CN1344555A

CN1344555A - Pure Chinese medicine prepn for treating erection mulfunction

Info

Publication number: CN1344555A
Application number: CN01131486A
Authority: CN
Inventors: 李军
Original assignee: Individual
Current assignee: Individual
Priority date: 2001-09-12
Filing date: 2001-09-12
Publication date: 2002-04-17
Anticipated expiration: 2021-09-12
Also published as: CN1218711C

Abstract

The Chinese medicine for treating male's non-organic erection mulfunction is prepared by using the Chinese medicinal materials epimedium, Gecko, Astragalus membranaceus, schisandra, polygala root etc. with the functions of filling life essence, benefiting vital energy, strengthening Yang, regulating heart, alleviating mental depression and dredging the meridian passage. The Chinese medicinal materials in certain proportion are stoved, ground into fine powder, mixed and capsulized to prepare the Chinese medicine capsule. The Chinese medicine has obvious curative effect and no toxic and side effect.

Description

The pure Chinese medicinal preparation of treatment erection disturbance

The present invention relates to field of medicaments, is a kind of pure Chinese medicine capsule preparation for the treatment of the non-organic erection disturbance of adult male.

Male erectile dysfunction (abbreviation) is commonly called as sexual impotence, be meant adult male can not with keep erection so that obtain satisfied sexual intercourse.Be divided into organic and non-organic (spirituality and Combination) sexual impotence clinically more.For the non-organic sexual impotence, doctor trained in Western medicine has drug oral, local injection, per urethra administration, the treatment of negative pressure constriction device in treatment.Oral viagra clinical effective rate can reach 81%, but heart disease, hyperpietic are used limited; The penis cavernosa injection therapy has pain, erects to prolong temporary hypotension, side effect such as cavernous body of penis fibrosis; The per urethra drug treatment has urethra scorching hot, temporary transient penile pain and easily cause side effect such as infection; Negative pressure constriction device, it is higher to lose the visit rate, so the overall satisfaction rate of patient is lower.The traditional Chinese medical science is thought: on male genetic physiology, and kidney master external genitals, liver department external genitals, The heart controls mental activities contracts so that the erection of dominating beautiful stem is soft, and convergence of vessels in the lung semen deposition is to support testis, and The spleen has the function to transport and transform nutrients receives to support congenital and main taking the photograph, and function of five internal organs is normal, and outer renal function is just gone.On pathology, wherein any one dirty function generation pathological change all can cause outer renal dysfunction.From characteristic of disease, existing deficiency syndrome have excess syndrome again.Can be summarized as: vital essence void, the liver failing to be nourished; All evil wounds, gaseous pulse is obstructed, the damp and hot muscle of stabing, dysfunction, sending out is sexual impotence.It is the main matter basis that Yang Dao rouses oneself that kidney essense fills with.Clinical multirow determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, as in the high traditional Chinese medical science universities and colleges teaching material with Yougui Yin, the kidney-Yang-Reinkforcing Decotion treatment insufficiency of kidney-YANG sexual impotence, with six drugs containing rehmanniae pill for curing deficiency of the kidney yin sexual impotence, with Decoction of Gentiana for Purging the Liver-fire treatment damp heat downward flowing type sexual impotence, or the like, eventually because of clinically one dirty due to the sexual dysfunction person less, mostly be two dirty or how dirty with disease clinical efficacy satisfied not to the utmost.

Aim of the present invention is increasing at the adult male of modern society its physical and mental burden under the more and more fierce environment of competition, and preference for fat and sweet food savoury or pungent product had again both been considered the one side of its deficiency syndrome in the treatment, consider the one side of excess syndrome again.The many drinking liquor instead of the other beveragess of moderns, leading an abnormal life instead of the normal life, impairment caused by overstrain heart spleen, dark consumption is cloudy smart, disarmony between the heart and kidney, so how empty its disease is, common lustreless complexion, tired, dizziness and tinnitus, insomnia and dreamful sleep; But because of its easy sentimentality again, thus the machine of many again stagnation of liver-QI, the time and depressed emotion, two sides of body are uncomfortable, pathogen usually intruding into collateral in protracted disease, phlegm-turbidity and blood stasis hinder, and whenever cause simulataneous insufficiency and excessive.Should dialectically combine so control sexual impotence, see treating both the principal and secondary aspects of a disease from integral body with differential diagnosis of diseases.

For realizing above-mentioned aim, the present invention has developed a clock pure Chinese medicine capsule preparation specially, and it is to form with Herba Epimedii, the Radix Astragali, Semen Cuscutae, Fructus Cnidii, Herba Cistanches, Fructus Schisandrae Chinensis, the Radix Paeoniae Alba, Radix Bupleuri, Rhizoma Acori Graminei, Radix Polygalae, Nidus Vespae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, Herba Lycopodii, Scolopendra, Gecko, bavin Testis et Pentis Canis, Radix Glycyrrhizae component that its prescription is formed.

But this medicament YIN and YANG balance regulating, benefiting vital QI and blood, kidney tonifying nourishes heart, and resolving depression is had one's ideas straightened out, dredge the meridian passage, obviously sexual function improving.Medicinal Herba Epimedii, the Radix Astragali, Gecko, bavin Testis et Pentis Canis be monarch drug with replenishing essence Xing Yang, vital energy benefiting and the kidney invigorating is a ministerial drug with Semen Cuscutae, Fructus Cnidii, Herba Cistanches, Fructus Schisandrae Chinensis, the Radix Paeoniae Alba, YIN nourishing and YANG strengthening, nourishing blood to suppress the hyperactive liver, gentle penis; Radix Bupleuri, Rhizoma Acori Graminei, Radix Polygalae, but dispersing the stagnated live-QI to relieve the stagnation of QI, restoring normal coordination between the heart and kidney makes regulation between water and fire; Nidus Vespae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, Herba Lycopodii, Scolopendra, the energy promoting blood circulation and detoxication, the gas in the conditioning blood, unobstructed meridians are had one's ideas straightened out; The messenger drug Radix Glycyrrhizae, coordinating the actions of various ingredients in a prescription.This medicine had both been avoided high in the past violent tonifying YANG, consumption impairment of YIN essence, again on the strong smart basis of kidney tonifying, than its medicine more pay attention to irritability transfer reach, The heart controls mental activities and make the effect of penis in order, be devoted to the recovery and the effect between each internal organs of function and coordinate, sexual impotence is cured.The clinical pharmacology experiment shows: the extract of Herba Epimedii, Fructus Cnidii, Gecko has androgen-like action; Tonics such as the Radix Astragali can strengthen people's immunity, and blood circulation promoting medicines such as Flos Carthami can improve the blood of human body rheology.

The inventor adopts pure Chinese drug-treated group cost preparation based on theory of integrated Chinese and western medicine, and each components contents of its material medicine (weight) scope is: Herba Epimedii 250--350g, Radix Astragali 200--300g, Semen Cuscutae 150--250g, Fructus Cnidii 100--200g, Herba Cistanches 100--200g, Fructus Schisandrae Chinensis 100--200g, Radix Paeoniae Alba 100--200g, Radix Bupleuri 100--200g, Rhizoma Acori Graminei 100--200g, Radix Polygalae 50--150g, Nidus Vespae 50--150g, Radix Salviae Miltiorrhizae 50--150g, Rhizoma Chuanxiong 50--150g, Flos Carthami 50--150g, Herba Lycopodii 50--150g, Scolopendra 15--25 bar, Gecko 3--8 is right, bavin Testis et Pentis Canis 3--8 tool, Radix Glycyrrhizae 30--100g.According to patient's concrete condition, in described content range, take the circumstances into consideration to adjust for each drug component.

The optimum ratio of each drug component is in the preparation of the present invention: Herba Epimedii 200g, Radix Astragali 300g, Semen Cuscutae 150g, Fructus Cnidii 100g, Herba Cistanches 100g, Fructus Schisandrae Chinensis 150g, Radix Paeoniae Alba 150g, Radix Bupleuri 100g, Rhizoma Acori Graminei 100g, Radix Polygalae 150g, Nidus Vespae 100g, Radix Salviae Miltiorrhizae 200g, Rhizoma Chuanxiong 100g, Flos Carthami 150g, Herba Lycopodii 150g, 15 of Scolopendras, 3 pairs of Geckos, bavin Testis et Pentis Canis 6 tools, Radix Glycyrrhizae 100g.

In addition, the proportioning of each drug component of preparation of the present invention also is preferably: Herba Epimedii 300g, Radix Astragali 250g, Semen Cuscutae 200g, Fructus Cnidii 150g, Herba Cistanches 150g, Fructus Schisandrae Chinensis 150g, Radix Paeoniae Alba 150g, Radix Bupleuri 150g, Rhizoma Acori Graminei 150g, Radix Polygalae 100g, Nidus Vespae 100g, Radix Salviae Miltiorrhizae 100g, Rhizoma Chuanxiong 100g, Flos Carthami 100g, Herba Lycopodii 100g, 20 of Scolopendras, 5 pairs of Geckos, bavin Testis et Pentis Canis 5 tools, Radix Glycyrrhizae 50g.

This medicaments preparation method: 1. get the medicine in proportion in the above-mentioned content range, Gecko is decaptitated, behind the foot, grinds into powder with said medicine, cross 120 mesh sieves; 2. medicated powder blendes together one, behind the drying machine inner drying, stirs; 3. with above-mentioned medicated powder, incapsulate, promptly make this preparation through the sterile working; 4 usefulness medical sterilization methods are sterilized to capsule; Described medical sterilization method such as irradiation sterilization, commonly used have cobalt-60 irradiation sterilization.

This preparation medicinal effects is remarkable, has no side effect, and taking convenience, preparation technology is simple, is the pure Chinese medicine capsule preparation of the non-organic erection disturbance of ideal treatment adult male, can supply wide clinical application.

Toxicity test research of the present invention is as follows:

One. acute toxicity testing

1. half causes death and tests:

Select healthy 20 rat (male and female half and half), body weight 250-400g gets this preparation 5g/ and only is dissolved in water, irritates stomach to rat, once feeding.Observed 7 days after the administration, do not find the variation of digestive system, respiratory system, nervous system aspect, the rat activity is as usual, and none example is dead.

2. maximum tolerance determination:

Get 20 of white mice (male and female half and half), body weight 25-40 gram is pressed this preparation of 8g/kg lumbar injection medicinal liquid, once injects, and observes 20 white mice health continuously 7 days.The test dosage is equivalent to 40 times of clinical application.

Two, long term toxicity test:

Select healthy 20 rat (male and female half and half), body weight 250-400g press the 1g/kg amount with this preparation filling stomach, and be administered once every day, and successive administration 30 days does not observe toxicity, and rat on the feed, each side such as activity, hair color and body weight are all normal.

Embodiment 1:

This medicaments preparation method: 1. Gecko decaptitated, behind the foot, grind into powder, cross 120 mesh sieves with the material medicine of forming this preparation; 2. above-mentioned medicated powder is blended together one, behind the drying machine inner drying, stir; 3. with above-mentioned medicated powder, the zero capsule of packing into through the sterile working (each capsule pack into medicine 0.5g); 4. with cobalt-60 irradiation sterilization.

Embodiment 2:

Press the optimum ratio of each material medicine content (weight) of this medicament: Herba Epimedii 300g, Radix Astragali 250g, Semen Cuscutae 200g, Fructus Cnidii 150g, Herba Cistanches 150g, Fructus Schisandrae Chinensis 150g, Radix Paeoniae Alba 150g, Radix Bupleuri 150g, Rhizoma Acori Graminei 150g, Radix Polygalae 100g, Nidus Vespae 100g, Radix Salviae Miltiorrhizae 100g, Rhizoma Chuanxiong 100g, Flos Carthami 100g, Herba Lycopodii 100g, 20 of Scolopendras, 5 pairs of Geckos, bavin Testis et Pentis Canis 5 tools, Radix Glycyrrhizae 50g; Preparation method with embodiment 1 is made this preparation.

Take this preparation for the male patient of 30 ages in 30-60 year, each 3-6 grain, every day three times, three weeks of continuous oral are a course of treatment.Take 1-2 the course of treatment, clinical effectiveness is good, and effective percentage and satisfaction rate are more than 95%.

Wherein a typical case is: Liu, and the man, 48 years old, it was aching and tired to tell the waist knee joint, sexual function seriously goes down, disposable life in every month approximately, the difficulty, not hard of erecing, i.e. ejaculation in 1-3 minute, not enough half a minute just ejaculates when the most serious, and tired behind the sexual life, waist lower limb acid precipitation sense increases the weight of.Once the doctor surplus ten that sought medical advice advance to obey pair Chinese medicine decoction surplus multiple medicine and 150, but life quality does not have improvement.Take the capsule that this optimum ratio prescription is made, each 5, every day three times, continuous oral is after three weeks, this disappearance of waist lower limb acid precipitation sensillary base, libido strengthens, and erection is rapid, erection number of times and intensity obviously increase, can carry out sexual life once weekly, the time reaches 4-6 minute, and ejaculate volume increases, climax is strong, and couple are satisfied.

Embodiment 3:

Press the optimum ratio of each material medicine content (weight) of this medicament: Herba Epimedii 200g, Radix Astragali 300g, Semen Cuscutae 150g, Fructus Cnidii 100g, Herba Cistanches 100g, Fructus Schisandrae Chinensis 150g, Radix Paeoniae Alba 150g, Radix Bupleuri 100g, Rhizoma Acori Graminei 100g, Radix Polygalae 150g, Nidus Vespae 100g, Radix Salviae Miltiorrhizae 200g, Rhizoma Chuanxiong 100g, Flos Carthami 150g, Herba Lycopodii 150g, 15 of Scolopendras, 3 pairs of Geckos, bavin Testis et Pentis Canis 6 tools, Radix Glycyrrhizae 80g; Preparation method with embodiment 1 is made this preparation.

Take this preparation for the male patient of 20 ages in 40-55 year, each 3-5 grain, every day three times, two weeks of continuous oral are a course of treatment.Take 1-3 the course of treatment, clinical effectiveness is good.

Claims

1. pure Chinese medicine capsule preparation for the treatment of the adult male erection disturbance, its material medicine is formed and proportioning is: Herba Epimedii 250--350g, Radix Astragali 200--300g, Semen Cuscutae 150--250g, Fructus Cnidii 100--200g, Herba Cistanches 100--200g, Fructus Schisandrae Chinensis 100--200g, Radix Paeoniae Alba 100--200g, Radix Bupleuri 100--200g, Rhizoma Acori Graminei 100--200g, Radix Polygalae 50--150g, Nidus Vespae 50--150g, Radix Salviae Miltiorrhizae 50--150g, Rhizoma Chuanxiong 50--150g, Flos Carthami 50--150g, Herba Lycopodii 50--150g, Scolopendra 15--25 bar, Gecko 3--8 is right, bavin Testis et Pentis Canis 3--8 tool, Radix Glycyrrhizae 30--100g.

2. preparation according to claim 1, wherein the proportioning of each material medicine is: Herba Epimedii 200g, Radix Astragali 300g, Semen Cuscutae 150g, Fructus Cnidii 100g, Herba Cistanches 100g, Fructus Schisandrae Chinensis 150g, Radix Paeoniae Alba 150g, Radix Bupleuri 100g, Rhizoma Acori Graminei 100g, Radix Polygalae 150g, Nidus Vespae 100g, Radix Salviae Miltiorrhizae 200g, Rhizoma Chuanxiong 100g, Flos Carthami 150g, Herba Lycopodii 150g, 15 of Scolopendras, 3 pairs of Geckos, bavin Testis et Pentis Canis 6 tools, Radix Glycyrrhizae 80g.

3. preparation according to claim 1, wherein the proportioning of each material medicine is: Herba Epimedii 300g, Radix Astragali 250g, Semen Cuscutae 200g, Fructus Cnidii 150g, Herba Cistanches 150g, Fructus Schisandrae Chinensis 150g, Radix Paeoniae Alba 150g, Radix Bupleuri 150g, Rhizoma Acori Graminei 150g, Radix Polygalae 100g, Nidus Vespae 100g, Radix Salviae Miltiorrhizae 100g, Rhizoma Chuanxiong 100g, Flos Carthami 100g, Herba Lycopodii 100g, 20 of Scolopendras, 5 pairs of Geckos, bavin Testis et Pentis Canis 5 tools, Radix Glycyrrhizae 50g.

4. the preparation method of any one described preparation of claim 1-4 is characterized in that: Gecko decaptitates, foot, with each medicine oven dry back porphyrize powder of corresponding proportioning, crosses 120 mesh sieves, and mixes and stir evenly, and the said medicine fine powder of mixing is incapsulated, and promptly gets this preparation.

5. method according to claim 4, after capsule is made, standby behind medical sterilization.

6. according to claim 4 or 5 described methods, after capsule is made, standby after cobalt-60 irradiation is sterilized.