CN1342476A - Chinese medicine for nourishing Yin and treating constipation - Google Patents
Chinese medicine for nourishing Yin and treating constipation Download PDFInfo
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- CN1342476A CN1342476A CN 00129139 CN00129139A CN1342476A CN 1342476 A CN1342476 A CN 1342476A CN 00129139 CN00129139 CN 00129139 CN 00129139 A CN00129139 A CN 00129139A CN 1342476 A CN1342476 A CN 1342476A
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- constipation
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- relieving constipation
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Abstract
A troditional Chinese medicine in the form of particles for treating constipation is prepared from 6 Chinese medicinal materials including fleece flower root, rehmannia root, Chinese angelica root, etc. through extraction, separating out and removing impurities, spray-drying and granulating. Its advantages are reliable curative effect, and high biological utilization rate.
Description
The present invention is a treatment treaitng Yin-deficiency constipation medicine, is the Chinese medicine granules of feedstock production with Chinese medicine specifically, is applicable to the treaitng Yin-deficiency constipation patient.
Constipation is a kind of common frequently-occurring disease, along with the improving constantly of people's living standard, the change of dietary habit and the quickening of work rhythm, daily life is being perplexed in constipation for a long time, and particularly treaitng Yin-deficiency constipation patient such as women puerperal, old people, habitual constipation suffers untold misery especially.At present, the Chinese patent medicine that is usually used in treating constipation clinically has Fructus Cannabis Bolus, CONGRONG TONGBIAN KOUFUYE, the prescriptions of Chinese medicine that also has some treatment constipation in addition, but these generally can only merely play defecating feces excretion, take and have bigger side effect, form the general back impairment of YIN of rushing down easily------strengthening dosage---the severely injured more cloudy vicious cycle that increases the weight of the constipation symptom for a long time.
Theory of Chinese medical science thinks that the kidney being the origin of congenital constitution, and kidney yin is that the cloudy liquid of the vital organs of the human body is basic, damage of kidney-YIN, and the weary source of the cloudy liquid of large intestine, Tianjin is dried-up puckery, constipation under the constipation difficulty.Existing patent of invention (patent No. 931062683) " can reduce the relieving constipation Chinese medicine of level of human free radical ", make by raw material of Chinese medicine such as the Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Polygoni Multiflori, Radix Achyranthis Bidentatae, Herba Cistanches, Radix Angelicae Sinensis, Fructus Aurantii, Rhizoma Cimicifugaes, has the admittance stool, the treatment functional constipation, senile constipation and with the middle aged constipation patient of senilism symptoms such as the soreness of waist, dizzy, insomnia.This patent patent " a kind of relieving constipation Chinese medicine that does not have purgatives medicine " (application number 991011511) of dividing an application is arranged again, is that raw material is formed by the Radix Rehmanniae, Radix Polygoni Multiflori, Radix Scrophulariae, Radix Ophiopogonis, Radix Angelicae Sinensis, Fructus Aurantii, can alleviate deficiency of YIN symptom again in the admittance stool.
But above-mentioned two prescriptions, the not enough refine of the former used medicine, latter's dosage is accurate inadequately.The present invention has consulted a large amount of documents and materials, and behind the pharmacy of having carried out different compatibilities, different amounts prescription under the guidance of theory of Chinese medical science, pharmacodynamics, toxicology test, main pathogenesis at treaitng Yin-deficiency constipation, determined can the YIN nourishing relieving constipation most preferred prescription: Radix Polygoni Multiflori 24g, Radix Rehmanniae 24g, Radix Ophiopogonis 12g, Radix Scrophulariae 12g, Radix Angelicae Sinensis 12g, Fructus Aurantii 6g, fundamentally treaitng Yin-deficiency constipation is treated.Radix Polygoni Multiflori, the Radix Rehmanniae are monarch drug in the side, and both all have the effect of nourishing kidney-yin relieving constipation.Chinese Angelica blood replonishing loosening bowel to relieve constipation, the relieving constipation of Radix Scrophulariae nourishing YIN to lower pathogenic fire are ministerial drug, and Radix Ophiopogonis, nourishing YIN and moistening the lung was an adjuvant drug, the relieving constipation of Fructus Aurantii circulation of qi promoting intestinal stasis relieving, return to have through large intestine and draw the meaning that all medicines are gone into large intestine, each medicine the kidney invigorating loosening bowel to relieve constipation that is harmonious.
Characteristics of the present invention:
1. compare with " can reduce the relieving constipation Chinese medicine of level of human free radical " (patent No. 931062683), medication refine of the present invention meets the aim of treatment must aim at the pathogenesis of disease.
2. compare with " a kind of relieving constipation Chinese medicine that does not have purgatives medicine " (application number 991011511), medication proportioning of the present invention is accurate.
3. above-mentioned two kinds of Chinese medicines are hospital preparation, and preparation is coarse, carry and take equal inconvenience.The present invention adopts the high-tech extracting method, by remove impurity, concentrate, spray drying, dry granulation, make sugar-free granule, have that dose is little, bioavailability is high, take advantage easy to carry, controlled in addition quality standard is controlled product quality.
4. pharmacodynamic index is clear and definite.Carried out influence respectively to the mouse small intestine motion; Morphine is caused the depressomotor influence of mouse intestinal; Influence to the guinea pig in vitro intestinal tube; Influence to the different intestinal segment moisture content of mice; A series of experiments such as diarrhea inducing effect to mice.The result shows: the present invention can significantly improve the enterokinesia function of mice; The intestinal tension force that morphine is caused increases and the wriggling that produces slows down antagonism is arranged; Reduce tensile the acting on of intestinal and also obtained proof on the intestine in vitro; And can increase moisture content in the mice large intestine intestinal, play loosening bowel to relieve constipation, increase the volumetrical effect of intestinal; Show that by the test of half diarrhea inducing amount diarrhea inducing effect of the present invention is definite, but the discharge function mitigation is applicable to the treaitng Yin-deficiency constipation patient.
5. toxic and side effects is little, does not have the untoward reaction of general cathartic.
The present invention is directed to the main pathogenesis of above-mentioned treaitng Yin-deficiency constipation---damage of kidney-YIN, large intestine Tianjin is withered and select the animal model that increases the big intestinal segment moisture of mice for use, four treatment treaitng Yin-deficiency constipation prescription drug prepared that comprise the present invention have been carried out contrast test, write out a prescription (each material medicine content all is converted into percentage by weight in the side) composed as follows:
Comparative Examples 1:
Prescription: Radix Polygoni Multiflori 21%, the Radix Rehmanniae 23%, Radix Achyranthis Bidentatae 12%, Radix Ophiopogonis 6%, Radix Scrophulariae 7%, Herba Cistanches 10%, Rhizoma Cimicifugae 2%, Radix Angelicae Sinensis 9%, Fructus Aurantii 10%.
This example is patent of invention (patent No. 931062683) embodiment 1 that " can reduce the relieving constipation Chinese medicine of level of human free radical ";
Comparative Examples 2:
Prescription: Radix Polygoni Multiflori 26.67%, Radix Rehmanniae 26.67%, Radix Angelicae Sinensis 13.33%, Radix Ophiopogonis 13.33%, Radix Scrophulariae 13.33%, Fructus Aurantii 6.67%.
This example is a medicine of the present invention;
Comparative Examples 3:
Prescription: Radix Polygoni Multiflori 25%, the Radix Rehmanniae 25%, Radix Ophiopogonis 12.5%, Radix Scrophulariae 12.5%, Radix Angelicae Sinensis 12.5%, Fructus Aurantii 12.5%.
This example is patent of invention " a kind of relieving constipation Chinese medicine that does not have purgatives medicine " (application number 991011511)
Embodiment 1;
Comparative Examples 4:
Prescription: Radix Polygoni Multiflori 38%, the Radix Rehmanniae 12%, Radix Ophiopogonis 12%, Radix Scrophulariae 8%, Radix Angelicae Sinensis 18%, Fructus Aurantii 12%.
This example is patent of invention " a kind of relieving constipation Chinese medicine that does not have purgatives medicine " (application number 991011511)
Embodiment 2.
With each 400g crude drug of above-mentioned Comparative Examples, decoct with water secondary, 2 hours for the first time, 1 hour for the second time, merge medicinal liquid, filter, filtrate is condensed into extractum, is made into 1g (crude drug)/ml, tests.Concrete grammar is as follows:
Select 120 of NIH mices for use, body weight is 20 ± 2g, male and female half and half, fasting is 16 hours before the experiment, can't help water, is divided into 5 groups at random by body weight, every group 24,1 group, 2 groups, 3 groups, 4 groups of Comparative Examples are all irritated stomach and are given the extractum of each Comparative Examples of 20g (crude drug)/Kg (concentration 1g crude drug/ml), the administration volume is 0.2ml/10g, and matched group gives the equal-volume normal saline.After administration 2 hours, 3 hours respectively, each group was got 12 mices and is put to death, and separates large intestine, with silk thread ligation two ends, in case fluid loss takes by weighing weight in wet base, put baking oven in 105 ℃ of bakings 20 hours, took by weighing dry weight.Press the water content that the column count formula calculates big intestinal segment.
The results are shown in following table (n=12) time Comparative Examples 1 Comparative Examples 2 Comparative Examples 3 Comparative Examples 4 contrast 2hr 4.08 ± 0.71** 4.34 ± 0.45*** 4.16 ± 0.77** 3.97 ± 0.70** 3.32 ± 0.3 1 t 3.41 6.53 3.52 2.963hr 4.02 ± 0.71*** 4.21 ± 0.57*** 4.13 ± 0.56*** 4.15 ± 0.71*** 3.05 ± 0.30 t 4.37 6.24 5.95 4.92
Through the t check, compare with matched group: * * *: P＜0.001, * *: P＜0.01.
The result shows: learning processing spec Comparative Examples 2 by statistics is that the present invention is best to the big intestinal segment moisture content increase of mice effect.
Experimental result by the animal model that increases the big intestinal segment moisture content of mice can clearly be seen that, at the main pathogenesis of above-mentioned treaitng Yin-deficiency constipation---and damage of kidney-YIN, large intestine Tianjin is withered and select medicine of the present invention, curative effect the best for use.
Content of the present invention is described further by following examples.
Embodiment 1: raw material of Chinese medicine of the present invention is formed (weight): Radix Polygoni Multiflori 24g, Radix Rehmanniae 24g, Radix Angelicae Sinensis 12g, Radix Ophiopogonis 12g, Radix Scrophulariae 12g, Fructus Aurantii 6g.
Embodiment 2: Radix Polygoni Multiflori 26.67%, Radix Rehmanniae 26.67%, Radix Angelicae Sinensis 13.33%, Radix Ophiopogonis 13.33%, Radix Scrophulariae 13.33%, Fructus Aurantii 6.67%.
Embodiment 3: the method for making of relieving constipation Chinese medicine of the present invention is put multi-function extractor for getting embodiment 1 or 2 Chinese medicines, adds 10 times of water gagings, decoct secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filters, and filtrate is concentrated into relative density 1.10～1.15 (60～65 ℃ of surveys), add dextrin 16.4%, stir, spray drying is granulated, packing, promptly.
Embodiment 4: with the relieving constipation Chinese medicinal granule of embodiment 3 productions, press Ministry of Public Health (92) ZL-04 official written reply, be responsible for jointly logical happy granule (being the present invention) is carried out II phase clinical observation by Longhua Hospital of Chinese Midicine Univ. of Shanghai, the attached SHUGUANG HOSPITAL of Shanghai College of Traditional Chinese Medicine, attached Yueyang hospital of Shanghai College of Traditional Chinese Medicine, Hangzhou, Zhejiang province city institute of traditional Chinese medicine, Hangzhou, Zhejiang province city Red Cross Hospital, between year May in May, 1992 to 1994 treaitng Yin-deficiency constipation is demonstrate,proved 412 examples and carried out random packet, double blind control, perspective clinical trial.The results are shown in following table: the routine % example of the total routine numerical example % example % of recovery from illness produce effects enabledisable total effective rate group % (%) treatment is organized 100 11 11 65 65 19 19 55 95 matched groups, 100 77 21 21 35 35 37 37 63 open-blind groups 212 36 16.98 108 50.94 57 26.88 11 5.18 94.81 and annotated: treatment back treatment group and matched group compare: R treatment group=0.6276, R matched group=0.3724, u=6.2511, P＜0.001
Credit is analysed by statistics, and the curative effect of logical happy groups of grains is apparently higher than matched group (P＜0.001).
Claims (5)
1. the Chinese drugs agentia of energy YIN nourishing relieving constipation.It is characterized in that it is to be made by the Chinese medicine of following weight proportion: Radix Polygoni Multiflori 24g, Radix Rehmanniae 24g, Radix Ophiopogonis 12g, Radix Scrophulariae 12g, Radix Angelicae Sinensis 12g, Fructus Aurantii 6g.
2. the Chinese drugs agentia of the YIN nourishing relieving constipation of claim 1 is characterized in that said medicament is a said dosage form on any pharmaceutics.
3. the Chinese drugs agentia of the YIN nourishing relieving constipation of claim 2 is characterized in that said dosage form is a granule.
4. the preparation method of the Chinese drugs agentia of the YIN nourishing relieving constipation of claim 3 is characterized in that material medicine is placed extraction pot, adds water, decocts secondary, collecting decoction, filter, filtrate concentrates, and adds adjuvant conventional on the pharmaceutics, stirs, spray drying is granulated, packing, promptly.
5. the preparation method of the Chinese drugs agentia of the YIN nourishing relieving constipation of claim 4 is characterized in that said adjuvant is a dextrin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00129139 CN1116063C (en) | 2000-09-14 | 2000-09-14 | Chinese medicine for nourishing yin and treating constipation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00129139 CN1116063C (en) | 2000-09-14 | 2000-09-14 | Chinese medicine for nourishing yin and treating constipation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1342476A true CN1342476A (en) | 2002-04-03 |
| CN1116063C CN1116063C (en) | 2003-07-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00129139 Expired - Fee Related CN1116063C (en) | 2000-09-14 | 2000-09-14 | Chinese medicine for nourishing yin and treating constipation |
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| CN (1) | CN1116063C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943712B (en) * | 2005-10-08 | 2011-12-14 | 刘国飞 | A Chinese traditional medicinal composition for treatment of astriction and its preparation method |
| CN101926877B (en) * | 2009-08-07 | 2012-03-07 | 顺天堂商业(深圳)有限公司 | Composite capable of relaxing bowel and tonifying |
| CN104435697A (en) * | 2014-12-22 | 2015-03-25 | 熊菊莲 | Mashed tea capable of relaxing bowels |
-
2000
- 2000-09-14 CN CN 00129139 patent/CN1116063C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943712B (en) * | 2005-10-08 | 2011-12-14 | 刘国飞 | A Chinese traditional medicinal composition for treatment of astriction and its preparation method |
| CN101926877B (en) * | 2009-08-07 | 2012-03-07 | 顺天堂商业(深圳)有限公司 | Composite capable of relaxing bowel and tonifying |
| CN104435697A (en) * | 2014-12-22 | 2015-03-25 | 熊菊莲 | Mashed tea capable of relaxing bowels |
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| Publication number | Publication date |
|---|---|
| CN1116063C (en) | 2003-07-30 |
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Granted publication date: 20030730 Termination date: 20170914 |