CN1375305A

CN1375305A - Externally applied anticancer analgesic ointment

Info

Publication number: CN1375305A
Application number: CN 01108155
Authority: CN
Inventors: 王文安
Original assignee: Individual
Current assignee: Individual
Priority date: 2001-03-20
Filing date: 2001-03-20
Publication date: 2002-10-23

Abstract

An external-use anti-cancer and pain-relieving ointment is prepared from Aconitum carmichaeli Debx, Aconitum kusnezoffii Reic, selfheal, Achillea alpina L, borneol and rape oil etc. through dry disintegrating, high-temp. extracting, mix decocting. Said medicine has the functions of fast pain-relieving, long last pain-relieving and anti-inflammation etc. and is suitable to treating the pain resulted from mid-term and late cancer, angina pectoris, proliferation of mammary land, osteoproliferation and gum gall etc.

Description

A kind of externally applied anticancer analgesic ointment

The present invention relates to a kind of Chinese medicine ointment, more particularly, is a kind of externally applied anticancer analgesic ointment.

At present, various cancers worldwide still do not have specific drug and effect a radical cure, and cancer pain is not had the permanent pain relieving of specific medicament yet.Doctor trained in Western medicine can only be treated with chemicals, chemotherapy or operation, and this type of therapy all has human body to stimulate and harm, makes the big wound of patient's QI and blood; The traditional Chinese medical science is many again comes reducing swelling and alleviating pain with Orally-administered decoction.But physical weakness is all had the cancer patient of inappetence or digestive system disease, and no matter Chinese medicine or Western medicine all are difficult to adhere to taking.And side effect is all arranged in these medicines mostly, some then makes patient's addiction.Because patient's digestive system function weakens, the drug effect that endo-medicine arrives focus is very little, and pain still makes patient's misery very much.

The objective of the invention is to avoid above-mentioned weak point of the prior art, provide a kind of treat various cancers and other pain diseases, have that pain relieving is fast, the externally applied anticancer analgesic ointment of pain relieving longer duration, anti-inflammation detumescence.

Purpose of the present invention is achieved through the following technical solutions.

The present invention is made up of following Chinese crude drug:

Radix Aconiti, Radix Aconiti Kusnezoffii, Spica Prunellae, Herba Achilleae, Semen Hyoscyami, Rhizoma Corydalis, Semen Momordicae, Radix Tripterygii Wilfordii, Semen Strychni, Rhizoma Arisaematis, Daphne giraldii Nitsche, Bufo siccus, Rhizoma Paridis, Resina garciniae, Resina Ferulae, Borneolum Syntheticum, vegetable oil.

Chinese crude drug respectively distinguish the flavor of among the present invention by following dosage formulation:

Radix Aconiti 40～60g, Radix Aconiti Kusnezoffii 40～60g, Spica Prunellae 40～50g, Herba Achilleae 40g, Semen Hyoscyami 20～30g,

Rhizoma Corydalis 20～30g, Semen Momordicae 10～20g, Radix Tripterygii Wilfordii 10～20g, Semen Strychni 10～20g, Rhizoma Arisaematis 10～20g,

Daphne giraldii Nitsche 10～20g, Bufo siccus 10～20g, Rhizoma Paridis 10～20g, Resina garciniae 10～20g, Resina Ferulae 40～50g,

Borneolum Syntheticum 40～50g, vegetable oil 2000g.

In the above-mentioned prescription of the present invention, Radix Aconiti, antalgic, the diffusing wind of damp eliminating; Radix Aconiti Kusnezoffii, dispersing cold for relieving pain, detumescence are had one's ideas straightened out; Spica Prunellae, liver heat removing eliminating stagnation, sterilization antiinflammatory; Herba Achilleae, expelling wind and activating blood circulation, detoxifcation pain relieving; Semen Hyoscyami is decided the epilepsy pain relieving; Rhizoma Corydalis, promoting blood circulation to remove blood stasis, regulating QI to relieve pain; Semen Momordicae, dispel poison detumescence, removing obstruction for relieving pain; Radix Tripterygii Wilfordii, eliminating inflammation and expelling toxin; Semen Strychni, heat radiation, detumescence, pain relieving; Rhizoma Arisaematis, sedation-analgesia, dispersing swelling and dissipating binds; Daphne giraldii Nitsche, pain relieving dissipating blood stasis, expelling wind and removing dampness; Bufo siccus, heat-clearing and toxic substances removing, diuretic relieving distension; Rhizoma Paridis, detoxifcation is controlled swollen; Resina garciniae, detumescence removing toxic substances, hemostasis parasite killing; Resina Ferulae, eliminating stagnated food and killing intestinal worms; Borneolum Syntheticum, fire, the alleviating pain and detumescence of loosing of having one's ideas straightened out; Vegetable oil is substrate.

The all drug matching of the present invention has the effect of anticancer analgetic, dispersing swelling and dissipating binds, antiinflammatory removing toxic substances, prevention pain nerve conduction.The present invention combines with the acupuncture point thermotherapy, enhanced sensitivity potentiation, and effect is better.

Indication: in various, card bitterly such as terminal cancer and angina pectoris, cyclomastopathy, hyperosteogeny, gingival swelling and pain, innominate toxic swelling.

Through clinical practice data record, 150 routine patients are treated pulmonary carcinoma 35 examples wherein, esophageal carcinoma 22 examples, hepatocarcinoma 20 examples, breast carcinoma, each 18 example of gastric cancer, nasopharyngeal carcinoma 17 examples, He Jiejinshi tumor 4 examples, hyperosteogeny 14 examples, other pain disease 2 examples; III level pain 88 examples wherein, IV level pain 62 examples.The pain relieving obvious effective rate reaches more than 90%, and total effective 100%.

The present invention has following advantage:

1, analgesic effect is rapid, paste medicine after, the fastest 5 minutes, onset in the slowest 30 minutes combined with the acupuncture point thermotherapy, then pain relieving, detumescence effect are better.

2, pain relieving longer duration reaches 24 hours account for more than 70%.

3, have no drug resistance, do not have addiction, no sensitization, have no side effect.

4, produce, use, carry, take care of all convenient, safety.

By the following examples the present invention is further described.

Embodiment one:

Present embodiment is pressed following prescription:

Radix Aconiti 60g, Radix Aconiti Kusnezoffii 60g, Spica Prunellae 50g, Herba Achilleae 40g, Semen Hyoscyami 30g, Rhizoma Corydalis 30g,

Semen Momordicae 20g, Radix Tripterygii Wilfordii 20g, Semen Strychni 20g, Rhizoma Arisaematis 20g, Daphne giraldii Nitsche 20g, Bufo siccus 20g,

Rhizoma Paridis 20g, Resina garciniae 20g, Resina Ferulae 50g, Borneolum Syntheticum 50g, vegetable oil 2000g.

Preparation method:

1, above-mentioned medical material is clean, drying and crushing is put into solvent and was soaked 10～15 days, extracts medicinal liquid again.

2, medicinal liquid and vegetable oil are heated to 200～230 ℃, cooling after 40 minutes, stirring.Filter medicine oil with the ferrum sieve, remove residue.

3, the medicine oil after will filtering is warming up to 300～320 ℃ in pot, and constantly stirs, endure to dropping liquid to become pearl flame-out, and red down, promptly add excipient Plumbum preparatium.Medicine oil and Plumbum preparatium amount ratio: winter 37～40%, spring and autumn 43～45%, summer 50～62%.

4, poultice stand is coated in is shaped to patch on the cloth, patch divides two kinds of specifications, No. 1 every net weight 12g, No. 2 every net weight 4g.

Using method:

1, patch is sticked tumor by local and relevant acupuncture point (acupuncture point is selected by accompanying drawing in the packing of product) after softening.Every day fomentation 3 times on patch, each 30 minutes, and the cream 1 time of changing dressings every day.

2, used the patient of morphine class analgesic, should unite use, progressively withdrew morphine class analgesic, to heighten the effect of a treatment with the present invention.

Points for attention:

1, the careful usefulness of anemia of pregnant woman.Oral administration not.Make an accurate selection of the acupuncture point, regularly heat.

2, this product need be airtight, puts shady and cool dry place.

Embodiment two:

Present embodiment is pressed following prescription:

Radix Aconiti 50g, Radix Aconiti Kusnezoffii 50g, Spica Prunellae 40g, Herba Achilleae 40g, Semen Hyoscyami 20g, Rhizoma Corydalis 20g,

Semen Momordicae 15g, Radix Tripterygii Wilfordii 15g, Semen Strychni 15g, Rhizoma Arisaematis 15g, Daphne giraldii Nitsche 15g, Bufo siccus 10g,

Rhizoma Paridis 10g, Resina garciniae 10g, Resina Ferulae 40g, Borneolum Syntheticum 40g, vegetable oil 2000g.

Preparation method: with embodiment one.

Using method: with embodiment one.

Points for attention: with embodiment one.

Embodiment three:

Present embodiment is pressed following prescription:

Radix Aconiti 40g, Radix Aconiti Kusnezoffii 40g, Spica Prunellae 40g, Herba Achilleae 40g, Semen Hyoscyami 20g, Rhizoma Corydalis 20g,

Semen Momordicae 10g, Radix Tripterygii Wilfordii 10g, Semen Strychni 10g, Rhizoma Arisaematis 10g, Daphne giraldii Nitsche 10g, Bufo siccus 10g,

Preparation method: with embodiment one.

Using method: with embodiment one.

Points for attention: with embodiment one.

Case 1

Lee, man, 65 years old.Examine to upper right pulmonary carcinoma companion pleura shifts (scale cancer), last breast outside persistence severe pain, and be emitted to the right upper extremity ulnar side, and need oral ibuprofen, tramadol 4 times every day, could moderate alleviate.Need inject buprenophine night also can only sleep 4 hours.After using the present invention instead, pain relief in 15 minutes, can fall asleep night, also need not take morphine class analgesic daytime.

Case 2

Liu, man, 44 years old.Be diagnosed as laryngeal carcinoma, the pain rank is treated preceding 4 grades.Behind application the present invention, pain relieving onset 30 minutes, the pain level is reduced to 2 grades, holds time 2 days, has no side effect.

Case 3

Beam, woman, 76 years old.Be diagnosed as cervical cancer, the pain rank is treated preceding 4 grades.Behind application the present invention, pain relieving onset 1 hour, pain is reduced to 2 grades, holds time 2 days, has no side effect.

Claims

1, a kind of externally applied anticancer analgesic ointment, it is characterized in that being furnished with following Chinese crude drug in its component: Radix Aconiti, Radix Aconiti Kusnezoffii, Spica Prunellae, Herba Achilleae, Semen Hyoscyami, Rhizoma Corydalis, Semen Momordicae, Radix Tripterygii Wilfordii, Semen Strychni, Rhizoma Arisaematis, Daphne giraldii Nitsche, Bufo siccus, Rhizoma Paridis, Resina garciniae, Resina Ferulae, Borneolum Syntheticum, vegetable oil, drying pulverizing, high-temp extracting, mixing boil and form.

2, externally applied anticancer analgesic ointment according to claim 1 is characterized in that listed each component is by following dosage formulation: Radix Aconiti 40～60g, Radix Aconiti Kusnezoffii 40～60g, Spica Prunellae 40～50g, Herba Achilleae 40g, Semen Hyoscyami 20～30g, Rhizoma Corydalis 20～30g, Semen Momordicae 10～20g, Radix Tripterygii Wilfordii 10～20g, Semen Strychni 10～20g, Rhizoma Arisaematis 10～20g, Daphne giraldii Nitsche 10～20g, Bufo siccus 10～20g, Rhizoma Paridis 10～20g, Resina garciniae 10～20g, Resina Ferulae 40～50g, Borneolum Syntheticum 40～50g, vegetable oil 2000g.