CN1362211A - Nano mixed zaofan medicine and its preparation - Google Patents
Nano mixed zaofan medicine and its preparation Download PDFInfo
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- CN1362211A CN1362211A CN 01100710 CN01100710A CN1362211A CN 1362211 A CN1362211 A CN 1362211A CN 01100710 CN01100710 CN 01100710 CN 01100710 A CN01100710 A CN 01100710A CN 1362211 A CN1362211 A CN 1362211A
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Abstract
The present invention discloses a nano complex formula melanterite preparatino medicine. It is made up by using the Chinese medicinal materials of nano melanterite, nano American ginseng, nano sea horse, nano cinnamon bark, nano jujube and nano walnut kernel as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to the strong marrow of a kind of the kidney warming, supplementing QI and nourishing YIN, hemopoietic hemostatic nano compound Melanteritum preparation medicine, the invention still further relates to the method for this medication preparation.
FUFANG ZAOFAN WAN is a kind of classical Chinese patent medicine, mainly contain effects such as the strong marrow of the kidney warming, supplementing QI and nourishing YIN, hemopoietic hemostasis, be used for the positive not enough qi-blood deficiency syndrome person of bone marrow injury, cytopenia, genus that aplastic anemia, leukopenia, thrombocytopenia, myelodysplastic syndrome and chemotherapy cause.But traditional FUFANG ZAOFAN WAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano compound Melanteritum preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano compound Melanteritum preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Melanteritum 5-50 part nano American ginseng 10-50 part nanometer Hippocampus 10-60 part
Nanometer Cortex Cinnamomi 10-50 part nanometer Fructus Jujubae 10-50 part nanometer Semen Juglandis 5-50 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Melanteritum 10-30 part nano American ginseng 15-30 part nanometer Hippocampus 20-40 part
Nanometer Cortex Cinnamomi 15-40 part nanometer Fructus Jujubae 20-40 part nanometer Semen Juglandis 10-30 part
The optimum weight proportioning of medicine of the present invention is:
0 part of 25 parts of nanometer hippocampus 3 of 20 parts of nano American ginsengs of nanometer Melanteritum
20 parts of 30 portions of nanometer Semen Juglandis of 26 portions of nanometer Fructus Jujubaes of nanometer Cortex Cinnamomi
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is;
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get compound recipe Melanteritum preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano compound Melanteritum preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common FUFANG ZAOFAN WAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano compound Melanteritum preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for effects such as the strong marrow of the kidney warming, supplementing QI and nourishing YIN, hemopoietic hemostasis, be used for treatment of conditions such as bone marrow injury that aplastic anemia, leukopenia, thrombocytopenia, myelodysplastic syndrome and chemotherapy cause, cytopenia, the positive not enough qi-blood deficiency syndrome person of genus, clinical efficacy significantly is better than traditional FUFANG ZAOFAN WAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
0 part of 25 parts of nanometer hippocampus 3 of 20 parts of nano American ginsengs of nanometer Melanteritum
20 parts of 30 portions of nanometer Semen Juglandis of 26 portions of nanometer Fructus Jujubaes of nanometer Cortex Cinnamomi
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is a 0.1-0.6 gram, and the patient takes 1-4 time every day, every day the 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
0 part of 25 parts of nanometer hippocampus 3 of 20 parts of nano American ginsengs of nanometer Melanteritum
20 parts of 30 portions of nanometer Semen Juglandis of 26 portions of nanometer Fructus Jujubaes of nanometer Cortex Cinnamomi
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nano compound Melanteritum powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
0 part of 25 parts of nanometer hippocampus 3 of 20 parts of nano American ginsengs of nanometer Melanteritum
20 parts of 30 portions of nanometer Semen Juglandis of 26 portions of nanometer Fructus Jujubaes of nanometer Cortex Cinnamomi
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nano compound Melanteritum membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano compound Melanteritum preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Melanteritum 5-50 part nano American ginseng 10-50 part nanometer Hippocampus 10-60 part
Nanometer Cortex Cinnamomi 10-50 part nanometer Fructus Jujubae 10-50 part nanometer Semen Juglandis 5-50 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano compound Melanteritum preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Melanteritum 10-30 part nano American ginseng 15-30 part nanometer Hippocampus 20-40 part
Nanometer Cortex Cinnamomi 15-40 part nanometer Fructus Jujubae 20-40 part nanometer Semen Juglandis 10-30 part
3, nano compound Melanteritum preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
0 part of 25 parts of nanometer hippocampus 3 of 20 parts of nano American ginsengs of nanometer Melanteritum
20 parts of 30 portions of nanometer Semen Juglandis of 26 portions of nanometer Fructus Jujubaes of nanometer Cortex Cinnamomi
4, according to claim 1 or 2 or 3 described nano compound Melanteritum preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano compound Melanteritum preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100710 CN1362211A (en) | 2001-01-08 | 2001-01-08 | Nano mixed zaofan medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100710 CN1362211A (en) | 2001-01-08 | 2001-01-08 | Nano mixed zaofan medicine and its preparation |
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| CN1362211A true CN1362211A (en) | 2002-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01100710 Pending CN1362211A (en) | 2001-01-08 | 2001-01-08 | Nano mixed zaofan medicine and its preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560441A (en) * | 2016-03-18 | 2016-05-11 | 陕西郝其军制药股份有限公司 | Traditional Chinese medicine composition for warming kidneys, strengthening marrow, tonifying qi, nourishing yin, promoting generation of blood and stopping bleeding and preparation method thereof |
-
2001
- 2001-01-08 CN CN 01100710 patent/CN1362211A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560441A (en) * | 2016-03-18 | 2016-05-11 | 陕西郝其军制药股份有限公司 | Traditional Chinese medicine composition for warming kidneys, strengthening marrow, tonifying qi, nourishing yin, promoting generation of blood and stopping bleeding and preparation method thereof |
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