CN1413188A - 基本纯的比卡鲁胺合成中中间体的拆分 - Google Patents

基本纯的比卡鲁胺合成中中间体的拆分 Download PDF

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Publication number
CN1413188A
CN1413188A CN00817760A CN00817760A CN1413188A CN 1413188 A CN1413188 A CN 1413188A CN 00817760 A CN00817760 A CN 00817760A CN 00817760 A CN00817760 A CN 00817760A CN 1413188 A CN1413188 A CN 1413188A
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alkyl
formula
carbon atoms
perfluoroalkyl
midbody compound
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CN00817760A
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Chinese (zh)
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N·N·埃克乌里贝
K·D·詹姆斯
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NOBECOS Inc
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NOBECOS Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN00817760A 1999-10-27 2000-10-25 基本纯的比卡鲁胺合成中中间体的拆分 Pending CN1413188A (zh)

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US16188499P 1999-10-27 1999-10-27
US60/161,884 1999-10-27

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CN1413188A true CN1413188A (zh) 2003-04-23

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CN00817760A Pending CN1413188A (zh) 1999-10-27 2000-10-25 基本纯的比卡鲁胺合成中中间体的拆分

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US (1) US6593492B1 (enExample)
EP (1) EP1224167A1 (enExample)
JP (1) JP4778178B2 (enExample)
KR (1) KR20020067509A (enExample)
CN (1) CN1413188A (enExample)
AU (1) AU2619501A (enExample)
BR (1) BR0015124A (enExample)
CA (1) CA2389100A1 (enExample)
CZ (1) CZ20021434A3 (enExample)
HK (1) HK1048299A1 (enExample)
HU (1) HUP0203186A2 (enExample)
IL (2) IL149256A0 (enExample)
MX (1) MXPA02004225A (enExample)
NO (1) NO20021999L (enExample)
NZ (1) NZ518552A (enExample)
PL (1) PL360059A1 (enExample)
TW (1) TWI271397B (enExample)
WO (1) WO2001034563A1 (enExample)
ZA (1) ZA200203228B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
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CN104897818A (zh) * 2015-06-19 2015-09-09 重庆医药高等专科学校 一种同时测定比卡鲁胺中6种有关物质的uplc方法
CN108069887A (zh) * 2016-11-17 2018-05-25 山西振东制药股份有限公司 一种(r)-比卡鲁胺中间体的制备方法

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US6995284B2 (en) 2000-08-24 2006-02-07 The University Of Tennessee Research Foundation Synthesis of selective androgen receptor modulators
US6071957A (en) 1996-11-27 2000-06-06 The University Of Tennessee Research Corporation Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
US7026500B2 (en) 2000-08-24 2006-04-11 University Of Tennessee Research Foundation Halogenated selective androgen receptor modulators and methods of use thereof
US6838484B2 (en) 2000-08-24 2005-01-04 University Of Tennessee Research Foundation Formulations comprising selective androgen receptor modulators
US6998500B2 (en) 2000-08-24 2006-02-14 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US8008348B2 (en) 2001-12-06 2011-08-30 University Of Tennessee Research Foundation Treating muscle wasting with selective androgen receptor modulators
US8445534B2 (en) 2000-08-24 2013-05-21 University Of Tennessee Research Foundation Treating androgen decline in aging male (ADAM)-associated conditions with SARMs
US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
WO2002100339A2 (en) * 2001-06-13 2002-12-19 Biogal Gyogyszergyar Rt. Novel process for preparing rac-bicalutamide and its intermediates
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
PT1463497E (pt) 2001-12-06 2011-12-20 Gtx Inc Tratamento do desgaste muscular com moduladores selectivos do receptor de androgénios
PT1462442E (pt) 2001-12-13 2009-10-09 Sumitomo Chemical Co Cristais de bicalutamida e processo para a sua produção
JP4677516B2 (ja) 2002-02-07 2011-04-27 ユニバーシティ オブ テネシー リサーチ ファウンデーション Ｓａｒｍを用いた前立腺肥大症治療
US7344700B2 (en) 2002-02-28 2008-03-18 University Of Tennessee Research Corporation Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy
US7772433B2 (en) 2002-02-28 2010-08-10 University Of Tennessee Research Foundation SARMS and method of use thereof
US7803970B2 (en) 2002-02-28 2010-09-28 University Of Tennessee Research Foundation Multi-substitued selective androgen receptor modulators and methods of use thereof
ES2528764T3 (es) 2002-02-28 2015-02-12 University Of Tennessee Research Foundation Moduladores selectivos multisustituidos del receptor de andrógeno y métodos de uso de los mismos
US7022870B2 (en) 2002-06-17 2006-04-04 University Of Tennessee Research Foundation N-bridged selective androgen receptor modulators and methods of use thereof
US7741371B2 (en) 2002-06-17 2010-06-22 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US6818766B2 (en) 2002-10-02 2004-11-16 Synthon Bv Process for making bicalutamide and intermediates thereof
US8309603B2 (en) 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
EP1669347A1 (en) * 2004-12-10 2006-06-14 Helm AG Process for the preparation of 3-¬(4-fluorophenyl) sulfonyl|-2-hydroxy-2-methyl propionic acid
US20060269596A1 (en) * 2005-01-12 2006-11-30 Gary Liversidge Controlled release compositions comprising an acylanilide
KR20070114343A (ko) * 2005-03-29 2007-12-03 유에스브이 리미티드 비칼루타미드의 제조 방법
WO2008013791A2 (en) * 2006-07-24 2008-01-31 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
KR101264820B1 (ko) 2006-08-24 2013-05-22 유니버시티 오브 테네시 리서치 파운데이션 치환된 아실아닐리드 및 그의 사용 방법
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
US10010521B2 (en) 2006-08-24 2018-07-03 University Of Tennessee Research Foundation SARMs and method of use thereof
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US7968603B2 (en) 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
WO2011008543A2 (en) * 2009-06-29 2011-01-20 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
WO2012042532A1 (en) 2010-09-29 2012-04-05 Shilpa Medicare Limited Process for preparing bicalutamide
CN103539710A (zh) * 2012-07-02 2014-01-29 国药一心制药有限公司 一种（r）-比卡鲁胺的合成方法
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
JP6226978B2 (ja) 2012-07-13 2017-11-08 ジーティーエックス・インコーポレイテッド 選択的アンドロゲン受容体モジュレーター（ｓａｒｍ）によりアンドロゲン受容体（ａｒ）陽性乳癌を処置する方法
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)

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JPS58183669A (ja) * 1982-04-19 1983-10-26 Teikoku Chem Ind Corp Ltd 光学活性なプロピオン酸誘導体の製造方法
EP0100172B1 (en) * 1982-07-23 1987-08-12 Imperial Chemical Industries Plc Amide derivatives
GB8617652D0 (en) * 1986-07-18 1986-08-28 Ici Plc Acylanilide derivatives
CA2146005A1 (en) 1992-10-21 1994-04-28 Charles W. Murtiashaw, Iii Enantiomeric cis-3-(4,6-dihydroxychroman-3-yl-methyl)benzoic acids
EP0748220A4 (en) * 1994-01-21 1997-09-10 Sepracor Inc METHOD AND COMPOSITIONS FOR TREATING ANDROGEN-DEPENDENT DISEASES USING OPTICALLY PURE R - (-) CASODEX
WO1998055153A1 (en) 1997-06-04 1998-12-10 The University Of Tennessee Research Corporation Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104897818A (zh) * 2015-06-19 2015-09-09 重庆医药高等专科学校 一种同时测定比卡鲁胺中6种有关物质的uplc方法
CN108069887A (zh) * 2016-11-17 2018-05-25 山西振东制药股份有限公司 一种(r)-比卡鲁胺中间体的制备方法
CN108069887B (zh) * 2016-11-17 2021-04-20 山西振东制药股份有限公司 一种(r)-比卡鲁胺中间体的制备方法

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Publication number Publication date
BR0015124A (pt) 2002-07-02
NZ518552A (en) 2003-10-31
TWI271397B (en) 2007-01-21
JP4778178B2 (ja) 2011-09-21
HK1048299A1 (zh) 2003-03-28
IL149256A (en) 2011-05-31
AU2619501A (en) 2001-06-06
EP1224167A1 (en) 2002-07-24
HUP0203186A2 (hu) 2003-01-28
NO20021999D0 (no) 2002-04-26
NO20021999L (no) 2002-06-20
US6593492B1 (en) 2003-07-15
WO2001034563A1 (en) 2001-05-17
KR20020067509A (ko) 2002-08-22
CA2389100A1 (en) 2001-05-17
IL149256A0 (en) 2002-11-10
ZA200203228B (en) 2003-07-23
PL360059A1 (en) 2004-09-06
MXPA02004225A (es) 2002-10-17
JP2003513955A (ja) 2003-04-15
CZ20021434A3 (cs) 2002-11-13

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