CN108273286A - A kind of technique removing ginkgoic acid from ginkgo biloba p.e - Google Patents
A kind of technique removing ginkgoic acid from ginkgo biloba p.e Download PDFInfo
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- CN108273286A CN108273286A CN201710650727.8A CN201710650727A CN108273286A CN 108273286 A CN108273286 A CN 108273286A CN 201710650727 A CN201710650727 A CN 201710650727A CN 108273286 A CN108273286 A CN 108273286A
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- CN
- China
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- extractant
- extraction
- tower
- ginkgo
- ginkgoic acid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0492—Applications, solvents used
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0426—Counter-current multistage extraction towers in a vertical or sloping position
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0488—Flow sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D2011/002—Counter-current extraction
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Extraction Or Liquid Replacement (AREA)
Abstract
A kind of technology field removing ginkgoic acid from ginkgo biloba p.e：In ginkgo biloba extract in bio-pharmaceuticals harmful substance ginkgoic acid removing process it is characterized in that：1, extraction process：Proportioning 24: 1 of (any for extractant with three kinds of petroleum ether, normal hexane or hexamethylene) and ginkgo leaf alcohol extracting concentrate；It is multistage.2, extraction equipment：It is tower for filler；Static counter-current extraction.3, technique extractant is recycled in a manner of distillation.4, the prevention of process contamination：Tower body and pipeline should be cleaned between each classification.5, the processing between being classified：Novel solvent will be added to remaining solvent and detaches.
Description
Technical field：The removing process of harmful substance ginkgoic acid in ginkgo biloba extract in bio-pharmaceuticals.
Technical background：Contain a certain amount of harmful substance ginkgoic acid in ginkgo biloba p.e.Ginkgoic acid has cytotoxicity, embryo
The skin infections of newborn infants, sensitization and mutation effect can be such that rat hepatocytes survival rate substantially reduces after ginkgo acid concentration reaches a certain level.
Therefore, American-European standards of pharmacopoeia is that Ginkgolic Acid in Extract of Ginkgo biloba Leaves content is less than 5ppm, and Chinese Pharmacopoeia standard is extracted for ginkgo leaf
Ginkgo acid content is less than 10ppm in object.Individual America and Europe pharmaceutical factories proposed to require to be less than 1PPM.With petroleum ether, n-hexane or ring
Ginkgoic acid in hexane extraction extract has been the accepted method of industry, three kinds of solvents, although title difference main component
Be sufficiently close to physicochemical property, extraction process and effect also very close to.The present invention can be any one of three kinds A.Due to
The selected solvent process of each producer of certain reason and equipment are different, and the effect and solvent consumption of extraction, expenditure of time are each
It is different.The present invention is undergone based on many decades chemical industry, the one kind proposed for the common issue present in most producers
The simple and practical method that solves the problems, such as simultaneously proposes the points for attention that problem easily occurs, the single tank interval taken with existing producer
Extraction process is compared, and static tower type extraction other manner is compared to advantage：1, the emulsification for being not susceptible to most producer's headaches is existing
As；2, efficient, stable quality；3, working hour is controllable；4, it avoids because demulsification uses influence of the demulsifier to product quality.
Invention content：1, it extracts：(any for extractant with three kinds of petroleum ether, n-hexane or hexamethylene) and ginkgo leaf-alcohol
Proportioning 2-4: 1 of concentrate is put forward, room temperature adverse current multi-stage static extracts (shown in attached drawing), and (two level can reach 5PPM hereinafter, three-level
1PPM or less can be reached).Counter-current extraction agent A enters in tower middle and lower part I, and ginkgo biloba p.e B is headed by tower middle and upper part II.After extraction
The extractant C of more ginkgoic acids most pushes up the portions III from tower and goes out；The extract D of low ginkgoic acid goes out from tower bottommost IV.The characteristics of equipment, exists
In the area and sufficient time of contact that there is sufficient ginkgo biloba extract to be contacted with extractant, upper and lower two standings area, to ensure
The two is layered.；2, extraction equipment-extraction equipment：Use is the tower static counter-current extraction of filler, the Gao Jing of tower packing layer
Than being extracted more than 3 and being extracted the area for mutually having and coming into full contact with, tower body upper and lower part is equipped with rest chamber in favor of extraction
It takes and is mutually sufficiently separated with being extracted.Solvent and material pipe require to empty.3, the recycling of extractant：It extracts and cleans and is used
The mode of solvent distillation is recycled, and liquid flooding is prevented by way of limiting liquid level and distillation speed；It is made of refrigerant
For condensing agent-from solvent consumption and security standpoint be necessary.4, the prevention of process contamination：With no ginkgo between extractions at different levels
The extractant cleaning tower body and pipeline of acid.5, the processing between being classified：It is when being classification that last time processed ginkgo biloba extract is molten
The top of liquid about 1/10th stands 1-2 hour liquid separations after the clean 2-3 times extractant measured mixing is added in a container
The extract addition that device (separatory funnel) separates waits for next extraction, and the extractant isolated is to be distilled..
Note：1, it illustrates：
Attached drawing is ginkgoic acid extraction equipment technique stream diagram
I is extractant；II is ginkgo leaf extraction concentrat to be extracted；III；For the extractant rich in ginkgoic acid；IV is low silver
The ginkgo biloba p.e of apricot acid.
2, with packed tower (separate case) (filler is stainless steel, glass, ceramics etc. to the free of contamination multilist area material of material)
The high ratio of tower is more than 3, it is proposed that 5-7 adds respectively on the top of the lower part of extractant A entrances and ginkgo leaf alcohol extracting concentrate B entrances
It is the container (referred to as standing area) of tower diameter 1.2-1.6 to have a diameter of tower diameter 1.1-1.5 height, to be in stratification.
Claims (5)
1. a kind of technique removing ginkgoic acid from ginkgo biloba p.e, it is characterized in that：
1), extraction process：(any for extractant with three kinds of petroleum ether, n-hexane or hexamethylene) and ginkgo leaf alcohol extracting concentrate
2-4: 1 room temperature adverse current multi-stage static of proportioning extraction.
2), extraction equipment (separate case)：It is the tower static counter-current extraction of filler to use, the ratio of height to diameter of tower packing layer be more than 3 with
Conducive to extracting and being extracted the area for mutually having and coming into full contact with, tower body upper and lower part is equipped with rest chamber in favor of extracting and being extracted
Mutually it is sufficiently separated.Solvent and material pipe require to empty.
3), the recycling of extractant：The mode of extraction and cleaning spent solvent distillation is recycled, and the steaming of liquid level is limited
Evaporating the mode of speed prevents liquid flooding；With refrigerant as condensing agent..
4), the prevention of process contamination：Between extractions at different levels tower body and pipeline are cleaned with the extractant of no ginkgoic acid.
5) processing between, being classified：Be classification when by the top about 1/10th of last time processed Ginkgo extract solution in
It is added in one container after the mixing of clean 2-3 times extractant measured and stands 1-2 hours and carried with what dispenser (separatory funnel) separated
Object addition is taken to wait for next extraction, the extractant isolated is to be distilled.
2. its technology characteristics is according to the requirement of right 1：(any for extractant with three kinds of petroleum ether, n-hexane or hexamethylene)
With proportioning 2-4: 1 of ginkgo leaf alcohol extracting concentrate.Multitple extraction.
3. its extraction equipment is characterized according to the requirement of right 1：Using the tower static counter-current extraction of filler, tower packing layer
Ratio of height to diameter be more than 3, tower body upper and lower part be equipped with rest chamber.Design installation requirement solvent and material pipe require to empty.
4. its prevention process contamination characteristics is according to the requirement of right 1：Between extractions at different levels with the extractant of no ginkgoic acid come
Clean tower body and pipeline, it is therefore an objective to which prevention process pollutes.
5. according to processing of the requirement of right 1 between classification it is characterized in that：Last time processed ginkgo is extracted when being classification
The top of object solution about 1/10th stands 1-2 hours use after the clean 2-3 times extractant measured mixing is added in a container
The extract addition that dispenser (separatory funnel) separates waits for next extraction, and the extractant isolated is to be distilled.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710650727.8A CN108273286A (en) | 2017-07-23 | 2017-07-23 | A kind of technique removing ginkgoic acid from ginkgo biloba p.e |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710650727.8A CN108273286A (en) | 2017-07-23 | 2017-07-23 | A kind of technique removing ginkgoic acid from ginkgo biloba p.e |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108273286A true CN108273286A (en) | 2018-07-13 |
Family
ID=62801211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710650727.8A Pending CN108273286A (en) | 2017-07-23 | 2017-07-23 | A kind of technique removing ginkgoic acid from ginkgo biloba p.e |
Country Status (1)
| Country | Link |
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| CN (1) | CN108273286A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1374302A (en) * | 2002-03-26 | 2002-10-16 | 贵州省生化工程中心 | Extracting process of eliminating ginkgolic acid from ginkgo leaf extractive |
| CN1470487A (en) * | 2003-06-18 | 2004-01-28 | 江苏扬子江药业集团有限公司 | Method for removing ginkgolic acid from ginkgo leaf extract by extraction method |
| CN201643778U (en) * | 2010-02-11 | 2010-11-24 | 山西翔宇化工有限公司 | Non-stirring type extracting tower |
| CN204261377U (en) * | 2014-09-16 | 2015-04-15 | 毛学峰 | A kind of liquid-liquid extractor continuously |
| CN105498284A (en) * | 2015-12-04 | 2016-04-20 | 中国天辰工程有限公司 | Extracting tower for liquid-liquid heterogeneous separation |
-
2017
- 2017-07-23 CN CN201710650727.8A patent/CN108273286A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1374302A (en) * | 2002-03-26 | 2002-10-16 | 贵州省生化工程中心 | Extracting process of eliminating ginkgolic acid from ginkgo leaf extractive |
| CN1470487A (en) * | 2003-06-18 | 2004-01-28 | 江苏扬子江药业集团有限公司 | Method for removing ginkgolic acid from ginkgo leaf extract by extraction method |
| CN201643778U (en) * | 2010-02-11 | 2010-11-24 | 山西翔宇化工有限公司 | Non-stirring type extracting tower |
| CN204261377U (en) * | 2014-09-16 | 2015-04-15 | 毛学峰 | A kind of liquid-liquid extractor continuously |
| CN105498284A (en) * | 2015-12-04 | 2016-04-20 | 中国天辰工程有限公司 | Extracting tower for liquid-liquid heterogeneous separation |
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| SE01 | Entry into force of request for substantive examination | ||
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180713 |
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| WD01 | Invention patent application deemed withdrawn after publication |