CN1418684A - Medicine composition for treating gynaecology inflammation and its prepn. method - Google Patents
Medicine composition for treating gynaecology inflammation and its prepn. method Download PDFInfo
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- CN1418684A CN1418684A CN 02153459 CN02153459A CN1418684A CN 1418684 A CN1418684 A CN 1418684A CN 02153459 CN02153459 CN 02153459 CN 02153459 A CN02153459 A CN 02153459A CN 1418684 A CN1418684 A CN 1418684A
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- 206010061218 Inflammation Diseases 0.000 title claims abstract description 12
- 230000004054 inflammatory process Effects 0.000 title claims abstract description 12
- 239000003814 drug Substances 0.000 title claims abstract description 9
- 229940079593 drug Drugs 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 6
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 40
- 239000000706 filtrate Substances 0.000 claims description 20
- 239000008194 pharmaceutical composition Substances 0.000 claims description 17
- 241000218176 Corydalis Species 0.000 claims description 15
- 239000000341 volatile oil Substances 0.000 claims description 15
- 238000004064 recycling Methods 0.000 claims description 10
- 210000000582 semen Anatomy 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 239000006071 cream Substances 0.000 claims description 5
- 230000006837 decompression Effects 0.000 claims description 5
- 239000000796 flavoring agent Substances 0.000 claims description 5
- 235000019634 flavors Nutrition 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 238000001256 steam distillation Methods 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- -1 mixing Substances 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000000890 drug combination Substances 0.000 claims 2
- 229920001353 Dextrin Polymers 0.000 claims 1
- 239000004375 Dextrin Substances 0.000 claims 1
- 235000019425 dextrin Nutrition 0.000 claims 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 244000077995 Coix lacryma jobi Species 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 240000001949 Taraxacum officinale Species 0.000 abstract 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 9
- 230000008961 swelling Effects 0.000 description 9
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 7
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 208000005171 Dysmenorrhea Diseases 0.000 description 4
- 206010013935 Dysmenorrhoea Diseases 0.000 description 4
- 208000004145 Endometritis Diseases 0.000 description 4
- 208000019255 Menstrual disease Diseases 0.000 description 4
- 206010049677 Salpingo-oophoritis Diseases 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 230000001629 suppression Effects 0.000 description 4
- 229920001525 carrageenan Polymers 0.000 description 3
- 235000010418 carrageenan Nutrition 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 208000007106 menorrhagia Diseases 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 240000006409 Acacia auriculiformis Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000606153 Chlamydia trachomatis Species 0.000 description 1
- 206010013183 Dislocation of vertebra Diseases 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 208000016908 Female Genital disease Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 241000588653 Neisseria Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 208000008350 Pruritus Vulvae Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000053227 Themus Species 0.000 description 1
- 208000007074 Trichomonas Vaginitis Diseases 0.000 description 1
- 208000025206 Trichomonas vaginitis urogenital infection Diseases 0.000 description 1
- 206010056530 Vulvovaginal pruritus Diseases 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003716 antitrichomonal agent Substances 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 229940038705 chlamydia trachomatis Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The present ivnention relates to a Chinese medicine composition for curing gynecological inflammation and its preparation method. Said Chinese medicine composition is made from 11 Chinese medicinal materials of dandelion, baijiang, coix seed, red peony root, atractylodes root, Chinese angelica root and others.
Description
The present invention relates to a kind of pharmaceutical composition for the treatment of gynecological inflammation and preparation method thereof.
The common menoxenia of gynaecopathia, dysmenorrhea, adnexitis, diseases such as gynecological inflammation and endometritis.Menoxenia is clinical common to have preceeded menorrhea, mid-term, later stage, successively do not have regularly, menorrhagia, very few and menostaxis etc.; Dysmenorrhea, adnexitis, female genital disease clinical manifestations such as gynecological inflammation and endometritis have pruritus vulvae, pain, even fester, and vaginal secretions is unusual, cervical erosion, hypertrophy etc.
The object of the invention is to provide a kind of Chinese medicine and preparation method thereof of the treatment gynaecopathia that has no side effect of evident in efficacy, taking convenience.
Technical solution of the present invention is achieved in that
Bulk drugs as described below:
180～540 parts of 180～540 parts of Semen Coiciss of 180～540 parts of Herba Patriniae of Herba Taraxaci
180～540 parts of 144～432 parts of Radix Angelicae Sinensis of 144～432 parts of Rhizoma Atractylodis of Radix Paeoniae Rubra
60～180 parts of 144～432 parts of Rhizoma Corydalis (processed)s of 144～432 portions of Rhizoma Cyperis of Rhizoma Chuanxiong
108～324 parts of 108～324 parts of Herba Hedyotidis Diffusaes of Rhizoma Alismatis
Get Rhizoma Corydalis (processed) with 50～90% alcohol reflux 2～3 times, each 1～3 hour, filter, filtrate recycling ethanol, clear paste is standby; Get Rhizoma Atractylodis, Rhizoma Cyperi, Radix Angelicae Sinensis, Rhizoma Chuanxiong four flavors again, extract volatile oil, and it is standby to collect aqueous solution with steam distillation; Medicinal residues add Herba Taraxaci, Herba Patriniae, Semen Coicis, Radix Paeoniae Rubra, Rhizoma Alismatis, Herba Hedyotidis Diffusae and decoct with water 2～3 times, each 1～3 hour, filter merging filtrate, add to extract the filtrate behind the volatile oil, concentrating under reduced pressure becomes clear paste, adds ethanol and makes and contain the alcohol amount and reach 40～70%, cold preservation 24 hours filters decompression filtrate recycling ethanol, add the Rhizoma Corydalis clear paste, and continue to be condensed into thick paste, vacuum drying, dried cream powder is broken, adds adjuvant and volatile oil, mixing, granulate, incapsulate, promptly.
Through laboratory observation, can reduce the mice capillary permeability after taking pharmaceutical composition of the present invention, minimizing is oozed out; The rat paw edema that mice auricle swelling that xylol brings out and Ovum Gallus domesticus album cause all has the obvious suppression effect; Gonococcus, chlamydia trachomatis, staphylococcus, streptococcus, escherichia coli, mycete and infusorian there is inhibitory action.Low dosage does not have obvious influence to normal uterus, during higher dosage uterine smooth muscle is inhibitory action; Anastalsis is arranged; The normal development of female mice reproductive system there is not obvious influence.Experimental result shows that pharmaceutical composition of the present invention has treatment menoxenia, dysmenorrhea, adnexitis, pelvic inflammatory disease, effects such as endometritis.
Pharmaceutical composition of the present invention has heat-clearing and toxic substances removing, and the blood stasis dispelling row stagnates, and effects such as eliminating dampness and arresting leucorrhea can be used for menoxenia, dysmenorrhea, adnexitis, gynecological inflammation, treatment of conditions such as endometritis.Experimental example 1: antiinflammatory action
(1) mice dimethylbenzene is brought out the influence of mice auricle swelling: get body weight 20-24g mice, be divided into 4 groups at random, irritate stomach respectively and give pharmaceutical composition extract of the present invention, high dose group 0.5g/kg, middle dosage group 0.25g/kg, low dose group 0.1g/kg, model control group gives with the volume distilled water, every day 1 time, continuous 7 days, be coated with dimethylbenzene 0.1ml in the Mus auris dextra back of the body in 30 minutes after the last administration, mice is put to death in the cervical vertebra dislocation after 2 hours, laying round auricle with card punch in left and right sides ear same area, weigh, is the swelling degree with the ratio of interaural difference and left ear.Experimental result shows that each dosage group xylol of pharmaceutical composition of the present invention brings out mice auricle swelling all the obvious suppression effect.
(2) the rat paw carrageenin is caused the influence of swelling: body weight 140-160g rat, be divided into 4 groups at random, left sufficient plantar aponeurosis is injection 1% carrageenin 0.1ml down.Be subjected to the examination group to give pharmaceutical composition extract of the present invention, irritating stomach respectively gives, high dose group 0.5g/kg, middle dosage group 0.25g/kg, low dose group 0.1g/kg, model control group gives with the volume distilled water, every day 1 time, continuous 7 days, modeling in 30 minutes after the last administration, press the micropipet algoscopy, mensuration causes before the inflammation and causes scorching back 3 hours right back sufficient volumes of rat.With its volume difference that causes scorching front and back is the swelling degree; The significance of the difference of row t test comparable group.Experimental result shows that swelling has the obvious suppression effect to pharmaceutical composition of the present invention to the rat paw carrageenin, and is a certain amount of effect relationship.
On end, pharmaceutical composition xylol of the present invention brings out mice auricle swelling and rat paw fork dish glue and causes swelling the obvious suppression effect is arranged, and its effect strengthens with increase of dosage.Experimental example 2: external bacteriostasis
Adopt conventional agar broth bouillon, show with the paper disk method measurement result, the extract of pharmaceutical composition of the present invention all has in various degree inhibitory action to Staphylococcus albus, Bacillus proteus, escherichia coli, and minimum inhibitory concentration respectively was 1: 800,1: 500,1: 600.Experimental example 3: anti-trichomonas vaginitis effect
Routine prepares the CPLM culture medium, and every milliliter contains 2 * 10
5The infusorian suspension of concentration.The extract of pharmaceutical composition of the present invention directly is dissolved in the culture medium, and drug level dilutes since 1: 20 by geometrical progression, and every test tube 8ml inoculation of medium 0.4ml infusorian suspension is put in 37 ℃ of incubators and hatched 24 hours.Under optical microscope, carry out the infusorian counting with blood counting chamber.Do not see in the visual field that the infusorian person is active drug concentration.The minimal effective concentration of the extract of pharmaceutical composition of the present invention is 1: 300 as a result.
Embodiment 1:
Herba Taraxaci 360g Herba Patriniae 360g Semen Coicis 360g Radix Paeoniae Rubra 288g
Rhizoma Atractylodis 288g Radix Angelicae Sinensis 360g Rhizoma Chuanxiong 288g Rhizoma Cyperi 288g
Rhizoma Corydalis (processed) 120g Rhizoma Alismatis 216g Herba Hedyotidis Diffusae 216g
Get Rhizoma Corydalis (processed) with 70% alcohol reflux secondary, each 1.5 hours, filter, filtrate recycling ethanol, clear paste is standby; Get Rhizoma Atractylodis, Rhizoma Cyperi, Radix Angelicae Sinensis, Rhizoma Chuanxiong four flavors again, extract volatile oil, and it is standby to collect aqueous solution with steam distillation; Medicinal residues add Herba Taraxaci, Herba Patriniae, Semen Coicis, Radix Paeoniae Rubra, Rhizoma Alismatis, Herba Hedyotidis Diffusae and decoct with water secondary, each 1.5 hours, filter merging filtrate, add to extract the filtrate behind the volatile oil, concentrating under reduced pressure becomes clear paste, adds ethanol and makes and contain the alcohol amount and reach 50%, cold preservation 24 hours, filter, decompression filtrate recycling ethanol adds the Rhizoma Corydalis clear paste, and continue to be condensed into thick paste, and vacuum drying, dried cream powder is broken, add starch and volatile oil to 400g, mixing is granulated, make 1000, incapsulate, promptly.
Embodiment 2:
Herba Taraxaci 360g Herba Patriniae 360g Semen Coicis 360g Radix Paeoniae Rubra 288g
Rhizoma Atractylodis 288g Radix Angelicae Sinensis 360g Rhizoma Chuanxiong 288g Rhizoma Cyperi 288g
Rhizoma Corydalis (processed) 120g Rhizoma Alismatis 216g Herba Hedyotidis Diffusae 216g
Get Rhizoma Corydalis (processed) with 70% alcohol reflux secondary, each 1.5 hours, filter, filtrate recycling ethanol, clear paste is standby; Get Rhizoma Atractylodis, Rhizoma Cyperi, Radix Angelicae Sinensis, Rhizoma Chuanxiong four flavors again, extract volatile oil, and it is standby to collect aqueous solution with steam distillation; Medicinal residues add Herba Taraxaci, Herba Patriniae, Semen Coicis, Radix Paeoniae Rubra, Rhizoma Alismatis, Herba Hedyotidis Diffusae and decoct with water secondary, each 1.5 hours, filter merging filtrate, add to extract the filtrate behind the volatile oil, concentrating under reduced pressure becomes clear paste, adds ethanol and makes and contain the alcohol amount and reach 50%, cold preservation 24 hours, filter, decompression filtrate recycling ethanol adds the Rhizoma Corydalis clear paste, and continue to be condensed into thick paste, and vacuum drying, dried cream powder is broken, add starch and volatile oil to 400g, mixing is granulated, make 1000, incapsulate, promptly.
Claims (4)
1, a kind of pharmaceutical composition for the treatment of gynecological inflammation is characterized in that this pharmaceutical composition made by following bulk drugs:
180～540 parts of 180～540 parts of Semen Coiciss of 180～540 parts of Herba Patriniae of Herba Taraxaci
180～540 parts of 144～432 parts of Radix Angelicae Sinensis of 144～432 parts of Rhizoma Atractylodis of Radix Paeoniae Rubra
60～180 parts of 144～432 parts of Rhizoma Corydalis (processed)s of 144～432 portions of Rhizoma Cyperis of Rhizoma Chuanxiong
108～324 parts of 108～324 parts of Herba Hedyotidis Diffusaes of Rhizoma Alismatis
2, a kind of pharmaceutical composition for the treatment of gynecological inflammation as claimed in claim 1 is characterized in that this pharmaceutical composition made by following bulk drugs:
360 parts of 360 parts of Semen Coiciss of 360 parts of Herba Patriniae of Herba Taraxaci
360 parts of 288 parts of Radix Angelicae Sinensis of 288 parts of Rhizoma Atractylodis of Radix Paeoniae Rubra
120 parts of 288 parts of Rhizoma Corydalis (processed)s of 288 portions of Rhizoma Cyperis of Rhizoma Chuanxiong
216 parts of 216 parts of Herba Hedyotidis Diffusaes of Rhizoma Alismatis
3, as claim 1,2 described a kind of preparation of drug combination methods for the treatment of gynecological inflammation, it is characterized in that this method is: get Rhizoma Corydalis (processed) with 50～90% alcohol reflux 2～3 times, each 1～3 hour, filter, filtrate recycling ethanol, clear paste is standby; Get Rhizoma Atractylodis, Rhizoma Cyperi, Radix Angelicae Sinensis, Rhizoma Chuanxiong four flavors again, extract volatile oil, and it is standby to collect aqueous solution with steam distillation; Medicinal residues add Herba Taraxaci, Herba Patriniae, Semen Coicis, Radix Paeoniae Rubra, Rhizoma Alismatis, Herba Hedyotidis Diffusae and decoct with water 2～3 times, each 1～3 hour, filter merging filtrate, add to extract the filtrate behind the volatile oil, concentrating under reduced pressure becomes clear paste, adds ethanol and makes and contain the alcohol amount and reach 40～70%, cold preservation 24 hours filters decompression filtrate recycling ethanol, add the Rhizoma Corydalis clear paste, and continue to be condensed into thick paste, vacuum drying, dried cream powder is broken, adds adjuvant and volatile oil, mixing, granulate, incapsulate, promptly.
4, a kind of preparation of drug combination method for the treatment of gynecological inflammation as claimed in claim 3 is characterized in that this method is: get Rhizoma Corydalis (processed) with 70% alcohol reflux secondary, and each 1.5 hours, filter, filtrate recycling ethanol, clear paste is standby; Get Rhizoma Atractylodis, Rhizoma Cyperi, Radix Angelicae Sinensis, Rhizoma Chuanxiong four flavors again, extract volatile oil, and it is standby to collect aqueous solution with steam distillation; Medicinal residues add Herba Taraxaci, Herba Patriniae, Semen Coicis, Radix Paeoniae Rubra, Rhizoma Alismatis, Herba Hedyotidis Diffusae and decoct with water secondary, each 1.5 hours, filter merging filtrate, add to extract the filtrate behind the volatile oil, concentrating under reduced pressure becomes clear paste, adds ethanol and makes and contain the alcohol amount and reach 50%, cold preservation 24 hours filters decompression filtrate recycling ethanol, add the Rhizoma Corydalis clear paste, and continue to be condensed into thick paste, vacuum drying, dried cream powder is broken, adds starch or dextrin and volatile oil, mixing, granulate, incapsulate, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021534594A CN1187072C (en) | 2002-11-29 | 2002-11-29 | Medicine composition for treating gynaecology inflammation and its prepn. method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021534594A CN1187072C (en) | 2002-11-29 | 2002-11-29 | Medicine composition for treating gynaecology inflammation and its prepn. method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1418684A true CN1418684A (en) | 2003-05-21 |
| CN1187072C CN1187072C (en) | 2005-02-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021534594A Expired - Lifetime CN1187072C (en) | 2002-11-29 | 2002-11-29 | Medicine composition for treating gynaecology inflammation and its prepn. method |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100352466C (en) * | 2005-07-22 | 2007-12-05 | 谢棋 | Gynecologic antipruritic capsule, an dits prepn. method |
| CN100367929C (en) * | 2004-03-17 | 2008-02-13 | 咸阳步长医药科技发展有限公司 | Preparation of Chinese traditional medicine for curing female inflammation and preparation method |
| CN102139072A (en) * | 2011-03-18 | 2011-08-03 | 山东步长神州制药有限公司 | Chinese medicinal preparation for treating gynecological inflammation |
| CN102357219A (en) * | 2011-10-27 | 2012-02-22 | 陈仁德 | Traditional Chinese medicament for curing gynaecological damp and hot morbid leucorrhea and preparation method thereof |
| CN103845664A (en) * | 2014-03-05 | 2014-06-11 | 王世英 | Medicine composition for treating gynecologic inflammation |
| CN111413442A (en) * | 2020-05-07 | 2020-07-14 | 山东步长神州制药有限公司 | Medicine content detection method and application thereof |
-
2002
- 2002-11-29 CN CNB021534594A patent/CN1187072C/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100367929C (en) * | 2004-03-17 | 2008-02-13 | 咸阳步长医药科技发展有限公司 | Preparation of Chinese traditional medicine for curing female inflammation and preparation method |
| CN100352466C (en) * | 2005-07-22 | 2007-12-05 | 谢棋 | Gynecologic antipruritic capsule, an dits prepn. method |
| CN102139072A (en) * | 2011-03-18 | 2011-08-03 | 山东步长神州制药有限公司 | Chinese medicinal preparation for treating gynecological inflammation |
| CN102139072B (en) * | 2011-03-18 | 2012-03-28 | 山东步长神州制药有限公司 | Chinese medicinal preparation for treating gynecological inflammation |
| CN102357219A (en) * | 2011-10-27 | 2012-02-22 | 陈仁德 | Traditional Chinese medicament for curing gynaecological damp and hot morbid leucorrhea and preparation method thereof |
| CN103845664A (en) * | 2014-03-05 | 2014-06-11 | 王世英 | Medicine composition for treating gynecologic inflammation |
| CN111413442A (en) * | 2020-05-07 | 2020-07-14 | 山东步长神州制药有限公司 | Medicine content detection method and application thereof |
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| Publication number | Publication date |
|---|---|
| CN1187072C (en) | 2005-02-02 |
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Owner name: QIYUANYIDE MEDICINES INST., BEIJING Free format text: FORMER OWNER: ZHANG HUIFANG Effective date: 20030812 |
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Effective date of registration: 20030812 Address after: 100027, Beijing, Chaoyang District, East Third Ring Road, Xin 2, di Yang building, room 10, 1007A Applicant after: Beijing Qi Yuan Yi De Pharmaceuticals Research Center Address before: 100027, Beijing, Chaoyang District, East Third Ring Road, Xin 2, di Yang building, room 10, 1007A Applicant before: Zhang Huifang |
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Assignee: Shandong Shenzhou Pharmaceutical Co.,Ltd. Assignor: BUCHANG Group Contract fulfillment period: 2009.10.12 to 2022.11.29 Contract record no.: 2009610000006 Denomination of invention: Pharmaceutical composition for treating gynecological inflammation and preparation method thereof Granted publication date: 20050518 License type: Exclusive license Record date: 20091022 |
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Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.10.12 TO 2022.11.29; CHANGE OF CONTRACT Name of requester: SHANDONG SHENZHOU PHARMACEUTICAL CO., LTD. Effective date: 20091022 |
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Assignee: Shandong Shenzhou Pharmaceutical Co.,Ltd. Assignor: BUCHANG Group Contract fulfillment period: 2009.10.12 to 2022.11.28 Contract record no.: 2009610000006 Denomination of invention: Pharmaceutical composition for treating gynecological inflammation and preparation method thereof Granted publication date: 20050518 License type: Exclusive license Record date: 20091022 |
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Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.10.12 TO 2022.11.28; CHANGE OF CONTRACT Name of requester: SHANDONG SHENZHOU PHARMACEUTICAL CO., LTD. Effective date: 20091022 |
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Owner name: SHANDONG SHENZHOU PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: XIANYANG BUCHANG PHARMACEUTICAL CO., LTD. Effective date: 20100225 |
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Free format text: CORRECT: ADDRESS; FROM: 712000 NO.123, WESTWARD EXTENSION SECTION, WEIYANG WEST ROAD, XIANYANG CITY TO: 274000 NO.1, YINCHUAN ROAD, HEZE CITY, SHANDONG PROVINCE |
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Effective date of registration: 20100225 Address after: 274000 No. 1, Yinchuan Road, Heze City, Shandong Patentee after: Shandong Shenzhou Pharmaceutical Co.,Ltd. Address before: 712000 Xianyang City Weiyang Road West No. 123 Patentee before: BUCHANG Group |
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Owner name: SHANDONG BUCHANG SHENZHOU PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: SHANDONG SHENZHOU PHARMACEUTICAL CO., LTD. |
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Address after: 274000 No. 1, Yinchuan Road, Heze City, Shandong Patentee after: Shandong Buchang Shenzhou Pharmaceutical Co.,Ltd. Address before: 274000 No. 1, Yinchuan Road, Heze City, Shandong Patentee before: Shandong Shenzhou Pharmaceutical Co.,Ltd. |
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Granted publication date: 20050202 |
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