CN1418646A - Traditional Chinese medicine for treating CAHD - Google Patents
Traditional Chinese medicine for treating CAHD Download PDFInfo
- Publication number
- CN1418646A CN1418646A CN 01131789 CN01131789A CN1418646A CN 1418646 A CN1418646 A CN 1418646A CN 01131789 CN01131789 CN 01131789 CN 01131789 A CN01131789 A CN 01131789A CN 1418646 A CN1418646 A CN 1418646A
- Authority
- CN
- China
- Prior art keywords
- unit
- weights
- leaf
- fine powder
- radix ginseng
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a pure Chinese medicine preparation which is made of ginseng stem and leaf saponin and white peony root which are used as basic prescription raw material, and can be used for curing coronary heart disease and can be made into capsule preparation and tablet preparation. Said medicine possesses the functions of promoting blood circualtion, removing stasis, replenishing qi and stopping pain, etc.
Description
Content of the present invention belongs to the preparing technical field of pharmaceuticals, relates to a kind of Chinese medicine preparation for the treatment of coronary heart disease and preparation method thereof that can be used for.
Coronary heart disease belongs to the traditional Chinese medical science " thoracic obstruction ", " pained ", " angina pectoris " category, be the particularly commonly encountered diseases and the frequently-occurring disease of middle-aged and elderly people health of a kind of serious harm human health that causes owing to the human body coronary flow is under-supply, be called as " human first killer ".According to the WHO statistics, whole world coronary heart disease crowd sickness rate is 14.4%, has every year more than 1,200 ten thousand people to die from coronary heart disease, accounts for 1/4th of the annual total death toll in the world, and in China, evidence of coronary heart diseases and mortality rate also are the trend that rises year by year in recent years.At present, doctor trained in Western medicine is clinical to be used for the medicine of coronary heart disease class disease treatment such as the alleviation that pentaerythritol tetranitrate sheet, persantin etc. mainly lay particular emphasis on acute symptom, and the treatment of the cause of disease is still lacked effective means, and the toxic and side effects of its medicine is also bigger; And the traditional Chinese medical science treat at present the used Chinese patent medicine of coronary heart disease such as FUFANG DANSHEN PIAN, DANQI PIAN etc. exist mostly medication not comprehensively, curative effect is low, onset is slow defective, and toward contact need with multiple medical drug combination.
The objective of the invention is to the existing defective of state of the art, by excavate the abundant Chinese medicine resource of motherland provide a kind of prescription science, easy to prepare, curative effect is high and the pure Chinese medicinal preparation that is exclusively used in treatment coronary heart disease that human body is had no side effect, and provide simultaneously and be exclusively used in the preparation method of producing this Chinese medicine preparation.
The preparation scheme of medicine of the present invention is according to the traditional Chinese medical science analytics of coronary heart disease cause pathology to be controlled the relevant pharmacological experiment of thought and modern medicine basis to obtain.The traditional Chinese medical science thinks that the etiology and pathology of coronary heart disease is many because " imbalance of YIN and YANG, mechanism of qi be contrary to cause disorderly that the painstaking effort stasis of blood stagnates, blockage of the cardiac vessels, stagnation of QI and blood may bring about pain "." element is asked a numbness opinion piece of writing " meaning: " obstruction of heart-QI person; arteries and veins is obstructed ", in view of the above as seen, qi depression to blood stasis is the main traditional Chinese medical science pathologic basis of coronary heart disease, because gas and blood are the sources of human life activity's energy, the pathological change of all diseases relates to the QI and blood problem invariably, influences each other and mutual dependence for existence between gas and the blood, so " the capable then blood of gas is capable; the stagnation of QI is blood stasis then " arranged, " qi as the commander of blood, the operation of blood must rely on the promotion of gas ", thereby blood circulation promoting and blood stasis dispelling is when being the Chinese traditional treatment thoracic obstruction, pained fundamentum.Chinese medicine preparation of the present invention promptly is on pathological analysis and clinical practice basis to this disease, dialectically combine with differential diagnosis of diseases, by to motherland's Chinese medicine resource selected making in addition, medicine material in the side is made up of stem and leaf of Radix Ginseng saponin, the Radix Paeoniae Alba and stevioside, have blood circulation promoting and blood stasis dispelling, the effect of QI invigorating analgesic, aspect the treatment of coronary heart disease, fabulous effect is being arranged, can significantly reduce or eliminate of the threat of this disease human health.
The weight proportion of forming each medicine material of Chinese medicine preparation of the present invention is: 8～20 unit of weights of stem and leaf of Radix Ginseng saponin, 1000～2500 unit of weights of the Radix Paeoniae Alba.
In the said medicine prescription, as monarch drug, be used for QI invigorating with Radix Ginseng.In the medical ancient books and records in China's successive dynasties, all, call: " Radix Ginseng master tonifying five ZANG-organs, peace spirit, the spasmolytic happy Fructus Alpiniae Oxyphyllae of throbbing with fear, make eye bright as Compendium of Material Medica relevant for the record of Radix Ginseng pharmacological action." also meaning in " Mingyi Bielu ": " Radix Ginseng is treated trusted subordinate's drum pain, promoting blood circulation, treatment angina pectoris." and also proof of modern pharmacology experiment; Radix Ginseng except that the arteria coronaria that tangible expansion animal is arranged, increase coronary flow, lower the cardiac muscle load, regulate the cardiovascular system effects such as the rhythm of the heart and blood pressure, still have enhancing body to the resistance of various diseases and destructive stimulus, strengthen the human body non-specific immunity, strengthen the effects such as detoxification ability of liver.The main chemical compositions of Radix Ginseng is the ginsenoside, and it can pass through blood brain barrier microcirculation improvement system, and can be by promoting each system of active and proteinic synthetic adjusting human body of RNA and DNA.The stem and leaf of Radix Ginseng saponin that adopts among the we is from the Radix Ginseng aerial parts---the Saponin that refines the stem and leaf, and the nationality supplementary Amplifications of the Compendium of Materia Medica is described according to curing ancient times, " all diseases need be joined and the unable person of using, and often city's leaf is with generation "; Modern age, pharmaceutical research also proved: the Saponin in stem and leaf of Radix Ginseng saponin and the Radix Ginseng not only kind and pharmacological action is all identical, and the stem and leaf Saponin still has stronger antiplatelet effects, can stop the formation of arterial thrombus by anticoagulant, its content is more than 4～6 times of Saponin in the root.
Getting the Radix Paeoniae Alba among the we is ministerial drug, because of its property of medicine is gentle, nourishes blood and effects such as the moon, clots absorbing pain relieving, blood circulation promoting and blood stasis dispelling.The Compendium of Material Medica meaning Radix Paeoniae Alba " removes pathogen stomachache, removes arthralgia due to stagnation of blood, pain relieving, diuresis "; Scientific research institution of family specialized in the comprehensive utilization of the Radix Paeoniae Alba surplus in the of nearly domestic during the last ten years existing 40, the proof Radix Paeoniae Alba is highly desirable drug for invigorating blood circulation and eliminating stasis, expansible arteria coronaria, attenuating myocardial oxygen consumption, antithrombotic formation, anti-hypoxia, resisting fatigue, raising immune function of human body.The Radix Paeoniae Alba and Radix Ginseng are shared, make that vim and vigour row, blood vessels are logical, pained to be ended, treating both the principal and secondary aspects of a disease, and " thoracic obstruction ", " pained " are explained by oneself.
In the concrete preparation of actual product of the present invention, this medicine that is used for the treatment of coronary heart disease can be processed into capsule and two kinds of basic preparation formulations of tablet by raw material constituent, the preparation method of each dosage form is as described below.
One, the method for making of capsule:
The Radix Paeoniae Alba of getting in the material quantity decocts with water 2～4 times, collecting decoction, filtration, filtrate decompression is concentrated into relative density 1.20～1.50 (50 ℃), dry, powder becomes fine powder, adds stem and leaf of Radix Ginseng saponin and the stevioside's fine powder (sweeting agent) of 20～80 unit of weights and the starch of 1～10 unit of weight in the material quantity again, with 60%～80% alcohol granulation, drying, incapsulate (the about 0.25g of powder charge in every capsules), promptly get product.
Two, the method for making of tablet:
The Radix Paeoniae Alba of getting in the material quantity decocts with water 2～4 times, collecting decoction, filter, filtrate decompression is concentrated into relative density 1.20～1.50 (50 ℃), dry, powder becomes fine powder, add stem and leaf of Radix Ginseng saponin and the stevioside's fine powder (sweeting agent) of 20～60 unit of weights and the starch of 1～10 unit of weight in the material quantity more successively, with 60%～80% alcohol granulation, dry, add 1～5 unit of weight of magnesium stearate, mixing, compacting is (0.3g/ of plate core weight sheet) in flakes, give the coated sugar-coat of label (every kg label white sugar 15～20kg afterwards, Pulvis Talci 14～20kg, polishing), promptly get product.
Clinical observation and curative effect
In the development process of pharmaceutical preparation of the present invention, once clinical treatment and observe case 248 examples, divide capsule treatment group and two treatment groups of tablet in treatment group, wherein capsule treatment group is observed totally 141 examples (male 104 examples, women 37 examples, 59.84 years old mean age, the course of disease 1～22 year), the tablet in treatment group is observed 107 examples (male 79 examples, women 28 examples altogether, 60.12 years old mean age, the course of disease 1～16 year).
One, diagnostic criteria: by angina pectoris diagnostic criteria and national coronary heart disease traditional Chinese medical science typing standard of working out in 1980 of whole nation revision in 1979.
Two, observation index and Therapeutic Method:
1, observation index: the Total Test patient is observed and recorded blood pressure, heart rate before treatment, check liver, renal function, blood fat, blood, routine urinalysis and platelet count, make rabat and conventional leads electrocardiogram, the some cases electrocardiogram of taking exercises is measured surface activity of blood platelet and aggregation under the ultramicroscope.Treatment finishes all above-mentioned projects of check of back.
2, Therapeutic Method: capsule treatment group oral Drug Capsule agent every day 3 times, each 3; Tablet in treatment group oral tablet every day 3 times, each 3.Per 21 days is a course of treatment, takes medicine altogether two courses of treatment.
Three, efficacy assessment standard: by the angina pectoris and the ECG curative effect evaluation criteria of whole nation revision in 1979.
Four, therapeutic outcome: the capsule treatment is organized 141 examples after treatment, produce effects 69 people, and effective 67 people, invalid 5 people, total effective rate is 96.45%; Tablet in treatment group 107 examples through the treatment after, produce effects 45 people, effective 57 people, invalid 5 people, total effective rate is 95.33%.
Claims (3)
1, a kind of Chinese medicine that is used for the treatment of coronary heart disease is characterized in that it is the medicament of being processed into by following materials of weight proportions: 8～20 unit of weights of stem and leaf of Radix Ginseng saponin, 1000～2500 unit of weights of the Radix Paeoniae Alba.
2, a kind of method that is used to prepare the described Chinese medicinal capsule agent of claim 1, the Radix Paeoniae Alba that it is characterized in that getting in the material quantity decocts with water 2～4 times, collecting decoction, filtration, filtrate decompression is concentrated into relative density 1.20～1.50 (50 ℃), drying, and powder becomes fine powder, add stem and leaf of Radix Ginseng saponin and the stevioside's fine powder of 20～80 unit of weights and the starch of 1～10 unit of weight in the material quantity again, with 60%～80% alcohol granulation, drying, incapsulate, promptly get product.
3, a kind of method that is used to prepare the described Chinese medicinal tablet of claim 1, the Radix Paeoniae Alba that it is characterized in that getting in the material quantity decocts with water 2～4 times, collecting decoction, filtration, filtrate decompression is concentrated into relative density 1.20～1.50 (50 ℃), dry, powder becomes fine powder, add stem and leaf of Radix Ginseng saponin and the stevioside's fine powder of 20～80 unit of weights and the starch of 1～10 unit of weight in the material quantity again, with 60%～80% alcohol granulation, drying, add 1～5 unit of weight of magnesium stearate, mixing, compacting be the coated sugar-coat in back in flakes, promptly gets product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01131789 CN1418646A (en) | 2001-11-12 | 2001-11-12 | Traditional Chinese medicine for treating CAHD |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01131789 CN1418646A (en) | 2001-11-12 | 2001-11-12 | Traditional Chinese medicine for treating CAHD |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1418646A true CN1418646A (en) | 2003-05-21 |
Family
ID=4670865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01131789 Pending CN1418646A (en) | 2001-11-12 | 2001-11-12 | Traditional Chinese medicine for treating CAHD |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1418646A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100381125C (en) * | 2003-12-02 | 2008-04-16 | 李文军 | Cardiac and cerebral vascular disease treating medicinal composition |
| CN1872178B (en) * | 2005-06-03 | 2010-09-29 | 天津天士力制药股份有限公司 | Application of medication composition of containing white peony root in preparing medication for treating chronic insufficiency of supplying blood for brain |
| CN102718325A (en) * | 2012-07-13 | 2012-10-10 | 广西湘桂糖业集团有限公司 | Method for culturing high-density oil microalgae to treat yeast industrial wastewater |
-
2001
- 2001-11-12 CN CN 01131789 patent/CN1418646A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100381125C (en) * | 2003-12-02 | 2008-04-16 | 李文军 | Cardiac and cerebral vascular disease treating medicinal composition |
| CN1872178B (en) * | 2005-06-03 | 2010-09-29 | 天津天士力制药股份有限公司 | Application of medication composition of containing white peony root in preparing medication for treating chronic insufficiency of supplying blood for brain |
| CN102718325A (en) * | 2012-07-13 | 2012-10-10 | 广西湘桂糖业集团有限公司 | Method for culturing high-density oil microalgae to treat yeast industrial wastewater |
| CN102718325B (en) * | 2012-07-13 | 2015-01-07 | 广西湘桂糖业集团有限公司 | Method for culturing high-density oil microalgae to treat yeast industrial wastewater |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1994451B (en) | Chinese medicinal composition for treating depression, its preparation method and application | |
| CN100502904C (en) | Medication of Astragalus root for activating blood and the channels, and preparation method | |
| CN102362881A (en) | Method for preparing ginkgo and American ginseng preparation | |
| CN102614387A (en) | Traditional Chinese medicine for prevention and treatment of stroke and preparation method thereof | |
| CN1306951C (en) | Medicine for curing qi deficiency induced thoracic obstruction (coronary heart disease) and technique for preparing the same | |
| CN100488539C (en) | Pharmaceutical composition for promoting blood circulation and preparation method thereof | |
| CN101584796A (en) | Application of traditional Chinese medicine composition in preparing medicament for treating melancholia | |
| CN1943620B (en) | Chinese medicine composition for treating cardio-cerabral vascular diseases and its preparing method | |
| CN1085083C (en) | Prescription and production method of medicine to cure stenocardia-type coronary heart disease | |
| CN1418646A (en) | Traditional Chinese medicine for treating CAHD | |
| CN1682837A (en) | Medicine for regulating blood fat and its preparing method | |
| CN1970050B (en) | Pharmaceutical composition for treating arrhythmia and preparation process thereof | |
| CN1745768B (en) | Use of medicine containing Milkvetch Root against aspirin | |
| CN1194724C (en) | Chinese medical preparation for treating coronary disease and angina pectoris and preparation thereof | |
| CN101129492B (en) | Traditional Chinese medicine formulated product for treating melancholia | |
| CN100546637C (en) | A kind of Chinese medicine composition for the treatment of coronary heart disease and preparation method thereof | |
| CN106109951A (en) | Prevent and treat medicine of hyperglycemia, hyperlipidemia, hypertension and preparation method thereof | |
| CN103768454B (en) | A kind of composition with prevention and treatment HIV/AIDS and preparation method thereof | |
| CN1097603A (en) | The prescription and the production method of treatment arrhythmia type coronary heart disease " multiple arteries and veins spirit " medicine | |
| CN102068520A (en) | Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof | |
| CN101053626B (en) | Traditional Chinese medicine for treating coronary heart disease and angina pectoris and its preparation method | |
| CN101559161B (en) | Application of traditional Chinese medicine composition in preparing medicament for curing tristimania | |
| CN1294961C (en) | Oral liquid for curing myocardial ischemia and process for preparing the same | |
| CN1839974B (en) | Medicine composition for treating rheumatoid disease and method for preparing the same | |
| CN100453093C (en) | Medicine for transient cerebral ischemia attack and its preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |