CN1943665A - A Chinese traditional medicinal composition and its preparation method - Google Patents
A Chinese traditional medicinal composition and its preparation method Download PDFInfo
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- CN1943665A CN1943665A CN 200510105942 CN200510105942A CN1943665A CN 1943665 A CN1943665 A CN 1943665A CN 200510105942 CN200510105942 CN 200510105942 CN 200510105942 A CN200510105942 A CN 200510105942A CN 1943665 A CN1943665 A CN 1943665A
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- rhizoma coptidis
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- filtering residue
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Abstract
This invention provides a Chinese traditional medicinal composition. The composition is composed by using Chinese corktree bark, kuhseng, canker-root and Pittosporum tobira according a certain processing technology. It has better curative effectiveness in treating abnormal fluor albus dui to downward flow of damp-heat, vulva itching, burning pain. The invention also revealed its' preparing method.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Vaginitis is the inflammation of connective tissue under vaginal mucosa and the mucosa, is the common disease of gynecological's outpatient service.Vaginitis changes with the character of leucorrhea clinically and the pudendum infections is itched, and causalgia is main clinical characters, and common vaginitis has bacterial vaginitis, trichomonal vaginitis, colpitis mycotica, senile vaginitis.Because vagina communicates with the external world, often bad because of menstrual period or sexual life health, or because of factors such as childbirth and uteroventral operation cause vaginal infection, even can make inflammation attack internal reproductive organ.Suffer from diabetes, vitamin B group shortage, ovarian function decline in addition, some allergy or infectious disease person be easy infection more, the infective pathogen body often is mycete, antibacterial, mycoplasma, chlamydia etc., except that senile vaginitis, trichomonal vaginitis, colpitis mycotica sickness rate in recent years are on the rise.Therefore, explore very necessity of a kind of medicine of alleviating and treating such disease.
Summary of the invention
Chinese medicine composition that the purpose of this invention is to provide and a kind ofly prepare that leukorrhagia due to the treatment damp invasion of lower energizer is unusual, uses in the pruritus vulvae, scorching hot pain medicine and preparation method thereof.
The present invention seeks to be achieved through the following technical solutions:
At first be that prescription is formed, comprise following crude drug:
Cortex Phellodendri 30～50 weight portion Radix Sophorae Flavescentiss 50～80 weight portions
Rhizoma Coptidis 30～50 weight portion Cortex erythrinaes 20～40 weight portions
Further after the research, determine that its best group becomes:
Cortex Phellodendri 40 weight portion Radix Sophorae Flavescentiss 60 weight portions
Rhizoma Coptidis 40 weight portion Cortex erythrinaes 30 weight portions
Should write out a prescription, invention is thought can make clinical required various dosage forms, is preferably washing liquid.Be directed to this, the inventor has carried out technical study again.In order to make washing liquid, must earlier former prescription medical material be extracted, its process is as follows:
More than four flavors, Rhizoma Coptidis powder is broken into coarse powder, soaks with 0.5% citric acid, decoct, filtration, filtrate, filtering residue are collected standby respectively.Three flavors such as Cortex Phellodendri, Radix Sophorae Flavescentis, Cortex erythrinae are soaked, and mix with above-mentioned Rhizoma Coptidis filtering residue, decoct, and filter, and filtering residue adds water, decocts, and filters, and filtrate and above-mentioned Rhizoma Coptidis filtrate merge, and concentrate, and obtain pharmaceutical intermediate.
Further research, with the technological parameter refinement:
More than four flavors, Rhizoma Coptidis powder is broken into coarse powder, with the about 200ml of 0.5% citric acid immersion 12 hours, decocted 45 minutes, filtration, filtrate, filtering residue are collected standby respectively.Three flavors such as Cortex Phellodendri, Radix Sophorae Flavescentis, Cortex erythrinae add water 600ml and soaked 12 hours, mix with above-mentioned Rhizoma Coptidis filtering residue, decoct 45 minutes, filter, and filtering residue adds water 500ml, decocts 45 minutes, filters, and filtrate and above-mentioned Rhizoma Coptidis filtrate merge, and concentrate, and obtain pharmaceutical intermediate.
Pharmaceutical intermediate is equipped with suitable adjuvant, just can make washing liquid.
The specific embodiment:
Pharmaceutical preparation of the present invention has the function of removing damp-heat, killing parasites for relieving itching, can be used for alleviating due to the damp invasion of lower energizer diseases such as leukorrhagia is unusual, pruritus vulvae, scorching hot pain.The inventor cures mainly according to its function, from parasite killing, antibacterial two aspects its pharmacodynamics is verified.
Be subjected to the reagent thing: No. 1, the preparation that makes according to technology of the present invention contains the washing liquid of 0.17g crude drug/ml.
FUYANXIAO PAOTENGPIAN: Guangzhou Zhongyi Medicine Industry Co., Ltd produces, lot number: 20040924.
Instrument: PB303-N electronic balance, Mettler-Toledo Instrument (Shanghai) Co., Ltd..
Animal: Kunming mouse 18～22g, the male and female dual-purpose is provided by Shandong University's Experimental Animal Center.
Test 1: external trichomonas vaginitis effect extremely
Separate from patient's vaginal secretions, inoculation contains in the liver-peptone-sugar culture-medium of penicillin and streptomycin, and every 4d transferred species 1 time is inoculated 4 times repeatedly, and counting makes when the infusorian number reaches 10,000/ml in the culture fluid, is for experiment.Culture medium is divided 4 groups, medicine carries out the two-fold dilution, in every pipe liver-peptone-sugar culture-medium, add 0.1ml trichomonal vaginitis culture fluid then, in 37 ℃ of following continuous culture 3d (under optical microscope, observing 1 time the infusorian active situation every day), 3d, every pipe is got the 0.1ml culture fluid, observes trichomonas vaginitis quantity and death condition, the results are shown in Table 1.
The effect of the external infusorian extremely of table 1
| Group | The medicinal liquid extension rate | |||||
| 1∶32 | 1∶16 | 1∶8 | 1∶4 | 1∶2 | 1∶1 | |
| Blank group this product preparation 1 positive drug group | + + + | + + + | + - + | + - + | + - - | + - - |
Annotate :+trichomonas vaginitis motion, active, cell is glossy, and infusorian quantity increases;-trichomonas vaginitis is in heaven, can not move cell tarnish, the cracking of part polypide.
Table 1 result shows that this product preparation has killing action to trichomonas vaginitis, and the medicinal liquid extension rate is visible infusorian death in 1: 8 o'clock, the cracking of part polypide.
Test 2: extracorporeal bacteria inhibitor test
This product preparation water proof is in 80 ℃ of water-baths sterilization 2h, and the bacterial classification inoculation that table 2 is listed is in the meat soup blood serum medium, and in 37 ℃ of following continuous culture 18h, the bacterium number reaches 900,000,000/ml in the bacterium liquid, gets broth bouillon and is diluted to 900,000/ml, uses for experiment.Candida albicans increases bacterium to be cultivated when reaching 5,000,000/ml, takes out and is diluted to 50,000/ml, standby.Make the training ware with chocolate blood meida, broth agar culture medium, blood agar culture-medium, sabouraud culture medium respectively, in the dish pipe of each bacterial strain training ware, add preparation, cultivate, survey inhibition zone behind 37 ℃ of following 18h, the result is the strongest to the streptococcus inhibitory action, and inferior is Candida albicans, sees Table 2.
Table 2 pair Candida albicans etc. suppress effect
| Strain name | Inhibition zone (mm) | |
| This product preparation | Positive control | |
| Bacterium escherichia coli Bacillus proteus streptococcus gonococcus is read bacterium in vain in the gold Portugal | 14.3±0.5 9.3±0.5 10.0±0.3 22.3±0.8 12.7±0.5 19.0±0.6 | 15.1±0.6 9.1±0.5 9.8±0.4 21.6±0.9 12.4±0.5 18.5±0.6 |
Result of the test shows: this product preparation is external to have certain inhibitory action to streptococcus, Candida albicans.
Further specify technical scheme of the present invention below by embodiment:
Embodiment one
[prescription] Cortex Phellodendri 40g Radix Sophorae Flavescentis 60g
Rhizoma Coptidis 40g Cortex erythrinae 30g
[method for making] above four flavors, Rhizoma Coptidis powder is broken into coarse powder, and about 200ml soaked 12 hours with 0.5% citric acid, decocted 45 minutes, filtered, and filtrate, filtering residue are collected standby respectively.Three flavors such as Cortex Phellodendri, Radix Sophorae Flavescentis, Cortex erythrinae add water 600ml and soaked 12 hours, mix with above-mentioned Rhizoma Coptidis filtering residue, decoct 45 minutes, filter, filtering residue adds water 500ml, decocts 45 minutes, filter, filtrate and above-mentioned Rhizoma Coptidis filtrate merge, and are concentrated into about 950ml, add ethyl hydroxybenzoate 0.5g, benzoic acid 1g stirs evenly, add water and adjust total amount, leave standstill, filter to 1000ml, packing, promptly.
Embodiment two
[prescription] Cortex Phellodendri 400g Radix Sophorae Flavescentis 600g
Rhizoma Coptidis 400g Cortex erythrinae 300g
[method for making] above four flavors, Rhizoma Coptidis powder is broken into coarse powder, and about 200ml soaked 12 hours with 0.5% citric acid, decocted 45 minutes, filtered, and filtrate, filtering residue are collected standby respectively.Three flavors such as Cortex Phellodendri, Radix Sophorae Flavescentis, Cortex erythrinae add water 600ml and soaked 12 hours, mix with above-mentioned Rhizoma Coptidis filtering residue, decoct 45 minutes, filter, filtering residue adds water 500ml, decocts 45 minutes, filters, filtrate and above-mentioned Rhizoma Coptidis filtrate merge, and being evaporated to relative density is the thick paste of 1.15～1.20 (60 ℃), oven drying at low temperature, pulverize, the powder that gets dry extract joins in the fused 36 type mixed aliphatic esters, mixing is made 2800g, moulding, take out the cooling back, makes 1000 pieces of bolts, promptly.
Claims (6)
1. Chinese medicine composition is characterized in that this pharmaceutical composition made by following raw material medicaments:
Cortex Phellodendri 30～50 weight portion Radix Sophorae Flavescentiss 50～80 weight portions
Rhizoma Coptidis 30～50 weight portion Cortex erythrinaes 20～40 weight portions
2. Chinese medicine composition as claimed in claim 1 is characterized in that this Chinese medicine composition made by following raw materials according:
Cortex Phellodendri 40 weight portion Radix Sophorae Flavescentiss 60 weight portions
Rhizoma Coptidis 40 weight portion Cortex erythrinaes 30 weight portions
3. Chinese medicine composition as claimed in claim 1 or 2 is characterized in that said composition can be made into clinical required various dosage forms, comprises washing liquid, suppository, soft capsule, spray, gel, effervescent tablet.
4. the preparation method of Chinese medicine composition as claimed in claim 1 or 2 is characterized in that:
More than four flavors, Rhizoma Coptidis powder is broken into coarse powder, soaks with 0.5% citric acid, decoct, filtration, filtrate, filtering residue are collected standby respectively.Three flavors such as Cortex Phellodendri, Radix Sophorae Flavescentis, Cortex erythrinae are soaked, and mix with above-mentioned Rhizoma Coptidis filtering residue, decoct, and filter, and filtering residue adds water, decocts, and filters, and filtrate and above-mentioned Rhizoma Coptidis filtrate merge, and concentrate, promptly.
5. the preparation method of Chinese medicine composition as claimed in claim 1 or 2 is characterized in that:
More than four flavors, Rhizoma Coptidis powder is broken into coarse powder, with the about 200ml of 0.5% citric acid immersion 12 hours, decocted 45 minutes, filtration, filtrate, filtering residue are collected standby respectively.Three flavors such as Cortex Phellodendri, Radix Sophorae Flavescentis, Cortex erythrinae add water 600ml and soaked 12 hours, mix with above-mentioned Rhizoma Coptidis filtering residue, decoct 45 minutes, filter, and filtering residue adds water 500ml, decocts 45 minutes, filters, and filtrate and above-mentioned Rhizoma Coptidis filtrate merge, and concentrate, promptly.
6. the application in the disease drugs such as Chinese medicine composition as claimed in claim 1 or 2 is unusual at leukorrhagia due to the preparation treatment damp invasion of lower energizer, vulva pruritus, scorching hot pain.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510105942 CN1943665A (en) | 2005-10-08 | 2005-10-08 | A Chinese traditional medicinal composition and its preparation method |
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| CN 200510105942 CN1943665A (en) | 2005-10-08 | 2005-10-08 | A Chinese traditional medicinal composition and its preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2445991C2 (en) * | 2010-05-06 | 2012-03-27 | Федеральное государственное бюджетное учреждение "Московский научно-исследовательский онкологический институт им. П.А. Герцена" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "МНИОИ им. П.А. Герцена" Минздравсоцразвития России) | Method of organ-preserving treatment of patients with initial carcinoma of vulva |
| CN103405646A (en) * | 2013-08-04 | 2013-11-27 | 张珍平 | TCM composition for treating recurrent-attack senile vaginitis |
| CN105012793A (en) * | 2013-07-01 | 2015-11-04 | 张世叶 | Preparation method of skin-wash liquid for treating vulvar cell hyperplasia |
-
2005
- 2005-10-08 CN CN 200510105942 patent/CN1943665A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2445991C2 (en) * | 2010-05-06 | 2012-03-27 | Федеральное государственное бюджетное учреждение "Московский научно-исследовательский онкологический институт им. П.А. Герцена" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "МНИОИ им. П.А. Герцена" Минздравсоцразвития России) | Method of organ-preserving treatment of patients with initial carcinoma of vulva |
| CN105012793A (en) * | 2013-07-01 | 2015-11-04 | 张世叶 | Preparation method of skin-wash liquid for treating vulvar cell hyperplasia |
| CN103405646A (en) * | 2013-08-04 | 2013-11-27 | 张珍平 | TCM composition for treating recurrent-attack senile vaginitis |
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Open date: 20070411 |