CN1344542A - Production process and product of instant osteocalcium composition - Google Patents
Production process and product of instant osteocalcium composition Download PDFInfo
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- CN1344542A CN1344542A CN01142106A CN01142106A CN1344542A CN 1344542 A CN1344542 A CN 1344542A CN 01142106 A CN01142106 A CN 01142106A CN 01142106 A CN01142106 A CN 01142106A CN 1344542 A CN1344542 A CN 1344542A
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Abstract
The osteocalcium powder composite consists of fast dissolved pearl powder, snake bone powder and eel bone powder, of which the last two is water insoluble and is extracted through modern biochemical process before composited with the fast dissolved pearl powder into instant osteocalcium powder. The instant osteocalcium powder is one kind of multifunctional solid products with complementary protein and calcium and is water soluble instant food.
Description
One, the invention belongs to medicine, health product, special dietary food field.Be that transformation of scientific findings is the productivity's a new product.Through the data-searching of Zhejiang Province Patent Office, do not find the technology identical (reporting attached) with this patent.Calendar year 2001, the conclusion of JIUYUE Nikkei State Patent Office data-searching chamber 1 retrieval was identical with above-mentioned report.
The present invention relates to a kind of Margarita powder, Monopterus albus (Zuiew) bone, the water-fast compositions of snake bone,, select compound carboxylic acid and enzyme (bilingual method) for use, above-mentioned back two kinds of raw materials are separated at normal temperature condition second line of a couplet Heshui, extract calcium (Ca wherein through biochemical method
2+) and 20 multiple trace elements such as range protein such as ossein and aminoacid, zinc, copper.Nutritions such as each seed amino acid to the human body beneficial all are dissolved in water, can improve bioavailability, and can form solid product, and instant, absorption rate are fast.Help the nutrition of skeleton, growth promoter.Bone density improving.So claim " instant bone calcium powder "; More help children's and drink, be called products such as " the instant bone calcium powder of children's ", sheet, capsule again.
Two, compare with existing technical products:
(1) CN1154855A discloses a kind of tonic " Margarita Jin Serpentis essence " primary raw material and extracted active ingredient from 6 kinds of valuable medicinal such as Margarita, Jin Serpentis, Radix Polygoni Multiflori, can be dissolved in water, but fail to form solid product; But liquid preparation.Its raw material, apparatus expensive, and canned transportation inconvenience.
(2) CN116566A discloses a kind of " the preparation of compositions method of snake powder, Testudinis powder " its primary raw material and has combined 80 days powder, the capsule of filling with black-snake, Agkistrodon halys, mountain Testudinis.But the raw material finished product is water insoluble, take after after digesting, can only partly be absorbed and used.
(3) CN126932A discloses " a kind of snake bone product and production method thereof ", its major technique, and snake bone is through cold drying, superfine grinding, granularity is very little, also has that microgranule is floating to be suspended from water and precipitation, and the nonionic state can not be absorbed and used entirely.And need jet mill cost price height.
Three, the know-why of the present invention and the technological process of production:
(1) snake bone, the preparation of Os Monopteri albi solution: with undissolved snake bone powder, inorganic salt in the Monopteri albi bone meal utilizes the biochemical reaction method, select for use Complex to close displacement liquid and snake bone powder that carboxylic acid is diluted to debita spissitudo, the calcium salt of Monopteri albi bone meal, under following condition, in reaction pot, play biochemical reaction, the inorganic calcium that (displacement) compound carboxylate is captured in the raw material generates micromolecule organic salt---multiple compound carboxylate, soluble in water, in order to make the material hydrolysis thorough, the acid protease that in material, adds the 1-2% of suitable raw material weight again, sour again enzyme associating hydrolysis, synchronously Os Monopteri albi, the range protein that dissociates and because of hydrolysis in the snake bone, the ossein hydrolysis produces several amino acids, comprise aminoacid and polypeptide class that human body is necessary, trace element isoreactivity material, all be dissolved in water, therefore, product of the present invention has multiple nutrients and is worth.
The invention is characterized in that the combination of three kinds of raw material science, through biochemical reaction by the biochemistry displacement undissolved " bone meal " being become can dissolved compound carboxylate.Use lactic acid, make displacement liquid, claim compound calcium lactate aqueous solution.Three kinds of material combination not only play complementary action.And, the function singleness auxotype, become composite multi-functional, got rid of the fiber impurity and the flavor of waking up in the raw material bone meal, improved bioavailability.
Embodiment
Four prescriptions:
1, instant Margarita powder (or Margarita powder) is 14 kilograms
2, Monopteri albi bone meal is 3 kilograms
3, the snake bone powder is 3 kilograms
4, deionized water is 64 kilograms
5, adjuvant (total accounts for total amount) 0.05-0.5%
(1), the water-soluble preparation of snake bone Os Monopteri albi:
1, raw material pre-treatment: execution, Serpentis Monopteri albi, remove internal organs, peel off Periostracum Serpentis and meat flesh.Stay vertebrae.And head.With whole vertebraes (comprising bone marrow) and the muscle that adheres to, clean and drain, cut off, with 80-100 ℃, the best remains in 90 ℃ of calorstats, through oven dry in 18 hours, checks that with " KETT " water content expects less than 6% o'clock mountain.1, select for use and put to death similar Serpentis alive and the Monopterus albus (Zuiew) of preceding size.Do experiment, after the drying, vertebrae, skull appearance similar, outward appearance sees that " Figure of description 1 " records calcium content, the snake bone calcic is 6%; 6.2% two kind of raw material calcium content of Monopteri albi calcic is identical substantially with protein.(seeing below table)
2, pulverize: snake bone or Os Monopteri albi, pulverize through high speed disintegrator, it is standby to cross 100 mesh sieves.Take by weighing snake bone powder and Monopterus albus (Zuiew) bone meal equivalent mixing to call " bone meal " in the following text.
3, acidolysis, take by weighing " bone meal " 6 kilograms, put into reaction pot, add and bone meal equal quantities deionized water puddle mixing, be heated to 70-80 ℃ and begin to splash into 15% lactic acid displacement liquid, keep PH3.5-4.5, continue puddle, hydrolysis (attention prevents that material is gone out outside the pot in the reaction pot), bubble (CO does not appear in material in reaction pot
2) shut down.Cooling.
4, sour enzyme associating hydrolysis; When the reaction kettle temperature drops to the 40-45 ℃ of acid protease of transferring PH4.0-4.5 to add suitable raw material 1-2%, puddle hydrolysis 5 hours.The material filtering that takes a morsel should not have microgranule or precipitate routinely and transparent at the bottom of " lamp inspection " test tube, expression hydrolysis biochemical reaction is finished.Otherwise the continuation hydrolysis repeats " lamp inspection ".
5, enzyme denaturing: raise the reaction kettle temperature to 60-65 ℃ 0.5-1 hour, removing simultaneously wakes up in upper foam impurity and the material distinguishes the flavor of.Get material filtering, slagging-off, filterable material returns reaction pot and transfers PH6.0-6.8 to claim " first material ".
(2) preparation of Margarita aqueous solution:
14kg slowly adds in " first material " by prescription middling speed dissolving pearl powder, and reinforced puddle simultaneously adds the back and transfers PH6-6.8, concentrates then → discharging → solidify (crystallization) → stripping and slicing → oven dry → packing → check → warehouse-in (claiming instant bone calcium powder).
Perhaps preparation temporarily, instant Margarita hydrolyzed solution:
Get " autoclave " commonly used, claim the 14Kg Margarita powder, in the stainless steel cask in the autoclave of packing into, add 4 times of water 56kg of suitable raw material weight, mixing therein, heating, pressure in 9-12MPa and relative temperature (106-110 ℃) through 1-2 hour, the raw material after the processing, structure is by the vegetables pine, dissolving, the disassemble autoclave adds compound carboxylic acid in " charging basket ", regulate PH3.0-4.0 under normal pressure, boil, kept 1-2 hour, and boiled on the limit, slightly puddle, get rid of the supernatant foam, remove fishy smell simultaneously, take out and filter, filtrate claims " second material "
(3) instant bone calcium powder is synthetic:
" second material " added reaction pot to be mixed with " first material " in crossing.Add sodium bicarbonate, levelling PH6.0-6.8, the reaction kettle temperature keeps 60-70 ℃, puddle → concentrate → discharging → cool off → solidify → shred → add adjuvant (or exempting to add) → pulverizing → packing → sterilization → check → warehouse-in.
(afterwards seeing Figure of description 2)
Five, the comparison of instant bone calcium powder and Monopteri albi bone meal, snake bone powder calcic and albumen quality: (seeing the following form)
Annotate: " snake bone powder " is " title " that manufacturer provides in the table.
| Instant Margarita powder | Instant bone calcium powder 1 | Instant bone calcium powder 2 | Monopteri albi bone meal | Dragon precious " snake bone powder " | Power good fortune " snake bone powder " | |
| Calcium (g) % | ??17.2 | ??11.3 | ??15.4 | ??6.2 | ????6.0 | ????3.2 |
| Protein (g) % | ??1.8 | ??7.8 | ??8.2 | ??48.1 | ????52.1 | ????53.3 |
| Moisture content (g % | ??6.0 | ??1.5 | ??1.8 | ??2.7 | ????1.6 | ????2.3 |
According to last table as seen: " snake bone powder " calcium content that Monopteri albi bone meal calcium content and other producers provide is basic identical.Therefore it is considered herein that; Available Monopteri albi bone meal replaces the snake bone powder to produce the raw material of calcium-enriching products.Turn waste into wealth.
2, contain protein (total nitrogen) 1.8kg in the instant Margarita powder, calcic 17.2% is that 13.3% protein is 8% when synthesizing the average calcic of instant bone calcium powder with power good fortune " snake bone powder ".Facts have proved and truly have mutual effect.
Claims (7)
1, a kind of Margarita powder, Monopteri albi bone meal, the compositions of snake bone powder insoluble in water, it comprises that both weight ratios of back are for being 15-20%.Instant Margarita weight ratio is 60-70%, selects lactic acid to make displacement liquid, obtains compound calcium lactate, and the solid dosage forms of " instant bone calcium powder " that zinc various trace elements and several amino acids isoreactivity thing are formed can be dissolved in water and can improve bioavailability.
2, according to claim 1: described in compound carboxylic acid mean: lactic acid, glacial acetic acid, phosphoric acid.
3, according to claim 1: described in Os Monopteri albi and snake bone calcium content and protein content, basic identical, therefore it is considered herein that available Os Monopteri albi substitutes snake bone.
4, a kind of production is as claim 1: as described in three kinds of raw materials, method for compositions and production method thereof is characterized in that the Serpentis that lives, Monopteri albi, remove internal organs, peeling meat wash clean dried by the fire 18 hours through 80-90 ℃ in having the baking oven of aerator, get powder then, through compound carboxylic acid, and enzyme hydrolysis, need not add adjuvant and can form solid product.
5, according to the present invention right require 1: described bioactive enzyme is characterized in that selecting for use acidic protein acid, carase, compound protease.
6, according to claim 1: described Monopterus albus (Zuiew) bone meal and its spy of snake bone powder are to find that Os Monopteri albi calcium content and protein content and snake bone powder are basic identical.Monopteri albi bone meal can replace snake bone (powder) as calcium-enriching products and nutriment, turns waste into wealth.
7, according to claim 1: " the instant bone calcium powder " of production is solid preparation, and its feature is filled a prescription selected in the present invention, and consumption is appropriate, and production method and technology are rationally and science.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011421061A CN1141943C (en) | 2001-09-12 | 2001-09-12 | Production process and product of instant osteocalcium composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011421061A CN1141943C (en) | 2001-09-12 | 2001-09-12 | Production process and product of instant osteocalcium composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1344542A true CN1344542A (en) | 2002-04-17 |
| CN1141943C CN1141943C (en) | 2004-03-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011421061A Expired - Fee Related CN1141943C (en) | 2001-09-12 | 2001-09-12 | Production process and product of instant osteocalcium composition |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773249A (en) * | 2010-03-01 | 2010-07-14 | 宋艳 | Method for preparing active peptide calcium from loach and eel bone and sheep placenta |
| CN107893094A (en) * | 2017-11-21 | 2018-04-10 | 常州市阿曼特化工有限公司 | A kind of preparation method of active snake gelatine polypeptide chelate calcium |
| CN108902793A (en) * | 2018-08-26 | 2018-11-30 | 卓小玲 | A kind of preparation method of snakehead enzymolysis liquid |
-
2001
- 2001-09-12 CN CNB011421061A patent/CN1141943C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773249A (en) * | 2010-03-01 | 2010-07-14 | 宋艳 | Method for preparing active peptide calcium from loach and eel bone and sheep placenta |
| CN101773249B (en) * | 2010-03-01 | 2012-05-23 | 宋艳 | Method for preparing active peptide calcium from loach and eel bone and sheep placenta |
| CN107893094A (en) * | 2017-11-21 | 2018-04-10 | 常州市阿曼特化工有限公司 | A kind of preparation method of active snake gelatine polypeptide chelate calcium |
| CN108902793A (en) * | 2018-08-26 | 2018-11-30 | 卓小玲 | A kind of preparation method of snakehead enzymolysis liquid |
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| Publication number | Publication date |
|---|---|
| CN1141943C (en) | 2004-03-17 |
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Granted publication date: 20040317 Termination date: 20100912 |