of selection meets the requirements using following methods：
As reference by the amount of taking-up 1/10th in the new fresh gynostemma pentaphylla of same a batch picking, gynostemma pentaphylla is crushed, then puts
Enter in pressure pan, the deionized water of identical weight is added, adds organic silicon modified by polyether, the organic silicon modified by polyether
Addition is the 0.5-0.8% of gynostemma pentaphylla aqueous solution total weight, is forced into 5kgf/cm2, 20min is kept, mistake after normal pressure is restored
Filter, obtains extracting solution；Gynostemma pentaphyllum Makino carries out aqueous two-phase extraction, obtains the upper phase of extraction and the lower phase of extraction, and aqueous two-phase extraction is used
Double-aqueous phase system be made of polyethylene glycol, sodium hydroxide and water, quality percentage of the polyethylene glycol in the double-aqueous phase system
Than for 15-25%, mass percent of the sodium hydroxide in the double-aqueous phase system is 10-15%, and surplus is water, described is poly-
The weight average molecular weight of diethanol is 5000-6000, will extraction is upper mutually uses dialysis desalination, that is, use molecular cut off for
The bag filter desalination of 1000-100000 is concentrated and dried, and by the lower phase of extraction, sodium hydroxide is added and is adopted using ultrafiltration desalination
The ultrafiltration membrane desalination for being 1000-100000 with molecular cut off is concentrated and dried, and addition amount of sodium hydroxide is phase quality hundred under extraction
Divide the 5-10% of ratio, merges dried object twice and obtain gynosaponin, detected with HPLC, content reaches 75% or more, that is, illustrates
The gynostemma pentaphylla of selection meets the requirements, and changes the period conversely, needing to rechange place and goes to pick another batch of gynostemma pentaphylla.
It is 0.1 that the mixture of Cordyceps militaris and eucommia Bark male flower, which both is according to mass ratio,:8.
The extracting solution that the root of Dahurain angelica extracting solution is 85 DEG C.
The addition of the gynostemma pentaphylla is 3.5 times of Cordyceps militaris addition.
The vitamin is vitamin B and ascorbic mixture, wherein the content of vitamin B is in vitamin
70%.
It preventives treatment of disease the preparation method of medicine materical crude slice, includes the following steps made of Cordyceps militaris and eucommia Bark male flower：
(1) it chooses Natural C.militaris and eucommia Bark male flower piece is pulverized and mixed uniformly, cross 600 mesh sieve；By satisfactory strand
Indigo plant smashes it through 80 mesh sieve；
(2) root of Dahurain angelica is crushed granulating, with the clean water heating and refluxing extraction 1 hour of ten times of quality, be repeated 3 times, filter off medicine
Slag obtains filtrate；
(3) filtrate obtained to step (2) is added in Cordyceps militaris and eucommia Bark male flower piece mixture after step (1) being sieved
In, it is extracted in ice bath by the way of ultrasonic oscillation, leaching process continues 3 hours；
(4) the extraction mixture obtained to step (3) by the way of evaporation is concentrated, during concentration, side
Concentrate is slowly stirred, gynostemma pentaphyllum powder is added in side, until when solid content is 65%, soy milk protein is added and vitamin is auxiliary
Material, the soy milk protein quality are the 65% of auxiliary material gross mass, and the preparation method of the soy milk protein is, according to mass ratio
1:2:1:1 takes the mixture of broad bean, soya bean, black soya bean, red bean, after impregnating 4 hours, wears into soya-bean milk under the conditions of 65 DEG C, filtering is abandoned
Filter residue；It is slow added into vitamin powder, water content is concentrated to and is no more than 15%, be placed in sterilizing oven, 40 DEG C are dried 2 hours,
Cooling is taken out, tabletting is made.
Hawthorn can be added in leaching process.
The addition of the hawthorn is the 1/5 of Cordyceps militaris quality.
The application of the medicine materical crude slice that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower is preventing or is treating bone class disease, closing
In terms of saving ponding class disease, internal growth of cancer cells, increment and infiltration metastasis, the drug of the nourishing and health preserving of the weak crowd of resistance
In application.
The SD male rats 16 provided using the scientific and technological joint-stock company in Beijing, carry out feed intervention, to every to it respectively
Add the pill of equal proportion embodiment 1-3 and comparative example 1 in SD male rat feedings, every group of 4 male rats give after four weeks
Be injected intraperitoneally with methotrexate (MTX) (MTX) solution 40mg/kg, the next day give MTX solution 20mg/kg intraperitoneal injection again, note within two days
The buffer solution intraperitoneal injection of same dosage is penetrated, simulation rat meets the standard for making a definite diagnosis skeletal defect or hydrarthrosis, rat and people
Between drug dose conversion according to Sun Jingfang, animal experiment method [M], Beijing, People's Health Publisher, 2005,12:
357 documents are recorded formula and are calculated.Surrounding is administered altogether, concrete outcome is as shown in the table：
Embodiment 2：
A kind of medicine materical crude slice that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower is used using the mixture of Cordyceps militaris and eucommia Bark male flower
After the extraction concentration of root of Dahurain angelica extracting solution, gynostemma pentaphylla is added in concentrate, the gynostemma pentaphylla of use, which need to once extract, can reach strand
The high-quality gynostemma pentaphylla that blue saponin content is 75% or more, then using soy milk protein and vitamin as the tablet of auxiliary material.
It is 0.5 that the mixture of Cordyceps militaris and eucommia Bark male flower, which both is according to mass ratio,:5.
The extracting solution that root of Dahurain angelica extracting solution is 110 DEG C.
The addition of gynostemma pentaphylla is 3.8 times of Cordyceps militaris addition.
Vitamin is the mixture of vitamin B and vitamin E, wherein the content of vitamin B is 80% in vitamin.
It preventives treatment of disease the preparation method of medicine materical crude slice, includes the following steps made of Cordyceps militaris and eucommia Bark male flower：
(1) it chooses Natural C.militaris and eucommia Bark male flower piece is pulverized and mixed uniformly, cross 600 mesh sieve；By satisfactory strand
Indigo plant smashes it through 80 mesh sieve；
(2) root of Dahurain angelica is crushed granulating, with the clean water heating and refluxing extraction 1 hour of ten times of quality, be repeated 3 times, filter off medicine
Slag obtains filtrate；
(3) filtrate obtained to step (2) is added in Cordyceps militaris and eucommia Bark male flower piece mixture after step (1) being sieved
In, it is extracted in ice bath by the way of ultrasonic oscillation, leaching process continues 4 hours；
(4) the extraction mixture obtained to step (3) by the way of evaporation is concentrated, during concentration, side
Concentrate is slowly stirred, gynostemma pentaphyllum powder is added in side, until when solid content is 70%, soy milk protein is added and vitamin is auxiliary
Material, the soy milk protein quality are the 75% of auxiliary material gross mass, and the preparation method of the soy milk protein is, according to mass ratio
1:2:1:1 takes the mixture of broad bean, soya bean, black soya bean, red bean, after impregnating 4 hours, wears into soya-bean milk under the conditions of 65 DEG C, filtering is abandoned
Filter residue；It is slow added into vitamin powder, water content is concentrated to and is no more than 15%, be placed in sterilizing oven, 40 DEG C of bakings 2.5 are small
When, cooling is taken out, tabletting is made.
Hawthorn can be added in leaching process.
The addition of hawthorn is the 1/4 of Cordyceps militaris quality.
The application of the medicine materical crude slice that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower is preventing or is treating bone class disease, closing
In terms of saving ponding class disease, internal growth of cancer cells, increment and infiltration metastasis, the drug of the nourishing and health preserving of the weak crowd of resistance
In application.
Embodiment 3：
A kind of medicine materical crude slice that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower is used using the mixture of Cordyceps militaris and eucommia Bark male flower
After the extraction concentration of root of Dahurain angelica extracting solution, gynostemma pentaphylla is added in concentrate, the gynostemma pentaphylla of use, which need to once extract, can reach strand
The high-quality gynostemma pentaphylla that blue saponin content is 75% or more, then using soy milk protein and sucrose as the tablet of auxiliary material.
It is 0.4 that the mixture of Cordyceps militaris and eucommia Bark male flower, which both is according to mass ratio,:6.
The extracting solution that root of Dahurain angelica extracting solution is 90 DEG C.
The addition of gynostemma pentaphylla is 3.65 times of Cordyceps militaris addition.
It preventives treatment of disease the preparation method of medicine materical crude slice, includes the following steps made of Cordyceps militaris and eucommia Bark male flower：
(1) it chooses Natural C.militaris and eucommia Bark male flower piece is pulverized and mixed uniformly, cross 600 mesh sieve；By satisfactory strand
Indigo plant smashes it through 80 mesh sieve；
(2) root of Dahurain angelica is crushed granulating, with the clean water heating and refluxing extraction 1 hour of ten times of quality, be repeated 3 times, filter off medicine
Slag obtains filtrate；
(3) filtrate obtained to step (2) is added in Cordyceps militaris and eucommia Bark male flower piece mixture after step (1) being sieved
In, it is extracted in ice bath by the way of ultrasonic oscillation, leaching process continues 3.5 hours；
(4) the extraction mixture obtained to step (3) by the way of evaporation is concentrated, during concentration, side
Concentrate is slowly stirred, gynostemma pentaphyllum powder is added in side, until when solid content is 68%, soy milk protein is added and sucrose is auxiliary
Material, the soy milk protein quality are the 69% of auxiliary material gross mass, and the preparation method of the soy milk protein is, according to mass ratio
1:2:1:1 takes the mixture of broad bean, soya bean, black soya bean, red bean, after impregnating 4 hours, wears into soya-bean milk under the conditions of 65 DEG C, filtering is abandoned
Filter residue；It is slow added into sucrose, water content is concentrated to and is no more than 15%, be placed in sterilizing oven, 40 DEG C are dried 2 hours, are taken out cold
But, tabletting is made.
Hawthorn can be added in leaching process.
The addition of hawthorn is the 1/5 of Cordyceps militaris quality.
The application of the medicine materical crude slice that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower is preventing or is treating bone class disease, closing
In terms of saving ponding class disease, internal growth of cancer cells, increment and infiltration metastasis, the drug of the nourishing and health preserving of the weak crowd of resistance
In application.
Comparative example 1：
The healthy product composition containing cordyceps sinensis and eucommia Bark male flower prepared using the method for Foochow pharmaceutcal corporation, Ltd, tool
Gymnastics is made as follows：
Recipe quantity by weight percentage, contains：Cordyceps militaris 40%, eucommia Bark male flower 26%, xylitol 30%, carboxymethyl are fine
The plain sodium 3% of dimension, natural perfume material 0.5%, magnesium stearate 0.5%；
Preparation method is：Low-temperature airflow powder is respectively adopted in Cordyceps militaris, eucommia Bark male flower, xylitol, sodium carboxymethylcellulose
Broken technology is crushed up to 1000 mesh, and equal increments are uniformly mixed, and natural perfume material is dissolved in purified water, wet granulation is dry, whole grain
Magnesium stearate mixing is added afterwards, tabletting is buccal or chewing is edible for oral cavity to get Cordyceps militaris eucommia Bark male flower piece, or swallows.
The pharmaceutical compositions that this method makes are suitable in anti-fatigue medicament, the drug of raising cellular immunity function, increasing
Application in the drug of the phagocytic function of strong monocytes/macrophages, and preventing or treating bone class disease, hydrarthrosis class disease
Show slightly inferior in terms of sick, internal growth of cancer cells, increment and infiltration metastasis, in terms of the nourishing and health preserving drug of the weak crowd of resistance
Color.
The above is only presently preferred embodiments of the present invention, not does limitation in any form to the present invention, it is every according to
According to any simple modification, equivalent variations made by above example, each falling within the guarantor of the present invention in the technical spirit of the present invention
Within the scope of shield.
Claims (10)
1. a kind of medicine materical crude slice that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower, which is characterized in that use Cordyceps militaris and eucommia Bark male flower
Mixture with root of Dahurain angelica extracting solution extract concentration after, gynostemma pentaphylla is added in concentrate, the gynostemma pentaphylla of use need to once extract i.e.
The high-quality gynostemma pentaphylla that gynosaponin content is 75% or more is can reach, then using soy milk protein and vitamin as the piece of auxiliary material
Agent.
2. the medicine materical crude slice according to claim 1 that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower, which is characterized in that described
It is 0.1~0.5 that the mixture of Cordyceps militaris and eucommia Bark male flower, which both is according to mass ratio,:5~8.
3. the medicine materical crude slice according to claim 1 that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower, which is characterized in that described
The extracting solution that root of Dahurain angelica extracting solution is 85~110 DEG C.
4. the medicine materical crude slice according to claim 1 that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower, which is characterized in that described
The addition of gynostemma pentaphylla is 3.5-3.8 times of Cordyceps militaris addition.
5. the medicine materical crude slice according to claim 1 that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower, which is characterized in that described
Vitamin is the mixture of vitamin B and vitamin C or vitamin E, wherein the content of vitamin B is no less than in vitamin
70%.
6. the preparation side for the medicine materical crude slice that preventiveed treatment of disease made of Cordyceps militaris and eucommia Bark male flower according to claim 1-5 any one of them
Method, which is characterized in that include the following steps：
(1) it chooses Natural C.militaris and eucommia Bark male flower piece is pulverized and mixed uniformly, cross 600 mesh sieve；By satisfactory gynostemma pentaphyllum powder
80 mesh sieve is crossed after broken；
(2) root of Dahurain angelica is crushed granulating, with the clean water heating and refluxing extraction 1 hour of ten times of quality, be repeated 3 times, filtered off the dregs of a decoction, obtain
To filtrate；
(3) Cordyceps militaris and eucommia Bark male flower piece mixture after step (1) being sieved are added in the filtrate obtained to step (2), adopt
It is extracted in ice bath with the mode of ultrasonic oscillation, leaching process continues 3-4 hours；
(4) the extraction mixture obtained to step (3) by the way of evaporation is concentrated, during concentration, while to dense
Contracting object is slowly stirred, and gynostemma pentaphyllum powder is added in side, until when solid content is 65-70%, soy milk protein is added and vitamin is auxiliary
Material, the soy milk protein quality are the 65-75% of auxiliary material gross mass, and the preparation method of the soy milk protein is, according to matter
Measure ratio 1:2:1:1 takes the mixture of broad bean, soya bean, black soya bean, red bean, and after impregnating 4 hours, soya-bean milk, mistake are worn under the conditions of 65 DEG C
Filter residue is abandoned in filter；It is slow added into vitamin powder, water content is concentrated to and is no more than 15%, be placed in sterilizing oven, 40 DEG C of baking 2-
2.5 hours, cooling is taken out, tabletting is made.
7. the preparation method of the medicine materical crude slice according to claim 6 that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower, feature
It is, hawthorn can be added in leaching process.
8. the preparation method of the medicine materical crude slice according to claim 7 that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower, feature
It is, the addition of the hawthorn is the 1/5~1/4 of Cordyceps militaris quality.
9. the preparation method of the medicine materical crude slice according to claim 1 that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower, feature
It is, sucrose can also be used to replace vitamin as auxiliary material.
10. a kind of application of medicine materical crude slice that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower as described in claim 1-5, feature
It is, in terms of preventing or treating bone class disease, hydrarthrosis class disease, internal growth of cancer cells, increment and infiltration metastasis,
Application in the drug of the nourishing and health preserving of the weak crowd of resistance.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810409009.6A CN108324746A (en) | 2018-05-02 | 2018-05-02 | A kind of medicine materical crude slice and preparation method thereof that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810409009.6A CN108324746A (en) | 2018-05-02 | 2018-05-02 | A kind of medicine materical crude slice and preparation method thereof that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108324746A true CN108324746A (en) | 2018-07-27 |
Family
ID=62934742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810409009.6A Pending CN108324746A (en) | 2018-05-02 | 2018-05-02 | A kind of medicine materical crude slice and preparation method thereof that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108324746A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113632905A (en) * | 2021-06-10 | 2021-11-12 | 李红星 | Ginseng and radix puerariae solid beverage and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660393A (en) * | 2004-12-22 | 2005-08-31 | 孙卫国 | Health products of anti fatigue, decreasing blood pressure and blood fat, against cancer and cancer preyention, and preparing method |
| CN103478820A (en) * | 2013-10-08 | 2014-01-01 | 山东贝隆杜仲生物工程有限公司 | Eucommia male flower beverage |
| CN104274509A (en) * | 2014-10-15 | 2015-01-14 | 福州乾正药业有限公司 | Health product composition containing cordyceps sinensis and male flower of eucommia ulmoides as well as preparation method and application of health product composition |
| CN107114634A (en) * | 2016-02-24 | 2017-09-01 | 王弘 | A kind of cordycepin beverage and preparation method thereof |
| CN107714814A (en) * | 2017-10-02 | 2018-02-23 | 刘新江 | Silkworm chrysalis Cordyceps sinensis preparation |
-
2018
- 2018-05-02 CN CN201810409009.6A patent/CN108324746A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660393A (en) * | 2004-12-22 | 2005-08-31 | 孙卫国 | Health products of anti fatigue, decreasing blood pressure and blood fat, against cancer and cancer preyention, and preparing method |
| CN103478820A (en) * | 2013-10-08 | 2014-01-01 | 山东贝隆杜仲生物工程有限公司 | Eucommia male flower beverage |
| CN104274509A (en) * | 2014-10-15 | 2015-01-14 | 福州乾正药业有限公司 | Health product composition containing cordyceps sinensis and male flower of eucommia ulmoides as well as preparation method and application of health product composition |
| CN107114634A (en) * | 2016-02-24 | 2017-09-01 | 王弘 | A kind of cordycepin beverage and preparation method thereof |
| CN107714814A (en) * | 2017-10-02 | 2018-02-23 | 刘新江 | Silkworm chrysalis Cordyceps sinensis preparation |
Non-Patent Citations (2)
| Title |
|---|
| 王梅: "《药食同源与健康》", 31 August 2016, 中国中医药出版社 * |
| 王贺祥 等: "《食用菌栽培手册》", 31 January 2015, 中国农业大学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113632905A (en) * | 2021-06-10 | 2021-11-12 | 李红星 | Ginseng and radix puerariae solid beverage and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1739626A (en) | Tea extract dripping pill | |
| CN104435749B (en) | A kind of dendrobium candidum compound preparation and its preparation method and application | |
| CN104187679B (en) | A kind of haematococcus pluvialis agate coffee health products and preparation method thereof | |
| CN101612315A (en) | A kind of compound Chinese medicinal preparation that is used to adjust function of human body | |
| CN103238798A (en) | Dendrobium nutrient tablet and preparation method | |
| CN103053908B (en) | Functional food capable of rising white blood cells and preparation method thereof | |
| CN103349121B (en) | Hyperglycemia-hyperlipidemia-hypertension relieving health protection tea and preparation method thereof | |
| CN110881602A (en) | Grifola frondosa and cordyceps militaris edible fungus solid beverage | |
| KR20200086792A (en) | Herbal composition for promoting growth and improving eye health and herbal medicine preparation using same | |
| CN103055157B (en) | Compound dendrobium huoshanense, cistanche and ganoderma granules and production process thereof | |
| CN105055897A (en) | Health tea tablet capable of preventing and treating diabetes and preparation method of health tea tablet | |
| CN108324746A (en) | A kind of medicine materical crude slice and preparation method thereof that preventives treatment of disease made of Cordyceps militaris and eucommia Bark male flower | |
| KR101681890B1 (en) | The herbal mixture extract as an active ingredient for prevention and treatment of osteoporosis composition and its manufacture method | |
| CN107647074A (en) | A kind of nourishing the stomach, stomach invigorating, the preparation method of dyspepsia hawthorn Chinese yam Hericium erinaceus pressed candy | |
| CN103461590A (en) | Food blood-nourishing tea granules for improving alimentary anemia | |
| CN108056461B (en) | Black fungus chewable tablet with intestine moistening function and preparation method thereof | |
| CN104825750A (en) | Preparation for preparing ginseng flower and preparation method | |
| CN104524359B (en) | A kind of Chinese medicine composition, its preparation method and application | |
| CN108651986A (en) | A kind of stem of noble dendrobium custard and preparation method thereof | |
| KR101652507B1 (en) | Herbal Medicine Composition and Pill for Ophthalmic Health | |
| CN103461603A (en) | Food blood-nourishing tea granule for improving alimentary anemia | |
| CN108324783A (en) | It is white to return ginseng Ling Donggan medicines for cancer | |
| CN110089735A (en) | A kind of bioactivity joins clever black garlic oral solution and preparation method thereof | |
| CN112843223B (en) | Traditional Chinese medicine weight-losing composition with homology of medicine and food | |
| CN106690048A (en) | Poria cocos and tremella noodles |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180727 |
|
| RJ01 | Rejection of invention patent application after publication |