CN101856425A - Externally applied medicine for alleviating cancer pain and preparation method thereof - Google Patents
Externally applied medicine for alleviating cancer pain and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an externally applied medicine for alleviating cancer pain, which is mainly prepared with nux vomica, henbane, szechwan Chinaberry fruit and biological ceramic according to a certain weight proportion, after being sufficiently mixed, the components are loaded into a pillow-shaped external application bag. The externally applied medicine, which has the functions of detoxification, cancer resistance, collateral activation and pain alleviation, can greatly alleviate the pain of a cancer patient when being externally applied on the painful area of the body surface of the patient, meanwhile, the externally applied medicine can be repetitively used, so that the treatment expense can be saved for the patient, and thereby the externally applied medicine provides safe, comfortable treatment environment and condition for the patient with terminal cancer.
Description
Technical field the present invention relates to the field of Chinese medicines, relates in particular to liniment of a kind of alleviating cancer pain and preparation method thereof.
Background technology whole world aged tendency of population, number of smokers increase, lack factors such as vegetable and fruit, environmental pollution and undesired water in the sports minimizing, diet is causing global cancer number surge.
Over nearly 50 years, the sickness rate of China's cancer is in ascendant trend always, just the cancer spectrum changes to some extent, the former esophageal carcinoma occurred frequently, cervical cancer, gastric cancer etc. have decline in various degree, and sickness rate such as pulmonary carcinoma, breast carcinoma, colon cancer are still rising, especially big city and coastal developed regions have by a relatively large margin increases, and this mainly is relevant with life style and dietary structure etc.Before estimating the year two thousand twenty, China's cancer morbidity can not descend.
The treatment of cancer pain and nursing are the important contents of whole treatment of cancer and nursery work, and it not only will make the cancer patient alleviating pain, also will help them to improve the quality of living.
(1) cancer pain notion
Cancer pain is different with general pain.The type of cancer pain is more, and character and intensity differ, and longer duration often is gradually and increases the weight of, and how with anxiety and fear, causes pain mechanism complexity, and morphine class medicine is difficult to prove effective sometimes, seldom can obtain satisfied fully analgesic effect.Investigate general cancer patient according to hygiene department, about 30% pain that has in various degree; Patients with advanced cancer, about 60%～90% has pain, and about 50% for having an intense pain.
(2) cancer pain classification
According to algogen because of, cancer pain can be divided into: the 1. pain that causes of cancerous tissue itself is because cancerous protuberance develop, soaks into, oozes out, swelling, compressing or destruction surrounding tissue and nerve; 2. pathophysiological change takes place because of cancer in body, causes the muscle arthralgia; 3. because of the cancer complication causes pain, as neuritis, stomatitis, herpes zoster; 4. cause pain because of cancer influences patient's life style, immunocompetence, overall health of patients, as postoperative pain, the mucositis that chemotherapy causes, neuritis, the inflammation that radiotherapy causes, burn, ulcer etc.
(3) cancer pain mechanism of production
The mechanism that produces cancer pain comprises: 1. cancerous protuberance pressuring nerve fiber excites the painful electric pulse; 2. histiocyte destroys, and discharges the pain material; 3. disorganization activates a series of enzyme systems, produces powerful pain material Kallidin I; 4. produce free arachidonic acid behind the cytoclasis, produce prostaglandin through the epoxidase effect, the latter can strengthen the effect of Kallidin I; 5. nervous tissue itself is undermined, causes neurogenic pain; 6. society, family and patient's oneself factor cause psychologic pain.
(4) cancer pain treatment
Cancer pain often is one of performance of cancer, and the cancer pain treatment also often is the part of treatment of cancer.The treatment method for cancer is also mostly to be means of treatment cancer pain, effectively treats the cancer multipotency and obtains and alleviate or the effect of alleviating cancer pain.For example: with the patient of the suitable again surgical intervention of cancerous protuberance local pain, cancer pain also often disappears thereupon behind the row resection operation.Other are as radiotherapy, chemotherapy, Biotherapeutics, even traditional Chinese medical herbal treatment, except that the therapeutical effect that has at cancer itself, cancer pain are also usually shown obvious analgesic effect.
The means of cancer pain symptom treatment are a lot, and are wherein important and commonly used with the analgesic drug product treatment especially, and medicine causes certain side effect to patient itself conversely, and the medicine cost is high, if life-time service is generally taken in family and can't be born.Therefore, the naturopathy of cancer pain just becomes and has superiority most at present and the treatment means of tool effect.
Summary of the invention the purpose of this invention is to provide a kind ofly can effectively alleviate the liniment of the pain that cancer causes and the preparation method of this liniment.
Liniment of the present invention comprises Chinese medicinal components and bioceramic, described Chinese medicinal components comprises that following raw materials in weight portion medicine makes: Semen Strychni 18-22, Semen Hyoscyami 18-22, Fructus Toosendan 50-70, the addition of described bioceramic be Chinese medicinal components weight 0.5-1.5 doubly.
Chinese medicinal components preferred weight part proportioning of liniment of the present invention is: Semen Strychni 20, Semen Hyoscyami 20, Fructus Toosendan 60.
Medicament selection Semen Strychni of the present invention, Semen Hyoscyami, Fructus Toosendan make up, and wherein Semen Strychni has detoxicating and fighting cancer, the activating collaterals to relieve pain effect; Semen Hyoscyami has the collateral dredging relieving convulsion, the antalgic effect; Fructus Toosendan has heat clearing away gets rid of evils, the promoting the circulation of QI to relieve pain effect, and each efficacy of drugs produces synergism, thereby can effectively alleviate the pain that cancer produces.
The Chinese medicinal components of liniment of the present invention can also be that following materials of weight proportions medicine is made: Semen Strychni 18-22, Semen Hyoscyami 18-22, Fructus Toosendan 50-70, Fructus Gardeniae 50-70, Fructus Evodiae 75-105.
Chinese medicinal components preferred weight part proportioning of liniment of the present invention is: Semen Strychni 20, Semen Hyoscyami 20, Fructus Toosendan 60, Fructus Gardeniae 60, Fructus Evodiae 90.
Medicament selection Semen Strychni of the present invention, Semen Hyoscyami, Fructus Toosendan, Fructus Gardeniae, Fructus Evodiae make up, and wherein Fructus Gardeniae has clearing away heat-damp and promoting diuresis, the cooling blood and relieving pain effect; Fructus Evodiae has warming spleen and stomach for dispelling cold, resolving depression pain relieving effect; Fructus Gardeniae, Fructus Evodiae help the Semen Strychni detoxicating and fighting cancer, the effect of activating collaterals to relieve pain jointly altogether as adjuvant drug
The preparation method of the liniment of alleviating cancer pain of the present invention is as follows: fully mix after taking by weighing Chinese medicinal components and bioceramic by described weight portion proportioning, in the outer deposited bag of the pincushion of packing into.
Bioceramic described in the present invention is a prior art, and as disclosed a kind of far infrared bioceramic in the patent No. 200410027144.2 " far infrared bioceramic ", it can constantly give off far infrared at normal temperatures.
Liniment of the present invention is by the afflicted areas of external application at patient's body surface, can alleviate cancer patient's pain significantly, simultaneously this liniment can use repeatedly, can save medical expense for the patient, thereby provides a comfortable treatment environment and a condition at cancer of late stage for the patient.
The specific embodiment
Embodiment 1:
Liniment of the present invention comprises Semen Strychni 18g, Semen Hyoscyami 22g, Fructus Toosendan 50g, bioceramic 90g.More than after each component fully mixes, in the outer deposited bag of the pincushion of packing into.
Embodiment 2:
Liniment of the present invention comprises Semen Strychni 18g, Semen Hyoscyami 22g, Fructus Toosendan 50g, bioceramic 72g.More than after each component fully mixes, in the outer deposited bag of the pincushion of packing into.
Embodiment 3:
Liniment of the present invention comprises Semen Strychni 22g, Semen Hyoscyami 18g, Fructus Toosendan 70g, bioceramic 110g.More than after each component fully mixes, in the outer deposited bag of the pincushion of packing into.
Embodiment 4:
Liniment of the present invention comprises Semen Strychni 22g, Semen Hyoscyami 18g, Fructus Toosendan 70g, bioceramic 55g.More than after each component fully mixes, in the outer deposited bag of the pincushion of packing into.
Embodiment 5:
Liniment of the present invention comprises Semen Strychni 22g, Semen Hyoscyami 18g, Fructus Toosendan 70g, bioceramic 165g.More than after each component fully mixes, in the outer deposited bag of the pincushion of packing into.
Embodiment 6:
Liniment of the present invention comprises Semen Strychni 20g, Semen Hyoscyami 20g, Fructus Toosendan 60g, bioceramic 100g.More than after each component fully mixes, in the outer deposited bag of the pincushion of packing into.
Embodiment 7:
Liniment of the present invention comprises Semen Strychni 20g, Semen Hyoscyami 20g, Fructus Toosendan 60g, bioceramic 120g.More than after each component fully mixes, in the outer deposited bag of the pincushion of packing into.
Embodiment 8:
Liniment of the present invention comprises Semen Strychni 18g, Semen Hyoscyami 22g, Fructus Toosendan 50g, Fructus Gardeniae 70g, Fructus Evodiae 75g, bioceramic 235g.More than after each component fully mixes, in the outer deposited bag of the pincushion of packing into.
Embodiment 9:
Liniment of the present invention comprises Semen Strychni 18g, Semen Hyoscyami 22g, Fructus Toosendan 50g, Fructus Gardeniae 70g, Fructus Evodiae 75g, bioceramic 117.5g.More than after each component fully mixes, in the outer deposited bag of the pincushion of packing into.
Embodiment 10:
Liniment of the present invention comprises Semen Strychni 18g, Semen Hyoscyami 22g, Fructus Toosendan 50g, Fructus Gardeniae 70g, Fructus Evodiae 75g, bioceramic 352.5g.More than after each component fully mixes, in the outer deposited bag of the pincushion of packing into.
Embodiment 11:
Liniment of the present invention comprises Semen Strychni 22g, Semen Hyoscyami 18g, Fructus Toosendan 70g, Fructus Gardeniae 50g, Fructus Evodiae 105g, bioceramic 159g.More than after each component fully mixes, in the outer deposited bag of the pincushion of packing into.
Embodiment 12:
Liniment of the present invention comprises Semen Strychni 22g, Semen Hyoscyami 18g, Fructus Toosendan 70g, Fructus Gardeniae 50g, Fructus Evodiae 105g, bioceramic 265g.More than after each component fully mixes, in the outer deposited bag of the pincushion of packing into.
Embodiment 13:
Liniment of the present invention comprises Semen Strychni 20g, Semen Hyoscyami 20g, Fructus Toosendan 60g, Fructus Gardeniae 60g, Fructus Evodiae 90g, bioceramic 250g.More than after each component fully mixes, in the outer deposited bag of the pincushion of packing into.
Embodiment 14:
Liniment of the present invention comprises Semen Strychni 20g, Semen Hyoscyami 20g, Fructus Toosendan 60g, Fructus Gardeniae 60g, Fructus Evodiae 90g, bioceramic 125g.More than after each component fully mixes, in the outer deposited bag of the pincushion of packing into.
Embodiment 15:
Liniment of the present invention comprises Semen Strychni 20g, Semen Hyoscyami 20g, Fructus Toosendan 60g, Fructus Gardeniae 60g, Fructus Evodiae 90g, bioceramic 375g.More than after each component fully mixes, in the outer deposited bag of the pincushion of packing into.
Bioceramic described in the present invention is a prior art, and as disclosed a kind of far infrared bioceramic in the patent No. 200410027144.2 " far infrared bioceramic ", it can constantly give off far infrared at normal temperatures.Utilize the calibration system check (NIM-06-03-2000) of assaying of method phase total radiation emissivity, this bioceramic is when 80 spend, and emissivity is 0.92.
This liniment can have following using method:
Conventional therapy: under normal room temperature (20-30 ℃), patient's whole body is all right, and the affected part does not have inclined to one side the moon when anxiety of sun partially, and the desirable outer deposited bag that liniment is housed directly is put in affected part, and do not limit standing time, with the comfortable degree of being of patient.
Cloudy disease treatment: cold weather, room temperature is below 20 ℃, or patient's coldness of the body with chills, the affected part cold type of pain can be inserted the outer deposited bag that liniment is housed in the microwave oven and heat, and be 1 minute 30 seconds to 3 minutes heat time heating time, the heating back is taken out the outer deposited bag that liniment is housed and is put in affected part immediately, according to patient's whole body situation, each hot compress time is 30-60 minute, every day 2-3 time.If the patient feels good, can use till cancer pain alleviation, the state of an illness improvement always.
Sun disease treatment: weather sweltering heat, room temperature is more than 38 ℃, or patient's flushed complexion deep red tongue, the affected part burning pain can be inserted the outer deposited bag that liniment is housed in the cold compartment of refrigerator (0-5 ℃) cold preservation time 15 to 30 minutes, take out the outer deposited bag that liniment is housed after the cold preservation and be put in affected part immediately, according to patient's whole body situation, each external application time is 30-60 minute, every day 2-3 time.If the patient feels good, can use till cancer pain alleviation, the state of an illness improvement always.
Below use the liniment of the concrete formulated alleviating cancer pain of the present invention among the embodiment 6, and further set forth the beneficial effect of liniment of the present invention by the clinical case statistics.
This group adopts the outer deposited bag treatment of Chinese medicine far infrared cancer pain totally 20 examples.Male's 12 examples wherein, women's 8 examples; 45～69 years old age, average 56 years old; Hospitalization 16 examples, out-patient treatment 4 examples; Hepatocarcinoma 5 examples, gastric cancer 5 examples, pulmonary carcinoma 3 examples, bone malignant tumour 5 examples, the breast carcinoma bone shifts 1 example, retroperitoeal sarcoma 1 example.
1. cancer pain observation
(1) pain evaluation
Painless 0, severe pain 100;
(2) pain intensity
0-is painless; 1-is slightly uncomfortable; The 2-discomfort; 3-feels bad; The pain that 4-is fearful; 5-is very painful;
2. curative effect determinate standard
Produce effects: treatment back pain integrated value descends 〉=70% than the preceding integrated value of treatment.
Effectively: treatment back pain integrated value descends 〉=30%,＜70% than the preceding integrated value of treatment.
Invalid: treatment back pain integrated value descends＜30% than the preceding integrated value of treatment.
Annotate: computing formula (nimodipine method): (integration before (integration before the treatment-treatment back integration) ÷ treatment) * 100%.
3. the outer deposited bag treatment of therapeutic outcome Chinese medicine far infrared cancer pain totally 20 examples, produce effects 11 examples wherein, effective 8 examples, invalid 1 example, total effective rate reaches 95%.
4, model case is as follows:
Model case 1:
Chen, the man, 64 years old, with general aching 4 months, the left side lumbago and skelalgia was chief complaint and is admitted to hospital in 45 days.Be admitted to hospital preceding 45 days, because of left side waist lower limb has an intense pain, can not sleep night, causes the whole family and be much troubled.Headache when being admitted to hospital, dizzy, vomiting repeatedly, blood pressure 240/120mmHg lifts and sends into institute.Outpatient service CT shows L3～S1 intervertebral disk hernia, and the equal hyperosteogeny of all breast lumbar vertebras is further checked and found that waist 2 vertebral bodys left side transverse process disappears, and vertebral bodies destroyed is about 1/3, and cartilaginous opereulum still exists.Chest films showed: left lung central type carcinoma of lung, the vertical about 11cm in footpath, the first tire is normal, serum ferritin 460.12ug/ml (normally being that 130ug/ml is following), carcinoembryonic antigen 34.5ug/ml (normally being that 15ug/ml is following), (normally be 1731 ± 281ug/ml), the diagnosis that left lung Ca waist 2 shifts is all supported in every inspection to B2-MG2840ug/ml.The patient uses liniment of the present invention the next day of being admitted to hospital, and advises and places waist its daytime, places occipitalia at night.The patient tells last night and likes to sleep when making the rounds of the wards in second day, since the one and a half months, has slept sound for the first time.Head not bitterly, is lost consciousness, and lumbago obviously alleviates, and blood pressure is reduced to 160/78mmHg.Left hospital April 20, useless depressor of while in hospital and analgesic, the affected part is from painless feel.
Model case 2:
Lin, the woman, 57 years old, with " retroperitoeal sarcoma " postoperative 7 years repeatedly, the out-patient treatment that is chief complaint in 6 days of lower back severe pain.The patient shows effect repeatedly because of " retroperitoeal sarcoma " over nearly 7 years, successively implements 5 operations, last operation imposes on went to a doctor preceding 3 months, but began to take place lower back severe pain before 6 days, it is upright uneasy to crouch, and can not fall asleep, analgesic can not be alleviated, poor appetite is become thin obviously, huge lump shade behind the CT examination discovery peritoneum, about 10 * 10cm size is considered the malignant tumor recurrence.Patient and family members' refusal are in hospital once more and are performed the operation, and satisfy with liniment treatment of the present invention, apply back low-back pain half an hour and alleviate, and the patient treats continuously, and can fall asleep that night, and next day, the mental status was obviously improved, the appetite enhancement.Treat after 14 days, low-back pain is alleviated, and weight increase recovers daily life and work.
Model case 3:
Chen, the woman, 46 years old, with " right breast carcinoma " postoperative 3 years half, coccydynia 1 month, abdominal part distending pain two weeks is chief complaint and is admitted to hospital.Diagnosis: right breast carcinoma postoperative left clavicle superior gluteal lymph node shifts; Put, rumpbone, left lung, abdomen pelvic cavity shift after the chemotherapy.Hyperpyrexia after being admitted to hospital, cough, expectoration, tachypnea, abdominal part and sacrum tail pain, edema of pair of lower extremities, whole skin and yellow sclera, the aggravation of carrying out property.Give treatments such as infection, pain relieving, fluid infusion support, the state of an illness does not have improvement, and pain fails to alleviate.Use the liniment of the present invention straight abdominal part of applying ointment or plaster, stomachache is alleviated after 30 minutes, put down for sleeping in falling asleep, and continues to apply ointment or plaster, the clothes Morphine, stomachache does not have aggravation, because of sacrococcygeal region pain still, changes the pain relieving of clothes bucinnazine, add and use liniment of the present invention, treated continuously 14 days, pain relief, whole body condition improved.
Model case 4:
Lin, the man 54 years old, was chief complaint and is admitted to hospital with the few food of the vexed pain companion of upper right abdomen, oliguria in 20 days.B ultrasonic prompting: 1, right excess of the liver occupy-place (primary hepatocarcinoma, canceration on the liver cirrhosis basis); 2, ascites (10.0cm is dark in the ascites dark space).AFP360ug/L。Diagnosis: primary hepatocarcinoma III phase.Abdominal circumference 80cm, through symptomatic treatment, abdominal distention and pain alleviates, but the urine amount is still few.Use the liniment of the present invention abdominal part of applying ointment or plaster, stomachache is alleviated after 30 minutes, and that night, the urine amount increased, and abdominal distention alleviates, after 1 week of external application, and abdominal circumference 78cm.Treatment was left hospital after 14 days continuously, and 8.5cm is reduced in B ultrasonic ascites dark space.
Model case 5:
Guo, the man, 59 years old, with the vexed pain of middle upper abdomen 2 months, abdominal distention 1 month, row was chief complaint and is admitted to hospital in 1 week of melena.Gastroscope prompting: pars cardiaca ulcer type cancerous protuberance; Stool OB (+++); In abdominal paracentesis ascites, find cancerous cell.Diagnosis: the carcinoma of gastric cardia peritoneum shifts also upper gastrointestinal hemorrhage, ascites.Patient's ordinary circumstance is not good enough, pot belly, abdominal circumference 82cm.The processing such as support, diuresis hemostasis of suiting the medicine to the illness after being admitted to hospital do not have and take a turn for the better, promptly give use liniment external application abdominal part of the present invention after 30 minutes after, stomachache, abdominal distention alleviate, but the urine amount is not seen obvious increase.Treatment is 14 days continuously, and abdominal distention subtracts again, but the urine amount does not increase yet.
Claims (5)
1. the liniment of an alleviating cancer pain, it is characterized in that: it comprises Chinese medicinal components and bioceramic, described Chinese medicinal components comprises that following raw materials in weight portion medicine makes: Semen Strychni 18-22, Semen Hyoscyami 18-22, Fructus Toosendan 50-70, the addition of described bioceramic be Chinese medicinal components weight 0.5-1.5 doubly.
2. the liniment of alleviating cancer pain according to claim 1 is characterized in that: described Chinese medicinal components comprises that following raw materials in weight portion medicine makes: Semen Strychni 20, Semen Hyoscyami 20, Fructus Toosendan 60.
3. the liniment of alleviating cancer pain according to claim 1 is characterized in that: described Chinese medicinal components comprises that also following materials of weight proportions medicine makes: Fructus Gardeniae 50-70, Fructus Evodiae 75-105.
4. the liniment of alleviating cancer pain according to claim 3 is characterized in that: described Chinese medicinal components comprises that also following materials of weight proportions medicine makes: Fructus Gardeniae 60, Fructus Evodiae 90.
5. according to the preparation method of the liniment of any one alleviating cancer pain of claim 1 to 4, it is characterized in that: fully mix after taking by weighing Chinese medicinal components and bioceramic by described weight portion proportioning, in the outer deposited bag of the pincushion of packing into.
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