CN1358458A - Jojoba seed and its extract in use of fat prevention and banting - Google Patents
Jojoba seed and its extract in use of fat prevention and banting Download PDFInfo
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- CN1358458A CN1358458A CN01135290A CN01135290A CN1358458A CN 1358458 A CN1358458 A CN 1358458A CN 01135290 A CN01135290 A CN 01135290A CN 01135290 A CN01135290 A CN 01135290A CN 1358458 A CN1358458 A CN 1358458A
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Abstract
The present invention relates to a Chinese natural plant Heheba seed and its extract, and their application in preparation of weight-reducing medicine and production of weight-reducing food. The oral administration of the invented product made up Heheba seed and its extract can attain the goal of controlling diet, preventing and curing obesity.
Description
Technical field
The present invention relates to natural plants in pharmacy or the new application in food, especially relate to plant seed and extract thereof the fat-reducing medicine or/and the application in the diet food.
Background technology
Obesity is the very serious factor of harm people's health and mental health.Studies show that obesity is to cause diabetes, hypertension and cardiopathic key factor.Statistical information shows that body-mass index (BMI) is minimum at people's mortality rate of 22-25 kg body weight square metre body surface area, and when BMI surpassed 27 kg body weight/square metre body surface area, mortality rate began to rise.Fat reason is a lot, summarizes to get up can be divided into: excessively diet, metabolism rate are low excessively, or above the two coexistence.But being diet, its basic reason takes in heat greater than metabolism and heat that motion consumed.That is energy is taken in greater than energy expenditure.
Appetrol a multitude of names in the market, but all have its shortcoming and can not effective and safe ground reaching separately to keep on a diet and the purpose of body weight.Its classification and mechanism and side effect are summarized as follows:
1. reach the medicine of fat-reducing purpose by appetite-suppressing: (1) stupid propylamine and derivant thereof.For spiritual class medicine and.Open up when treating, show tangible mental excitation effect, eliminate drowsiness and feeling of fatigue, can treat narcolepsy, also have the effect of appetite-suppressing simultaneously with it.Because of this medicine can produce the sense of euphoria, use easy addiction for a long time, produce untoward reaction such as drug dependence.The antiobesity action of its derivant trifluoromethyl amfetamine is better than amfetamine, and side effect but weakens to some extent.(2) mazindol.Act on similar to amfetamine, the appetite-suppressing effect is also arranged and be used to the fat-reducing.That the side reaction of this medicine has is thirsty, weak, insomnia, headache, constipation etc.
2. by disturbing food absorption to bring into play the medicine of fat-reducing effect: alpha-amylase inhibitor, alpha-glucosidase inhibitor are arranged.The latter is a new oral blood sugar lowering, combines with enzyme with the carbohydrate competition in small intestinal, and the effect of inhibitory enzyme makes food be obstructed digesting and assimilating of intestinal, and the absorption of sugar reduces, and blood glucose reduces, and then the absorption of influence fat, the performance antiobesity action.Its major side effects is a gastrointestinal reaction.Hypoglycemia person forbidding.
3. utilize the fat-reducing of biguanides oral antidiabetic drug: oral antidiabetic drug metformin, phenformin can cause dyspepsia when heavy dose is used, so also can be used for fat-reducing.But phenformin with causing lacticemia, can reach 50% in case mortality rate takes place for a long time.Hypoglycemia person forbidding.
4. use the laxative fat-reducing: promptly cause fluid loss and cause and lose weight, but also make people's weakness simultaneously with cathartic.
5. hormone medicine (also claiming the metabolism stimulant): be representative with thyroxine mainly, it can improve the metabolism of body, increases decomposition, the consumption of fat, thereby loses weight.Herba Ephedrae class medicine also belongs to this type of.But if surpass normal physiological doses, often can have a negative impact during this type of drug use to cardiovascular system.Need be under physician guidance, the prudent use.
At present, also have a lot of appetrol to be in experimental stage abroad, as orlistat (Orlistat), sabadinine (Sibutramine), leptin (Leptin) etc.
From above-mentioned slimming medicine introduction as can be seen, at present the curative effect of the most drug of using is still undesirable, takes for a long time and can cause many untoward reaction, comprises rebound phenomenon after addiction, toxicity and the drug withdrawal etc.
Simmondsia chinensis (English Jojoba, formal name used at school are jojoba, Latin formal name used at school Simmondsia chinensis) is the green shrub of length of spontaneous growth in the Mexico northwestward and the Southwestern United Stares desert, and its well developed root system is heat-resisting, drought-enduring, barren-resistant.At southwest China plantation is also arranged at present.Oil content is up to 45-65% in Jojoba seed, Jojoba oil (Jojoba oil) chemical constitution uniqueness, it has antioxidation, high temperature resistant, high-melting-point and high stability, now extensively make lubricant, and be used to produce the antiferment and the medicament carrier of penicillin, and be widely used in the skin-care product.
Summary of the invention
The objective of the invention is to overcome the defective of above slimming medicine and diet food, provide a kind of Jojoba seed and extract thereof preparing appetrol or/and the application in diet food.
Another object of the present invention is a kind of appetrol are provided or/and the Jojoba seed preparation method of extract of using in diet food.
The present invention provides a safety, approach effective, that easily go for the fat people of needs control, and it takes the seed of natural plants or/and the extract of natural plants is desired with the feed that reduces the people by people, takes in thereby reach the minimizing heat.Can reach fundamentally and to solve fat problem, be used to help to reduce people's appetite and reach and keep on a diet and prevent and treat fat.
The objective of the invention is to realize by the following technical solutions: with Jojoba seed and with it is that the product of raw material is kept on a diet to reach by oral, and prevention and treatment are fat.
The inventor thinks that the basic reason that causes people's obesity is the heat of the continuous Excessive Intake of people, forms fat in the health inner accumulated for a long time, causes obesity.During the three meals in a day feed, the overweight people can produce hunger sensation, and this hunger sensation is a kind of trained reflex, be not somagenic need heat this moment, should have taken food, but arrived the time of feed, the hunger sensation that the stomach trained reflex produces makes brain produce the desire of feed.The present inventor finds quantitatively to take every day the product that contains Simmondsin. (Simmondsin) composition, the Jojoba seed after the defat particularly, can alleviate hunger sensation, before the time on the feed arrives, make stomach produce full sensation, no longer feed, reduce the absorption of heat, when health really needs heat, the excess fat of body inner accumulated is changed into energy, incremental like this, reach the purpose of preventing and treating human obesity.The present invention proved Jojoba seed and has been the various products of raw material with it in experiment, keep on a diet and prevent and treat fat safety, practicality and effectiveness to reach by oral.It is extensive that it has the crowd of benefiting from, and the bounce-back after the fat-reducing is little, can not cause other fat-reducing dependency complication etc.
Jojoba seed of the present invention (seed) wherein still contains 30% protein after squeezing defat, contain a kind of Simmondsin. (Simmondsin, molecular formula C of crying in Jojoba seed
16H
25O
9N, molecular weight are 75.37) composition, be experimental results show that by the inventor to be determined as the reason that causes the people to take food reducing.
The dosage of eating of the Jojoba seed after Jojoba seed of the present invention or the defat is the gram of 1-300 for each person every day, Jojoba seed after Jojoba seed or the defat, or any effective ingredient Simmondsin. that from Jojoba seed (seed), extracts that contains, or synthetic but with the identical chemical compound of effective ingredient Simmondsin. structure that from Jojoba seed, extracts, dosage is equivalent to the contained amount of natural constituent in the Jojoba seed after 1-300 gram/sky Jojoba seed or the defat.To not reach curative effect when the dosage of Jojoba seed is lower than 1 gram/sky after the people eats Jojoba seed or defat, and when eating dosage and be higher than 300 gram/skies, then might human body be had side effects, as cause symptoms such as anorexia.
Feature of the present invention is that made dosage form can be the powder of Jojoba seed after Jojoba seed or the defat or granule capsule, tablet, electuary, liquid beverage, tea bag.Capsule and tablet are applicable to the high purity effective component Simmondsin. that extracts from Jojoba seed, powder of drinking after liquid beverage, tea bag, the immersion or granule are applicable to the Jojoba seed after the natural crude defat.
1, the acute toxicity testing of rat,
(1) oral give rat disposable stomach tube administration 2.5 gram/kg body weight Simmondsin .s do not find any unusually.It is any unusual also not find for the disposable oral administration 4 gram/kg body weight Simmondsin .s of rat.
(2) injection is not found any unusual to rat disposable celiac drug administration by injection 3.6 gram/kg body weight Simmondsin .s.
2, with conventional pharmacological evaluation observe do not find to continuous five days oral 250 gram/kg body weight Simmondsin .s of rat any unusual.
The preparation method of Simmondsin.: with hexane with Jojoba seed or the complete Jojoba seed after the defat, select apparatus,Soxhlet's for use, with methane, water or other any solvent extraction Jojoba seeds, make powder or graininess after the Jojoba seed extracting solution drying with defat or not defat.
Other any solvents comprise ethanol, methanol, acetone, chloroform, petroleum ether etc.
Using method:
1, Jojoba seed after Jojoba seed or the defat and extract Simmondsin. 1-300 restrain in ante cibum or/and use after meal.Through clinical experiment, use Jojoba seed of the present invention and the extract Simmondsin. can be mixed with preparations such as oral liquid, tablet, electuary, capsule, take the back fat-reducing effect rapidly, significantly, and do not have toxicity; Jojoba seed after Jojoba seed or the defat or/and Simmondsin. goods can comprise powder or granule capsule, tablet, electuary, liquid beverage, tea bag etc.
2, available Jojoba seed of the present invention and extract Simmondsin. can be used as food additive, are stirred in that to be processed into prepared food in the various staple food flours edible for slimmer and prevention of obesity person, become the medicated food that integrates fat-reducing, keeps healthy, treats.As join and make noodles, steamed bread etc. in the flour.
Specific embodiments
For showing safety of the present invention, practicality and effectiveness on existing zooperal basis, have carried out a series of clinical trials and observation especially.
Application examples one
Patient number: 1, sex: the woman, the age: 24 years old, height: 1.60M.
The fat-reducing reason: body weight constantly increased in nearly 2 years, wished by taking the purpose that Jojoba seed of the present invention reaches prevention and loses weight.
Body weight before the experiment: 49 kilograms (98 jin)
First month: 3 gram Jojoba seed/skies, every day, supper was taken in last hour, and body weight reduces to 46 kilograms, reduces 3 kilograms;
The second month: 2 gram/skies, every day, supper was taken in last hour, and body weight reduces to 44 kilograms, reduces 2 kilograms;
Three month: 1 gram/sky, every day, supper was taken in last hour, and weight maintenance does not have big variation about 44 kilograms.
Analyze: this is that an example is utilized the fat-reducing of success of the present invention and the example of prevention of obesity.
Application examples two:
Patient number: 2, sex: the man, the age: 30 years old, height: 1.72M.
Fat-reducing reason:, among the age setses, just belong to and be too obese from little, fatly make troubles for work, study, life.
Body weight before the experiment: 115 kilograms (230 jin).Take Jojoba seed as requested.
First month: each 25 gram before the 50 gram/skies, lunch and supper.Body weight reduces to 110 kilograms, has reduced 5 kilograms.
The second month: each 50 gram before the 100 gram/skies, lunch and dinner.Body weight reduces to 102.7 kilograms, has reduced 7.3 kilograms.
Three month: each 75 gram before the 150 gram/skies, lunch and dinner.Body weight reduces to 93.5 kilograms, has reduced 9.2 kilograms.
Four month: each 50 gram before the 100 gram/skies, lunch and dinner.Body weight reduces to kilogram 86.6, has reduced 6.9 kilograms.
Five month: each 25 gram before the 50 gram/skies, lunch and dinner.Body weight reduces to 81.8 kilograms, has reduced 4.8 kilograms.
Six month: each 25 gram before the 50 gram/skies, lunch and dinner.Body weight reduces to 77.6 kilograms, has reduced 4.2 kilograms.
Analyze: the patient is because gastrointestinal absorption is good, from little eating and drinking too much at one meal, body weight is too obese, we have designed the way advanced in proper order for him specially, reduce his appetite gradually, reduce the intake of food, excess fat in the consumer is converted into heat with fat gradually, after treating that body weight drops to a certain degree, adopt the way of gradually falling in proper order to reduce consumption again, its demand and actual demand amount of health own to food is consistent substantially, thereby reach the effect of fat-reducing and prevention of obesity.This experiment lasts half a year, and the side effect of too fast generation even the patient has avoided losing weight has reached the purpose of fat-reducing again, does not find any abnormal phenomena in the middle of the whole process, produces any harmful effect to patient body is healthy, and is not safe and reliable.The patient dose that body weight is higher can suitably increase.But should not surpass 300 gram/skies.
Application examples three:
Select 20 obese patients, their BMI value (kg body weight/square metre body surface area) is all above 25.Do not taking other fat-reducing means and do not controlling under their situation of dietary habit, use Jojoba seed after the defat of the present invention, it is a graininess, includes 8-10% Simmondsin. (Simmondsin), every day, oral 25 gram/skies were promptly respectively taken 12.5 grams in last hour at lunch and dinner.Report all after taking that appetite and food intake dose obviously lower, average weight alleviates 11% (8.69 kilograms) in one month.Particulars is with reference to following table 1.
Contrast patient patient's property experiment precursor experiment back body body weight change BMI changed before and after table 1 20 routine overweight peoples took
BMI BMI ( ) ( ) ( ) ( ％ ) 1 56 1.7 76.5 26.47059 69.4 24.01384-7.1-9.282 65 1.65 72 26.44628 67.5 24.79339-4.5-6.253 45 1.72 78.2 26.43321 65.6 22.17415-12.6-16.114 48 1.78 92.4 29.16298 72.3 22.81909-20.1-21.755 35 1.67 79.8 28.61343 69.7 24.99193-10.1-12.666 39 1.72 75.6 25.55435 69.2 23.39102-6.4-8.477 59 1.64 70.2 26.10054 65.1 24.20434-5.1-7.268 42 1.67 75.9 27.21503 64.5 23.1274-11.4-15.029 47 1.56 75.6 31.06509 72.3 29.70907-3.3-4.3710 39 1.68 95.6 33.87188 88.9 31.49802-6.7-7.0111 48 1.55 70.8 29.4693 60.9 25.3486-9.9-13.9812 46 1.6 65.7 25.66406 58.2 22.73438-7.5-11.4213 37 1.66 70.2 25.4754 59.1 21.44723-11.1-15.8114 32 1.62 73.4 27.9683 64.3 24.50084-9.1-12.415 58 1.64 77.5 28.81469 65.4 24.31588-12.1-15.6116 31 1.65 74.3 27.29109 68.7 25.23416-5.6-7.5417 45 1.63 65.6 24.69043 64.3 24.20114-1.3-1.9818 51 1.57 67.5 27.38448 56.7 23.00296-10.8-1619 57 1.66 72.9 26.45522 64.6 23.44317-8.3-11.3920 29 1.74 80.9 26.72083 70.1 23.15365-10.8-13.35 45 1.66 75.53 27.54336 66.8 24.40521-8.69-11.38
Do not find any side effect in the whole experiment.Routine blood test and biochemical index are not seen any ANOMALOUS VARIATIONS yet.
From above result, can draw and the invention has the advantages that:
(1) the present invention has excavated new purposes to the known plants Simmondsia chinensis, has opened up a new application;
(2) Simmondsia chinensis of the present invention is safe and reliable eating of appropriate amount;
(3) intake is controlled at certain scope, not only can loses weight, can also prevention of obesity.
Below further specify the present invention by several embodiment, but do not limit the present invention in any way.
Embodiment 1
100 kilograms of exsiccant Jojoba seeds as in the apparatus,Soxhlet's, are added 50 liter acetone and reflux and extract 12 hours, and reclaim acetone distillation (but distilling under reduced pressure) back, obtains 3.8 kilograms of brown extracts.Dried extract is added in the 100 liter deionized waters, stirred 10 hours after discard insoluble sludge after the centrifugalize (2000RPM).1.2 kilograms of pale yellow powders that contain 58% Simmondsin. (Simmondsin) will be obtained after the supernatant partial vacuum drying.
Embodiment 2
Adopt Jojoba seed to add 30 liter methane for 50 kilograms, discard supernatant after centrifugal.Solid portion adds the backflow of 25 liter acetone and extracts 19 hours as in the apparatus,Soxhlet's, and reclaim acetone distillation (but distilling under reduced pressure) back, obtains 2 kilograms of brown extracts.Dried extract is added in the 40 liter deionized waters, stirred 10 hours after discard insoluble sludge after the centrifugalize (2000RPM).20 liter ethanol stirring recentrifuge separation (4000RPM) after 4 hours will must be added after the supernatant partial vacuum drying.To obtain 0.4 kilogram of pale yellow powder that contains 65% Simmondsin. (Simmondsin) after this supernatant partial vacuum drying.
Embodiment 3
Pulverize with Jojoba seed and to make capsular production method: after the defat Jojoba seed or Simmondsin. with add into No. 00 capsule after silicon dioxide mixes.
Embodiment 4
Pulverize with Jojoba seed and to make capsular production method: after the defat Jojoba seed or Simmondsin. with add into No. 00 capsule after silicon dioxide and multivitamin mix.The method can prevent to take food and reduce the malnutrition that may cause.
Embodiment 5
Pulverize technology with Jojoba seed as food additive: Jojoba seed or Simmondsin. and flavoring agent after the defat, sugar, xanthan gum, Semen Glycines powder, vitamin, protein, and edible wet goods is made cakes.Jojoba seed or the Simmondsin., other steps and traditional food technology are as good as inferior technology after need add defat.
Claims (10)
1, Jojoba seed and extract thereof are in preparation prevention of obesity medicine, appetrol or the application in preparation prevention of obesity food, diet food.
2, the application in preparation prevention of obesity medicine, appetrol according to described Jojoba seed of claim 1 and extract thereof is characterized in that the molecular formula of the extract Simmondsin. (Simmondsin) of Jojoba seed is C
16H
25O
9N, molecular weight are 75.37.
3, according to the described Jojoba seed of claim 1 and extract thereof in preparation prevention of obesity medicine, appetrol or the application in preparation prevention of obesity food, diet food, it is characterized in that the dosage of eating of Jojoba seed after Jojoba seed or the defat restrains for 1-300 for each person every day.
4,, it is characterized in that Jojoba seed after Jojoba seed or the defat or/and the powder of Simmondsin. or granule capsule, tablet, electuary, liquid beverage, tea bag according to claim 1 or 2 or 3 described Jojoba seeds and the application of extract Simmondsin. in preparation prevention of obesity medicine, appetrol thereof.
5, the application in preparation prevention of obesity medicine, appetrol according to described Jojoba seed of claim 4 and extract thereof is characterized in that Simmondsin. is applicable to capsule and tablet.
6,, it is characterized in that the Jojoba seed after the powder drunk after liquid beverage, tea bag, the immersion or granule are applicable to natural crude defat according to the application in the preparation appetrol of the described Jojoba seed of claim 4 and extract thereof.
7, according to claim 1 or 2 or 3 described Jojoba seeds and the application of extract in preparation prevention of obesity food, diet food thereof, Jojoba seed is stirred in the various edible powder and is processed into prepared food or/and Simmondsin. can be used as food additive after it is characterized in that Jojoba seed or defat.
8, according to claim 1 or 2 described Jojoba seeds and the application of extract in the preparation appetrol thereof, it is characterized in that comprising synthetic but with the identical chemical compound of effective ingredient structure that from Jojoba seed, extracts.
9, Jojoba seed preparation method of extract, it is characterized in that with hexane Jojoba seed or the complete Jojoba seed after the defat, select apparatus,Soxhlet's for use, with methane, water or other any solvent extraction Jojoba seeds, make powder or graininess after the Jojoba seed extracting solution drying with defat or not defat.
10,, it is characterized in that said other any solvents comprise ethanol, methanol, acetone, chloroform, petroleum ether according to the described Jojoba seed preparation method of extract of claim 9.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN01135290A CN1358458A (en) | 2001-12-18 | 2001-12-18 | Jojoba seed and its extract in use of fat prevention and banting |
| US10/212,577 US7138134B2 (en) | 2001-12-18 | 2002-08-05 | Preparation and administration of jojoba product for reducing weight, fat and blood lipid levels |
| US11/536,920 US8673343B2 (en) | 2001-12-18 | 2006-09-29 | Preparation and administration of jojoba product for reducing weight, fat and blood lipid levels and for the prevention and treatment of cancer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN01135290A CN1358458A (en) | 2001-12-18 | 2001-12-18 | Jojoba seed and its extract in use of fat prevention and banting |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1358458A true CN1358458A (en) | 2002-07-17 |
Family
ID=4673097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN01135290A Pending CN1358458A (en) | 2001-12-18 | 2001-12-18 | Jojoba seed and its extract in use of fat prevention and banting |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1358458A (en) |
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2001
- 2001-12-18 CN CN01135290A patent/CN1358458A/en active Pending
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