CN1377282A - 脂肪酸－抗癌缀合物及其应用 - Google Patents

脂肪酸－抗癌缀合物及其应用 Download PDF

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Publication number
CN1377282A
CN1377282A CN00804762A CN00804762A CN1377282A CN 1377282 A CN1377282 A CN 1377282A CN 00804762 A CN00804762 A CN 00804762A CN 00804762 A CN00804762 A CN 00804762A CN 1377282 A CN1377282 A CN 1377282A
Authority
CN
China
Prior art keywords
fatty acid
acid
taxane
conjugate
anticancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00804762A
Other languages
English (en)
Chinese (zh)
Inventor
奈杰尔·L·韦布
马修斯·O·布拉德利
福雷斯特·安东尼
马克·菲希尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Protarga Inc
Original Assignee
Protarga Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/265,307 external-priority patent/US7235583B1/en
Application filed by Protarga Inc filed Critical Protarga Inc
Publication of CN1377282A publication Critical patent/CN1377282A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN00804762A 1999-03-09 2000-03-09 脂肪酸－抗癌缀合物及其应用 Pending CN1377282A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/265,307 1999-03-09
US09/265,307 US7235583B1 (en) 1999-03-09 1999-03-09 Fatty acid-anticancer conjugates and uses thereof
US18615200P 2000-03-01 2000-03-01
US60/186,152 2000-03-01

Publications (1)

Publication Number Publication Date
CN1377282A true CN1377282A (zh) 2002-10-30

Family

ID=26881822

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00804762A Pending CN1377282A (zh) 1999-03-09 2000-03-09 脂肪酸－抗癌缀合物及其应用

Country Status (10)

Country Link
EP (1) EP1163011A2 (ko)
JP (1) JP2002538224A (ko)
KR (1) KR20020000147A (ko)
CN (1) CN1377282A (ko)
AU (1) AU3733300A (ko)
CA (1) CA2366723C (ko)
CZ (1) CZ20013123A3 (ko)
HK (1) HK1040486A1 (ko)
RU (1) RU2001127313A (ko)
WO (1) WO2000053231A2 (ko)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101137395B (zh) * 2005-03-14 2012-10-31 株式会社大塚制药工场 含有水难溶性药物的医药组合物
WO2023221961A1 (zh) * 2022-05-20 2023-11-23 上海维洱生物医药科技有限公司 一种雷公藤甲素木蜡酸酯及其脂质体与制备方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994392A (en) * 1988-02-26 1999-11-30 Neuromedica, Inc. Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid
WO2002076402A2 (en) * 2001-03-23 2002-10-03 Protarga, Inc. Fatty amine drug conjugates
EP1423107B1 (en) * 2001-03-23 2012-05-09 Luitpold Pharmaceuticals, Inc. Fatty alcohol drug conjugates
US7169752B2 (en) 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
CN101134119A (zh) 2002-05-24 2008-03-05 血管技术国际股份公司 用于涂覆医用植入物的组合物和方法
EP1633380A4 (en) * 2003-06-19 2010-08-11 Yeda Res & Dev ANTIMICROBIAL AND ANTICANCER LIPOPEPTIDES
EP1703904B1 (en) * 2003-10-30 2013-02-13 The Research Foundation of the State University of New York Taxoid-fatty acid conjugates and pharmaceutical compositions thereof
KR100753112B1 (ko) * 2007-02-26 2007-08-29 (주)고려다이나믹스 카드 발권 시스템
US9480752B2 (en) * 2012-07-10 2016-11-01 Baseclick Gmbh Anandamide-modified nucleic acid molecules
KR20230174082A (ko) * 2022-06-20 2023-12-27 (주) 바이오인프라생명과학 약물을 전달하기 위한 초음파 감응형 약물전달체를 생성하는 방법 및 이를 이용한 초음파 감응형 약물전달체
WO2024110843A1 (en) 2022-11-21 2024-05-30 Segena Corporation S.A. Enhancing oligonucleotide immunomodulatory activity through dianophore long-lasting modification: methods and applications
CN116676355B (zh) * 2023-08-03 2023-10-24 成都第一制药有限公司 一种催化合成山莨菪碱的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925327A (ja) * 1982-07-31 1984-02-09 Hidematsu Hirai 抗腫瘍性複合体の製造方法
EP0616493A4 (en) * 1991-12-10 1994-11-09 Rush Presbyterian St Luke METHODS AND COMPOSITIONS FOR REDUCING MULTIRESISTANCE TO MEDICINES.
US5925669A (en) * 1994-03-22 1999-07-20 Molecular/Structural Bio Technologies, Inc. Carrier compositions for anti-neoplastic drugs
US5580899A (en) * 1995-01-09 1996-12-03 The Liposome Company, Inc. Hydrophobic taxane derivatives
JP4172726B2 (ja) * 1996-05-22 2008-10-29 ルイトポルド・ファーマシューティカルズ・インコーポレーテッド シス―ドコサヘキサエン酸とドセタキセルとの共有複合体を含有する製剤
US5919815A (en) * 1996-05-22 1999-07-06 Neuromedica, Inc. Taxane compounds and compositions
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US6136988A (en) * 1998-04-10 2000-10-24 Hauser, Inc. 7-hexanoyltaxol and methods for preparing the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101137395B (zh) * 2005-03-14 2012-10-31 株式会社大塚制药工场 含有水难溶性药物的医药组合物
WO2023221961A1 (zh) * 2022-05-20 2023-11-23 上海维洱生物医药科技有限公司 一种雷公藤甲素木蜡酸酯及其脂质体与制备方法

Also Published As

Publication number Publication date
EP1163011A2 (en) 2001-12-19
HK1040486A1 (zh) 2002-06-14
RU2001127313A (ru) 2003-09-20
AU3733300A (en) 2000-09-28
KR20020000147A (ko) 2002-01-04
WO2000053231A3 (en) 2001-10-04
CA2366723A1 (en) 2000-09-14
CZ20013123A3 (cs) 2002-03-13
JP2002538224A (ja) 2002-11-12
WO2000053231A2 (en) 2000-09-14
CA2366723C (en) 2011-08-02

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ASS Succession or assignment of patent right

Owner name: LOUTBLEDE PHARMACEUTICALS CO., LTD.

Free format text: FORMER OWNER: PROTARGA INC.

Effective date: 20060310

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20060310

Address after: American New York

Applicant after: Root Bolide Pharmaceutical Co. Ltd.

Address before: American Pennsylvania

Applicant before: Protarga Inc.