CN1332704C - Process for preparing film coated brain-invigorating kidney-tonifying pills - Google Patents
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Abstract
The present invention relates to a method for preparing film coated pills for invigorating brains and tonifying kidneys, which firstly prepares medicine pill cores and then carries out film coating. The present invention is characterized in that medicine pill cores are made of the following traditional Chinese medicinal material of ginseng, pilose antlers, dog testes and penis, cinnamon, smallflower milkwort herbs with roots, stir-baked fructus arctii, cherokee rose fruits, charred cortex eucommiae, cyathula roots, honeysuckle flowers, forsythia fruits, cicada slough, Chinese yams, radix polygalae preparata, jujube seeds, amomum fruits, Chinese angelica roots, calcined os draconis, calcined concha ostreae, tuckahoe, parched white peony roots, cassia twigs, licorice, stir-baked radix polygalae preparata and nutmeg through cleaning, pulverizing and pelletizing processes, a coating machine uses a spray gun to uniformly spray macromolecule film forming and coating solution on the qualified pill cores in a film coating process, and the macromolecule film forming and coating solution is made from cellulose, colorant, a covering agent and a solvent.
Description
Technical field
The invention belongs to a kind of art for coating of pill, relate in particular to a kind of film-coated brain-tonifying and kidney-nourishing method for producing pills.
Background technology
Brain-invigorating and kidney-tonifying pill is the Chinese patent medicine (16 in Chinese traditional patent formulation preparation records) of brain-tonifying and kidney-nourishing, replenishing QI to invigorate the spleen, tranquilizing the mind, is the Cinnabaris coating originally, and Chinese medicine uses when rectifying that iron oxide red is painted, sugar coating technology instead, uses till today.Its defective is: the operating time is long, and it is many to expend the energy, dust from flying, and environmental pollution is serious, and it is healthy to influence pill quality and workman.Its main coating material is iron oxide red, Pulvis Talci, starch, Resina persicae and sucrose, and wherein amount of talc accounts for 18% of pill weight, and Pulvis Talci is a Chinese crude drug, also is commonly used for coating material; It is cold in nature, and gastrointestinal tract is had zest, and the tissue that is polluted by Pulvis Talci easily granulates swollen, sucks the Pulvis Talci dust enduringly and can cause pneumoconiosis, takes for a long time, to healthy potential hazard is arranged.
Film coating and traditional art for coating comparison, with short production cycle, save coating material, labor strength is low, can " locked in " operation, and clean environment, finished product outward appearance rounding light, humidity resistance is strong, is the art for coating of a kind of development in recent years update of getting up.
Summary of the invention
The objective of the invention is by experimental study, processability is good, contain the less film-coated brain-invigorating and kidney-tonifying pill of adjuvant.
Technical scheme of the present invention is:
Develop a kind of film-coated brain-tonifying and kidney-nourishing method for producing pills, press pill manufacture method preparation medicine ball core earlier, carry out film coating again, it is characterized in that:
(1) by the Chinese crude drug of following part by weight, prepares medicine ball core by clean system, pulverizing, pelletizing process;
Radix Ginseng 26.25～33.75g, Cornu Cervi Pantotrichum 5.13～7.88g, Penis et testis canitis 12.25～15.75g, Cortex Cinnamomi 26.25～33.75g, Herba Polygalae Telephioidis 10.5～13.5g, Fructus Arctii (parched) 15.75～20.25g, Fructus Rosae Laevigatae 10.5～13.5 g, charred Cortex Eucommiae 31.5～40.5g, Radix Cyathulae 31.5～40.5g, Flos Lonicerae 22.75～29.25g, Fructus Forsythiae 21～27g, Periostracum Cicadae 21～27g, Rhizoma Dioscoreae 42～54g, Radix Polygalae (processed) 36.75～47.25g, Semen Ziziphi Spinosae 36.75～47.25g, Fructus Amomi 36.75～47.25g, Radix Angelicae Sinensis 31.5～40.5g, Os Draconis (calcined) 30.65～39.35g, Concha Ostreae (calcined) 36.75～47.25g, Poria 73.5～94.5g, Rhizoma Atractylodis Macrocephalae (parched) 36.75～47.25g, Ramulus Cinnamomi 30.65～39.35g, Radix Glycyrrhizae 24.5～31.5g, Radix Paeoniae Alba (parched) 30.65～39.35g, Fructus Amomi Rotundus 30.65～39.35g;
(2) film coating process, be in the coating machine with spray gun with the macromolecule filming coating solution, evenly be sprayed onto on the qualified ball core of preparation;
(3) the macromolecule filming coating solution is by the film former cellulose, coloring agent, covering agent and solvent preparation.
Above-mentioned a kind of film-coated brain-tonifying and kidney-nourishing method for producing pills is characterized in that:
(1) film coating liquid is formed film former cellulose 14.7～24.5 weight portions,
Covering agent 15～25 weight portions,
Coloring agent 11.25～18.75 weight portions,
Solvent 500～900 weight portions;
1. with the film former cellulose with dissolution with solvents or soak 6～12h;
2. covering agent, coloring agent are under agitation added mixing in the cellulosic ethanol solution, filter, promptly get film coating liquid;
(2) film-coated method is
The brain-invigorating and kidney-tonifying pill ball core of suitable size is placed coating pan, to ball core progressive spraying coating solution, the ball core is evenly wrapped up under the rolling condition, form complete red film coating ball promptly.
Above-mentioned a kind of film-coated brain-tonifying and kidney-nourishing method for producing pills is characterized in that the film former cellulose is a hydroxypropyl emthylcellulose, hydroxypropyl cellulose, methylcellulose or ethyl cellulose; Coloring agent is Hongqu powder (red colouring agent), Sunset yellow aluminum lake or amaranth; Covering agent is Pulvis Talci or titanium dioxide; Solvent is 60～90% ethanol or purified water.
The present invention compared with prior art has the following advantages:
1. the film forming matter chemical property is stable and do not have physiology toxicity;
2. new art for coating material-saving, power saving, saving of labor, and coatings fast drying, medicine is influenced by heat little, helps improving drug quality;
3. behind the coating, ball heavily increases seldom, usually only be ball heavy 2～4%, significantly reduced the consumption of adjuvant Pulvis Talci etc.;
4. the protection against the tide of this film-coat, heat resistanceheat resistant, the cold-resistant abrasion resistance properties that reaches all are better than traditional sugar coating technology, have improved the stability of pill, have prolonged storage period.
The specific embodiment
Embodiment 1
1. make brain-invigorating and kidney-tonifying pill ball core, its medicine dosage is as follows:
Radix Ginseng 30g, Cornu Cervi Pantotrichum 7g, Penis et testis canitis 14g, Cortex Cinnamomi 30g, Herba Polygalae Telephioidis 12g, Fructus Arctii (parched) 18g, Fructus Rosae Laevigatae 12, charred Cortex Eucommiae 36g, Radix Cyathulae 36g, Flos Lonicerae 26g, Fructus Forsythiae 24g, Periostracum Cicadae 24g, Rhizoma Dioscoreae 48g, Radix Polygalae (processed) 42g, Semen Ziziphi Spinosae 42g, Fructus Amomi 42g, Radix Angelicae Sinensis 36g, Os Draconis (calcined) 35g, Concha Ostreae (calcined) 42g, Poria 84g, Rhizoma Atractylodis Macrocephalae (parched) 42g, Ramulus Cinnamomi 35g, Radix Glycyrrhizae 28g, Radix Paeoniae Alba (parched) 35g, Fructus Amomi Rotundus 35g;
Wherein, described medical material is meant:
Radix Ginseng Radix Ginseng, Cornu Cervi Pantotrichum Cornu Cervi Pantotrichum, Penis et testis canitis Penis Et Testis Canis, Cortex Cinnamomi CortexCinnamomi, Herba Polygalae Telephioidis (being the dry herb of Sinopteridaceae plant Aleuritopteris argentea (Gmel.) Fee Aleurito prerisargentea (Gmel) Fe ' e), Fructus Arctii (stir-fry) Fructus Arctii, Fructus Rosae Laevigatae Fructus Rosae Laevigatae, the Cortex Eucommiae (charcoal) Cortex Eucommiae, Radix Cyathulae Radix Cyathulae, Flos Lonicerae Flos Lonicerae, Fructus Forsythiae Fructus Forsythiae, Periostracum Cicadae Periostracum Cicadae, Rhizoma Dioscoreae Rhizoma Dioscoreae, Radix Polygalae (liquorice beverage system) Radix Polygalae, Semen Ziziphi Spinosae (stir-fry) Semen Ziziphi Spinosae, Fructus Amomi Fructus Amomi, Radix Angelicae Sinensis Radix Angelicae Sinensis, Os Draconis (forging) Os Draconis, Concha Ostreae (forging) Concha Ostreae, Poria Poria, the Rhizoma Atractylodis Macrocephalae (parched with bran) Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi Ramulus Cinnamomi, Radix Glycyrrhizae RadixGlycyrrhizae, the Radix Paeoniae Alba (wine stir-fry) Radix Paeoniae Alba, Fructus Amomi Rotundus Fructus Amomi Rotundus.
All concocting methods, as stir-fry, charcoal, liquorice beverage system, forge, parched with bran and wine fries, all by Chinese Pharmacopoeia this item time pertinent regulations respectively.
The method for making of brain-invigorating and kidney-tonifying pill ball core is: be ground into fine powder, mixing with being mixed in proportion after the clean system of above-mentioned 25 flavor Chinese medicines; With general system or mould system method pill, drying.
2. the composition of film coating liquid:
Hydroxypropyl emthylcellulose 14.7g
Pulvis Talci 15.0g
Hongqu powder (red colouring agent) 11.25g
Sunset yellow aluminum lake 0.60g
90% ethanol 500
*Hydroxypropyl emthylcellulose also claims hypromellose (Hypromellose), 2-hydroxypropyl ether methylcellulose.
Used pigment, Hongqu powder (red colouring agent) (Red Yeast Rice), Sunset yellow aluminum lake (Sunset yellow aluminium lake), amaranth (Amaranth) all mean the pigment commodity that are used for the painted acquisition safety approval of food, medicine, cosmetics.
Purified water is drinking water meets the Chinese Pharmacopoeia regulation through the quality of distillation, ion exchange or hyperfiltration preparation a purified water.
3. film-coated manufacturing process is
(1) with hydroxypropyl emthylcellulose with dissolve with ethanol or soak 6～12h;
(2) Hongqu powder (red colouring agent), Pulvis Talci, Sunset yellow aluminum lake are under agitation added mixing in the cellulosic ethanol solution, filter, promptly get film coating liquid;
(3) the brain-invigorating and kidney-tonifying pill ball core with suitable size places coating pan, sprays coating solution to the ball core under the rolling condition, evenly is wrapped to form complete thin film promptly.Ratio spraying coating solution in per kilogram pill spray coating solution 400 ± 50ml.
(4) pill behind the taking-up coating is drying to obtain film-coated brain-invigorating and kidney-tonifying pill.
Embodiment 2
1. make brain-invigorating and kidney-tonifying pill ball core, its medicine dosage is as follows:
Radix Ginseng 26.25g, Cornu Cervi Pantotrichum 5.13g, Penis et testis canitis 12.25g, cinnamon 26.25g, Herba Polygalae Telephioidis 10.5g, Fructus Arctii (parched) 15.75g, Fructus Rosae Laevigatae 10.5g, charred Cortex Eucommiae 31.5g, Radix Cyathulae 31.5g, Flos Lonicerae 22.75g, Fructus Forsythiae 21g, Periostracum Cicadae 21g, Rhizoma Dioscoreae 42g, Radix Polygalae (processed) 36.75g, Semen Ziziphi Spinosae 36.75g, Fructus Amomi 36.75g, Radix Angelicae Sinensis 31.5g, Os Draconis (calcined) 30.65g, Concha Ostreae (calcined) 36.75g, Poria 73.5g, Rhizoma Atractylodis Macrocephalae (parched) 36.75g, Ramulus Cinnamomi 30.65g, Radix Glycyrrhizae 24.5g, Radix Paeoniae Alba (parched) 30.65g, Fructus Amomi Rotundus 30.65g.
2. the composition of film coating liquid:
Hydroxypropyl cellulose 19.6g
Titanium dioxide 20.0g
Hongqu powder (red colouring agent) 15.0g
Sunset yellow aluminum lake 0.60g
60% ethanol 600g
*Hydroxypropyl cellulose also claims hyprolose (Hyprolose), the low 2-of replacement hydroxypropyl ether cellulose; All the other are with embodiment 1.
Embodiment 3
1. make brain-invigorating and kidney-tonifying pill ball core, its medicine dosage is as follows:
Radix Ginseng 33.75g, Cornu Cervi Pantotrichum 7.88g, Penis et testis canitis 15.75g, Cortex Cinnamomi 33.75g, Herba Polygalae Telephioidis 13.5g, Fructus Arctii (parched) 20.25g, Fructus Rosae Laevigatae 13.5g, charred Cortex Eucommiae 40.5g, Radix Cyathulae 40.5g, Flos Lonicerae 29.25g, Fructus Forsythiae 27g, Periostracum Cicadae 27g, Rhizoma Dioscoreae 54g, Radix Polygalae (processed) 47.25g, Semen Ziziphi Spinosae 47.25g, Fructus Amomi 47.25g, Radix Angelicae Sinensis 40.5g, Os Draconis (calcined) 39.35g, Concha Ostreae (calcined) 47.25g, Poria 94.5g, Rhizoma Atractylodis Macrocephalae (parched) 47.25g, Ramulus Cinnamomi 39.35g, Radix Glycyrrhizae 31.5g, Radix Paeoniae Alba (parched) 39.35g, Fructus Amomi Rotundus 39.35g.
2. the composition of film coating liquid:
Methylcellulose 24.5g
Pulvis Talci 25.0g
Amaranth 18.15g
Sunset yellow aluminum lake 0.60g
90% ethanol 200g
Purified water 400g
*Methylcellulose (Methylcellulose) also claim the methyl ether cellulose;
Earlier with methylcellulose with dissolve with ethanol or soak 6～12h, stirring adds purified water down, Hongqu powder (red colouring agent), Pulvis Talci, Sunset yellow aluminum lake is added mixing under stirring again, filters, and promptly gets film coating liquid.All the other are with embodiment 1.
Embodiment 4
1. the medicine dosage of brain-invigorating and kidney-tonifying pill ball core is as follows:
Radix Ginseng 33.75g, Cornu Cervi Pantotrichum 7.88g, Penis et testis canitis 15.75g, Cortex Cinnamomi 33.75g, Herba Polygalae Telephioidis 13.5g, Fructus Arctii (parched) 20.25g, Fructus Rosae Laevigatae 13.5g, charred Cortex Eucommiae 40.5g, Radix Cyathulae 40.5g, Flos Lonicerae 29.25g, Fructus Forsythiae 27g, Periostracum Cicadae 27g, Rhizoma Dioscoreae 54g, Radix Polygalae (processed) 47.25g, Semen Ziziphi Spinosae 47.25g, Fructus Amomi 47.25g, Radix Angelicae Sinensis 40.5g, Os Draconis (calcined) 39.35g, Concha Ostreae (calcined) 47.25g, Poria 94.5g, Rhizoma Atractylodis Macrocephalae (parched) 47.25g, Ramulus Cinnamomi 39.35g, Radix Glycyrrhizae 31.5g, Radix Paeoniae Alba (parched) 39.35g, Fructus Amomi Rotundus 39.35g.
2. the composition of film coating liquid:
Ethyl cellulose 20.0g
Titanium dioxide 15.0g
Amaranth 15.0g
60% ethanol 600g
*Ethyl cellulose (Ethylcellulose) also claim the ethylether cellulose.
Earlier with ethyl cellulose with dissolve with ethanol or soaked overnight; Again amaranth, Pulvis Talci are joined mixing in the cellulosic ethanol solution under stirring, filter, promptly get film coating liquid.All the other are with embodiment 1.
Embodiment 5
1. the medicine dosage of brain-invigorating and kidney-tonifying pill ball core is as follows:
Radix Ginseng 26.25g, Cornu Cervi Pantotrichum 5.13g, Penis et testis canitis 12.25g, Cortex Cinnamomi 26.25g, Herba Polygalae Telephioidis 10.5g, Fructus Arctii (parched) 15.75g, Fructus Rosae Laevigatae 10.5g, charred Cortex Eucommiae 31.5g, Radix Cyathulae 31.5g, Flos Lonicerae 22.75g, Fructus Forsythiae 21g, Periostracum Cicadae 21g, Rhizoma Dioscoreae 42g, Radix Polygalae (processed) 36.75g, Semen Ziziphi Spinosae 36.75g, Fructus Amomi 36.75g, Radix Angelicae Sinensis 31.5g, Os Draconis (calcined) 30.65g, Concha Ostreae (calcined) 36.75g, Poria 73.5g, Rhizoma Atractylodis Macrocephalae (parched) 36.75g, Ramulus Cinnamomi 30.65g, Radix Glycyrrhizae 24.5g, Radix Paeoniae Alba (parched) 30.65g, Fructus Amomi Rotundus 30.65g.
2. the composition of film coating liquid:
Ethyl cellulose 24.5g
Titanium dioxide 25.0g
Amaranth 11.25g
Purified water 500g
Earlier ethyl cellulose is dissolved or soak 6～12h with purified water, stirring adds purified water down, amaranth, titanium dioxide is added mixing under stirring again, filters, and promptly gets film coating liquid.All the other are with embodiment 1.
Embodiment 6
Brain-invigorating and kidney-tonifying pill ball core, its medicine dosage is as follows:
Radix Ginseng 26.25g, Cornu Cervi Pantotrichum 5.13g, Penis et testis canitis 12.25g, Cortex Cinnamomi 26.25g, Herba Polygalae Telephioidis 10.5g, Fructus Arctii (parched) 15.75g, Fructus Rosae Laevigatae 10.5g, charred Cortex Eucommiae 31.5g, Radix Cyathulae 31.5g, Flos Lonicerae 22.75g, Fructus Forsythiae 21g, Periostracum Cicadae 21g, Rhizoma Dioscoreae 42g, Radix Polygalae (processed) 36.75g, Semen Ziziphi Spinosae 36.75g, Fructus Amomi 36.75g, Radix Angelicae Sinensis 31.5g, Os Draconis (calcined) 30.65g, Concha Ostreae (calcined) 36.75g, Poria 73.5g, Rhizoma Atractylodis Macrocephalae (parched) 36.75g, Ramulus Cinnamomi 30.65g, Radix Glycyrrhizae 24.5g, Radix Paeoniae Alba (parched) 30.65g, Fructus Amomi Rotundus 30.65g.
2. the composition of film coating liquid:
Hydroxypropyl emthylcellulose 14.7g
Titanium dioxide 15.0g
Amaranth 11.25g
Sunset yellow aluminum lake 0.60g
90% ethanol 900g
Film-coated manufacturing process is
1, with hydroxypropyl emthylcellulose with dissolve with ethanol or soak 6～12h;
2, titanium dioxide, amaranth, Sunset yellow aluminum lake are joined mixing in the cellulosic ethanol solution under stirring, filter, promptly get film coating liquid.All the other are with embodiment 1.
Claims (1)
1. a film-coated brain-tonifying and kidney-nourishing method for producing pills is pressed pill manufacture method preparation medicine ball core earlier, carries out film coating again, it is characterized in that:
(1) by the Chinese crude drug of following part by weight, prepares medicine ball core by clean system, pulverizing, pelletizing process;
Radix Ginseng 26.25～33.75g, Cornu Cervi Pantotrichum 5.13～7.88g, Penis et testis canitis 12.25～15.75g, Cortex Cinnamomi 26.25～33.75g, Herba Polygalae Telephioidis 10.5～13.5g, Fructus Arctii (parched) 15.75～20.25g, Fructus Rosae Laevigatae 10.5～13.5g, charred Cortex Eucommiae 31.5～40.5g, Radix Cyathulae 31.5～40.5g, Flos Lonicerae 22.75～29.25g, Fructus Forsythiae 21～27g, Periostracum Cicadae 21～27g, Rhizoma Dioscoreae 42～54g, Radix Polygalae (processed) 36.75～47.25g, Semen Ziziphi Spinosae 36.75～47.25g, Fructus Amomi 36.75～47.25g, Radix Angelicae Sinensis 31.5～40.5g, Os Draconis (calcined) 30.65～39.35g, Concha Ostreae (calcined) 36.75～47.25g, Poria 73.5～94.5g, Rhizoma Atractylodis Macrocephalae (parched) 36.75～47.25g, Ramulus Cinnamomi 30.65～39.35g, Radix Glycyrrhizae 24.5～31.5g, Radix Paeoniae Alba (parched) 30.65～39.35g, Fructus Amomi Rotundus 30.65～39.35g;
(2) film coating liquid is formed
The film former cellulose is a hydroxypropyl emthylcellulose, hydroxypropyl cellulose, methylcellulose or ethyl cellulose;
Coloring agent is Hongqu powder (red colouring agent), Sunset yellow aluminum lake or amaranth;
Covering agent is Pulvis Talci or titanium dioxide;
Solvent is purified water or 60%～90% ethanol;
Wherein:
Film former cellulose 14.7～24.5 weight portions,
Covering agent 15～25 weight portions,
Coloring agent 11.25～18.75 weight portions,
Solvent 500～900 weight portions;
(3) film-coated method is:
1. with the film former cellulose with dissolution with solvents or soak 6～12h;
2. covering agent, coloring agent are joined mixing in the cellulose solution under stirring, filter, get film coating liquid;
The brain-invigorating and kidney-tonifying pill ball core of suitable size is placed coating pan, under the rolling condition, with the macromolecule membrane coating solution, evenly be sprayed onto on the qualified ball core of preparation, the ball core is evenly wrapped up, form complete red film coating ball with spray gun.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100127643A CN1332704C (en) | 2005-08-27 | 2005-08-27 | Process for preparing film coated brain-invigorating kidney-tonifying pills |
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| CNB2005100127643A CN1332704C (en) | 2005-08-27 | 2005-08-27 | Process for preparing film coated brain-invigorating kidney-tonifying pills |
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| CN1332704C true CN1332704C (en) | 2007-08-22 |
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| CN107789568B (en) * | 2016-08-31 | 2021-06-11 | 荣昌制药(淄博)有限公司 | A Chinese medicinal composition for strengthening brain and invigorating kidney, and its preparation method |
| CN114223864A (en) * | 2021-12-30 | 2022-03-25 | 山东双贝食品有限公司 | Chinese yam product with fruit composite flavor and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1117389A (en) * | 1994-08-25 | 1996-02-28 | 山东临清中药厂 | Method for prepn. of bolus with function of invigorating brain and tonifying kidney |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1117389A (en) * | 1994-08-25 | 1996-02-28 | 山东临清中药厂 | Method for prepn. of bolus with function of invigorating brain and tonifying kidney |
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