CN1034474C - Preparation of traditional Chinese medicine sophora flower and producing process thereof - Google Patents
Preparation of traditional Chinese medicine sophora flower and producing process thereof Download PDFInfo
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- CN1034474C CN1034474C CN91109971A CN91109971A CN1034474C CN 1034474 C CN1034474 C CN 1034474C CN 91109971 A CN91109971 A CN 91109971A CN 91109971 A CN91109971 A CN 91109971A CN 1034474 C CN1034474 C CN 1034474C
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Abstract
The present invention provides the preparation of traditional Chinese medicine-compound sophora flower for treating acne and a manufacturing technique. The preparation forms formulation for aiming to solve pathogeny causing acne in vivo by the theory analysis of Chinese medicine. The technique can completely extract effective constituents in raw material, increase the content of the effective constituents of the medicine, and reduce the dosage and the cost of the medicine; thus, the present invention improves the administration route of the existing medicine for clinically treating acne. The present invention has obvious clinical curative effect, reaches an effective rate of 91%, and has small toxic and side effect and high safety.
Description
The present invention relates to a kind of preparation and production technology for the treatment of the Chinese medicine compound Flos ulmi pumilae of acne.It belongs to tcm field.
At present, be used for treating the medicine of acne clinically, many externally applied liniments of producing with synthetic method, as: vitamin B
6Ointment or erythromycin ointment.These medicines are embrocated in the affected part, though can solve partial and problem for the moment, curative effect can not be lasting, and its reason just is not solve the basic reason that acne takes place.Theory according to the traditional Chinese medical science: various macules, furuncle are amassed in interior many being accumulate by evil poison, and the smooth or wet impatency of pathogenic wind-warm of QI-blood circulation is in myocutaneous junction, site where the skin and muscle are joined, long-pending and give birth to heat, corrupt flesh and blood forms.Therefore when this class disease of treatment, work as and consider heat-clearing and toxic substances removing, removing heat from blood blood stasis expelling, dispeiling pathogenic wind and removing dampness.Start with from solving the cause of disease that produces acne, reach the purpose of treatment acne.
The object of the invention is to provide a kind of preparation and production technology of the treatment acne medicine that can address the above problem, and fundamentally solves the cause of disease that produces acne, reaches the purpose of controlling acne.
The objective of the invention is to realize by the following method:
With Radix Et Rhizoma Rhei 10g, Radix Angelicae Sinensis 15g, Flos Sophorae 15g, Fructus Forsythiae 15g, Radix Achyranthis Bidentatae 15g, Radix Clematidis 15g, Radix Rehmanniae 15g, Flos Lonicerae 15g, Cacumen Platycladi 15g, Radix Sanguisorbae 15g, Radix Paeoniae Rubra 15g, Rhizoma Atractylodis 15g cleans, decoct with water twice, each 2 hours, collecting decoction, filter, filtrate decompression is concentrated into the clear paste of relative density 1.15-1.25 (50 ℃ of heat are surveyed), put coldly, add ethanol and make and contain alcohol amount and reach 65-75%, stir, left standstill 24 hours, the extraction supernatant, decompression recycling ethanol gets thick paste to there not being the alcohol flavor, with thick paste 70-80 ℃ bake drying, can make any dosage form of oral medicine as required.
Adopt above-mentioned preparation and process, can extract the effective ingredient in the raw material and improve yield, thereby reduce dosage, reduce the cost of this medicine, this effective elements of the medicine content is improved.The Chinese medicine compound Flos Sophorae has changed the route of administration of in the past treating the acne medicine, and the change externally applied liniment is oral medicine.This medical instrument has the effect of heat reliving and toxin-eliminating, removing heat from blood blood stasis expelling, dispeiling pathogenic wind and removing dampness and reducing swelling and alleviating pain.By conditioning, eliminate the cause of disease that produces acne, reach the purpose of treatment acne, so clinical efficacy is remarkable, through clinical 100 example checkings, total effective rate reaches 91%.Mixed hemorrhoids also had certain curative effect.Because the acne course of disease is generally longer, often need long-term continuous use treatment, and this poison of drug side effect is little, 100 routine experimenters serve on did not all have the discovery obvious toxic-side effects in 4 weeks.These characteristics are just meeting the needs for the treatment of acne.
To further specify below by following examples:
Embodiment 1: the best preparation and the production technology of Chinese medicine compound Flos Sophorae:
Radix Et Rhizoma Rhei 10g Radix Angelicae Sinensis 15g Flos Sophorae 15g
Fructus Forsythiae 15g Radix Achyranthis Bidentatae 15g Radix Clematidis 15g
Radix Rehmanniae 15g Flos Lonicerae 15g Cacumen Platycladi 15g
Radix Sanguisorbae 15g Radix Paeoniae Rubra 15g Rhizoma Atractylodis 15g
Above-mentioned raw materials is cleaned, decocted with water twice, each 2 hours, collecting decoction filtered.Filtrate decompression is concentrated into the clear paste that relative density is 1.20 (50C heat is surveyed), puts cold.Add ethanol and make and contain alcohol amount and reach 70%, stir, left standstill 24 hours, extract supernatant, decompression recycling ethanol is not to there being the alcohol flavor, thick paste.With 80 ℃ of bake dryings of thick paste.Can make any peroral dosage form as required.
The inventor finds: make solvent with ethanol in production technology, 70% ethanol is detergent and standardize solution solvent, and the method that adopts hot reflux to extract 3 hours can be clean with the extracts active ingredients in the raw material.
Experimental example 1: the pharmacodynamic study of Chinese medicine compound Flos Sophorae.
Extracorporeal bacteria inhibitor test:
The Chinese medicine compound Flos Sophorae that uses aforementioned preparation and production technology to produce, by China Microbial Culture Preservation Commission medical mycology center on behalf of carrying out extracorporeal bacteria inhibitor test.Check the Proprionbacterium acnes counts (No.P.37) of bacterial strain uses therefor for providing, three kinds of P.acnes ATCC6919 and P.acnes Su969U.S.A by bacterium base method by kind university in the Britain.Gained is the result point out: compound recipe Flos Sophorae 1.0mg is above to have antibacterial action to three strain bacterium.(No. 901108, survey report numbering)
Experimental example 2: the acute and long term toxicity test of Chinese medicine compound Flos Sophorae
The Chinese medicine compound Flos Sophorae that uses aforementioned preparation and production technology to produce, the acute and long term toxicity test of doing via Chinese Radiation Medical Science Inst., Chinese Academy of Military Medical Science (CN shows: this medicine LD
50Greater than the 6.3g/kg body weight, day clothes maximum dosage-feeding is greater than the 18.9g/kg body weight.Mice oral 6.3g/kg body weight every day serve on 7 days and does not see animal dead, and body weight and main organs weight and normal control group are than equal first significant difference.Oral this medicine of rat 0.21-2.1g/kg body weight serve on 60 days, and with normal control animal ratio, external blood phase and blood parameters are not seen significant variation.(raw data is stored in Chinese Radiation Medical Science Inst., Chinese Academy of Military Medical Science (CN)
Experimental example 3: the clinical verification of Chinese medicine compound Flos Sophorae
Curative effect % group example number total effective rate %
Cure produce effects enabledisable papular type 65 80.0 15.4 3.1 1.5 98.5 born of the same parents' skin ulcer types 13 69.2 15.4 7.7 7.7 92.3 nodular types 10 10.0 30.0 40.0 20.0 80.0 cyst types 70 57.1 14.3 28.6 71.4 aggretion types 50 20.0 20.0 60.0 40.0 and add up to 100 82.0 20.0 9.0 9.0 91.0
Illustrate:
1. clinical verification material therefor and method:
(1) medicine: the Chinese medicine compound Flos Sophorae that uses aforementioned formula and production technology to manufacture.
(2) observational technique: select homeliness type acne patient by the diagnosis of " clinical dermatology " required standard.Every day 3 times, each 0.6g, serveing on for 4 weeks is a course of treatment.Advise the experimenter weekly further consultation once, observed and recorded skin lesion situation of change and and relevant symptom, the sign of taking medicine.
(3) curative effect determinate standard:
Clinical cure: skin is complete and disappear no New Development skin lesion;
Produce effects: 70% above skin lesion disappears, no New Development skin lesion;
Effectively: 50% left and right sides skin lesion disappears, no New Development skin lesion;
Invalid: period in a medicine only has a small amount of skin lesion to disappear, and the New Development skin lesion is arranged.
2. papular type acne group has 5 routine patients to suffer from the Combination hemorrhoid simultaneously, takes all very fast recovery from illness behind this medicine.
3. side effect: 100 routine experimenters apparent side effect all do not occur at period in a medicine.
Claims (2)
1, a kind of treatment acne preparation method of Chinese medicine is characterized in that choosing raw material by following composition and proportioning
Radix Et Rhizoma Rhei 10 grams
Radix Angelicae Sinensis 15 grams
Flos Sophorae 15 grams
Fructus Forsythiae 15 grams
Radix Achyranthis Bidentatae 15 grams
Radix Clematidis 15 grams
The Radix Rehmanniae 15 grams
Flos Lonicerae 15 grams
Cacumen Platycladi 15 grams
Radix Sanguisorbae 15 grams
Radix Paeoniae Rubra 15 grams
Rhizoma Atractylodis 15 grams
Above-mentioned raw materials is cleaned, decocted with water twice, each two hours, collecting decoction filters, and filtrate decompression is concentrated into the clear paste of relative density 1.15-1.25 (50 ℃ of heat are surveyed), put coldly, add ethanol and make and contain alcohol amount and reach 65-75%, stir, left standstill 24 hours, extract supernatant, decompression recycling ethanol gets thick paste to tasteless, thick paste in 70-80 ℃ of bake drying, is prepared into medicinal preparation for oral administration.
2, according to the preparation method of claim 1, wherein filtrate decompression is concentrated into the clear paste of relative density 1.20 (50 ℃ of heat are surveyed), put coldly, add ethanol and make and contain alcohol amount and reach 70%, stir, left standstill 24 hours, extract supernatant, decompression recycling ethanol gets thick paste to tasteless, thick paste in 80 ℃ of bake dryings, is prepared into medicinal preparation for oral administration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN91109971A CN1034474C (en) | 1991-10-31 | 1991-10-31 | Preparation of traditional Chinese medicine sophora flower and producing process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN91109971A CN1034474C (en) | 1991-10-31 | 1991-10-31 | Preparation of traditional Chinese medicine sophora flower and producing process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1071841A CN1071841A (en) | 1993-05-12 |
| CN1034474C true CN1034474C (en) | 1997-04-09 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN91109971A Expired - Fee Related CN1034474C (en) | 1991-10-31 | 1991-10-31 | Preparation of traditional Chinese medicine sophora flower and producing process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1034474C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1050519C (en) * | 1995-12-14 | 2000-03-22 | 祝继兴 | Chinese medicine granule for acne |
| CN1069539C (en) * | 1999-08-18 | 2001-08-15 | 遇存英 | Medicinal composition for curing acne and folliculitis and its preparation method |
-
1991
- 1991-10-31 CN CN91109971A patent/CN1034474C/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 《中医药信息》89年(6)-27-32 1989.1.1 《中医药信息》编辑部89年11月10日出版 * |
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| Publication number | Publication date |
|---|---|
| CN1071841A (en) | 1993-05-12 |
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