CN1415631A - 右旋糖酐生产新工艺 - Google Patents
右旋糖酐生产新工艺 Download PDFInfo
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- CN1415631A CN1415631A CN 01132045 CN01132045A CN1415631A CN 1415631 A CN1415631 A CN 1415631A CN 01132045 CN01132045 CN 01132045 CN 01132045 A CN01132045 A CN 01132045A CN 1415631 A CN1415631 A CN 1415631A
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- FZWBNHMXJMCXLU-UHFFFAOYSA-N 2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexanal Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OCC(O)C(O)C(O)C(O)C=O)O1 FZWBNHMXJMCXLU-UHFFFAOYSA-N 0.000 claims description 4
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
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- 229910052757 nitrogen Inorganic materials 0.000 description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
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Landscapes
- Separation Using Semi-Permeable Membranes (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Description
项目 | 中国药典标准 | 英国药典标准 | 美国药典标准 | 本品检测结果 |
性状 | 热水中易溶,乙醇中不溶 | 水中易溶,溶液无色、澄清 | ~ | 水中易溶,溶液无色、澄清 |
鉴别 | 硫酸铜变色 | 红外吸收 | A:红外吸收B:粘度曲线 | 与对照品一致 |
比旋度 | +190°至200° | +195°至201° | +195°至203° | +198° |
细菌内毒素 | 无此项目 | <10Eu | <10Eu | <10Eu |
氯化物 | 0.25% | 无此项目 | 无此项目 | 未检出 |
氮 | 0.007% | 0.01% | 0.01% | <0.007% |
干燥失重 | 5.0% | 7.0% | 7.0% | 4.0% |
炽灼残渣 | *0.5% | 0.3% | 0.03% | 0.01% |
重金属 | 8ppm | 10ppm | 5ppm | <5ppm |
PH(酸碱度) | 无此项目 | 滴定合格 | 4.5~7.0 | 符合规定 |
有机溶剂限量 | 无此项目 | 符合规定 | 符合规定 | 符合规定 |
异常毒性 | 无此项目 | 无此项目 | 符合规定 | 符合USP规定 |
过敏试验 | 无此项目 | 无此项目 | 符合规定 | 符合USP规定 |
Dextran40 | Mw32000~42000M10<120000M90>5000 | Mw35000~45000M10<110000M90>7000 | Mw35000~45000M10<120000M90>5000 | Mw=37418M10=108548M90=8948 |
好氧微生物 | 无此项目 | <102/g | 无此项目 | 符合BP规定 |
大肠杆菌 | 无此项目 | 无检出 | 无此项目 | 未检出 |
Claims (12)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 01132045 CN1200005C (zh) | 2001-10-30 | 2001-10-30 | 右旋糖酐的生产方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 01132045 CN1200005C (zh) | 2001-10-30 | 2001-10-30 | 右旋糖酐的生产方法 |
Publications (2)
Publication Number | Publication Date |
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CN1415631A true CN1415631A (zh) | 2003-05-07 |
CN1200005C CN1200005C (zh) | 2005-05-04 |
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Application Number | Title | Priority Date | Filing Date |
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CN 01132045 Expired - Fee Related CN1200005C (zh) | 2001-10-30 | 2001-10-30 | 右旋糖酐的生产方法 |
Country Status (1)
Country | Link |
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CN (1) | CN1200005C (zh) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103266149A (zh) * | 2013-05-22 | 2013-08-28 | 广西壮族自治区分析测试研究中心 | 双酶耦合多级膜分离制备药用右旋糖酐和果糖的方法 |
CN104744606A (zh) * | 2007-11-13 | 2015-07-01 | 卡吉尔公司 | 净化的β-(1,3)-D-葡聚糖的制备方法 |
CN107936136A (zh) * | 2018-01-09 | 2018-04-20 | 河北赛诺膜技术有限公司 | 一种高回收率的右旋糖酐分离提纯方法 |
CN108017721A (zh) * | 2018-01-09 | 2018-05-11 | 北京赛诺膜技术有限公司 | 一种大分子右旋糖酐的分离提纯方法 |
CN109173422A (zh) * | 2018-10-09 | 2019-01-11 | 飞潮(无锡)过滤技术有限公司 | 一种医药生产中转晶前工序api药液的批次完全过滤工艺 |
CN113387774A (zh) * | 2021-05-28 | 2021-09-14 | 赛普特环保技术(厦门)有限公司 | 一种赤藓糖醇的提取工艺及系统 |
CN113567371A (zh) * | 2021-07-23 | 2021-10-29 | 广西南宁市桃源兽药厂 | 一种用于控制右旋糖酐原料质量的糖酐含量的检测方法 |
CN113567372A (zh) * | 2021-07-23 | 2021-10-29 | 广西南宁市桃源兽药厂 | 一种通过测定糖酐含量来控制右旋糖酐铁生产投料比的方法 |
-
2001
- 2001-10-30 CN CN 01132045 patent/CN1200005C/zh not_active Expired - Fee Related
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104744606A (zh) * | 2007-11-13 | 2015-07-01 | 卡吉尔公司 | 净化的β-(1,3)-D-葡聚糖的制备方法 |
CN103266149A (zh) * | 2013-05-22 | 2013-08-28 | 广西壮族自治区分析测试研究中心 | 双酶耦合多级膜分离制备药用右旋糖酐和果糖的方法 |
CN107936136A (zh) * | 2018-01-09 | 2018-04-20 | 河北赛诺膜技术有限公司 | 一种高回收率的右旋糖酐分离提纯方法 |
CN108017721A (zh) * | 2018-01-09 | 2018-05-11 | 北京赛诺膜技术有限公司 | 一种大分子右旋糖酐的分离提纯方法 |
CN109173422A (zh) * | 2018-10-09 | 2019-01-11 | 飞潮(无锡)过滤技术有限公司 | 一种医药生产中转晶前工序api药液的批次完全过滤工艺 |
CN113387774A (zh) * | 2021-05-28 | 2021-09-14 | 赛普特环保技术(厦门)有限公司 | 一种赤藓糖醇的提取工艺及系统 |
CN113567371A (zh) * | 2021-07-23 | 2021-10-29 | 广西南宁市桃源兽药厂 | 一种用于控制右旋糖酐原料质量的糖酐含量的检测方法 |
CN113567372A (zh) * | 2021-07-23 | 2021-10-29 | 广西南宁市桃源兽药厂 | 一种通过测定糖酐含量来控制右旋糖酐铁生产投料比的方法 |
CN113567372B (zh) * | 2021-07-23 | 2024-07-12 | 广西南宁市桃源兽药厂 | 一种通过测定糖酐含量来控制右旋糖酐铁生产投料比的方法 |
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Publication number | Publication date |
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CN1200005C (zh) | 2005-05-04 |
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