CN1470487A - Method for removing ginkgolic acid from ginkgo leaf extract by extraction method - Google Patents
Method for removing ginkgolic acid from ginkgo leaf extract by extraction method Download PDFInfo
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- CN1470487A CN1470487A CNA031319157A CN03131915A CN1470487A CN 1470487 A CN1470487 A CN 1470487A CN A031319157 A CNA031319157 A CN A031319157A CN 03131915 A CN03131915 A CN 03131915A CN 1470487 A CN1470487 A CN 1470487A
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Abstract
The present invention discloses a method for removing ginkgolic acid from ginkgo leaf extract by orgnaic solvent extraction process, and said process mainly includes: extracting and drying. In which the refining procedure includes: adding methyl alcohol or ethyl alcohol to pulverized ginkgo leaf extract, stirring, dissolving, standing still, filtering, reduced pressure concentrating and drying; and its extracting procedure includes: stirring the pulverzed ginkgo leaf extract with ethyl alcohol or acetone, dissolving and placing said material into extract, adding paraffins material, uniformly mixing them, standing still and demixing, removing upper layer, repeatedly operating lower layer for several times, drying.
Description
Technical field
The present invention relates to a kind of method that adopts organic solvent extraction from Folium Ginkgo extract, to take off ginkgoic acid.
Background technology
Pharmacological component in the Folium Ginkgo extract is mainly Ginkgo total flavones alcohol glycosides and ginkgo terpene lactone.They have definite curative effect for cardiovascular and cerebrovascular diseases, but contain a large amount of ginkgoic acid mixtures in the at present commercially available Folium Ginkgo extract, and it has the intensive sensitization for human body, can cause contact dermatitis etc.So ginkgoic acid content is to guarantee its preparation security in the control finished product, it is requisite to improve the quality of products.Traditional deacidifying process adopts resin method, but its method relates to the problem of the organic residual quantity of resin, and mass production needs special equipment, and flushing etc. is repeatedly operated cumbersome.
Summary of the invention
For addressing the above problem, the invention provides a kind of simple for processly, what can be used for industrialized production removes the method for ginkgoic acid with extraction process from Folium Ginkgo extract.
That the present invention mainly comprises is refining, extraction, dry several procedures, and wherein refining step is that the ginkgo biloba p.e after pulverizing is added methyl alcohol or the placement of ethanol stirring and dissolving, filtration, reduced pressure concentration drying; Extraction process is to get ginkgo biloba p.e after refining to join in the extractor after with ethanol or acetone stirring and dissolving, add alkanes substance, mixed evenly rear standing demix, remove the upper strata, the lower floor repetitive operation is placed on lower floor's material and is drying to obtain ginkgoic acid in the drying equipment less than the ginkgo biloba p.e of 5ppm for several times.
Its preferred version is: get ginkgo biloba p.e 1-35 kilogram after refining in the extraction process and add ethanol or methyl alcohol, acetone 100L, join after the stirring and dissolving in the extractor of 90-3000L, add alkanes substance 900L, mixed evenly rear standing demix behind the removal upper strata, takes off layer material and continues to add alkanes substance 900L again, mixed evenly rear standing demix, so repeat 3-8 time, lower floor's material is placed on carries out drying in the drying equipment, obtain taking off the ginkgo biloba p.e of ginkgoic acid.
Its more preferably scheme be: extraction is that 20 kilograms of the ginkgo biloba p.es of getting after refining add ethanol or acetone 100L, be transferred in the extractor after the stirring and dissolving, add alkanes substance 900L, mixed evenly rear standing demix behind the removal upper strata, takes off layer material and continues to add alkanes 900L again, mixed evenly rear standing demix, so repeat 7 times, lower floor's material is placed on carries out drying in the drying equipment, obtain taking off the ginkgo biloba p.e of ginkgoic acid.
The present invention does not use resin method technology, does not therefore relate to organic residue problem, and the no particular requirement of big production, the raw material cheapness, and easy and simple to handle, deacidification effect is better, is easy to industrialized production.
Embodiment:
Embodiment one, to get the ginkgo leaf CE an amount of, add and filter again after 10 times of amount absolute ethyl alcohols or methyl alcohol stirring and dissolving are spent the night, the benzinum that adds again equivalent after the drying after 50% the ethanol dissolving with 5 times of amounts, extract 3-8 time, the Recycled ethanol layer, reduced pressure concentration, vacuum drying namely gets the ginkgo biloba p.e that takes off ginkgoic acid.
Embodiment two, to get the ginkgo leaf CE an amount of, add 10 times of amount absolute ethyl alcohols or methyl alcohol stirring and dissolving, placement is spent the night, and filters, and residue adds absolute ethyl alcohol or the methyl alcohol stirring and dissolving of 5 times of amounts again, filter, merging filtrate extracts 3-8 time with the n-hexane that adds equivalent behind 50% acetone solution of 5 times of amounts or cyclohexane after the reduced pressure concentration drying again, reclaims the acetone layer, reduced pressure concentration, vacuum drying namely get the ginkgo biloba p.e that takes off ginkgoic acid.
Claims (5)
1, a kind of method of removing ginkgolic acid from ginkgo leaf extract by extraction method, it is characterized in that it mainly contains refining, extraction, dry several procedures, wherein refining step is that the ginkgo biloba p.e after pulverizing is added methyl alcohol or the placement of ethanol stirring and dissolving, filtration, reduced pressure concentration drying; Extraction process is to get ginkgo biloba p.e after refining to join in the extractor after with ethanol or acetone stirring and dissolving, add alkanes substance, mixed evenly rear standing demix is removed the upper strata, the lower floor repetitive operation is placed on lower floor's material and carries out drying in the drying equipment for several times.
2, method according to the described a kind of removing ginkgolic acid from ginkgo leaf extract by extraction method of claim 1, the ginkgo biloba p.e 1-35 kilogram that it is characterized in that getting in the extraction process after making with extra care adds ethanol or methyl alcohol, acetone 100L, join after the stirring and dissolving in the extractor of 90-3000L, add alkanes substance 900L, mixed evenly rear standing demix, after removing the upper strata, take off layer material and continue to add again alkanes substance 900L, mixed evenly rear standing demix, so repeat 3-8 time, lower floor's material is placed on carries out drying in the drying equipment, obtain taking off the ginkgo biloba p.e of ginkgoic acid.
3, according to the method for claims 1 described removing ginkgolic acid from ginkgo leaf extract by extraction method, it is characterized in that extracting is ginkgo biloba p.e 20 kilograms of addings ethanol or the acetone 100L that gets after making with extra care, be transferred in the extractor after the stirring and dissolving, add alkanes substance 900L, mixed evenly rear standing demix, after removing the upper strata, take off layer material and continue to add again alkanes 900L, mixed evenly rear standing demix, so repeat 7 times, lower floor's material is placed on carries out drying in the drying equipment, obtain taking off the ginkgo biloba p.e of ginkgoic acid.
4, remove the method for ginkgoic acid from Folium Ginkgo extract according to claim 1,2 or 3 described extraction processs, the concentration that it is characterized in that ethanol or acetone is 30%-80%.
5, from Folium Ginkgo extract, remove the method for ginkgoic acid according to claim 1,2 or 3 described extraction processs, it is characterized in that the alkanes substance that uses comprises gasoline, hexane, pentane, hexanaphthene, heptane, sherwood oil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031319157A CN1470487A (en) | 2003-06-18 | 2003-06-18 | Method for removing ginkgolic acid from ginkgo leaf extract by extraction method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031319157A CN1470487A (en) | 2003-06-18 | 2003-06-18 | Method for removing ginkgolic acid from ginkgo leaf extract by extraction method |
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| CN1470487A true CN1470487A (en) | 2004-01-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA031319157A Pending CN1470487A (en) | 2003-06-18 | 2003-06-18 | Method for removing ginkgolic acid from ginkgo leaf extract by extraction method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614229A (en) * | 2012-04-25 | 2012-08-01 | 江苏神龙药业有限公司 | Method for removing ginkgolic acid from ginkgo biloba extract |
| CN108273286A (en) * | 2017-07-23 | 2018-07-13 | 杭州众盛新科技有限公司 | A kind of technique removing ginkgoic acid from ginkgo biloba p.e |
| CN114288705A (en) * | 2021-11-19 | 2022-04-08 | 广东青云山药业有限公司 | Method for removing ginkgolic acid from ginkgo biloba extract |
-
2003
- 2003-06-18 CN CNA031319157A patent/CN1470487A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614229A (en) * | 2012-04-25 | 2012-08-01 | 江苏神龙药业有限公司 | Method for removing ginkgolic acid from ginkgo biloba extract |
| CN102614229B (en) * | 2012-04-25 | 2015-04-08 | 江苏神龙药业有限公司 | Method for removing ginkgolic acid from ginkgo biloba extract |
| CN108273286A (en) * | 2017-07-23 | 2018-07-13 | 杭州众盛新科技有限公司 | A kind of technique removing ginkgoic acid from ginkgo biloba p.e |
| CN114288705A (en) * | 2021-11-19 | 2022-04-08 | 广东青云山药业有限公司 | Method for removing ginkgolic acid from ginkgo biloba extract |
| CN114288705B (en) * | 2021-11-19 | 2023-11-17 | 广东青云山药业有限公司 | Method for removing ginkgolic acid from ginkgo leaf extract |
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