CN1071841A - Preparation of traditional chinese medicine sophora flower and producing process thereof - Google Patents

Preparation of traditional chinese medicine sophora flower and producing process thereof Download PDF

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Publication number
CN1071841A
CN1071841A CN 91109971 CN91109971A CN1071841A CN 1071841 A CN1071841 A CN 1071841A CN 91109971 CN91109971 CN 91109971 CN 91109971 A CN91109971 A CN 91109971A CN 1071841 A CN1071841 A CN 1071841A
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chinese medicine
traditional chinese
sophora
preparation
15g
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CN 91109971
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CN1034474C (en )
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张明
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张明
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Abstract

The present invention provides the preparation of traditional Chinese medicine, sophora flower mixture, and its production process. The said process features complete extraction of effective components from raw materials, thus increasing drug effective components content with reduced dosage and cost. The said medicine has obvious curative effect of 91% curative rate, less toxic side reactions, and increased safety.

Description

本发明涉及一种治疗痤疮的中药复方榆花的配制及生产工艺。 The present invention relates to a method for treating acne in traditional Chinese medicine Sorbus preparation and production process. 它属于中医药领域。 It belongs to the field of medicine.

目前,临床上用来治疗痤疮的药物,多以调制的方法生产的外用擦剂,如:维生素B6软膏或红霉素软膏。 Currently, the drug is used to treat acne Clinically, much to the modulation method of producing topical liniment, such as: vitamin B6 ointment or erythromycin ointment. 这些药涂擦于患处,虽然能解决局部的和一时的问题,但疗效不能持久,其原因就在于没有解决发生痤疮的根本原因。 These drugs rubbed on the affected area, although able to solve partial and temporary problem, but the effect can not be sustained, the reason is that does not solve the root cause of acne. 依据中医的理论:各种斑疹、疔疮多由邪毒蕴积于内,气血运行不畅或风温湿闭阻于皮腠,积而生热、腐败血肉而成。 According to the theory of Chinese medicine: various rash, boils stored up by the multi-cult poison in poor blood running wind or temperature and humidity resistance in the closed Cou skin, and accumulated heat, flesh from corruption. 因此在治疗这类疾病时当考虑清热解毒,凉血行淤,祛风燥湿。 Therefore, when considering the treatment of such diseases detoxification, cooling line silt, chills and dampness. 从解决产生痤疮的病因入手,达到治疗痤疮之目的。 Start from the cause with produce acne, achieve the purpose of acne treatment.

本发明目的在于提供一种能解决上述问题的治疗痤疮药的配制及生产工艺,从根本上解决产生痤疮的病因,达到治痤疮的目的。 Object of the present invention is to solve the above problems to provide a therapeutic drug for acne formulation and production technology to solve the cause of acne is generated from the fundamental purpose of acne treatment.

本发明的目的是通过以下方法实现的:将大黄10g、归尾15g、槐花15g、连翘15g、牛膝15g、威灵仙15g、生地15g、银花15g、侧柏叶15g、地榆15g、赤芍15g、苍术15g洗净,加水煎煮两次,每次2小时,合并煎液,滤过,滤液减压浓缩至相对密度1.15-1.25(50℃热测)的清膏,放冷,加乙醇使含醇量达65-75%,搅拌均匀,静置24小时,制取上清液,减压回收乙醇至无醇味,得稠膏,将稠膏70-80℃烘干干燥,根据需要可做成口服药的任何一种剂型。 Object of the present invention is achieved by the following method: rhubarb 10g, the final end 15g, SJ 15g, forsythia 15g, Achyranthes 15g, Clematis 15g, habitat 15g, honeysuckle 15g, Biota orientalis 15g, Burnet 15g, Radix 15g, 15g herb washed twice with boiling water for two hours each, decoctions were combined, filtered, and the filtrate was concentrated to the relative density of 1.15-1.25 (50 ℃ calorimetric) clear paste under reduced pressure, the discharge cool, add ethanol containing 65-75% alcohol content, stir and let stand for 24 hours to the supernatant, recovering ethanol under reduced pressure until no alcohol taste to give a thick paste, drying the thick paste 70-80 ℃ drying, if necessary, can be made of any oral dosage form.

采用上述配制和工艺方法,可提取出原料中的有效成分并提高收率,从而减少用药量,降低该药的成本,也使此药的有效成分含量提高。 Formulation and method of the above-described processes, the active ingredients can be extracted and to increase the yield of the raw material, thereby reducing the amount of medication, to reduce the cost of the drug, but also the content of the effective ingredient of the drug is improved. 中药复方槐花改变了以往治疗痤疮药的给药途径,变外用擦剂为内服药。 SJ traditional Chinese medicine has changed the route of administration in the past to treat acne medication, topical liniment to change internal medicine. 此药具有消热解毒、凉血行淤、祛风燥湿及消肿止痛的作用。 This drug has a heat dissipation detoxifying, cooling line silt, chills and dampness swelling analgesic effect. 通过调理,消除产生痤疮的病因,达到治疗痤疮之目的,因此临床疗效显著,经临床100例验证,总有效率达91%。 By conditioning, eliminate the cause of acne, the purpose of the treatment of acne, thus significant clinical effect, clinical validation 100 cases, the total effective rate was 91%. 对混合痔疮也具有一定的疗效。 Mixed hemorrhoids also have a certain effect. 由于痤疮病程一般较长,往往需要长期连续用药治疗,而此药毒副作用小,100例受试者连服4周均无发现明显毒副作用。 Because acne is generally longer course, often require long-term continuous drug treatment, drug toxicity and side effects, 100 cases of subjects and even served four weeks found no obvious side effects. 这一特点正符合治疗痤疮的需要。 This characteristic is in line with the need to treat acne.

下面通过以下实施例将进一步说明:实施例1:中药复方槐花的最佳配制及生产工艺:大黄10g 归尾15g 槐花15g连翘15g 牛膝15g 威灵仙15g生地15g 银花15g 侧柏叶15g地榆15g 赤芍15g 苍术15g将上述原料洗净,加水煎煮两次,每次2小时,合并煎液,滤过。 By following examples will further illustrate the following embodiments: Example 1: preparation of compound of Sophora japonica and Chinese best production process: SJ rhubarb 15g 15g 15g forsythia Achyranthes 15g 15g Clematis orientalis habitat 15g 15g 10g Silver Flower Dangguiwei Burnet leaves 15g 15g 15g herb Radix 15g the raw material washed twice with boiling water for two hours each, combined decoction, filtration. 滤液减压浓缩至相对密度为1.20(50℃热测)的清膏,放冷。 The filtrate was concentrated under reduced pressure to a relative density of 1.20 (50 ℃ calorimetric) clear paste, allowed to cool. 加乙醇使含醇量达70%,搅拌均匀,静置24小时,抽取上清液,减压回收乙醇至无醇味,得稠膏。 Ethanol was added 70% alcohol content, stir and let stand for 24 hours, extracting the supernatant, recovering ethanol under reduced pressure until no alcohol taste to give a thick paste. 将稠膏80℃烘干干燥。 Drying the thick paste and dried 80 deg.] C. 根据需要可做成任何一种口服剂型。 It can be made according to need any oral dosage form.

本发明人发现:在生产工艺中以乙醇作溶剂,70%的乙醇为洗涤剂和定容溶剂,采用热回流提取3小时的方法能将原料中的有效成分提取干净。 The present inventors found that: in a production process to ethanol as solvent, 70% ethanol solvent detergent and constant volume, by thermal reflux extraction for 3 hours to extract the active ingredient can a clean feedstock.

实施例2:中药复方槐花的药效学研究。 Example 2: Pharmacodynamic Study of traditional Chinese medicine Sophora japonica.

体外抑菌试验:使用前述配制及生产工艺生产的中药复方槐花,由中国微生物菌种保藏委员会医学真菌中心代为进行体外抑菌试验。 Antibacterial test: the formulation and production technology of traditional Chinese medicine Sophora japonica, by the China Medical Fungal Culture Collection Center Committee on behalf of in vitro antibacterial test. 按菌基法检查所用菌株为由英国里慈大学提供的Proprionbacterium acnes counts(No.P.37),P.acnes ATCC 6919,和P.acnes Su 969 USA三种。 Check-yl bacteria by law in the United Kingdom by Chi University provided Proprionbacterium acnes counts (No.P.37), P.acnes ATCC 6919, and by three kinds of P.acnes Su 969 USA strains. 所得结果指出:复方槐花1.0mg以上对三株菌有抗菌作用。 The results pointed out: more than 1.0mg Compound Sophora japonica have an antibacterial effect against three strains. (检验报告编号901108号)实施例3:中药复方槐花的急性和长期毒性试验使用前述配制及生产工艺生产的中药复方槐花,经由中国军事医学科学院放射医学研究所所做的急性和长期毒性试验表明:该药LD50大于6.3g/kg体重,日服最大给药量大于18.9g/kg体重。 (Inspection Report No. No. 901 108) Example 3: Compound Sophora japonica Chinese medicine acute and long-term toxicity tests using the aforementioned production process preparation and production of traditional Chinese medicine Sophora japonica, radiation through the Chinese Academy of Military Medical Institute of Medicine, acute and long-term toxicity do test showed that: the drug LD50 greater than 6.3g / kg body weight, administered daily doses greater than the maximum 18.9g / kg body weight. 小鼠每日口服6.3g/kg体重,连服7天未见动物死亡,体重与主要脏器重量与正常对照组比均无明显差别。 Mice daily oral 6.3g / kg body weight, for 7 days, no animal death, and the main body organ weight than the control group had no significant difference. 大鼠口服该药0.21-2.1g/kg体重,连服60天,与正常对照动物比,外用血相和血液生化指标未见有意义的变化。 Rat oral drug 0.21-2.1g / kg body weight, even 60 days, compared with normal control animals, the external phase of blood and blood biochemical indices no significant changes. (原始资料存于中国军事医学科学院放射医学研究所)实施例4:中药复方槐花的临床验证疗效% 总有效率%组别 例数治愈 显效 有效 无效丘疹型 65 80.0 15.4 3.1 1.5 98.5胞疮型 13 69.2 15.4 7.7 7.7 92.3结节型 10 10.0 30.0 40.0 20.0 80.0囊肿型 7 0 57.1 14.3 28.6 71.4聚合型 5 0 20.0 20.0 60.0 40.0合计 100 82.0 20.0 9.0 9.0 91.0说明:1.临床验证所用材料与方法:(1)药物:使用前述配方和生产工艺制做的中药复方槐花。 (Raw data stored in the Chinese Military Academy of Medical Sciences Institute of Radiation Medicine) Example 4: clinical validation of the efficacy of traditional Chinese medicine compound Huaihua% total efficiency% group number of cases markedly effective cure for pimples invalid type 65 80.0 15.4 3.1 1.5 98.5 sore cell type 13 69.2 15.4 7.7 7.7 10 10.0 30.0 92.3 nodular cystic 40.0 20.0 80.0 57.1 14.3 70 28.6 71.4 50 20.0 20.0 polymer 60.0 40.0 82.0 20.0 9.0 9.0 total 100 91.0 Note: 1 clinical validation of the method and materials used :( 1) Drug: using the formulation and process of making traditional Chinese medicine Sophora japonica.

(2)观察方法:选择按《临床皮肤病学》规定标准诊断的寻常型痤疮病人。 (2) observation methods: by selecting "Clinical Dermatology" provides patients with acne vulgaris standard diagnosis. 每日3次,每次0.6g,连服4周为一疗程。 3 times a day, each 0.6g, even for 4 weeks for a course. 嘱受试者每周复诊一次,观察记录皮损变化情况及与服药有关的症状、体征。 He told his subjects visit once a week, observe and record changes in skin lesions and medication-related symptoms and signs.

(3)疗效判定标准: (3) Clinical criteria:

临床治愈:皮完全并消退,无新发皮损; Clinical cure: skin and completely dissipated, no new lesions;

显效:70%以上皮损消退,无新发皮损; Markedly: more than 70% regression of lesions, no new lesions;

有效:50%左右皮损消退,无新发皮损; Effective: 50% regression of lesions, no new lesions;

无效:服药期间仅有少量皮损消退,有新发皮损。 Invalid: medication during only a small amount of skin lesions subsided, new skin lesions.

2.丘疹型痤疮组有5例病人同时患有混合性痔疮,服用该药后均很快痊愈。 2. acne pimples group, 5 patients also suffer from mixed hemorrhoids, after taking the drug were quickly recovered.

3.副作用:100例受试者在服药期间均未出现明显副作用。 3. side: 100 subjects were no obvious side effects during the medication.

Claims (2)

  1. 1.中药复方槐花的配制及生产工艺其特征是:原料为:大黄 归尾 槐花连翘 牛膝 威灵仙生地 银花 侧柏叶地榆 赤芍 苍术 1. Compound Sophora medicine preparation and production process wherein: materials: rhubarb Dangguiwei SJ forsythia Achyranthes Clematis Radix Rehmannia honeysuckle Biota orientalis herb Burnet
  2. 2.中药复方槐花的配制及生产工艺其特征是:将原料洗净,加水煎煮两遍,每次2小时,滤液减压浓缩至相对密度为1.15-1.25(50℃热测)的清膏,放冷,加乙醇使含醇量达65-75%,搅拌均匀,静置24小时,抽取上清液,减压回收乙醇至无醇味,得稠膏,将稠膏70-80℃烘干干燥,根据需要可做成任何一种口服剂型。 2. The herbal composition Sophora formulation and production technology wherein: Wash feedstock, boiling water twice, 2 hours each time, and the filtrate was concentrated under reduced pressure to a relative density of 1.15-1.25 (50 ℃ calorimetric) clear cream, cool, add ethanol containing alcohol amounted to 65-75%, stir for 24 hours, extracting the supernatant, recovering ethanol under reduced pressure until no alcohol taste to give a thick paste, the thick paste 70-80 ℃ drying dried, if necessary, can be made of any oral dosage form.
CN 91109971 1991-10-31 1991-10-31 Method for producing traditional Chinese medicine for treatment of acne CN1034474C (en)

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1050519C (en) * 1995-12-14 2000-03-22 祝继兴 Chinese medicine granule for treatment of acne
CN1069539C (en) * 1999-08-18 2001-08-15 遇存英 Medicinal composition for curing acne and folliculitis and its preparation method
CN100490851C (en) 2007-02-08 2009-05-27 刘海刚 Chinese-western medicine composition for treating acne
CN100496560C (en) 2007-02-08 2009-06-10 国 李 Medicament containing garamycin
CN100496557C (en) 2007-02-05 2009-06-10 汪甬伟 Chinese-western medicine composition containing jiemycin for treating acne
CN100496559C (en) 2007-02-05 2009-06-10 国 李 Drug containing ranitidine
CN100500185C (en) 2007-02-08 2009-06-17 国 李 Composition containing isotretinoin for treating acne
CN100502909C (en) 2007-02-05 2009-06-24 谦 陈 Chinese-western medicine composition containing cimetidine for treating acne
CN100502910C (en) 2007-02-07 2009-06-24 国 李 Chinese-western medicine composition containing erythromycin for treating acne
CN100560105C (en) 2007-02-08 2009-11-18 徐雪娟 Medicine composition for treating acne
CN100569256C (en) 2007-02-08 2009-12-16 谦 陈 A composition for treating acne

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100496556C (en) 2007-02-05 2009-06-10 汪甬伟 Medicine containing clindamycin for treating acne
CN100496558C (en) 2007-02-05 2009-06-10 汪甬伟 Drug containing metronidazole
CN100490852C (en) 2007-02-07 2009-05-27 华丽特 Synergistic composition containing benzoyl peroxide

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1050519C (en) * 1995-12-14 2000-03-22 祝继兴 Chinese medicine granule for treatment of acne
CN1069539C (en) * 1999-08-18 2001-08-15 遇存英 Medicinal composition for curing acne and folliculitis and its preparation method
CN100496557C (en) 2007-02-05 2009-06-10 汪甬伟 Chinese-western medicine composition containing jiemycin for treating acne
CN100496559C (en) 2007-02-05 2009-06-10 国 李 Drug containing ranitidine
CN100502909C (en) 2007-02-05 2009-06-24 谦 陈 Chinese-western medicine composition containing cimetidine for treating acne
CN100502910C (en) 2007-02-07 2009-06-24 国 李 Chinese-western medicine composition containing erythromycin for treating acne
CN100496560C (en) 2007-02-08 2009-06-10 国 李 Medicament containing garamycin
CN100500185C (en) 2007-02-08 2009-06-17 国 李 Composition containing isotretinoin for treating acne
CN100490851C (en) 2007-02-08 2009-05-27 刘海刚 Chinese-western medicine composition for treating acne
CN100560105C (en) 2007-02-08 2009-11-18 徐雪娟 Medicine composition for treating acne
CN100569256C (en) 2007-02-08 2009-12-16 谦 陈 A composition for treating acne

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