CN1413619A - Sheqi facial appearance capsule and its preparation technology - Google Patents

Sheqi facial appearance capsule and its preparation technology Download PDF

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Publication number
CN1413619A
CN1413619A CN 02114688 CN02114688A CN1413619A CN 1413619 A CN1413619 A CN 1413619A CN 02114688 CN02114688 CN 02114688 CN 02114688 A CN02114688 A CN 02114688A CN 1413619 A CN1413619 A CN 1413619A
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China
Prior art keywords
capsule
preparation technology
ginseng
appearance
stilbene
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CN 02114688
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CN1194721C (en
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王四旺
谢艳华
孙纪元
王剑波
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Pharmaceutic Inst No 4 Millitary Medical Univ P L A
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Pharmaceutic Inst No 4 Millitary Medical Univ P L A
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Priority to CNB021146888A priority Critical patent/CN1194721C/en
Publication of CN1413619A publication Critical patent/CN1413619A/en
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Publication of CN1194721C publication Critical patent/CN1194721C/en
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Abstract

A Chinese medicine in the form of capsule for treating ephelis, acne, vulval leukoderma, etc is prepared from 4 Chinese-medicinal materials: ginseng, Chinese angelica root, astragalus root and Chuan-xiong rhizome through pre-treating, extracting, decocting, mixing, drying, pulverizing, sieving and loading in capsules. It has high curative effect.

Description

Ginseng stilbene appearance capsule and preparation technology thereof
Affiliated technical field
The present invention joins stilbene appearance capsule and preparation technology belongs to medicine and the preparation technology thereof who treats pigment obstacle dermatoses and the sick caused facial area skin disorder of skin gland secretion obstacle.Relate in particular to the oral drugs and the preparation technology thereof of skin disorders such as insidious speckle that a kind of pure treatment by Chinese herbs facial area suffers from, freckle, skin sore, acne.
Background technology
Skin disorders such as insidious the speckle that present treatment facial area suffers from, freckle, skin sore, acne adopt local treatment more, select corrosive medicine or anti-inflammation and sterilization class ointment coating affected parts such as decolouring ointment, freckle ointment such as carbolic acid, trichloroacetic acid, mercuric chloride, impel skin lesion place skin ulcer speckle to come off; Also useful Chinese medicine by enriching yin and nourishing kidney, liver-smoothing, qi-regulating, in and QI and blood, the damp and hot whole body therapeutic that is equipped with of lung heat clearing stomach.Through the theoretical confirmation of modern medicine, insidious speckle, freckle, skin sore, skin disorders such as acne belong to pigment obstacle and glandular integumentaria obstacle dermatoses more, though suffer from facial area skin, but the cause of disease comes from hypophysis cerebri or hypothalamic endocrine regulation, cause ovarian dysfunction, it is low to make ovary produce estrogen function, excited melanocyte of gonadal hormone and progesterone, influence menoxenia, impel sebaceous gland to increase, sebum secretion increases, skin lesion place melanin increases, the stasis of blood is long-pending, is crineous behind ultraviolet radiation, yellowish-brown, bronzing speckle or as hatpin head size taper acne, acne can develop into the pustule skin sore, not only sufferings and directly influence appearance unbearably.Said medicine at speckle, acne and pustule skin sore smear remove or strengthen liver, kidney, the stomach function is auxiliary controls it, all cure the symptoms, not the disease, slow curative effect, can not effect a radical cure, often facial area leaves cicatrix, and easily recurrence does not reach by the treatment endocrine regulation and realizes blood circulation promoting and blood stasis dispelling, menstruation-regulating and speckle-dispelling, the purpose of nourishing skin.
Summary of the invention
Suffer from insidious speckle for fear of existing treatment facial area, freckle, skin sore, disease curative effect of medicine such as acne slowly can not effect a radical cure with facial area and leave cicatrix and the high defective of relapse rate, the present invention joins stilbene appearance capsule and preparation technology gives insidious speckle of facial area, freckle, skin sore, acne patient provides and has selected YAOJING few, scientific formulation, complementary action is remarkable, oral novel easily again pure Chinese medicine capsule, and employing modernization of Chinese medicine production technology, make that each Chinese crude drug active ingredient is integrated in one in the prescription, consumption is few, the curative effect height, after the patient takes, treating both the principal and secondary aspects of a disease, directly head hypophysis and hypothalamus are produced curative effect, improve the adrenocortical hormone secretion activity, patient's endocrine regulation is improved in a short time, it is unimpeded to impel sebum to drain, and the dissipation sebum stasis of blood is long-pending, the scabbing of dispelling, acne, abscess disappears voluntarily, make insidious speckle of patient face portion, freckle, skin sore, acne all disappear, and recover to moisten, and reappear the youth gloss.
In order to realize the foregoing invention purpose, the present invention joins stilbene appearance capsule and technical scheme that preparation technology adopted is: ginseng stilbene appearance capsule is made up of Radix Ginseng, Radix Angelicae Sinensis, the Radix Astragali, Rhizoma Chuanxiong four flavor Chinese crude drugs and the solubility adjuvant side of closing, wherein Radix Ginseng is a monarch drug, when being classified as ministerial drug, the Radix Astragali is an adjuvant drug, and Rhizoma Chuanxiong is a messenger drug.Mix after above-mentioned Chinese crude drug concocted into decoction pieces respectively by formula ratio, earlier from decoction pieces, extract extractum with a percolation, after adopting twice decocting method that the extractum filtering residue is decocted 2 times with aquae destillata again, the collecting decoction filtering and concentrating becomes soft extracts, at last extractum and soft extracts merging adding adjuvant are stirred evenly, spray drying is pulverized, and promptly gets patent medicine in No. 1 capsule of packing into behind 40 mesh sieves excessively, and is oral for the patient.The theory of Chinese medical science of reportedly uniting, four flavor prescription medicines integrally combine, and monarch drug Radix Ginseng promoting blood circulation is broken hard long-pending, clear pox speckle, it is insidious to loose; The sweet gentle blood of ministerial drug Radix Angelicae Sinensis helps heart cold expelling, supports battalion's Shujin, arranges dense pain relieving, and each returns short QI and blood to some extent, and speckle dispelling stasis of blood appearance renews; Adjuvant drug Radix Astragali invigorating QI to consolidate the body surface resistance is given birth to cloudy blood, rushes down YANG-fire, the flat skin ulcer of evacuation of pus, and the hemopoietic granulation promoting is closed Radix Ginseng treatment of smallpox void and is not risen, and adds the Radix Angelicae Sinensis QI-insufficiency of enriching blood, and adds Rhizoma Chuanxiong and becomes skin ulcer speckle panacea; Messenger drug Rhizoma Chuanxiong and blood circulation of qi promoting, the up head of all medicines of rate, the descending sea of blood is searched the wind dissipating blood stasis, pain relieving regulating menstruation, outstanding treatment of smallpox skin ulcer.All medicines are worked in coordination with blood circulation promoting and blood stasis dispelling, and menstruation-regulating and speckle-dispelling nourishes skin, controls insidious speckle, freckle, skin sore, acne altogether, and the curative effect height does not recur, and preventing from scar, facial area reappear moist smooth.According to modernization of Chinese medicine theory, the present invention joins in the stilbene appearance capsule prescription, the Radix Ginseng extract active ingredient is based on Radix Ginseng total saponins, can increase the adrenocortical hormone secretion activity, get rid of ovarian dysfunction, improve ovarian hypofunction morbid state, accelerate estrogen secretion, control melanocyte and progesterone steadily grow and wither away, thereby sebaceous gland is dwindled, and sebum secretion reduces, and impels patient face skin lesion place melanin to reduce, and the regeneration of Skin Cell had activation, make the reproduction speed of Skin Cell can improve 22-35 doubly more than; The Radix Angelicae Sinensis extract active ingredient is based on ethereal oil, has calmness, pain relieving, regulating menstruation, enriches blood, effect such as hemostasis; The Radix Astragali extract active ingredient is a flavonoid glycoside, invigorating QI to consolidate the body surface resistance is arranged, diuresis is antitoxin, row is dense, the expelling pus and promoting granulation function, and is excellent to carbuncle difficultly burst, burst for a long time insidious speckle, skin sore, the acne curative effect of not holding back; The Rhizoma Chuanxiong extract active ingredient is based on the alkaloid ligustrazine, invigorates blood circulation, eliminates the phlegm, circulation of qi promoting, analgesia, calmness, the effect of stimulating the menstrual flow.Each effective ingredient is worked in coordination with in patient's body and is improved endocrine, get rid of ovarian dysfunction, recover ovarian function, accelerate estrogen secretion, make and reappear rule menstrual period, control melanocyte and progesterone steadily grow and wither away, patient face portion skin lesion place melanin is reduced, arrange dense quickening, the accelerating ated test of speckle skin ulcer, the regeneration Skin Cell is expanded rapidly, and newborn skin substitutes the speckle skin ulcer makes the skin lesion place moist smooth.
The beneficial effect that the present invention joins stilbene appearance capsule and preparation technology thereof is: ginseng stilbene appearance capsule formula is used and is updated through long-term prescription, select for use each medicine side of closing to have complementary functions, play the function that blood circulation promoting and blood stasis dispelling, regulating menstruation remove speckle, nourish skin altogether, allow insidious speckle of patient face portion, freckle, skin sore, acne, dim very fast healing, and gynaecopathia such as women's face melanosis of causing because of endocrine regulation, poikiloderma, menstrual eruption, leukoplakia vulvae, menstrual mucosal ulcer and acne vulgaris are all had good curative effect.This ginseng stilbene appearance capsule adopts percolation and decocting method simultaneously in preparation technology, make that oil-soluble and water solublity active ingredient can both extract effectively in all medicines, the technical matters standard, effective component extraction rate height, patent medicine taking convenience, the curative effect height has no side effect.
The specific embodiment:
1, the best effectively prescription amount of each prescription in the ginseng stilbene appearance capsule, degree are as shown in the table:
Prescription Chinese crude drug title Formula ratio (gram) Content (%)
Radix Ginseng ????75 ????7.5
Radix Angelicae Sinensis ????300 ????30.0
The Radix Astragali ????300 ????30.0
Rhizoma Chuanxiong ????250 ????25.0
Adjuvant ????75 ????7.5
Add up to ????1000 ????100.0
2, ginseng stilbene appearance capsules preparation technique:
1. four flavor tcm and herbal slice processing procedures.Get crude drug by the formula ratio branch, Radix Ginseng is selected for use and is steamed the after drying Radix Ginseng Rubra, with being 0.1mm with the ultra-thin thickness that is cut into of Radix Ginseng Rubra after the steeping in wine profit, and diameter 1.5cm left and right sides thin slice; Radix Angelicae Sinensis is selected the horse hair Radix Angelicae Sinensis for use, and the well sifted roguing after the steeping in wine profit, is cut into 1mm thickness thin slice from the beginning to the end; The Radix Astragali is selected the roguing of Radix Astagali well sifted for use, gets the Mel heated and boiled, adds boiling water dilution after-filtration again, while hot the standby Radix Astragali is soaked, and keeps 70 ℃-80 ℃ to smoke and be cut into the oblique sheet of 1mm thickness behind the one-tenth fritting Radix Astragali in 2 hours; Rhizoma Chuanxiong selects for use the river to produce the bulk Rhizoma Chuanxiong, and is with being cut into 1mm thickness thin slice after the steeping in wine profit, that above four flavor herbal decoction piece uniform mixing are standby.
2. percolation prepares extractum.Make solvent with 80% ethanol, standby herbal decoction piece is pressed percolation extract live part,, the filtration liquid of filtering is put that to be condensed into extractum in the decompression evaporator standby to the yellow after-filtration of the little band of the liquid of filtering.
3. decocting method is produced soft extracts.Medicinal residues behind the percolation are decocted twice with 8 times of amount aquae destillatas, 2 hours for the first time, 1 hour for the second time, merge decoction liquor and filter, it is that 1.12-1.15 becomes soft extracts standby that the filtrate heating is concentrated into relative density.
4. capsule preparation.Standby extractum and soft extracts merged stir evenly, add the adjuvant spray drying, pulverized No. 1 capsule of packing into behind 40 mesh sieves and get patent medicine.
3, ginseng stilbene appearance capsule instructions of taking and consumption:
Oral for the patient, be grown up one day twice, each 3, the child is not taken by pregnant women.

Claims (3)

1, the present invention joins the pure Chinese medicine medicine that stilbene appearance capsule and preparation technology thereof provide skin disorders such as treating insidious speckle, freckle, skin sore, acne, preparation technology can be divided into process of preparing, percolation extracts extractum, decocting method extracts technological processes such as soft extracts, combination drying, crushing screening system capsule, it is characterized in that: ginseng stilbene appearance capsule is made up of Radix Ginseng, Radix Angelicae Sinensis, the Radix Astragali, Rhizoma Chuanxiong four flavor Chinese crude drugs and the solubility adjuvant side of closing, in preparation technology, above four flavor tcm and herbal slices are taked percolation, decocting method and usefulness, extract effective ingredient and be applied to patent medicine.
2, ginseng stilbene appearance capsule as claimed in claim 1 and preparation technology thereof is characterized in that: each prescription optimized percentage content of ginseng stilbene appearance capsule is as follows:
Radix Ginseng: 7.5 Radix Angelicae Sinensis: 30.0 Radixs Astragali: 30.0
Rhizoma Chuanxiong: 25.0 adjuvants: 7.5
3, ginseng stilbene appearance capsule as claimed in claim 1 and preparation technology thereof, it is characterized in that: in ginseng stilbene appearance capsules preparation technique, all medicine decoction pieces are adopted percolation and decocting method and are used for extracting oil-soluble effective ingredient and aqueous soluble active constituent in all medicines, be used for patent medicine after the merging.
CNB021146888A 2002-07-22 2002-07-22 Sheqi facial appearance capsule and its preparation technology Expired - Fee Related CN1194721C (en)

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Application Number Priority Date Filing Date Title
CNB021146888A CN1194721C (en) 2002-07-22 2002-07-22 Sheqi facial appearance capsule and its preparation technology

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CN1194721C CN1194721C (en) 2005-03-30

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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102579608A (en) * 2011-01-17 2012-07-18 高国华 Freckle removing liquid
CN105520869A (en) * 2014-10-21 2016-04-27 株式会社韩国人参公社 Composition for Acne Improvement Containing Red Ginseng Extract
CN108969697A (en) * 2018-08-31 2018-12-11 河南科大外阴白斑研究院有限公司 A kind of pharmaceutical formulation that treating leukoplakia vulvae and its preparation process
CN109260320A (en) * 2018-11-12 2019-01-25 江苏千药堂国医研究院有限公司 A kind of composition and purposes of tea polyphenols and Chinese medical extract
CN109364113A (en) * 2018-11-12 2019-02-22 江苏千药堂国医研究院有限公司 A kind of composition and purposes of resveratrol and Chinese medical extract
CN109453266A (en) * 2018-11-12 2019-03-12 江苏千药堂国医研究院有限公司 A kind of composition and purposes of green-tea extract and Chinese medical extract
CN109453227A (en) * 2018-11-12 2019-03-12 江苏千药堂国医研究院有限公司 A kind of composition and purposes of procyanidine and Chinese medical extract
CN109453224A (en) * 2018-11-12 2019-03-12 江苏千药堂国医研究院有限公司 A kind of composition and purposes of bryonia alcohol acid and Chinese medical extract
CN109464321A (en) * 2018-11-12 2019-03-15 江苏千药堂国医研究院有限公司 A kind of traditional Chinese medicine extract composition and application
CN110339322A (en) * 2019-07-23 2019-10-18 郑州巨人生化集团有限公司 A kind of Chinese medicine composition and preparation method thereof for treating kraurosis vulcae
CN112156130A (en) * 2020-11-05 2021-01-01 金华寿仙谷药业有限公司 Traditional Chinese medicine composition for removing chloasma as well as preparation method and application thereof
CN114504543A (en) * 2020-11-16 2022-05-17 广东一芙化妆品有限公司 Plant whitening composition

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102579608A (en) * 2011-01-17 2012-07-18 高国华 Freckle removing liquid
CN102579608B (en) * 2011-01-17 2015-07-29 高国华 Spot-dispelling liquid
CN105520869A (en) * 2014-10-21 2016-04-27 株式会社韩国人参公社 Composition for Acne Improvement Containing Red Ginseng Extract
CN105520869B (en) * 2014-10-21 2020-08-04 株式会社韩国人参公社 Composition containing Ginseng radix Rubri concentrate for improving acne
CN108969697A (en) * 2018-08-31 2018-12-11 河南科大外阴白斑研究院有限公司 A kind of pharmaceutical formulation that treating leukoplakia vulvae and its preparation process
CN108969697B (en) * 2018-08-31 2021-06-18 河南科大外阴白斑研究院有限公司 Medicine formula for treating leukoplakia vulvae and preparation process thereof
CN109453266A (en) * 2018-11-12 2019-03-12 江苏千药堂国医研究院有限公司 A kind of composition and purposes of green-tea extract and Chinese medical extract
CN109453227A (en) * 2018-11-12 2019-03-12 江苏千药堂国医研究院有限公司 A kind of composition and purposes of procyanidine and Chinese medical extract
CN109453224A (en) * 2018-11-12 2019-03-12 江苏千药堂国医研究院有限公司 A kind of composition and purposes of bryonia alcohol acid and Chinese medical extract
CN109464321A (en) * 2018-11-12 2019-03-15 江苏千药堂国医研究院有限公司 A kind of traditional Chinese medicine extract composition and application
CN109364113A (en) * 2018-11-12 2019-02-22 江苏千药堂国医研究院有限公司 A kind of composition and purposes of resveratrol and Chinese medical extract
CN109260320A (en) * 2018-11-12 2019-01-25 江苏千药堂国医研究院有限公司 A kind of composition and purposes of tea polyphenols and Chinese medical extract
CN110339322A (en) * 2019-07-23 2019-10-18 郑州巨人生化集团有限公司 A kind of Chinese medicine composition and preparation method thereof for treating kraurosis vulcae
CN112156130A (en) * 2020-11-05 2021-01-01 金华寿仙谷药业有限公司 Traditional Chinese medicine composition for removing chloasma as well as preparation method and application thereof
CN114504543A (en) * 2020-11-16 2022-05-17 广东一芙化妆品有限公司 Plant whitening composition

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