CN1418667A - Chinese patent drug for treating diabets mellitus - Google Patents

Abstract

The Chinese patent medicine for curing diabetes with obvious therapeutic effect is made of the Chinese medicinal materials of astragalus root, siberian solomonseal rhizome, dried rehmannia root, pseudostella root and trichosanthes root. Said invented medicine has the functions of boosting qi, nourishing yin and engendering liquid, and is applicable for using qi and yin vacuity type wasting-thirst disease, non-insulin dependent diabetes.

Description

The Chinese patent medicine of treatment diabetes

Technical field: the present invention is a kind of Chinese patent medicine for the treatment of diabetes, specifically is the Chinese patent medicine of feedstock production with middle dish.

Technical background: the common frdquently encountered disease of diabetes serious harm human health, diabetics surpasses 100,000,000 people in the world at present, and China is near 20,000,000, and has and increase trend year by year, case fatality rate is only second to malignant tumor and cardiovascular disease, is to jeopardize the third-largest disease of human life; Diabetes do not heal all the life, complication extensively and seriously, because insulin lacks relatively or definitely in the blood flow, cause sugar, fat, protein metabolism disorder, cause the rising of hypertension, hyperlipidemia and blood viscosity, extensively microangiopathies of the whole body appears in middle and advanced stage, and wherein the patient of 70-80% dies from the cardiovascular diseases, and renal failure and cerebrovascular accident are the common causes of death of middle and elderly diabetic patient; At present this sick Drug therapy is run into several stubborn problems both at home and abroad: 1, the biguanide drug curative effect is low, side effect is big, for a long time with producing hyperlactacidemia; 2, iodine ureas medicine is for a long time with infringement liver, kidney and hemocyte, and with the sulphonamides cross allergy, the later stage produces secondary failure; 3, with producing antibody, biological activity reduces insulin for a long time, and dosage increases, produces hyperinsulinemia, promotes microangiopathies to take place and development.Treat this sick Chinese patent medicine though some appear in China recent years, because DeGrain, the patient still has to rely on some Western medicine, so still has some problems.

Summary of the invention: the objective of the invention is to: a kind of Chinese patent medicine for the treatment of diabetes is provided, this medicine is to develop on the proved recipe basis that the compatriot of China Miao ethnic group uses for a long time, have the function that supplementing QI and nourishing YIN promotes the production of body fluid, be applicable to the treatment of type of deficiency of both QI and YIN diabetes (non-insulin-dependent diabetes mellitus); Tradition the present invention constitutes like this: it is made according to following method by the Radix Astragali, Rhizoma Polygonati, Radix Rehmanniae, Radix Pseudostellariae, the Radix Trichosanthis of equivalent weight: it is fine powder that Radix Pseudostellariae is pulverized, the Radix Astragali, Rhizoma Polygonati, Radix Rehmanniae, Radix Trichosanthis decoct with water several times, the medicinal liquid that obtains is merged after-filtration to be concentrated, alcohol extraction then, drying, add Radix Pseudostellariae powder and appropriate amount of auxiliary materials again, granulate; Specifically: it is by the 312.5g Radix Astragali, 312.5g Rhizoma Polygonati, 312.5g Radix Rehmanniae, 312.5g Radix Pseudostellariae, 312.5g Radix Trichosanthis is made according to following method: it is fine powder that Radix Pseudostellariae is pulverized, the Radix Astragali, Rhizoma Polygonati, Radix Rehmanniae, Radix Trichosanthis decocts with water three times, amount of water is respectively 8 times of medical material weight, 6 times, 6 times, decocting time was respectively 2 hours, 1 hour, 1 hour, it is 1.1 that the medicinal liquid merging after-filtration that obtains is concentrated into relative density, it is 60% that adding ethanol in cooling back makes it contain the alcohol amount, stir, leave standstill, filter, reclaim ethanol, it is 1.06-1.08 that medicinal liquid is adjusted to relative density, is spray dried to fine powder, adds Radix Pseudostellariae powder and appropriate amount of auxiliary materials, granulate, get granule 1000 grams; The present invention also can be made according to following method by the Radix Astragali, Rhizoma Polygonati, Radix Rehmanniae, Radix Pseudostellariae, the Radix Trichosanthis of equivalent weight: it is fine powder that Radix Pseudostellariae is pulverized, other four Chinese medicine material adopts the extraction process of prior art to extract, concentrate, obtain extract, again extract is mixed with the Radix Pseudostellariae powder, can be made into different dosage forms.

Compared with prior art: raw material of the present invention constitutes simply, therapeutic effect is remarkable, has the function that supplementing QI and nourishing YIN promotes the production of body fluid, be applicable to the treatment of type of deficiency of both QI and YIN diabetes (non-insulin-dependent diabetes mellitus), it is developed on the proved recipe basis that the compatriot of China Miao ethnic group uses for a long time, so toxic and side effects is little, apparent in view therapeutic effect is arranged for thirsty polydipsia, dysphoria with feverish sensation in the chest palms and soles, weak hyperhidrosis, nervous symptom such as breathe hard; Radix Astragali sweet in the mouth temperature, QI invigorating tonify deficiency in this medicine is formed, pharmacological research have the effect that suppresses liver glycogen decomposition, blood sugar lowering; The sweet Han Zhirun of Radix Rehmanniae, removing heat from blood hemopoietic, Kidney-Yin in the energy the kidney invigorating, pharmacological research has the hepatic glycogen of increasing effect, promptly promotes liver glycogen synthetic; The Rhizoma Polygonati sweet in the mouth is flat, the strengthening the spleen stomach, moistens cardiopulmonary, mends all void, can help the merit of Radix Astragali invigorating the spleen and replenishing QI, can strengthen the effect of Radix Rehmanniae YIN nourishing and the production of body fluid promoting again, and the pharmacological evaluation proof has inhibitory action to adrenal gland's disposition hyperglycemia; The Radix Pseudostellariae sweet-bitter flavor, invigorating qi and benefiting blood, spleen invigorating is promoted the production of body fluid; The Radix Trichosanthis bitter in the mouth is cold, controls the stuffy sensation with restlessness of quenching one's thirst, and removes chronic heat in the stomach, more than all medicines share, amount to the gas of invigorating middle warmer void, the moon of Ji lung stomach is to play the effect of supplementing QI and nourishing YIN; The present invention selects for use natural plant crude drugs as crude drug, and each component meets the regulation of national departments concerned, has obtained to produce and sell certification at present, and it is with low cost that product is treated, day clothes three times, each 6 grams.

Embodiments of the invention 1: it is by the 312.5g Radix Astragali, 312.5g Rhizoma Polygonati, 312.5g Radix Rehmanniae, 312.5g Radix Pseudostellariae, 312.5g Radix Trichosanthis is made according to following method: it is fine powder that Radix Pseudostellariae is pulverized, the Radix Astragali, Rhizoma Polygonati, Radix Rehmanniae, Radix Trichosanthis decocts with water three times, amount of water is respectively 8 times of medical material weight, 6 times, 6 times, decocting time was respectively 2 hours, 1 hour, 1 hour, it is 1.1 that the medicinal liquid merging after-filtration that obtains is concentrated into relative density, it is 60% that adding ethanol in cooling back makes it contain the alcohol amount, stir, leave standstill, filter, reclaim ethanol, it is 1.06-1.08 that medicinal liquid is adjusted to relative density, is spray dried to fine powder, adds Radix Pseudostellariae powder and appropriate amount of auxiliary materials, granulate, get the not sacchariferous product of granule 1000 grams.

Embodiments of the invention 2: it is made according to following method by the Radix Astragali, Rhizoma Polygonati, Radix Rehmanniae, Radix Pseudostellariae, the Radix Trichosanthis of equivalent weight: it is fine powder that Radix Pseudostellariae is pulverized, the Radix Astragali, Rhizoma Polygonati, Radix Rehmanniae, Radix Trichosanthis decoct with water several times, the medicinal liquid that obtains is merged after-filtration to be concentrated, alcohol extraction then, drying, add Radix Pseudostellariae powder and appropriate amount of auxiliary materials again, the glue capsule.

Embodiments of the invention 3: the Radix Astragali, Rhizoma Polygonati, Radix Rehmanniae, Radix Pseudostellariae, Radix Trichosanthis by equivalent weight are made according to following method: it is fine powder that Radix Pseudostellariae is pulverized, other four Chinese medicine material adopts the extraction process of prior art to extract, concentrate, obtain extract, again extract is mixed with the Radix Pseudostellariae powder, can be made into different dosage forms, existing extractive technique can be a supercritical carbon dioxide extraction method etc.

Claims (3)

1, a kind of Chinese patent medicine for the treatment of diabetes, it is characterized in that: it is made according to following method by the Radix Astragali, Rhizoma Polygonati, Radix Rehmanniae, Radix Pseudostellariae, the Radix Trichosanthis of equivalent weight: it is fine powder that Radix Pseudostellariae is pulverized, the Radix Astragali, Rhizoma Polygonati, Radix Rehmanniae, Radix Trichosanthis decoct with water several times, the medicinal liquid that obtains is merged after-filtration to be concentrated, alcohol extraction then, drying, add Radix Pseudostellariae powder and appropriate amount of auxiliary materials again, granulate.

2, Chinese patent medicine according to the described this treatment diabetes of claim 1, it is characterized in that: it is by the 312.5g Radix Astragali, 312.5g Rhizoma Polygonati, 312.5g Radix Rehmanniae, 312.5g Radix Pseudostellariae, 312.5g Radix Trichosanthis is made according to following method: it is fine powder that Radix Pseudostellariae is pulverized, the Radix Astragali, Rhizoma Polygonati, Radix Rehmanniae, Radix Trichosanthis decocts with water three times, amount of water is respectively 8 times of medical material weight, 6 times, 6 times, decocting time was respectively 2 hours, 1 hour, 1 hour, it is 1.1 that the medicinal liquid merging after-filtration that obtains is concentrated into relative density, it is 60% that adding ethanol in cooling back makes it contain the alcohol amount, stir, leave standstill, filter, reclaim ethanol, it is 1.06-1.08 that medicinal liquid is adjusted to relative density, be spray dried to fine powder, add Radix Pseudostellariae powder and appropriate amount of auxiliary materials, granulate, get granule 1000 grams.

3, according to the Chinese patent medicine of claim 1,2 described this treatment diabetes, it is characterized in that: the Radix Astragali, Rhizoma Polygonati, Radix Rehmanniae, Radix Pseudostellariae, Radix Trichosanthis by equivalent weight are made according to following method: it is fine powder that Radix Pseudostellariae is pulverized, other four Chinese medicine material adopts the extraction process of prior art to extract, concentrate, obtain extract, again extract is mixed with the Radix Pseudostellariae powder, can be made into different dosage forms.