CN1362101A - Nano Huolisu medicine for restoring vitality and its preparation - Google Patents
Nano Huolisu medicine for restoring vitality and its preparation Download PDFInfo
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- CN1362101A CN1362101A CN 01100117 CN01100117A CN1362101A CN 1362101 A CN1362101 A CN 1362101A CN 01100117 CN01100117 CN 01100117 CN 01100117 A CN01100117 A CN 01100117A CN 1362101 A CN1362101 A CN 1362101A
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Abstract
The present inventino discloses a nano Huolisu preparation medicine. It is made up by using the Chinese medicinal materials of nano flowery knotweed, nano edimedium, nano polygonatum, nano lycium, nano astragalus and nano salvia as raw material through the processes of microwave extraction, veduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to the nano Huolisu medicine for restoring vitality of a kind of vigorate qi and replenish the blood, nourishing the liver and kidney, the invention still further relates to the method for this medication preparation.
Vigor Soviet Union oral liquid is a kind of classical Chinese patent medicine, mainly contains effects such as vigorate qi and replenish the blood, nourishing the liver and kidney, is used for worn with age, lethargy, insomnia forgetfulness, dim eyesight deafness, alopecia or early whitening of hair and belongs to insufficiency of vital energy and blood, caused by liver and kidney deficiency person.. but traditional vigor Soviet Union oral liquid absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Huolisu medicine for restoring vitality of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Huolisu medicine for restoring vitality.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Polygoni Multiflori Preparata 10-70 part nanometer Herba Epimedii 5-60 part nanometer Rhizoma Polygonati 10-70 part
Nanometer Fructus Lycii 5-60 part nano astragalus 5-50 part nano red sage 5-50 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Polygoni Multiflori Preparata 20-50 part nanometer Herba Epimedii 15-40 part nanometer Rhizoma Polygonati 20-50 part
Nanometer Fructus Lycii 15-40 part nano astragalus 15-40 part nano red sage 10-30 part
The optimum weight proportioning of medicine of the present invention is:
30 parts of 25 parts of nanometer Rhizoma Polygonatis of 30 parts of nanometer Herba Epimedii of nanometer Radix Polygoni Multiflori Preparata
20 parts of 25 parts of nano red sages of 25 parts of nano astragalus of nanometer Fructus Lycii
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get made in CCCP dose of nano powder of vigor with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano Huolisu medicine for restoring vitality is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common seed viability Soviet Union oral liquid formulations material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano Huolisu medicine for restoring vitality etc. had no precedent in the past.
That pharmaceutical preparation of the present invention can be used for is worn with age, lethargy, insomnia forgetfulness, dim eyesight deafness, alopecia or early whitening of hair belong to treatment of conditions such as insufficiency of vital energy and blood, caused by liver and kidney deficiency, and clinical efficacy significantly is better than traditional vigor Soviet Union oral liquid.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
Nanometer Radix Polygoni Multiflori Preparata 10-70 part nanometer Herba Epimedii 5-60 part nanometer Rhizoma Polygonati 10-70 part
Nanometer Fructus Lycii 5-60 part nano astragalus 5-50 part nano red sage 5-50 part
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
30 parts of 25 parts of nanometer Rhizoma Polygonatis of 30 parts of nanometer Herba Epimedii of nanometer Radix Polygoni Multiflori Preparata
20 parts of 25 parts of nano red sages of 25 parts of nano astragalus of nanometer Fructus Lycii
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer vigor Soviet Union powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
30 parts of 25 parts of nanometer Rhizoma Polygonatis of 30 parts of nanometer Herba Epimedii of nanometer Radix Polygoni Multiflori Preparata
20 parts of 25 parts of nano red sages of 25 parts of nano astragalus of nanometer Fructus Lycii
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer vigor Soviet Union membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano Huolisu medicine for restoring vitality is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Polygoni Multiflori Preparata 10-70 part nanometer Herba Epimedii 5-60 part nanometer Rhizoma Polygonati 10-70 part
Nanometer Fructus Lycii 5-60 part nano astragalus 5-50 part nano red sage 5-50 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Huolisu medicine for restoring vitality according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Polygoni Multiflori Preparata 20-50 part nanometer Herba Epimedii 15-40 part nanometer Rhizoma Polygonati 20-50 part
Nanometer Fructus Lycii 15-40 part nano astragalus 15-40 part nano red sage 10-30 part
3, nano Huolisu medicine for restoring vitality according to claim 1, wherein the weight proportion of each nano raw material is:
30 parts of 25 parts of nanometer Rhizoma Polygonatis of 30 parts of nanometer Herba Epimedii of nanometer Radix Polygoni Multiflori Preparata
20 parts of 25 parts of nano red sages of 25 parts of nano astragalus of nanometer Fructus Lycii
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Huolisu medicine for restoring vitality.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Huolisu medicine for restoring vitality; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100117 CN1362101A (en) | 2001-01-05 | 2001-01-05 | Nano Huolisu medicine for restoring vitality and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100117 CN1362101A (en) | 2001-01-05 | 2001-01-05 | Nano Huolisu medicine for restoring vitality and its preparation |
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| CN1362101A true CN1362101A (en) | 2002-08-07 |
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| CN 01100117 Pending CN1362101A (en) | 2001-01-05 | 2001-01-05 | Nano Huolisu medicine for restoring vitality and its preparation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101559168B (en) * | 2008-04-17 | 2012-11-21 | 成都地奥集团天府药业股份有限公司 | Pharmaceutical composition for invigorating Qi, tonifying blood and nourishing liver and kidney as well as preparation method and application thereof |
| CN114306491A (en) * | 2021-12-22 | 2022-04-12 | 江苏七○七天然制药有限公司 | Fleece-flower root hair growth capsule and preparation, detection and component identification methods thereof |
-
2001
- 2001-01-05 CN CN 01100117 patent/CN1362101A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101559168B (en) * | 2008-04-17 | 2012-11-21 | 成都地奥集团天府药业股份有限公司 | Pharmaceutical composition for invigorating Qi, tonifying blood and nourishing liver and kidney as well as preparation method and application thereof |
| CN102836340B (en) * | 2008-04-17 | 2015-08-12 | 成都地奥集团天府药业股份有限公司 | A kind of vigorate qi and replenish the blood, nourishing the liver and kidney pharmaceutical composition and its production and use |
| CN114306491A (en) * | 2021-12-22 | 2022-04-12 | 江苏七○七天然制药有限公司 | Fleece-flower root hair growth capsule and preparation, detection and component identification methods thereof |
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