CN1364507A - Nano seven ingredient axially choerospondias fruit medicine and its preparing method - Google Patents
Nano seven ingredient axially choerospondias fruit medicine and its preparing method Download PDFInfo
- Publication number
- CN1364507A CN1364507A CN 01100281 CN01100281A CN1364507A CN 1364507 A CN1364507 A CN 1364507A CN 01100281 CN01100281 CN 01100281 CN 01100281 A CN01100281 A CN 01100281A CN 1364507 A CN1364507 A CN 1364507A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- nano
- parts
- ingredient
- axially
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The nano seven ingredient axially choerospondias fruit medicine is prepared with nano axiallary choerospondias fruit, nano mutmeg, nano clove, nano sweetgum resin, nano eagle wood and other two kinds of nano Chinese medicinal materials in certain proportion as raw material. The new medicine preparatino has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm, mostly below 100 nm, and physical property. It is prepared through microwave extraction, decompression concentration, spray drying in supersonic jet and other steps. It has high biological utilization and obvious treating effect.
Description
The present invention relates to a kind of heart-nourishing and Qi-benefiting, calm the nerves, cure mainly pain uncomfortable in chest, shortness of breath and palpitation, irritability, the nano seven ingredient axially choerospondias fruit medicine of insomnia forgetfulness the invention still further relates to the method for this medication preparation.
Seven flavor Fructus Choerospondiatis balls are a kind of classical Chinese patent medicines, and effect such as mainly contain heart-nourishing and Qi-benefiting, calm the nerves is used for pain uncomfortable in chest, shortness of breath and palpitation, irritability, insomnia forgetfulness.But seven traditional flavor Fructus Choerospondiatis ball disintegrates are slower, absorb not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano seven ingredient axially choerospondias fruit medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano seven ingredient axially choerospondias fruit medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Fructus Choerospondiatis 350-650 part nanometer Semen Myristicae 40-95 part nano clove 40-95 part
Nanometer Radix Aucklandiae 40-95 part nanometer Resina Liquidambaris 40-95 part nanometer Lignum Aquilariae Resinatum 45-95 part
Nanometer Cor Bovis seu Bubali powder 40-95 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Fructus Choerospondiatis 400-550 part nanometer Semen Myristicae 50-90 part nano clove 50-95 part
Nanometer Radix Aucklandiae 50-90 part nanometer Resina Liquidambaris 50-90 part nanometer Lignum Aquilariae Resinatum 50-90 part
Nanometer Cor Bovis seu Bubali powder 50-90 part
The optimum weight proportioning of medicine of the present invention is:
75 parts of 75 parts of nano cloves of 450 parts of nanometer Semen Myristicaes of nanometer Fructus Choerospondiatis
75 parts of 75 parts of nanometer Lignum Aquilariae Resinatum of 75 parts of nanometer Resina Liquidambarises of the nanometer Radix Aucklandiae
75 parts in nanometer Cor Bovis seu Bubali powder
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the seven ingredient axially choerospondias fruit nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano seven ingredient axially choerospondias fruit medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common seven flavor Fructus Choerospondiatis pill materials are micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano seven ingredient axially choerospondias fruit medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for pain uncomfortable in chest, shortness of breath and palpitation, and irritability, treatment of conditions such as insomnia forgetfulness, clinical efficacy significantly is better than seven traditional flavor Fructus Choerospondiatis balls.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
75 parts of 75 parts of nano cloves of 450 parts of nanometer Semen Myristicaes of nanometer Fructus Choerospondiatis
75 parts of 75 parts of nanometer Lignum Aquilariae Resinatum of 75 parts of nanometer Resina Liquidambarises of the nanometer Radix Aucklandiae
75 parts in nanometer Cor Bovis seu Bubali powder
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
75 parts of 75 parts of nano cloves of 450 parts of nanometer Semen Myristicaes of nanometer Fructus Choerospondiatis
75 parts of 75 parts of nanometer Lignum Aquilariae Resinatum of 75 parts of nanometer Resina Liquidambarises of the nanometer Radix Aucklandiae
75 parts in nanometer Cor Bovis seu Bubali powder
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nano seven flavor Fructus Choerospondiatis powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
75 parts of 75 parts of nano cloves of 450 parts of nanometer Semen Myristicaes of nanometer Fructus Choerospondiatis
75 parts of 75 parts of nanometer Lignum Aquilariae Resinatum of 75 parts of nanometer Resina Liquidambarises of the nanometer Radix Aucklandiae
75 parts in nanometer Cor Bovis seu Bubali powder
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nano seven flavor Fructus Choerospondiatis membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano seven ingredient axially choerospondias fruit medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Fructus Choerospondiatis 350-650 part nanometer Semen Myristicae 40-95 part nano clove 40-95 part
Nanometer Radix Aucklandiae 40-95 part nanometer Resina Liquidambaris 40-95 part nanometer Lignum Aquilariae Resinatum 45-95 part
Nanometer Cor Bovis seu Bubali powder 40-95 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano seven ingredient axially choerospondias fruit medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Fructus Choerospondiatis 400-550 part nanometer Semen Myristicae 50-90 part nano clove 50-95 part
Nanometer Radix Aucklandiae 50-90 part nanometer Resina Liquidambaris 50-90 part nanometer Lignum Aquilariae Resinatum 50-90 part
Nanometer Cor Bovis seu Bubali powder 50-90 part
3, nano seven ingredient axially choerospondias fruit medicine according to claim 1, wherein the weight proportion of each nano raw material is:
75 parts of 75 parts of nano cloves of 450 parts of nanometer Semen Myristicaes of nanometer Fructus Choerospondiatis
75 parts of 75 parts of nanometer Lignum Aquilariae Resinatum of 75 parts of nanometer Resina Liquidambarises of the nanometer Radix Aucklandiae
75 parts in nanometer Cor Bovis seu Bubali powder
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano seven ingredient axially choerospondias fruit medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano seven ingredient axially choerospondias fruit medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100281 CN1364507A (en) | 2001-01-12 | 2001-01-12 | Nano seven ingredient axially choerospondias fruit medicine and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100281 CN1364507A (en) | 2001-01-12 | 2001-01-12 | Nano seven ingredient axially choerospondias fruit medicine and its preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1364507A true CN1364507A (en) | 2002-08-21 |
Family
ID=4651454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100281 Pending CN1364507A (en) | 2001-01-12 | 2001-01-12 | Nano seven ingredient axially choerospondias fruit medicine and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1364507A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101288702B (en) * | 2008-04-11 | 2011-04-27 | 奥·乌力吉 | Mongolian medicine for treating sleep disorder |
-
2001
- 2001-01-12 CN CN 01100281 patent/CN1364507A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101288702B (en) * | 2008-04-11 | 2011-04-27 | 奥·乌力吉 | Mongolian medicine for treating sleep disorder |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1368334A (en) | Nano emdicine 'Weiling' and its preparing process | |
| CN1368063A (en) | Nano medicine 'Yushangling' and its preparing process | |
| CN1364507A (en) | Nano seven ingredient axially choerospondias fruit medicine and its preparing method | |
| CN1364543A (en) | Nano apricot kernel and perilla antitussive medicine and its preparing method | |
| CN1364505A (en) | Nano seven ingredient iron filing medicine and its prepairng method | |
| CN1368100A (en) | Nano medicine 'Xiaoying' and its preparing process | |
| CN1364534A (en) | Nano eight ingredient ingredient and eagled wood medicine for clearing away pericardium heat and its preparing method | |
| CN1364539A (en) | Nano Yushusan medicine and its preparing method | |
| CN1368333A (en) | Nano medicine 'Weikang' and its preparing process | |
| CN1364581A (en) | Nano Children heat fast clearing away medicine and its preparing method | |
| CN1368071A (en) | Nano medicine 'Qianzihong' and its preparing process | |
| CN1366951A (en) | Nano Fengshi Maqian preparation medicine and preparation method | |
| CN1364605A (en) | Nano compound sichuan fritillary bulb medicine and its preparing method | |
| CN1360938A (en) | Nanometer rhinitis-treaitng Qianbai medicine and its prepn | |
| CN1368357A (en) | Nano medicine 'Weitongding' and its preparing process | |
| CN1368282A (en) | Nano medicine 'Zhitejia' and its preparing process | |
| CN1364606A (en) | Nano compound loquat leaf medicine and its preparing method | |
| CN1364582A (en) | Nano children heat clearing away and cough arresting medicine and its preparing method | |
| CN1364565A (en) | Nano wind-evil expelling medicine and its preparing method | |
| CN1362157A (en) | Nano Sanjiuweitai medicine and its preparation | |
| CN1365709A (en) | Nano medicine for child to relieve cough and its preparing process | |
| CN1368132A (en) | Nano musk medicine and its preparing process | |
| CN1365802A (en) | Nano antitussive loquat medicine and its preparing process | |
| CN1368098A (en) | Nano antitrussive laiyang pear medicine and its preparing process | |
| CN1364560A (en) | Nano astragalus root-acanthopanax medicine and its preparing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |