CN1374302A - Extracting process of eliminating ginkgolic acid from ginkgo leaf extractive - Google Patents
Extracting process of eliminating ginkgolic acid from ginkgo leaf extractive Download PDFInfo
- Publication number
- CN1374302A CN1374302A CN 02113531 CN02113531A CN1374302A CN 1374302 A CN1374302 A CN 1374302A CN 02113531 CN02113531 CN 02113531 CN 02113531 A CN02113531 A CN 02113531A CN 1374302 A CN1374302 A CN 1374302A
- Authority
- CN
- China
- Prior art keywords
- folium ginkgo
- ginkgo extract
- jolting
- methyl alcohol
- extraction process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Extraction Or Liquid Replacement (AREA)
Abstract
The present invention is the extracting process of eliminating ginkgolic acid from gingko leaf extractive. The process includes several steps of depuration, dissolving, extraction and drying. Through several times of methanol dissolving and petroleum ether extraction, ginkgo leaf extractive containing no ginkgolic acid may be obtained. Compared with available technology, the process invention has simple and partical process, low cost and high quality of ginkgo leaf extractive, which contains residual ginkgolic acid less than 5 ppm.
Description
The present invention is a kind of technology of taking off ginkgoic acid with extraction process from Folium Ginkgo extract,
Folium Ginkgo extract has reasonable health care, therapeutic efficiency for human body, this point proves for global medical organization mechanism, but contain this objectionable impurities of ginkgoic acid in the Folium Ginkgo extract that present production method obtains, it has certain toxic side effect, influence the performance of effective ingredient, so influenced the use of related products even hindered the outlet of raw material; How to remove this objectionable impurities of ginkgoic acid in the Folium Ginkgo extract that obtains is the project that many domestic and international producers are being studied, but is limited to the limitation of research and the consideration of protection, and many methods are not open; So can not from existing document, relatively more direct acquisition solve this problem for information about.
The objective of the invention is to: a kind of technology of taking off ginkgoic acid with extraction process from Folium Ginkgo extract is provided, this simple for process, through suitability for industrialized production, the product that obtains has reached export standard, ginkgoic acid in the product is separated from Folium Ginkgo extract substantially, thereby guarantees the quality of Folium Ginkgo extract.
The present invention constitutes like this: it comprises impurity elimination, dissolving, extraction, dry these several procedures, wherein impurity elimination operation is the Folium Ginkgo extract after pulverizing to be added ethanol stir, dissolving, filter, finish after the drying, dissolution process is to get to dissolve at the room temperature-Celsius 60 water-bath internal heating of spending after Folium Ginkgo extract adds methyl alcohol, filter, collect methanol solution, extraction process is performed such: get methyl alcohol filtrate and join in the extractor, add alkanes substance, standing demix after the jolting, after removing the upper strata, take off layer material and continue to add again alkanes substance, standing demix after the jolting, so repeat 3-7 time, lower floor's material is placed on carries out drying process in the drying plant; Specifically: dissolution process is that the Folium Ginkgo extract 1-35 kilogram of removing after mixing adds methyl alcohol 100L, in room temperature---dissolving under 60 degree Celsius, filter, collect methanol solution, extraction process is performed such: get in the extractor that methyl alcohol filtrate joins 90-3000L, add alkanes substance 900L, standing demix after the jolting, after removing the upper strata, take off layer material and continue to add again alkanes substance 900ml, standing demix after the jolting, so repeat 3-7 time, lower floor's material is placed in the drying plant below 60 degree Celsius carries out drying process, obtain taking off the Folium Ginkgo extract of ginkgoic acid; More specifically say: dissolution process is
The Folium Ginkgo extract of removing after mixing adds methyl alcohol 100L for 20 kilograms, water-bath internal heating dissolving at room temperature-60 degree Celsius, filter, collect methanol solution, extraction process is performed such: get in the extractor that methyl alcohol filtrate joins 1000L, add alkanes substance 900L, jolting is standing demix after 2 minutes, after removing the upper strata, take off layer material and continue to add again alkanes substance 900L, standing demix after the jolting, so repeat 7 times, lower floor's material is placed in the drying plant below 60 degree Celsius carries out drying process, obtain taking off the Folium Ginkgo extract of ginkgoic acid; The alkanes substance that the present invention uses comprises gasoline, hexane, pentane, hexanaphthene, heptane.In extraction process, an extractor is used in extraction reply each time, can not adopt an extractor re-extract, methanol layer can not have caking phenomenon in addition, again extract after then should adding methyl alcohol, dissolving, the entire operation process can not have pollution, otherwise may take off clean ginkgoic acid.
Compared with prior art: simple for process, cost economy, cheap, through suitability for industrialized production, the product that obtains has reached export standard, ginkgoic acid in the product is separated from Folium Ginkgo extract substantially, ginkgoic acid residual quantity＜5ppm, thereby the quality of assurance Folium Ginkgo extract have reached the purpose of inventing.
Embodiments of the invention 1: it comprises impurity elimination, dissolving, extraction, dry these several procedures, wherein impurity elimination operation is the Folium Ginkgo extract after pulverizing to be added ethanol stir, dissolving, filter, finish after the drying, dissolution process is to get to dissolve at the room temperature-Celsius 60 jacketed kettle internal heating of spending after Folium Ginkgo extract adds methyl alcohol, filter, collect methanol solution, extraction process is performed such: get methyl alcohol filtrate and join in the extractor, add sherwood oil, standing demix after the jolting, after removing the upper strata, take off layer material and continue to add again sherwood oil, standing demix after the jolting, so repeat 3-7 time, lower floor's material is placed on carries out drying process in the drying plant.
Embodiments of the invention 2: it comprises impurity elimination, dissolving, extraction, dry these several procedures, the impurity elimination operation is 5 kilograms of the Folium Ginkgo extracts after pulverizing to be added the 300L absolute ethyl alcohol and stirring it is fully dissolved, filter, residue continues to mix stirring with the 100L dehydrated alcohol, filter merging filtrate, the Folium Ginkgo extract that crushed after being dried obtains, dissolution process is that the Folium Ginkgo extract of removing after mixing adds methyl alcohol 100L for 1 kilogram, reactor internal heating dissolving at 60 degree Celsius, filter, collect methanol solution, extraction process is performed such: get in the extractor that methyl alcohol filtrate joins 90L, add hexane 900L, standing demix after the jolting, after removing the upper strata, take off layer material and continue to add again hexane 900L, standing demix after the jolting, so repeat 7 times, lower floor's material is placed in the drying plant below 60 degree Celsius carries out drying process, obtain taking off the Folium Ginkgo extract of ginkgoic acid.
Embodiments of the invention 3: it comprises impurity elimination, dissolving, extraction, dry these several procedures, the impurity elimination operation is carried out according to prior art, dissolution process is that the Folium Ginkgo extract of removing after mixing adds methyl alcohol 100L for 35 kilograms, jacketed kettle internal heating dissolving at 40-60 degree Celsius, filter, collect methanol solution, extraction process is performed such: get in the extractor that methyl alcohol filtrate joins 3000L, add hexanaphthene 900L, standing demix after the jolting, after removing the upper strata, take off layer material and continue to add again hexanaphthene 900L, standing demix after the jolting, so repeat 6 times, lower floor's material is placed in the vacuum dryer below 60 degree Celsius carries out drying process, obtain taking off the Folium Ginkgo extract of ginkgoic acid.
Embodiments of the invention 4: it comprises impurity elimination, dissolving, extraction, dry these several procedures, the impurity elimination operation is 30 kilograms of the Folium Ginkgo extracts after pulverizing to be added the 300L absolute ethyl alcohol and stirring it is fully dissolved, filter, residue continues to mix stirring with the 100L dehydrated alcohol, filter merging filtrate, the Folium Ginkgo extract that crushed after being dried obtains, dissolution process is that the Folium Ginkgo extract of removing after mixing adds methyl alcohol 100L for 20 kilograms, jacketed kettle internal heating dissolving at 18-60 degree Celsius, filter, collect methanol solution, extraction process is performed such: get in the extractor that methyl alcohol filtrate joins 1000L, add white gasoline 900L, jolting is standing demix after 2 minutes, after removing the upper strata, take off layer material and continue to add again white gasoline 900L, standing demix after the jolting, so repeat 7 times, lower floor's material is placed in the drying plant below 60 degree Celsius carries out drying process, obtain taking off the Folium Ginkgo extract of ginkgoic acid.
Claims (5)
1, a kind of technology of from Folium Ginkgo extract, taking off ginkgoic acid with extraction process, it is characterized in that: it comprises impurity elimination, dissolving, extraction, dry these several procedures, wherein impurity elimination operation is the Folium Ginkgo extract after pulverizing to be added ethanol stir, dissolving, filter, finish after the drying, dissolution process is to get to dissolve at the room temperature-Celsius 60 water-bath internal heating of spending after Folium Ginkgo extract adds methyl alcohol, filter, collect methanol solution, extraction process is performed such: get methyl alcohol filtrate and join in the extractor, add alkanes substance, standing demix after the jolting, after removing the upper strata, take off layer material and continue to add again alkanes substance, standing demix after the jolting, so repeat 3-7 time, lower floor's material is placed on carries out drying process in the drying plant.
2, according to the described this technology of from Folium Ginkgo extract, taking off ginkgoic acid with extraction process of claim 1, it is characterized in that: dissolution process is that the Folium Ginkgo extract 1-35 kilogram of removing after mixing adds methyl alcohol 100L, in room temperature---the water-bath internal heating dissolving of 60 degree Celsius, filter, collect methanol solution, extraction process is performed such: get in the extractor that methyl alcohol filtrate joins 90-3000L, add alkanes substance 900L, standing demix after the jolting, after removing the upper strata, take off layer material and continue to add again alkanes substance 900ml, standing demix after the jolting, so repeat 3-7 time, lower floor's material is placed in the drying plant below 60 degree Celsius carries out drying process, obtain taking off the Folium Ginkgo extract of ginkgoic acid.
3, according to claim 1,2 described this technologies of from Folium Ginkgo extract, taking off ginkgoic acid with extraction process, it is characterized in that: dissolution process is that the Folium Ginkgo extract of removing after mixing adds methyl alcohol 100L for 20 kilograms, dissolving under room temperature-60 degree Celsius, filter, collect methanol solution, extraction process is performed such: get methyl alcohol filtrate and join in the extractor, add alkanes substance 900L, jolting is standing demix after 2 minutes, after removing the upper strata, take off layer material and continue to add again alkanes substance 900L, standing demix after the jolting, so repeat 7 times, lower floor's material is placed in the drying plant below 60 degree Celsius carries out drying process, obtain taking off the Folium Ginkgo extract of ginkgoic acid.
4, according to claim 1,2 described this technologies of taking off ginkgoic acid with extraction process from Folium Ginkgo extract, it is characterized in that: the alkanes substance of use comprises gasoline, hexane, pentane, hexanaphthene, heptane.
5, according to the described this technology of taking off ginkgoic acid with extraction process from Folium Ginkgo extract of claim 3, it is characterized in that: the alkanes substance of use comprises gasoline, hexane, pentane, hexanaphthene, heptane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02113531 CN1374302A (en) | 2002-03-26 | 2002-03-26 | Extracting process of eliminating ginkgolic acid from ginkgo leaf extractive |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02113531 CN1374302A (en) | 2002-03-26 | 2002-03-26 | Extracting process of eliminating ginkgolic acid from ginkgo leaf extractive |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1374302A true CN1374302A (en) | 2002-10-16 |
Family
ID=4742663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02113531 Pending CN1374302A (en) | 2002-03-26 | 2002-03-26 | Extracting process of eliminating ginkgolic acid from ginkgo leaf extractive |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1374302A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773528B (en) * | 2010-02-23 | 2011-09-28 | 广州汉方现代中药研究开发有限公司 | Preparation method of total terpene lactones with low phenolic acid |
| CN105558732A (en) * | 2016-01-20 | 2016-05-11 | 武汉理工大学 | Natural health care gingko testa beverage and preparation method thereof |
| CN106234418A (en) * | 2016-08-18 | 2016-12-21 | 江苏绿洲园艺绿化有限公司 | A kind of method utilizing gingko episperm to prepare flowering cherry insecticide |
| CN108273286A (en) * | 2017-07-23 | 2018-07-13 | 杭州众盛新科技有限公司 | A kind of technique removing ginkgoic acid from ginkgo biloba p.e |
-
2002
- 2002-03-26 CN CN 02113531 patent/CN1374302A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773528B (en) * | 2010-02-23 | 2011-09-28 | 广州汉方现代中药研究开发有限公司 | Preparation method of total terpene lactones with low phenolic acid |
| CN105558732A (en) * | 2016-01-20 | 2016-05-11 | 武汉理工大学 | Natural health care gingko testa beverage and preparation method thereof |
| CN106234418A (en) * | 2016-08-18 | 2016-12-21 | 江苏绿洲园艺绿化有限公司 | A kind of method utilizing gingko episperm to prepare flowering cherry insecticide |
| CN108273286A (en) * | 2017-07-23 | 2018-07-13 | 杭州众盛新科技有限公司 | A kind of technique removing ginkgoic acid from ginkgo biloba p.e |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101961371B (en) | Method for extracting and separating ginsenoside, flavone and polysaccharide from sweet gynostemma pentaphylla | |
| CN100372556C (en) | Active component extraction method of plant polyphenol kind substance | |
| CN108179065A (en) | A kind of extracting method of jasmine essential oil | |
| CN1374302A (en) | Extracting process of eliminating ginkgolic acid from ginkgo leaf extractive | |
| CN105732741A (en) | Method for extracting anthocyanin and ursolic acid from perilla leaves | |
| CN101613278B (en) | Industrial technology for quickly extracting high-purity chlorogenic acid from sweet potato leaf | |
| CN1303078C (en) | Process for preparing effective constituent in tea | |
| CN102228473B (en) | Extraction method for active substances in cornua cervi pantotrichum | |
| CN102432573B (en) | Method for preparing lovastatin | |
| KR101223193B1 (en) | Water soluble pearl powder process | |
| CN101433322B (en) | Functional food rich in anthocyanidin and preparation method thereof | |
| CN106866691A (en) | A kind of method for extracting sesamin | |
| KR100227609B1 (en) | Preparation of health food made of houttuynia cordata and seaweed | |
| CN1522596A (en) | Method for extracting composite corn embryo health care functional factor having corn embryo cake as raw material | |
| US20130272974A1 (en) | Hydroxytyrosol Product, Method of Making, and Uses Thereof | |
| CN112516012A (en) | Soothing agilawood compound perfume and preparation method thereof | |
| CN113425655B (en) | Method for extracting coix seed active substance | |
| JPH01305034A (en) | Production of 'ougon' extract and cosmetic containing the same | |
| CN1935810A (en) | Method for extracting artemisine by enriched supercritical fluid | |
| CN113230174B (en) | Macadamia nut whitening extract and preparation method thereof | |
| RU2810497C1 (en) | Method of obtaining plant extracts | |
| RU2799883C1 (en) | Method for obtaining dry plant extract | |
| CN109394562A (en) | A method of preparing peanut coat procyanidine children's lip gloss | |
| CN103599256B (en) | A kind of spraying extraction binding resin legal system that utilizes is for the method for tea-polyphenol | |
| CN1470487A (en) | Method for removing ginkgolic acid from ginkgo leaf extract by extraction method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |