CN1425133A - 检测和识别试样中分子事件的系统和方法 - Google Patents

检测和识别试样中分子事件的系统和方法 Download PDF

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Publication number
CN1425133A
CN1425133A CN00817005A CN00817005A CN1425133A CN 1425133 A CN1425133 A CN 1425133A CN 00817005 A CN00817005 A CN 00817005A CN 00817005 A CN00817005 A CN 00817005A CN 1425133 A CN1425133 A CN 1425133A
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sample
fluid
signal
response
molecular
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Chinese (zh)
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罗伯特·G·查普曼
约翰·J·赫夫蒂
巴雷特·J·巴特尔
马克·A·罗兹
赵民
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Signature Bioscience Inc
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Signature Bioscience Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0418—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N22/00—Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN00817005A 1999-10-13 2000-10-13 检测和识别试样中分子事件的系统和方法 Pending CN1425133A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15917599P 1999-10-13 1999-10-13
US60/159,175 1999-10-13
US19170200P 2000-03-23 2000-03-23
US60/191,702 2000-03-23

Publications (1)

Publication Number Publication Date
CN1425133A true CN1425133A (zh) 2003-06-18

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CN00817005A Pending CN1425133A (zh) 1999-10-13 2000-10-13 检测和识别试样中分子事件的系统和方法

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EP (1) EP1224453A2 (fi)
JP (1) JP2003535310A (fi)
KR (1) KR20020071853A (fi)
CN (1) CN1425133A (fi)
AU (3) AU8023500A (fi)
CA (1) CA2386193A1 (fi)
IL (1) IL149001A0 (fi)
MX (1) MXPA02003815A (fi)
NO (1) NO20021687L (fi)
WO (1) WO2001027610A2 (fi)

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CN101617209B (zh) * 2006-03-16 2013-10-02 麦克罗威斯克有限公司 流体探针
TWI569017B (zh) * 2014-11-14 2017-02-01 Nippon Mektron Kk Coaxial probe holding mechanism and electrical characteristics check device
CN108257052A (zh) * 2018-01-16 2018-07-06 中南大学 一种在线学生知识评估方法及其系统
CN108602065A (zh) * 2015-12-23 2018-09-28 维京遗传学Fmba 用于低温吸管的rfid识别系统
CN109192250A (zh) * 2018-08-01 2019-01-11 华东理工大学 一种多相催化中克服表面物种快速迁移的加速模拟方法
JP2020098202A (ja) * 2013-03-15 2020-06-25 イナノベイト， インコーポレイテッド アッセイシステムおよびカートリッジデバイス
CN111500680A (zh) * 2013-06-25 2020-08-07 普罗格诺西斯生物科学公司 检测样品中生物靶标的空间分布的方法和系统
CN115598464A (zh) * 2022-10-08 2023-01-13 金华乐馨发制品有限公司（Cn） 一种电缆末端高低压电路的检测和修复装置及其方法
US11733238B2 (en) 2010-04-05 2023-08-22 Prognosys Biosciences, Inc. Spatially encoded biological assays
US11732292B2 (en) 2010-04-05 2023-08-22 Prognosys Biosciences, Inc. Spatially encoded biological assays correlating target nucleic acid to tissue section location
US11739372B2 (en) 2015-04-10 2023-08-29 Spatial Transcriptomics Ab Spatially distinguished, multiplex nucleic acid analysis of biological specimens
US11788122B2 (en) 2011-04-13 2023-10-17 10X Genomics Sweden Ab Methods of detecting analytes
US11866767B2 (en) 2020-05-22 2024-01-09 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
US12031177B1 (en) 2021-06-03 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts

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WO2002066983A2 (en) * 2001-02-01 2002-08-29 Signature Bioscience, Inc. Bioassay device for detecting molecular events
WO2002065127A2 (en) * 2001-02-12 2002-08-22 Signature Bioscience, Inc. A system and method for characterizing the permittivity of molecular events
GB0117715D0 (en) * 2001-07-19 2001-09-12 Mrbp Res Ltd Microwave biochemical analysis
CA2454570C (en) 2001-07-25 2016-12-20 The Trustees Of Princeton University Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
US9678038B2 (en) 2001-07-25 2017-06-13 The Trustees Of Princeton University Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
US20030032000A1 (en) * 2001-08-13 2003-02-13 Signature Bioscience Inc. Method for analyzing cellular events
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US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
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US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
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US9791453B2 (en) * 2012-12-26 2017-10-17 International Business Machines Corporation Methods for determining binding capability of target ligands with G protein-coupled receptors using translocation through nanochannels
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CN102269686B (zh) * 2003-12-04 2015-05-06 麦克罗威斯克有限公司 流体探针
CN1914498B (zh) * 2003-12-04 2012-01-04 麦克罗威斯克有限公司 流体探针
CN102269687B (zh) * 2006-03-16 2014-11-05 麦克罗威斯克有限公司 流体探针
CN101617209B (zh) * 2006-03-16 2013-10-02 麦克罗威斯克有限公司 流体探针
CN101849174B (zh) * 2007-08-11 2013-05-29 麦克罗威斯克有限公司 流体探测器
US11767550B2 (en) 2010-04-05 2023-09-26 Prognosys Biosciences, Inc. Spatially encoded biological assays
US11761030B2 (en) 2010-04-05 2023-09-19 Prognosys Biosciences, Inc. Spatially encoded biological assays
US11732292B2 (en) 2010-04-05 2023-08-22 Prognosys Biosciences, Inc. Spatially encoded biological assays correlating target nucleic acid to tissue section location
US11866770B2 (en) 2010-04-05 2024-01-09 Prognosys Biosciences, Inc. Spatially encoded biological assays
US11733238B2 (en) 2010-04-05 2023-08-22 Prognosys Biosciences, Inc. Spatially encoded biological assays
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US11788122B2 (en) 2011-04-13 2023-10-17 10X Genomics Sweden Ab Methods of detecting analytes
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CN111500680A (zh) * 2013-06-25 2020-08-07 普罗格诺西斯生物科学公司 检测样品中生物靶标的空间分布的方法和系统
US11821024B2 (en) 2013-06-25 2023-11-21 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
CN111500680B (zh) * 2013-06-25 2024-04-16 普罗格诺西斯生物科学公司 检测样品中生物靶标的空间分布的方法和系统
US11753674B2 (en) 2013-06-25 2023-09-12 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
TWI569017B (zh) * 2014-11-14 2017-02-01 Nippon Mektron Kk Coaxial probe holding mechanism and electrical characteristics check device
US11739372B2 (en) 2015-04-10 2023-08-29 Spatial Transcriptomics Ab Spatially distinguished, multiplex nucleic acid analysis of biological specimens
CN108602065A (zh) * 2015-12-23 2018-09-28 维京遗传学Fmba 用于低温吸管的rfid识别系统
CN108257052A (zh) * 2018-01-16 2018-07-06 中南大学 一种在线学生知识评估方法及其系统
CN108257052B (zh) * 2018-01-16 2022-04-22 中南大学 一种在线学生知识评估方法及其系统
CN109192250B (zh) * 2018-08-01 2021-12-07 华东理工大学 一种多相催化中克服表面物种快速迁移的加速模拟方法
CN109192250A (zh) * 2018-08-01 2019-01-11 华东理工大学 一种多相催化中克服表面物种快速迁移的加速模拟方法
US11866767B2 (en) 2020-05-22 2024-01-09 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
US12031177B1 (en) 2021-06-03 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
CN115598464A (zh) * 2022-10-08 2023-01-13 金华乐馨发制品有限公司（Cn） 一种电缆末端高低压电路的检测和修复装置及其方法

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WO2001027610A9 (en) 2002-08-01
AU2008203111A1 (en) 2008-08-07
WO2001027610A2 (en) 2001-04-19
IL149001A0 (en) 2002-11-10
JP2003535310A (ja) 2003-11-25
NO20021687D0 (no) 2002-04-10
KR20020071853A (ko) 2002-09-13
MXPA02003815A (es) 2002-09-30
AU2005203756A1 (en) 2005-09-15
EP1224453A2 (en) 2002-07-24
CA2386193A1 (en) 2001-04-19
AU8023500A (en) 2001-04-23
NO20021687L (no) 2002-06-12
WO2001027610A3 (en) 2002-03-28

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