CN1404864A - Chinese medicine for treatment of depression - Google Patents
Chinese medicine for treatment of depression Download PDFInfo
- Publication number
- CN1404864A CN1404864A CN 02139217 CN02139217A CN1404864A CN 1404864 A CN1404864 A CN 1404864A CN 02139217 CN02139217 CN 02139217 CN 02139217 A CN02139217 A CN 02139217A CN 1404864 A CN1404864 A CN 1404864A
- Authority
- CN
- China
- Prior art keywords
- grams
- radix
- depression
- treatment
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 25
- 208000020401 Depressive disease Diseases 0.000 title claims description 4
- 239000006187 pill Substances 0.000 claims abstract description 32
- 239000000843 powder Substances 0.000 claims abstract description 16
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 13
- 238000002156 mixing Methods 0.000 claims abstract description 6
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 12
- 210000000582 semen Anatomy 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 7
- 235000003392 Curcuma domestica Nutrition 0.000 claims description 5
- 244000008991 Curcuma longa Species 0.000 claims description 5
- 235000003373 curcuma longa Nutrition 0.000 claims description 5
- 235000013976 turmeric Nutrition 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 2
- 239000011812 mixed powder Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract 2
- 240000007185 Albizia julibrissin Species 0.000 abstract 1
- 235000011468 Albizia julibrissin Nutrition 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241000202726 Bupleurum Species 0.000 abstract 1
- 235000014375 Curcuma Nutrition 0.000 abstract 1
- 244000164480 Curcuma aromatica Species 0.000 abstract 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
- 241000234435 Lilium Species 0.000 abstract 1
- 244000236658 Paeonia lactiflora Species 0.000 abstract 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 1
- 235000021307 Triticum Nutrition 0.000 abstract 1
- 244000098338 Triticum aestivum Species 0.000 abstract 1
- 244000126002 Ziziphus vulgaris Species 0.000 abstract 1
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 229940010454 licorice Drugs 0.000 abstract 1
- 238000010298 pulverizing process Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 21
- 208000024891 symptom Diseases 0.000 description 19
- 210000004185 liver Anatomy 0.000 description 15
- 210000004369 blood Anatomy 0.000 description 10
- 239000008280 blood Substances 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 210000000481 breast Anatomy 0.000 description 8
- 210000000952 spleen Anatomy 0.000 description 8
- 208000002193 Pain Diseases 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 230000002936 tranquilizing effect Effects 0.000 description 5
- 206010000060 Abdominal distension Diseases 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 4
- 206010022437 insomnia Diseases 0.000 description 4
- 230000010354 integration Effects 0.000 description 4
- 208000005946 Xerostomia Diseases 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 230000001914 calming effect Effects 0.000 description 3
- 210000000038 chest Anatomy 0.000 description 3
- 206010013781 dry mouth Diseases 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 238000004062 sedimentation Methods 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 2
- 206010022998 Irritability Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000000881 depressing effect Effects 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 208000006750 hematuria Diseases 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 230000036651 mood Effects 0.000 description 2
- 239000002547 new drug Substances 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 description 1
- 206010057315 Daydreaming Diseases 0.000 description 1
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241000406668 Loxodonta cyclotis Species 0.000 description 1
- 208000019914 Mental Fatigue Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000035568 catharsis Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000003001 depressive effect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 231100001252 long-term toxicity Toxicity 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007074 memory dysfunction Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- 230000036299 sexual function Effects 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 208000020685 sleep-wake disease Diseases 0.000 description 1
- 230000008925 spontaneous activity Effects 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000008539 xiaoyao Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a Chinese medicine pill preparation for curing depression. Its preparation method includes the following steps: pulverizing the Chinese medicinal materials of bupleurum root, Chinese angelica root, white peony root and curcuma tuber to obtain medicinal powder, decocting other 6 Chinese medicinal materials of poria, lily bulb, silk tree bark, licorice, wheat and jujube at twice, combining two decoctions, filtering and concentrating to obtain medicinal paste, mixing the said medicinal powder with said medicinal paste and making them into pill preparatino which has therapeutic effect for curing depression.
Description
(1) technical field
The present invention relates to a kind of Chinese medicine depression alleviating pills that is used for the treatment of depression.
(2) background technology
Depression is a kind of common frdquently encountered disease, is now just becoming serious global problems, is listed in the big mental illness of the first in the world, is only second to the second largest killer of cancer.Be tangible rising situation at home, China's Ministry of Public Health is also classified depression as control emphasis from now on, the sickness rate of depression in the women is up to 20%-26% according to statistics, and the male is up to 8%-12%, and the economic loss that the U.S. causes because of depression every year reaches 43,700,000,000 dollars.The work of perplexing the patient and life that depression is serious bring white elephant for country, family and society.The Western medicine of at present commercially available treatment depression not only costs an arm and a leg, and the course of treatment is long, and has that xerostomia, vision touch that paste, sinus rhythm are overrun, memory dysfunction, influences side effect such as sexual function.How to excavate motherland's medicine and pharmacology treasure-house, development good effect, short treating period, the little Chinese patent medicine of side effect have become pharmacy worker's sacred duty.
(3) content of the present invention
At above-mentioned situation, the present invention's purpose is to provide a kind of Chinese medicine depression alleviating pills for the treatment of depression, can solve the treatment problem of depression effectively.Chinese medicine medical science is thought, feelings will is not smooth, mood is not relaxed, can cause multiple disease, also be a variety of Disease Inducement, that people run in work life is unsatisfactory, do not comply with one's wishes or important event after, produces disgruntled, ponder over, grief, heavy heart attitude, cause depression of liver-QI, strongly fragrant fire-transformation, qi depression to blood stasis, liver mistake bar reach, gas loses catharsis.Stagnation of liver-QI and spleen are thought emptyly not understand, overstrain impairing the spleen, spleen lose fortuneization.That stagnation of liver-QI presses down spleen, consumes sad gas, nutrient blood gradually consumes, the heart is become homeless is foster, god becomes homeless Tibetans, the mind is not normal, thus produce depressed, have a sleepless night.So feelings will is happy, happy is the basis of health.Depression alleviating pills is gloomy by removing just, conditioning feelings will, tranquilizing by nourishing the heart and reach the purpose of cure diseases, and full side is auxilliary to be adjusted to the master with benefit, transfers to mend combination treating both the principal and secondary aspects of a disease.Therefore, the present invention adopts the Radix Paeoniae Alba, Radix Bupleuri, Radix Angelicae Sinensis, Radix Curcumae, Poria, Bulbus Lilii, Cortex Albiziae, Radix Glycyrrhizae, Semen Tritici aestivi, the Fructus Jujubae reasonable compatibility, through science processing the Chinese medicine depression alleviating pills of treatment depression, count with weight percent: the Radix Paeoniae Alba 16.395%, Radix Bupleuri 12.298%, Radix Angelicae Sinensis 8.195%, Radix Curcumae 8.195%, Poria 9.835%, Bulbus Lilii 9.835%, Cortex Albiziae 9.835%, Radix Glycyrrhizae 4.919%, Semen Tritici aestivi 12.298% and Fructus Jujubae 8.195%, Radix Bupleuri wherein, Radix Angelicae Sinensis, the Radix Paeoniae Alba, turmeric powder is broken into powder, Poria, Bulbus Lilii, Cortex Albiziae, Radix Glycyrrhizae, Semen Tritici aestivi, Fructus Jujubae mixing decocting secondary, collecting decoction, filter, be condensed into extractum, extractum mixes with above-mentioned medicated powder, make the watered pill, drying promptly gets depression alleviating pills, taking convenience of the present invention, good effect, have no side effect, easily produce development prospect light, be the new drug of present ideal treatment depression, good economic and social benefit is arranged.
(4) specific embodiment
Below in conjunction with embodiment and practical situation the present invention is elaborated.
The prescription requirement according to the present invention, in the weight percent Radix Paeoniae Alba 16.395%, Radix Bupleuri 12.298%, Radix Angelicae Sinensis 8.195%, Radix Curcumae 8.195%, Poria 9.835%, Bulbus Lilii 9.835%, Cortex Albiziae 9.835%, Radix Glycyrrhizae 4.919%, Semen Tritici aestivi 12.298% and Fructus Jujubae 8.195%, through Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, turmeric powder is broken into powder, again with Poria, Bulbus Lilii, Cortex Albiziae, Radix Glycyrrhizae, Semen Tritici aestivi and Fructus Jujubae decoct with water secondary, add for the first time 12 times of amounts that water is medicine, decocted 1.5 hours, pour out medicinal liquid, add for the second time 10 times of amounts that water is medicine, decocted 1 hour, and merged decocting liquid twice, filter, concentrated filtrate becomes extractum, 60 ℃ of heat surveys down, making its relative density is 1.30-1.35, extractum and four Chinese medicine powder mixing, make the watered pill, dry getting final product.
As restraining depression alleviating pills to make 1000, by above-mentioned compatibility requirement be, the Radix Paeoniae Alba 285.7 grams, Radix Bupleuri 214.3 grams, Radix Angelicae Sinensis 142.8 grams, Radix Curcumae 142.8 grams, Poria 171.4 grams, Bulbus Lilii 171.4 grams, Cortex Albiziae 171.4 grams, Radix Glycyrrhizae 85.7 grams, Semen Tritici aestivi 214.3 grams and Fructus Jujubae 142.8 grams, with Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, turmeric powder is broken into mixed powder, again with Poria, Bulbus Lilii, Cortex Albiziae, Radix Glycyrrhizae, Semen Tritici aestivi and Fructus Jujubae add water 11484 grams (being 11484ml), fried in shallow oil 1.5 hours, and poured out decocting liquid for the first time, add water 9570 grams (being 9570ml) again, fried in shallow oil 1 hour, merge decocting liquid twice, filter reconcentration, 60 ℃ of heat surveys down, making its relative density is the extractum of 1.30-1.35, be mixed into the watered pill with the four Chinese medicine powder, be dried to 1000 grams and get final product, be taking convenience, per 15 balls heavily are 1 gram, oral, 3 times on the one, each 4 grams.
In above-mentioned prescription, the Radix Paeoniae Alba, Radix Bupleuri, Radix Angelicae Sinensis, Poria and Radix Glycyrrhizae are formed the XIAOYAO POWDER of soothing liver-QI for relieving depression spleen invigorating and nutrition, cure mainly breast association distension due to hepatic depression and blood deficiency, the dysfunction of the spleen in transportation, uncomfortable in chestly do not relax, headache and dizziness and mental fatigue with loss of appetite, have that dispersing the stagnated live-QI to relieve the stagnation of QI, nourishing blood to suppress the hyperactive liver, spleen invigorating are dried, an effect of the urgency of invigorating the spleen and replenishing QI, slow liver.Radix Glycyrrhizae, Semen Tritici aestivi, Fructus Jujubae are formed tranquilizing by nourishing the heart and middle emergency GANMAI DAZAO TANG, and the spirit that cures mainly due to the stagnation of liver-QI of having a guilty conscience is absentminded, and normal compassion is desired to cry, and sleep disorder can not be autonomous, have sweetly slowly gradually to mend easing the affected liver emergency, the effect of mind tranquilizing and the heart calming; Radix Curcumae energy promoting blood circulation and stopping pain, promoting QI circulation for relieving depression; The Cortex Albiziae resolving depression of calming the nerves, hemostasia and detumescence; Bulbus Lilii can clearing away heart-fire for tranquillization.Above-mentioned science compatibility can reach dispersing the stagnated live-QI to relieve the stagnation of QI jointly, tranquilizing by nourishing the heart, and the effect of conditioning mood, thus make depression be able to effective treatment.The present invention can by the prescription requirement, make the depression alleviating pills of any amount as required.Its production is very simple, easily row.
The present invention can be used for stagnation of QI due to depression of the liver effectively, and the breast side of body is filled due to the irritability, gloomyly do not relax, and vexed cardiopalmus, irritability, insomnia, diseases such as dreaminess below have all obtained fully proving to mouse test and clinical practice treatment depression.
A, pharmacodynamics pharmacological toxicology are learned situation
According to bureau of drug administration of People's Republic of China (PRC) new drug research guideline, show after deliberation, depression alleviating pills has inhibitory action to nervus centralis, the appropriate sleeping number of subliminal hypnosis dosage of receiving of experiment mice penta crust is obviously increased, the sleep time-lag action is arranged, scopolamine induced mice memory acquisition disturbance there is the improvement effect, the experiment mice spontaneous activity is obviously reduced.Show through animal acute toxicity test, be equivalent to 315 times of people's clinical application amount with the depression alleviating pills suspension to mouse stomach, mice does not have movable unusual, does not more see death, so the depression alleviating pills oral administration is very safe.The depression alleviating pills long term toxicity test studies show that depression alleviating pills does not have influence to the normal growth growth of rat, and the every index of hemogram checking is all in normal range, and depression alleviating pills has no adverse effects to the hemopoietic function of rat, does not damage hepatic and renal function.The all no abnormal pathologic of main organs pathological examination changes, and illustrates that depression alleviating pills is a kind of safe Chinese medicine preparation.
In order further to estimate the clinical efficacy of depression alleviating pills, on the basis of over thousands of routine clinical verification, observed 100 routine depressive patients in 95 years-96 years in No.1 Hospital Attached to He'nan Traditional Chinese Medical College, second Affiliated Hospital and three tame hospitals of Henan Prov. Inst. of Chinese Medicine ﹠ Pharmacology again, and establish the ease pill matched group, the observation of system has been carried out in its curative effect, safety and side effect, and situation is as follows:
(1) case choice criteria
Suffer from lassitude with local and the person of seing patients, heart anger uncomfortable in chest, headache and dizziness, diet is depressed etc., and the age, the men and women did not limit, and meets liver depression diagnostic criteria person all as including the observation case between 18-65 year.But conscience lung kidney is had serious organic disease and psychotic, and the age is at under-18s, the women of over-65s and gestation, age of sucking, and not medication in accordance with regulations, or data is not congruent to affect the treatment or safety judgement person, except this medicine allergy sufferers.
(2) diagnostic criteria
Liver gloomy: main symptom (1) spirit depressing, kind sigh uncomfortable in chest; (2) the breast side of body or few distention and fullness in the abdomen are scurried pain; (3) susceptible to lose temper due to restlessness; (4) premenstruum distending pain of the breast; (5) pharyngeally block if any foreign body; (6) xerostomia hardship; (7) body of the tongue is light red, and tongue is white; (8) stringy pulse.All have in main symptom (1)-(6) 3 and meet picture of the tongue, pulse condition person, and diagnosable is liver depression.
(3) administrated method and the course of treatment
Test group is taken depression alleviating pills, each 4 grams, and every day three times, warm water delivery service, 7 days is a course of treatment, takes 2 courses of treatment continuously; Matched group is taken ease pill, each 6 the gram, every day three times, 7 days was 1 course of treatment, took 2 courses of treatment continuously, during comprise general health check-up project, the hematuria routine, GPT, BUN, the treatment before and after respectively look into once.
Four, efficacy assessment standard
Cure: the liver depression cardinal symptom disappears, and treatment back integrated value is 0.
Produce effects: the liver depression cardinal symptom takes a turn for the better, and treatment back symptom integral reduces by 2/3 above person.
Take a turn for the better: the liver depression cardinal symptom takes a turn for the better, and treatment back symptom integral reduces more than 1/3 deficiency.
Invalid: treatment back symptom integral reduces less than 1/3.
(5) statistical procedures situation
1, the comparison of two groups of curative effects sees Table 1
The comparison of table 1 liang group curative effect
| Group | The example number | The curative effect classification | |||
| Recovery from illness (%) | Produce effects (%) | Take a turn for the better (%) | Invalid (%) | ||
| Test group | 100 | ?33(33) | ?45(45) | 17(17) | ??5(5) |
| Matched group | 30 | ?2(6.67) | ?9(30.0) | 10(53.3) | ??3(10) |
Through X
2Check, two groups of above rates of produce effects and cure rate have significant difference (P＜0.05).
2, the comparison of two groups of treatment back symptom total marks sees Table 2.
The comparison of table 2 liang group treatment back symptom total mark
| Group | The example number | Integration | |||
| ????0～2 | ????3～4 | ????5～7 | ????8 | ||
| Test group | ????100 | ????33 | ????45 | ????17 | ????5 |
| Matched group | ????30 | ????2 | ????9 | ????16 | ????3 |
Through X
2Check, two groups of treatment back symptom total mark situations have significant difference (P＜0.05), illustrate that the present invention is better than ease pill aspect the clinical symptoms improving.
3, the comparison of cardinal symptom integration before and after the test group treatment sees Table 3
Comparison (the X of cardinal symptom integration before and after the treatment of table 3 test group
2± SD)
| Cardinal symptom | The example number | Before the treatment | After the treatment | The P value |
| Spirit depressing kind sigh uncomfortable in chest | ????95 | ????2.41±0.32 | ????1.15±0.41 | ????＜0.05 |
| Distending pain is coerced or answered less to breast | ????81 | ????2.11±0.52 | ????0.46±0.57 | ????＜0.01 |
| Susceptible to lose temper due to restlessness | ????78 | ????1.74±0.35 | ????0.40±0.32 | ????＜0.01 |
| Mammary swelling in the past | ????52 | ????1.47±0.53 | ????0.76±0.47 | ????＜0.05 |
| Distention and pain of breast before menstruation blocks | ????37 | ????2.16±0.58 | ????±1.65±0.76 | ????＜0.05 |
| The xerostomia hardship | ????39 | ????1.33±0.31 | ????0.67±0.52 | ????＜0.05 |
| The insomnia or the dreaminess of sleeping less | ????68 | ????1.53±0.35 | ????0.31±0.52 | ????＜0.01 |
As can be seen from the table, before and after the test group cardinal symptom treatment there be significantly and utmost point significant difference (P＜0.05 or＜0.01) variation of integration.Illustrate that the present invention can effectively improve the liver depression clinical symptoms, especially insomnia or sleep the less dreaminess and the breast side of body or distention and pain in the lower abdomen are had curative effect preferably.
4, the situation of change of two groups of every indexs of treatment front and back blood relatively sees Table 4.
| Detect index | Matched group | Test group | ||
| Before the treatment | After the treatment | Before the treatment | After the treatment | |
| The whole blood height is cut viscosity | ??4.60±3.2 | ????4.34±0.52 | ????4.70±0.52 | ????3.21±0.52Δ * |
| The low viscosity of cutting of whole blood | ??9.81±2.51 | ????8.92±2.49 | ????10.91±1.51 | ????8.51±1.47Δ * |
| Erythrocyte sedimentation rate | ??1.93±0.32 | ????1.92±0.31 | ????1.94±0.33 | ????1.51±0.04Δ * |
| Packed cell volume | ??42.1±2.35 | ????41.5±0.53 | ????42.05±3.35 | ????35.5±0.63Δ * |
Annotate: treat the back own control before " △ " represents two groups to treat, △ P＜0.05; Comparison after " * " representative treatment between two groups,
*P＜0.05.
As can be seen from the table, contrast had obvious reduction before the every index homogeneous in test group treatment back was treated, and learning by statistics to handle has significant difference, and matched group is except that erythrocyte sedimentation rate, all the other with treat before compare there was no significant difference; Treat and to compare except that erythrocyte sedimentation rate between two groups of backs and whole blood is low cuts the viscosity, significant difference is all arranged.Illustrate that the present invention has vital energy regualting and blood circulation-promoting, blood viscosity lowering improves sanguimotor effect, and significantly is better than ease pill.
5, the observation of safety indexes to 100 routine patients with TCM liver depression, finds no side effect and untoward reaction and takes place during treating, hematuria routine and hepatic and renal function there is no unusually at the treatment before and after look, illustrate that this medicine is safe and reliable.
(6) conclusion
1, the present invention has dispersing the stagnated live-QI to relieve the stagnation of QI, mind tranquilizing and the heart calming, and the effect of harmonizing emotions is the pure Chinese medicine product of treatment liver gloomy, by systematic observation 100 these patients of example, its total digit rate is 95%, cures 33 examples and accounts for 33%; Remarkable 45 examples account for 45%; 17 examples that take a turn for the better account for 17%, and compare with ease pill, see Table 1 and above rate of produce effects and cure rate are significantly higher than matched group (p＜0.05).
2, the present invention can significantly improve the clinical symptoms of liver gloomy, especially insomnia and dreamful sleep and the breast side of body or distention and pain in the lower abdomen is had significant curative effect.Treatment back symptom total mark and ease pill contrast have significant difference (P＜0.05), see Table 2.
3, the present invention can significantly improve this patient's hemorheology index, has better popularizing value.
Claims (2)
1, a kind of Chinese medicine depression alleviating pills for the treatment of depression, it is characterized in that it being the Radix Paeoniae Alba 16.395% by in heavy percentage, Radix Bupleuri 12.298%, Radix Angelicae Sinensis 8.195%, Radix Curcumae 8.195%, Poria 9.835%, Bulbus Lilii 9.835%, Cortex Albiziae 9.835%, Radix Glycyrrhizae 4.919%, Semen Tritici aestivi 12.298% and Fructus Jujubae 8.195%, Radix Bupleuri wherein, Radix Angelicae Sinensis, the Radix Paeoniae Alba, turmeric powder is broken into powder, Poria, Bulbus Lilii, Cortex Albiziae, Radix Glycyrrhizae, Semen Tritici aestivi, Fructus Jujubae mixing decocting secondary, add for the first time 12 amounts that water is medicine, fried in shallow oil 1.5 hours, add for the second time 10 times of amounts of water, fried in shallow oil 1 hour, merge decocting liquid twice, filter reconcentration, 60 ℃ of heat surveys down, making its relative density is the extractum of 1.30-1.35, the pill made from four Chinese medicine powder mixing.
2, the Chinese medicine depression alleviating pills of treatment depression according to claim 1, it is characterized in that it being by the said Radix Paeoniae Alba 285.7 grams, Radix Bupleuri 214.3 grams, Radix Angelicae Sinensis 142.8 grams, Radix Curcumae 142.8 grams, Poria 171.4 grams, Bulbus Lilii 171.4 grams, Cortex Albiziae 171.4 grams, Radix Glycyrrhizae 85.7 grams, Semen Tritici aestivi 214.3 grams and Fructus Jujubae 142.8 grams, with Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, turmeric powder is broken into mixed powder, again with Poria, Bulbus Lilii, Cortex Albiziae, Radix Glycyrrhizae, Semen Tritici aestivi and Fructus Jujubae add water 11484 grams, fried in shallow oil 1.5 hours, pour out medicinal liquid, add water 9570 grams again, fried in shallow oil 1 hour, merge decocting liquid twice, filter reconcentration, 60 ℃ of heat surveys down, making its relative density is the extractum of 1.30-135, makes 1000 gram pills with four Chinese medicine powder mixing drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB02139217XA CN1161145C (en) | 2002-10-27 | 2002-10-27 | Chinese medicine for treatment of depression |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB02139217XA CN1161145C (en) | 2002-10-27 | 2002-10-27 | Chinese medicine for treatment of depression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1404864A true CN1404864A (en) | 2003-03-26 |
| CN1161145C CN1161145C (en) | 2004-08-11 |
Family
ID=4749964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB02139217XA Expired - Lifetime CN1161145C (en) | 2002-10-27 | 2002-10-27 | Chinese medicine for treatment of depression |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1161145C (en) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1292792C (en) * | 2005-07-11 | 2007-01-03 | 杨永信 | Chinese medicine for treating depression |
| CN1317027C (en) * | 2005-02-21 | 2007-05-23 | 李有田 | Chinese medicine for treating depression |
| WO2007133886A3 (en) * | 2006-05-08 | 2010-01-07 | Vita Green Health Products Inc. | Herbal formulation for treatment of depression and other related disorders and method of preparing the same |
| CN101757552B (en) * | 2008-12-03 | 2011-07-27 | 郑州豫密药业股份有限公司 | Application of jieyu pill in drug treatment |
| CN102198253A (en) * | 2011-05-27 | 2011-09-28 | 上海市中医医院 | Traditional Chinese medicine composition for resisting depression, and preparation method as well as application thereof |
| CN103479880A (en) * | 2013-08-27 | 2014-01-01 | 王学松 | Chinese herbal composition for treating neurasthenia |
| CN104288664A (en) * | 2014-10-31 | 2015-01-21 | 哈尔滨市海江科技开发有限公司 | Medicine curing hypochondriacal neurosis and preparation method for medicine |
| CN104522653A (en) * | 2014-12-19 | 2015-04-22 | 杨毅 | Food for treating blocking of liver qi and preparation method of food |
| CN104922591A (en) * | 2015-06-19 | 2015-09-23 | 赵永峰 | Traditional Chinese ointment for treating tristimania and preparation method of traditional Chinese ointment |
| CN105288279A (en) * | 2015-11-04 | 2016-02-03 | 闫超 | Traditional Chinese medicine preparation for preventing and treating depression and preparation method thereof |
| CN105288281A (en) * | 2015-11-04 | 2016-02-03 | 闫超 | Liver-soothing qi-regulating preparation for treating depression and preparation method thereof |
| CN105688094A (en) * | 2016-04-12 | 2016-06-22 | 杨海娟 | Traditional Chinese medicine composition for treating depression and preparation method thereof |
| CN105853907A (en) * | 2016-04-12 | 2016-08-17 | 杨海娟 | Traditional Chinese medicinal composition and preparation method of depression resolving pills |
| CN105920447A (en) * | 2016-06-12 | 2016-09-07 | 贵州神奇药物研究院 | Antidepressant health product and preparation method thereof |
| CN109289009A (en) * | 2018-12-10 | 2019-02-01 | 河南泰丰生物科技有限公司 | A kind of Chinese medicine composition and its preparation method and application |
-
2002
- 2002-10-27 CN CNB02139217XA patent/CN1161145C/en not_active Expired - Lifetime
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1317027C (en) * | 2005-02-21 | 2007-05-23 | 李有田 | Chinese medicine for treating depression |
| CN1292792C (en) * | 2005-07-11 | 2007-01-03 | 杨永信 | Chinese medicine for treating depression |
| WO2007133886A3 (en) * | 2006-05-08 | 2010-01-07 | Vita Green Health Products Inc. | Herbal formulation for treatment of depression and other related disorders and method of preparing the same |
| CN101757552B (en) * | 2008-12-03 | 2011-07-27 | 郑州豫密药业股份有限公司 | Application of jieyu pill in drug treatment |
| CN102198253A (en) * | 2011-05-27 | 2011-09-28 | 上海市中医医院 | Traditional Chinese medicine composition for resisting depression, and preparation method as well as application thereof |
| CN102198253B (en) * | 2011-05-27 | 2012-09-05 | 上海市中医医院 | Traditional Chinese medicine composition for resisting depression, and preparation method as well as application thereof |
| CN103479880A (en) * | 2013-08-27 | 2014-01-01 | 王学松 | Chinese herbal composition for treating neurasthenia |
| CN104288664A (en) * | 2014-10-31 | 2015-01-21 | 哈尔滨市海江科技开发有限公司 | Medicine curing hypochondriacal neurosis and preparation method for medicine |
| CN104522653A (en) * | 2014-12-19 | 2015-04-22 | 杨毅 | Food for treating blocking of liver qi and preparation method of food |
| CN104922591A (en) * | 2015-06-19 | 2015-09-23 | 赵永峰 | Traditional Chinese ointment for treating tristimania and preparation method of traditional Chinese ointment |
| CN105288279A (en) * | 2015-11-04 | 2016-02-03 | 闫超 | Traditional Chinese medicine preparation for preventing and treating depression and preparation method thereof |
| CN105288281A (en) * | 2015-11-04 | 2016-02-03 | 闫超 | Liver-soothing qi-regulating preparation for treating depression and preparation method thereof |
| CN105688094A (en) * | 2016-04-12 | 2016-06-22 | 杨海娟 | Traditional Chinese medicine composition for treating depression and preparation method thereof |
| CN105853907A (en) * | 2016-04-12 | 2016-08-17 | 杨海娟 | Traditional Chinese medicinal composition and preparation method of depression resolving pills |
| CN105920447A (en) * | 2016-06-12 | 2016-09-07 | 贵州神奇药物研究院 | Antidepressant health product and preparation method thereof |
| CN109289009A (en) * | 2018-12-10 | 2019-02-01 | 河南泰丰生物科技有限公司 | A kind of Chinese medicine composition and its preparation method and application |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1161145C (en) | 2004-08-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1161145C (en) | Chinese medicine for treatment of depression | |
| CN103007206A (en) | Oral liquid for treating chronic atrophic gastritis | |
| CN102284049A (en) | Traditional Chinese medicine compound preparation for resisting ulcer and relieving chemoradiotherapeutic toxic and side effects, and preparation method and application thereof | |
| CN101757553A (en) | Method for preparing depression alleviating pills | |
| CN101670011A (en) | Medicament for treating rheumatism and rheumatoid and preparation method thereof | |
| CN110478452A (en) | A kind of Chinese medicine composition and preparation method thereof for treating gout | |
| CN101433586B (en) | Medicament for treating ischemic cerebrovascular disease and preparation method thereof | |
| CN104548029A (en) | Pharmaceutical composition for treating epigastric pain | |
| CN103479737A (en) | Traditional Chinese medicine composition for treating senile cutaneous pruritus and application thereof | |
| CN103990009A (en) | Traditional Chinese medicine for treatment of type II diabetes by invigorating spleen and purging turbidness | |
| CN100540030C (en) | A kind of topical agent for the treatment of dysmenorrhes | |
| CN104013704B (en) | Pharmaceutical composition for treating chronic pelvic inflammatory disease and preparation method of composition | |
| CN103860894B (en) | A kind of medicine for the treatment of chronic prostatitis | |
| CN100577199C (en) | Application of stomachic pill with cyperus and amomum | |
| CN103157048B (en) | Traditional Chinese medicine composition for treating chronic pelvic inflammation and preparation method thereof | |
| CN102283993B (en) | Traditional Chinese medicine composition for treating systemic lupus erythematosus | |
| CN105056077A (en) | Traditional Chinese medicine composition for treating functional dyspepsia | |
| CN1141965C (en) | Medicine for treating heart disease | |
| CN104435545A (en) | Traditional Chinese medicine preparation for treating leucopenia caused by benzene poisoning | |
| CN102949656A (en) | Health care product capsule used for preventing and treating depression and preparation method thereof | |
| CN1177597C (en) | Nose drops for rhinitis | |
| CN102488797B (en) | Medicinal composition for treating dysmenorrhea | |
| CN102488825A (en) | Traditional Chinese medicine composition for treating beriberoid pyretic arthralgia and application of traditional Chinese medicine composition | |
| CN101890145B (en) | Medicament for treating diabetes and preparation thereof | |
| CN100551389C (en) | A kind of medicine for the treatment of early bone tumor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: HE'NAN KANGQI PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: YUMI PHARMACEUTICAL CO., LTD., ZHENGZHOU |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 450003, block B, building 15, Star digital building, No. three, No. 26, Henan, Zhengzhou, China Patentee after: He'nan Kangqi Pharmaceutical Co.,Ltd. Address before: 450003, block B, building 15, Star digital building, No. three, No. 26, Henan, Zhengzhou, China Patentee before: ZHENGZHOU YUMI PHARMACEUTICAL Co.,Ltd. |
|
| C56 | Change in the name or address of the patentee |
Owner name: HENAN TAIFENG PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: HE'NAN KANGQI PHARMACEUTICAL CO., LTD. |
|
| CP03 | Change of name, title or address |
Address after: Xinmi City, Henan province 452392 Zhengzhou City No. 168 Deng Lu Zheng Patentee after: Henan Taifeng Pharmaceutical Co.,Ltd. Address before: 450003, block B, building 15, Star digital building, No. three, No. 26, Henan, Zhengzhou, China Patentee before: He'nan Kangqi Pharmaceutical Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20181019 Address after: 475000 intersection of seven Avenue and Longhai two road in Kaifeng, Henan Patentee after: HENAN TAIFENG BIOTECHNOLOGY Co.,Ltd. Address before: 452392 zhengdeng Road, Xinmi, Zhengzhou, Henan 168 Patentee before: Henan Taifeng Pharmaceutical Co.,Ltd. |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20040811 |